Published in J Biol Chem on December 21, 2001
Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci U S A (2010) 1.54
The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids (2007) 1.46
Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J (2010) 1.42
Understanding obesity and endometrial cancer risk: opportunities for prevention. Am J Obstet Gynecol (2011) 1.42
Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements. J Biol Chem (2009) 1.38
Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PLoS One (2009) 1.35
Estradiol-17beta regulates mouse uterine epithelial cell proliferation through insulin-like growth factor 1 signaling. Proc Natl Acad Sci U S A (2007) 1.34
IGF-1R as an anti-cancer target--trials and tribulations. Chin J Cancer (2013) 1.31
Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. Steroids (2008) 1.30
Soy diet worsens heart disease in mice. J Clin Invest (2006) 1.29
Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A (2006) 1.17
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology (2008) 1.16
GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERα) phosphorylation signals. Endocrinology (2011) 1.11
Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus. Biol Reprod (2009) 1.06
CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP. Genes Dev (2010) 1.05
Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends Mol Med (2013) 1.05
Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathway. BMC Cancer (2007) 1.02
Regulation of ERalpha-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: implications for breast cancer cell survival. Int J Oncol (2010) 1.01
BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site. Cell Death Dis (2012) 0.99
Genetic evidence that thyroid hormone is indispensable for prepubertal insulin-like growth factor-I expression and bone acquisition in mice. J Bone Miner Res (2012) 0.97
Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth. Breast Cancer Res Treat (2011) 0.96
Placental expression of estrogen receptor beta and its hormone binding variant--comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells. Reprod Biol Endocrinol (2003) 0.96
Genomics of signaling crosstalk of estrogen receptor alpha in breast cancer cells. PLoS One (2008) 0.93
Liganded and unliganded activation of estrogen receptor and hormone replacement therapies. Biochim Biophys Acta (2011) 0.93
Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function. Breast Cancer Res (2002) 0.91
Estrogen hormone physiology: reproductive findings from estrogen receptor mutant mice. Reprod Biol (2013) 0.91
Regulation of Akt expression and phosphorylation by 17beta-estradiol in the rat uterus during estrous cycle. Reprod Biol Endocrinol (2003) 0.89
Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-α and -β via the IGF-1 and the insulin receptors in breast cancer cells. Growth Factors (2011) 0.88
Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology. Steroids (2008) 0.88
Regulation of facilitative glucose transporters and AKT/MAPK/PRKAA signaling via estradiol and progesterone in the mouse uterine epithelium. Biol Reprod (2009) 0.87
Role of nuclear receptors in blastocyst implantation. Semin Cell Dev Biol (2013) 0.87
Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer. Discov Med (2012) 0.87
The role of estrogen in the pathophysiology of tubal ectopic pregnancy. Am J Transl Res (2012) 0.86
Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Am J Pathol (2011) 0.84
Dopaminergic activation of estrogen receptors induces fos expression within restricted regions of the neonatal female rat brain. PLoS One (2008) 0.84
Chemical communication threatened by endocrine-disrupting chemicals. Environ Health Perspect (2004) 0.83
The effect of relaxin on cell proliferation in mouse cervix requires estrogen receptor {alpha} binding to estrogen response elements in stromal cells. Endocrinology (2010) 0.83
Cell cycle dependent oscillatory expression of estrogen receptor-α links Pol II elongation to neoplastic transformation. Proc Natl Acad Sci U S A (2014) 0.82
The conundrum of estrogen receptor oscillatory activity in the search for an appropriate hormone replacement therapy. Endocrinology (2011) 0.81
Estrogen signaling crosstalk: Implications for endocrine resistance in ovarian cancer. J Steroid Biochem Mol Biol (2014) 0.81
Insulin-like growth factor 1 mRNA expression in the uterus of streptozotocin-treated diabetic mice. J Reprod Dev (2013) 0.79
Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer. Breast Cancer Res (2003) 0.79
Gαo potentiates estrogen receptor α activity via the ERK signaling pathway. J Endocrinol (2012) 0.79
Long-term consequences of estrogens administered in midlife on female cognitive aging. Horm Behav (2015) 0.77
Protein reporter bioassay systems for the phenotypic screening of candidate drugs: a mouse platform for anti-aging drug screening. Sensors (Basel) (2012) 0.77
Is there an estrogenic component in the metabolic syndrome? Genes Nutr (2006) 0.77
A Role for Androgens in Epithelial Proliferation and Formation of Glands in the Mouse Uterus. Endocrinology (2016) 0.77
IGF-1 gene expression is differentially regulated by estrogen receptors α and β in mouse endometrial stromal cells and ovarian granulosa cells. J Reprod Dev (2014) 0.76
Biologic roles of estrogen receptor-β and insulin-like growth factor-2 in triple-negative breast cancer. Biomed Res Int (2015) 0.75
Growth Hormone Ameliorates the Radiotherapy-Induced Ovarian Follicular Loss in Rats: Impact on Oxidative Stress, Apoptosis and IGF-1/IGF-1R Axis. PLoS One (2015) 0.75
Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1. Endocrinology (2017) 0.75
Estrogen receptors and human disease. J Clin Invest (2006) 4.91
Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med (2007) 4.21
Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12
Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron (2006) 3.04
Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res (2004) 2.98
Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A (2006) 2.59
In vivo imaging of transcriptionally active estrogen receptors. Nat Med (2002) 2.50
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Critical in vivo roles for classical estrogen receptors in rapid estrogen actions on intracellular signaling in mouse brain. Endocrinology (2004) 2.26
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med (2007) 2.18
International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev (2006) 2.15
Estrogen receptor-beta is critical to granulosa cell differentiation and the ovulatory response to gonadotropins. Endocrinology (2005) 2.15
Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen. Mol Endocrinol (2003) 2.12
Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta. Mol Endocrinol (2003) 2.11
Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol Endocrinol (2003) 2.03
Lessons in estrogen biology from knockout and transgenic animals. Annu Rev Physiol (2005) 1.99
An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc Natl Acad Sci U S A (2003) 1.93
Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol Sci (2004) 1.92
Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest (2010) 1.90
Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci U S A (2003) 1.87
Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice. Am J Respir Crit Care Med (2006) 1.86
FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (2010) 1.86
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J (2010) 1.82
17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization. Mol Cell Biol (2005) 1.80
Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol Endocrinol (2002) 1.78
Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity. Endocrinology (2003) 1.73
It's all about sex: gender, lung development and lung disease. Trends Endocrinol Metab (2007) 1.72
Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinology (2002) 1.67
Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues. Reproduction (2003) 1.67
Silver paper: the future of health promotion and preventive actions, basic research, and clinical aspects of age-related disease--a report of the European Summit on Age-Related Disease. Aging Clin Exp Res (2009) 1.61
Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements. J Biol Chem (2006) 1.60
Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo. J Neurosci (2003) 1.58
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. J Clin Invest (2011) 1.55
Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci U S A (2010) 1.54
A lack of ovarian function increases neuroinflammation in aged mice. Endocrinology (2012) 1.53
Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes (2009) 1.53
Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol (2009) 1.52
Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A (2011) 1.52
Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J (2010) 1.48
The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad. Endocrinology (2006) 1.48
Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury. J Mol Cell Cardiol (2005) 1.47
The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids (2007) 1.46
Regulation of postnatal lung development and homeostasis by estrogen receptor beta. Mol Cell Biol (2003) 1.44
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One (2008) 1.44
Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J (2010) 1.42
Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am J Physiol Heart Circ Physiol (2004) 1.41
Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements. J Biol Chem (2009) 1.38
Signal transduction. A new mediator for an old hormone? Science (2005) 1.38
The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies. Am J Physiol Lung Cell Mol Physiol (2007) 1.38
Myelination is altered in insulin-like growth factor-I null mutant mice. J Neurosci (2002) 1.37
Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J Immunol (2007) 1.36
Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PLoS One (2009) 1.35
Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions. Biol Reprod (2002) 1.32
Estrogens in the nervous system: mechanisms and nonreproductive functions. Annu Rev Physiol (2004) 1.32
Increased blood pressure in mice lacking cytochrome P450 2J5. FASEB J (2008) 1.30
Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J Biol Chem (2003) 1.28
Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc Natl Acad Sci U S A (2010) 1.28
CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products. J Pharmacol Exp Ther (2004) 1.26
Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor. Biochem Pharmacol (2004) 1.26
Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J Biol Chem (2006) 1.26
Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism. Mol Endocrinol (2004) 1.24
Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases. Front Neuroendocrinol (2008) 1.23
Estrogen receptors and human disease: an update. Arch Toxicol (2012) 1.22
Estren behaves as a weak estrogen rather than a nongenomic selective activator in the mouse uterus. Endocrinology (2006) 1.22
Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer. Cancer Res (2008) 1.21
Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Stroke (2005) 1.20
Research resource: whole-genome estrogen receptor α binding in mouse uterine tissue revealed by ChIP-seq. Mol Endocrinol (2012) 1.20
The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype. Cancer Res (2005) 1.19
In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER){alpha} and ER{beta} null mice indicate a role for ER{beta} in follicular maturation. Endocrinology (2005) 1.19
Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu. Cancer Res (2002) 1.18
Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell. Endocrinology (2003) 1.17
Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol. Mol Endocrinol (2009) 1.17
Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A (2006) 1.17
Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction. Circulation (2005) 1.17
Estrogen induces estrogen receptor alpha-dependent cAMP response element-binding protein phosphorylation via mitogen activated protein kinase pathway in basal forebrain cholinergic neurons in vivo. J Neurosci (2006) 1.16
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology (2008) 1.16
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities. Mol Pharmacol (2004) 1.15
Critical role for estrogen receptor alpha in negative feedback regulation of gonadotropin-releasing hormone mRNA expression in the female mouse. Neuroendocrinology (2003) 1.14
The endogenous estrogen status regulates microglia reactivity in animal models of neuroinflammation. Endocrinology (2006) 1.13
Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model. Endocrinology (2012) 1.13
Estrogen receptors: structure, mechanisms and function. Rev Endocr Metab Disord (2002) 1.12
Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environ Health Perspect (2013) 1.12
Impact on bone of an estrogen receptor-alpha gene loss of function mutation. J Clin Endocrinol Metab (2008) 1.12
Effect of ER-beta gene disruption on estrogenic regulation of anxiety in female mice. Physiol Behav (2008) 1.12
Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro. Environ Health Perspect (2012) 1.11
Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms. Environ Health Perspect (2009) 1.11
Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice. Brain Res Mol Brain Res (2002) 1.10
Evolutionary trace-based peptides identify a novel asymmetric interaction that mediates oligomerization in nuclear receptors. J Biol Chem (2005) 1.10
A novel peroxisome proliferator-activated receptor responsive element-luciferase reporter mouse reveals gender specificity of peroxisome proliferator-activated receptor activity in liver. Mol Endocrinol (2006) 1.10
Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1. Cell Metab (2011) 1.10
Estrogen receptor knockout mice as a model for endocrine research. ILAR J (2004) 1.09
Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators. Proc Natl Acad Sci U S A (2011) 1.08