Published in Diabetes on February 22, 2007
Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes. Diabetes (2010) 1.48
MerTK regulates thymic selection of autoreactive T cells. Proc Natl Acad Sci U S A (2009) 0.95
Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. Mol Ther (2009) 0.95
Natural regulatory T cells in autoimmunity. Autoimmunity (2010) 0.94
Antigen-based therapy for the treatment of type 1 diabetes. Diabetes (2009) 0.93
Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice. PLoS One (2011) 0.92
Antigen-specific therapeutic approaches in Type 1 diabetes. Cold Spring Harb Perspect Med (2012) 0.85
Lower frequency of CD62L(high) and higher frequency of TNFR2(+) Tregs are associated with inflammatory conditions in type 1 diabetic patients. Mediators Inflamm (2011) 0.85
Cachexia in the non-obese diabetic mouse is associated with CD4+ T-cell lymphopenia. Immunology (2008) 0.84
Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice. Clin Immunol (2008) 0.84
The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity. Vaccines (Basel) (2015) 0.83
A novel role for CD4+ T cells in the control of cachexia. J Immunol (2008) 0.81
Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes. Hum Vaccin (2011) 0.77
Destabilization of peptide:MHC interaction induces IL-2 resistant anergy in diabetogenic T cells. J Autoimmun (2013) 0.76
Inducing immune tolerance: a focus on Type 1 diabetes mellitus. Diabetes Manag (Lond) (2013) 0.75
A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45
Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proc Natl Acad Sci U S A (2007) 2.81
Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity (2010) 2.56
Influenza virus targets the mRNA export machinery and the nuclear pore complex. Proc Natl Acad Sci U S A (2007) 2.44
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell (2008) 2.00
Peripheral leptin regulates bone formation. J Bone Miner Res (2013) 2.00
B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol (2008) 1.96
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells. Blood (2006) 1.71
The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy. Cancer Res (2011) 1.56
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol (2010) 1.54
Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes. Immunotherapy (2009) 1.53
Cellular immune response to cryptic epitopes during therapeutic gene transfer. Proc Natl Acad Sci U S A (2009) 1.53
MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med (2008) 1.48
Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J Exp Med (2011) 1.39
Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype. J Clin Invest (2011) 1.37
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2. Mol Neurodegener (2014) 1.36
Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Blood (2004) 1.35
Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J Immunol (2002) 1.35
The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Immunity (2006) 1.32
Immunoregulation of dendritic cells. Clin Med Res (2005) 1.23
The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells. Front Immunol (2012) 1.23
Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res (2010) 1.20
TREM2 sustains microglial expansion during aging and response to demyelination. J Clin Invest (2015) 1.12
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics (2011) 1.12
Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice. J Immunol (2006) 1.08
Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells. J Immunol (2010) 1.07
Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets. J Immunol (2007) 1.01
Characteristic and in vitro bioactivity of a microarc-oxidized TiO(2)-based coating after chemical treatment. Acta Biomater (2007) 1.01
In vivo fluorescence imaging of muscle cell regeneration by transplanted EGFP-labeled myoblasts. Mol Ther (2010) 1.00
Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. Eur J Immunol (2006) 0.98
Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. J Virol (2009) 0.97
Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection. J Immunol (2012) 0.97
Plasmacytoid dendritic cells contribute to systemic but not local antiviral responses to HSV infections. PLoS Pathog (2013) 0.97
Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr (2008) 0.96
Immunotherapy for the prevention and treatment of type 1 diabetes. Int Rev Immunol (2005) 0.96
MerTK regulates thymic selection of autoreactive T cells. Proc Natl Acad Sci U S A (2009) 0.95
Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export. J Cell Biol (2012) 0.94
Adiponectin lowers glucose production by increasing SOGA. Am J Pathol (2010) 0.94
beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct. J Immunol (2009) 0.93
Options for tracking GFP-Labeled transplanted myoblasts using in vivo fluorescence imaging: implications for tracking stem cell fate. BMC Biotechnol (2014) 0.92
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res (2015) 0.92
Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study. Eur J Cancer (2010) 0.91
Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells. J Immunol (2014) 0.90
Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. J Immunol (2009) 0.90
Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct. Autoimmunity (2009) 0.90
NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J Immunol (2003) 0.89
Zinc transporter expression in zebrafish (Danio rerio) during development. Comp Biochem Physiol C Toxicol Pharmacol (2011) 0.89
A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells. Blood (2009) 0.89
T-cell promiscuity in autoimmune diabetes. Diabetes (2008) 0.88
CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Eur J Immunol (2009) 0.88
Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes. J Immunol (2011) 0.88
Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. J Immunol (2013) 0.86
Consumption of green tea extract results in osteopenia in growing male mice. J Nutr (2009) 0.85
Combination of immune and viral factors distinguishes low-risk versus high-risk HIV-1 disease progression in HLA-B*5701 subjects. J Virol (2012) 0.85
L-selectin is not required for T cell-mediated autoimmune diabetes. J Immunol (2002) 0.85
IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells. Eur J Immunol (2012) 0.84
Immunogenic versus tolerogenic dendritic cells: a matter of maturation. Int Rev Immunol (2010) 0.84
Application of kernel principal component analysis and support vector regression for reconstruction of cardiac transmembrane potentials. Phys Med Biol (2011) 0.84
Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice. Clin Immunol (2008) 0.84
Combined treatment of rituximab, idarubicin, dexamethasone, cytarabine, methotrexate with radiotherapy for primary central nervous system lymphoma. J Cell Mol Med (2014) 0.84
TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes. J Leukoc Biol (2011) 0.84
Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies. Diabetes (2012) 0.83
β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice. Diabetes (2013) 0.83
More stringent conditions of plasmid DNA vaccination are required to protect grafted versus endogenous islets in nonobese diabetic mice. J Immunol (2003) 0.83
Proteome bioprofiles distinguish between M1 priming and activation states in human macrophages. J Leukoc Biol (2010) 0.83
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy. Cancer Immunol Res (2013) 0.82
Sparsity-constrained SENSE reconstruction: an efficient implementation using a fast composite splitting algorithm. Magn Reson Imaging (2013) 0.82
Efficient site-specific integration of large transgenes by an enhanced herpes simplex virus/adeno-associated virus hybrid amplicon vector. J Virol (2006) 0.82
Hollow multilayer microcapsules for pH-/thermally responsive drug delivery using aliphatic poly(urethane-amine) as smart component. Macromol Biosci (2013) 0.82
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res (2014) 0.81
Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc. Biometals (2009) 0.81
Overexpression of cyclin D1 in meningioma is associated with malignancy grade and causes abnormalities in apoptosis, invasion and cell cycle progression. Med Oncol (2014) 0.81
Kinetics of adeno-associated virus serotype 2 (AAV2) and AAV8 capsid antigen presentation in vivo are identical. Hum Gene Ther (2013) 0.81
Acute exposure to high dose γ-radiation results in transient activation of bone lining cells. Bone (2013) 0.80
Active antitumor immunity elicited by vaccine based on recombinant form of epidermal growth factor receptor. J Immunother (2005) 0.80
Osseointegration of bioactive microarc oxidized amorphous phase/TiO2 nanocrystals composited coatings on titanium after implantation into rabbit tibia. J Mater Sci Mater Med (2014) 0.80
Autotransplantation in mdx mice of mdx myoblasts genetically corrected by an HSV-1 amplicon vector. Cell Transplant (2002) 0.79
Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage. PLoS One (2012) 0.79
Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells. Ann N Y Acad Sci (2003) 0.79
Structure, MC3T3-E1 cell response, and osseointegration of macroporous titanium implants covered by a bioactive microarc oxidation coating with microporous structure. ACS Appl Mater Interfaces (2014) 0.79
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron (2016) 0.79
An image processing pipeline to detect and segment nuclei in muscle fiber microscopic images. Microsc Res Tech (2014) 0.78
Sandwich ELISA for detecting urinary Survivin in bladder cancer. Chin J Cancer Res (2013) 0.78
Parameters influencing antigen-specific immunotherapy for type 1 diabetes. Immunol Res (2008) 0.78
Dynamics of transgene expression in human glioblastoma cells mediated by herpes simplex virus/adeno-associated virus amplicon vectors. Hum Gene Ther (2002) 0.78
Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice. Eur J Immunol (2006) 0.78