Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 2930681)

Published in J Biol Chem on June 17, 2010

Authors

Cheryl Habrukowich1, David K Han, Andrew Le, Karim Rezaul, Wei Pan, Mallika Ghosh, Zaiguo Li, Kimberly Dodge-Kafka, Xuejun Jiang, Robert Bittman, Timothy Hla

Author Affiliations

1: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, Center for Vascular Biology, New York, New York 10065, USA.

Articles citing this

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol (2010) 1.53

Sphingolipid signaling in metabolic disorders. Cell Metab (2012) 1.37

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood (2013) 1.14

The tumor suppressor CDKN3 controls mitosis. J Cell Biol (2013) 1.01

Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease. Future Med Chem (2011) 0.98

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase. FEBS J (2015) 0.93

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages. Eur J Immunol (2011) 0.92

Cracking the ANP32 whips: important functions, unequal requirement, and hints at disease implications. Bioessays (2014) 0.88

Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules (2014) 0.83

Aging- and injury-related differential apoptotic response in the dentate gyrus of the hippocampus in rats following brain trauma. Front Aging Neurosci (2013) 0.83

FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatr Blood Cancer (2013) 0.82

The emerging role of FTY720 (Fingolimod) in cancer treatment. Oncotarget (2016) 0.82

Regulation of PP2A by Sphingolipid Metabolism and Signaling. Front Oncol (2015) 0.81

Overexpression of the pp32r1 (ANP32C) oncogene or its functional mutant pp32r1Y140H confers enhanced resistance to FTY720 (Finguimod). Cancer Biol Ther (2013) 0.79

The expression and distributions of ANP32A in the developing brain. Biomed Res Int (2015) 0.76

Effects of cyclopiazonic acid and dexamethasone on serotonin-induced calcium responses in vascular smooth muscle cells. J Physiol Biochem (2016) 0.75

Articles cited by this

The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J Biol Chem (1960) 21.21

Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol (2003) 9.29

Cyclooxygenase in biology and disease. FASEB J (1998) 7.17

Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry. Nat Biotechnol (2001) 5.69

Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A (1992) 5.21

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (2003) 3.59

Bioactive sphingolipids: metabolism and function. J Lipid Res (2008) 2.73

Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J Cell Biol (2000) 2.69

Lysophospholipids--receptor revelations. Science (2001) 2.61

Code developments to improve the efficiency of automated MS/MS spectra interpretation. J Proteome Res (2003) 2.53

Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol (2000) 2.45

Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell (2003) 2.15

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J (2003) 2.10

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation. J Biol Chem (1994) 2.07

Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. EMBO J (2000) 2.06

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol (2006) 2.04

Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest (2007) 1.89

Sphingolipids and cell death. Apoptosis (2007) 1.71

Sphingosine in apoptosis signaling. Biochim Biophys Acta (2002) 1.69

Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. Biochemistry (1996) 1.46

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J Biol Chem (1992) 1.36

Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. Endocrinology (2006) 1.34

COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med (2007) 1.16

A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils. J Biol Chem (2002) 1.15

A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. J Biol Chem (1998) 1.13

Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal. J Cell Sci (1993) 1.13

Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. Cancer Res (2000) 1.09

Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res (1995) 1.06

PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. J Biol Chem (2009) 1.05

Anp32e (Cpd1) and related protein phosphatase 2 inhibitors. Cerebellum (2003) 1.01

Sphingomyelin in the suppression of colon tumors: prevention versus intervention. Arch Biochem Biophys (2003) 1.01

The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins. Protein Sci (2007) 0.97

Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast. Yeast (2002) 0.97

Activation of p38 mitogen-activated protein kinase is required for death receptor-independent caspase-8 activation and cell death in response to sphingosine. Mol Cancer Res (2009) 0.96

Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets. J Nutr (1997) 0.88

Sphingolipids in vascular biology. Adv Exp Med Biol (2002) 0.85

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34

A data-adaptive sum test for disease association with multiple common or rare variants. Hum Hered (2010) 5.95

Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell (2007) 5.62

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell (2007) 5.20

Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev (2004) 4.41

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell (2006) 4.36

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci U S A (2004) 4.20

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med (2007) 3.58

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature (2008) 3.48

Comparison of statistical tests for disease association with rare variants. Genet Epidemiol (2011) 3.42

Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res (2008) 3.36

Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem (2007) 3.07

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell (2002) 3.06

SNARE proteins are required for macroautophagy. Cell (2011) 2.99

S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol (2005) 2.98

Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem (2003) 2.98

Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila) (2011) 2.97

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal (2009) 2.92

Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer Discov (2014) 2.79

International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev (2002) 2.75

Structural and functional characteristics of S1P receptors. J Cell Biochem (2004) 2.75

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant (2004) 2.70

1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem (2007) 2.61

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nat Chem Biol (2007) 2.57

A note on using permutation-based false discovery rate estimates to compare different analysis methods for microarray data. Bioinformatics (2005) 2.31

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice. J Clin Invest (2011) 2.23

Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A (2003) 2.23

Likelihood-based selection and sharp parameter estimation. J Am Stat Assoc (2012) 2.21

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc Natl Acad Sci U S A (2011) 2.18

Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev (2004) 2.16

Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res (2004) 2.15

Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell (2003) 2.15

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev (2010) 2.10

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell (2011) 2.09

Selective caveolin-1-dependent endocytosis of glycosphingolipids. Mol Biol Cell (2003) 2.05

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol (2006) 2.04

The Research Diagnostic Criteria for Temporomandibular Disorders. V: methods used to establish and validate revised Axis I diagnostic algorithms. J Orofac Pain (2010) 2.00

Role of spectral counting in quantitative proteomics. Expert Rev Proteomics (2010) 2.00

Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res (2006) 1.98

Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem (2001) 1.97

Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Res (2005) 1.94

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. Nat Immunol (2011) 1.94

Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol (2007) 1.91

Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest (2007) 1.89

Lysophosphatidic acid induces neointima formation through PPARgamma activation. J Exp Med (2004) 1.86

Linear regression and two-class classification with gene expression data. Bioinformatics (2003) 1.85

A comparative study of discriminating human heart failure etiology using gene expression profiles. BMC Bioinformatics (2005) 1.85

Penalized model-based clustering with cluster-specific diagonal covariance matrices and grouped variables. Electron J Stat (2008) 1.76

Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J Biol Chem (2007) 1.74

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal (2010) 1.73

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med (2010) 1.73

Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta (2002) 1.72

Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochem J (2006) 1.72

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest (2013) 1.72

The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy (2013) 1.71

Excerpts from the United States Renal Data System 2003 Annual Data Report: atlas of end-stage renal disease in the United States. Am J Kidney Dis (2003) 1.70

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.67

Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest (2004) 1.67

BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms. Traffic (2008) 1.67

Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem (2007) 1.66

Time-critical social mobilization. Science (2011) 1.65

Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase. J Biol Chem (2002) 1.63

Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. J Biol Chem (2006) 1.63

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell (2012) 1.62

Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis. J Biol Chem (2006) 1.61

Autophagy is involved in influenza A virus replication. Autophagy (2009) 1.60

Incorporating gene networks into statistical tests for genomic data via a spatially correlated mixture model. Bioinformatics (2007) 1.60

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. Cell Signal (2010) 1.60

Subclinical changes in serum creatinine and mortality after coronary artery bypass grafting. J Thorac Cardiovasc Surg (2011) 1.60

Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum (2006) 1.59

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest (2009) 1.58

Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc. J Biol Chem (2004) 1.58

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. J Clin Invest (2013) 1.57

HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. Cancer Res (2006) 1.55

The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Res (2005) 1.55

The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. J Biol Chem (2003) 1.52

Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res (2003) 1.50

Network-based support vector machine for classification of microarray samples. BMC Bioinformatics (2009) 1.49

Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma. Cell Res (2009) 1.48

Preoperative statin therapy decreases risk of postoperative renal insufficiency. Cardiovasc Ther (2010) 1.47

TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity. Arterioscler Thromb Vasc Biol (2003) 1.46

Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. J Biol Chem (2007) 1.46

FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J Biol Chem (2009) 1.46

Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine. Mol Cell (2006) 1.46

A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol. J Lipid Res (2011) 1.45

Proteomics analysis of human coronary atherosclerotic plaque: a feasibility study of direct tissue proteomics by liquid chromatography and tandem mass spectrometry. Mol Cell Proteomics (2007) 1.45

First synthesis of free cholesterol-BODIPY conjugates. J Org Chem (2006) 1.45

PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Mol Cell (2008) 1.44

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci U S A (2012) 1.41

Double-stranded RNA-binding protein regulates vascular endothelial growth factor mRNA stability, translation, and breast cancer angiogenesis. Mol Cell Biol (2007) 1.41