ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.

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Published in J Exp Med on November 03, 2008

Authors

Jared M Odegard1, Benjamin R Marks, Leah D DiPlacido, Amanda C Poholek, Dwight H Kono, Chen Dong, Richard A Flavell, Joe Craft

Author Affiliations

1: Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.

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Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol (2002) 3.04

Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol (2005) 2.96

CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A (2003) 2.94

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest (2008) 2.91

Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity (2010) 2.90

Characterization of mouse and human B7-H3 genes. J Immunol (2002) 2.86

Regulation of the Th2 cytokine locus by a locus control region. Immunity (2003) 2.84