Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes.

PubWeight™: 2.05‹?› | Rank: Top 2%

🔗 View Article (PMC 2213147)

Published in J Exp Med on April 18, 2005

Authors

Shannon M Pop1, Carmen P Wong, Donna A Culton, Stephen H Clarke, Roland Tisch

Author Affiliations

1: Curriculum in Oral Biology, University of North Carolina at Chapel Hill, NC 27599, USA.

Articles citing this

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08

Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med (2007) 2.86

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A (2008) 1.85

Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes. Immunotherapy (2009) 1.53

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A (2007) 1.51

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A (2006) 1.41

Diabetes in non-obese diabetic mice is not associated with quantitative changes in CD4+ CD25+ Foxp3+ regulatory T cells. Immunology (2007) 1.35

TGFbeta1 and Treg cells: alliance for tolerance. Trends Mol Med (2007) 1.30

The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice. J Clin Immunol (2008) 1.19

Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS One (2009) 1.16

FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes. J Immunol (2010) 1.15

Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection? PLoS Med (2006) 1.13

Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot. J Mol Cell Biol (2010) 1.11

Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proc Natl Acad Sci U S A (2009) 1.09

Regulatory T cells in experimental autoimmune disease. Springer Semin Immunopathol (2006) 1.06

Influence of dietary components on regulatory T cells. Mol Med (2012) 1.01

Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes. J Leukoc Biol (2008) 1.00

Induction of regulatory T cells by green tea polyphenol EGCG. Immunol Lett (2011) 0.99

Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. J Immunol (2008) 0.98

Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function. PLoS One (2012) 0.97

Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proc Natl Acad Sci U S A (2009) 0.97

An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. Immunology (2007) 0.96

Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapy. Diabetes (2010) 0.96

Natural regulatory T cells in autoimmunity. Autoimmunity (2010) 0.94

TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis. J Immunol (2010) 0.92

Targeting regulatory T cells in the treatment of type 1 diabetes mellitus. Curr Mol Med (2012) 0.92

The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model. J Immunol (2012) 0.92

Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct. Autoimmunity (2009) 0.90

Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance. Blood (2006) 0.90

A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function. Gut Microbes (2015) 0.89

Targeting the B7 family of co-stimulatory molecules: successes and challenges. BioDrugs (2013) 0.89

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity. Eur J Immunol (2011) 0.88

APC activation restores functional CD4(+)CD25(+) regulatory T cells in NOD mice that can prevent diabetes development. PLoS One (2008) 0.86

H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease. J Immunol (2010) 0.86

The biology of FoxP3: a key player in immune suppression during infections, autoimmune diseases and cancer. Adv Exp Med Biol (2009) 0.85

B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms. J Autoimmun (2013) 0.85

Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis? Diabetes (2008) 0.85

Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice. Clin Immunol (2008) 0.84

Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development. BMC Immunol (2008) 0.84

Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection. J Virol (2010) 0.83

Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies. Diabetes (2012) 0.83

β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice. Diabetes (2013) 0.83

Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes. Cell Mol Immunol (2011) 0.82

In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy. PLoS One (2010) 0.81

Regulatory function of a novel population of mouse autoantigen-specific Foxp3 regulatory T cells depends on IFN-gamma, NO, and contact with target cells. PLoS One (2009) 0.81

Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice. PLoS One (2012) 0.81

Serum transforming growth factor β1 during diabetes development in non-obese diabetic mice and humans. Clin Exp Immunol (2010) 0.81

Stable activity of diabetogenic cells with age in NOD mice: dynamics of reconstitution and adoptive diabetes transfer in immunocompromised mice. Immunology (2014) 0.81

Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn's-like ileitis. Mucosal Immunol (2014) 0.80

Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clin Immunol (2006) 0.80

Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. PLoS One (2011) 0.80

The role of foxp3-expressing regulatory T cells and T helpers in immunopathogenesis of multidrug resistant pulmonary tuberculosis. Tuberc Res Treat (2012) 0.79

Multimerized T cell epitopes protect from experimental autoimmune diabetes by inducing dominant tolerance. Proc Natl Acad Sci U S A (2007) 0.79

Reversible lacrimal gland-protective regulatory T-cell dysfunction underlies male-specific autoimmune dacryoadenitis in the non-obese diabetic mouse model of Sjögren syndrome. Immunology (2015) 0.78

Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells. PLoS One (2009) 0.78

Novel technologies to engineer graft for tolerance induction. Curr Opin Organ Transplant (2016) 0.78

β-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice. Eur J Immunol (2016) 0.78

Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice. Immunol Cell Biol (2016) 0.78

Tregs and kidney: From diabetic nephropathy to renal transplantation. World J Transplant (2016) 0.77

Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes. Hum Vaccin (2011) 0.77

Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice. PLoS One (2015) 0.77

Inhibition of S-phase kinase-associated protein 2 (Skp2) reprograms and converts diabetogenic T cells to Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2012) 0.77

Altered connexin 43 expression underlies age-dependent decrease of regulatory T cell suppressor function in nonobese diabetic mice. J Immunol (2015) 0.76

Mechanisms of autoimmunity in the non-obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation. Immunology (2016) 0.76

MicroRNA-26a Promotes Regulatory T cells and Suppresses Autoimmune Diabetes in Mice. Inflammation (2016) 0.76

Type I diabetes-associated tolerogenic properties of interleukin-2. Clin Dev Immunol (2011) 0.75

Gene Expression in Single Cells Isolated from the CWR-R1 Prostate Cancer Cell Line and Human Prostate Tissue Based on the Side Population Phenotype. Single Cell Biol (2016) 0.75

Evaluation of T regulatory cell apoptosis in children with newly recognized type 1 diabetes mellitus. Eur J Med Res (2010) 0.75

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. Immunogenetics (2016) 0.75

IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease. J Transl Med (2010) 0.75

Combination treatment of mice with CRx-153 (nortriptyline and desloratadine) decreases the severity of experimental autoimmune encephalomyelitis. Cell Immunol (2011) 0.75

Articles cited by this

Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05

An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol (2003) 19.16

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 16.28

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med (2000) 16.09

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity (2000) 15.44

CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol (2002) 12.73

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67

Regulatory T cells in autoimmmunity*. Annu Rev Immunol (2000) 9.36

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol (2002) 9.18

Natural versus adaptive regulatory T cells. Nat Rev Immunol (2003) 8.74

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med (2001) 8.69

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity (2002) 8.28

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev (2001) 7.60

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol (2004) 7.41

Regulatory T cells in the control of immune pathology. Nat Immunol (2001) 6.98

Following a diabetogenic T cell from genesis through pathogenesis. Cell (1993) 6.46

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (1993) 5.47

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (1993) 5.10

Insulin-dependent diabetes mellitus. Cell (1996) 5.06

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med (2002) 4.56

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med (2003) 4.39

Role of LAG-3 in regulatory T cells. Immunity (2004) 4.36

Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med (1999) 3.85

TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol (2004) 3.79

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med (2004) 3.57

The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity (1997) 3.44

Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev (2001) 3.31

TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proc Natl Acad Sci U S A (2004) 3.26

The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol (2002) 3.09

A defect in central tolerance in NOD mice. Nat Immunol (2001) 2.59

Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci U S A (1996) 2.53

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med (1993) 2.47

Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice. Proc Natl Acad Sci U S A (2002) 2.45

Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature (2000) 2.39

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol (2003) 2.32

Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest (2004) 2.20

Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity (2002) 2.20

CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol (2003) 2.19

CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism. J Immunol (2003) 1.75

NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice. Diabetes (1992) 1.69

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J Clin Invest (1995) 1.55

Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse. J Immunol (1998) 1.55

Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience. J Immunol (2004) 1.01

Disorganization of thymic medulla precedes evolution towards diabetes in female NOD mice. Autoimmunity (1999) 0.82

Articles by these authors

Peripheral leptin regulates bone formation. J Bone Miner Res (2013) 2.00

B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol (2008) 1.96

IgG autoantibody response against keratinocyte cadherins in endemic pemphigus foliaceus (fogo selvagem). J Invest Dermatol (2012) 1.54

Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes. Immunotherapy (2009) 1.53

Cellular immune response to cryptic epitopes during therapeutic gene transfer. Proc Natl Acad Sci U S A (2009) 1.53

MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med (2008) 1.48

Early preplasma cells define a tolerance checkpoint for autoreactive B cells. J Immunol (2006) 1.41

Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Blood (2004) 1.35

Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J Immunol (2002) 1.35

Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1. J Immunol (2002) 1.27

Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells. J Immunol (2004) 1.25

Immunoregulation of dendritic cells. Clin Med Res (2005) 1.23

Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res (2010) 1.20

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics (2011) 1.12

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. Clin Immunol (2008) 1.08

Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice. J Immunol (2006) 1.08

Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells. J Immunol (2010) 1.07

EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. J Immunol (2006) 1.07

Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets. J Immunol (2007) 1.01

Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. Eur J Immunol (2006) 0.98

Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages. J Immunol (2005) 0.97

Positive selection focuses the VH12 B-cell repertoire towards a single B1 specificity with survival function. Immunol Rev (2004) 0.97

Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. J Virol (2009) 0.97

The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice. Diabetes (2007) 0.96

Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells. J Nutr (2008) 0.96

Immunotherapy for the prevention and treatment of type 1 diabetes. Int Rev Immunol (2005) 0.96

Dissecting the anti-desmoglein autoreactive B cell repertoire in pemphigus vulgaris patients. J Immunol (2007) 0.96

MerTK regulates thymic selection of autoreactive T cells. Proc Natl Acad Sci U S A (2009) 0.95

Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus. J Invest Dermatol (2009) 0.95

Adiponectin lowers glucose production by increasing SOGA. Am J Pathol (2010) 0.94

Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell. J Immunol (2003) 0.93

beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct. J Immunol (2009) 0.93

Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss. J Clin Immunol (2006) 0.92

Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract. Mol Nutr Food Res (2015) 0.92

Regulation of B-cell development by antibody specificity. Curr Opin Immunol (2004) 0.90

Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct. Autoimmunity (2009) 0.90

Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance. Blood (2006) 0.90

Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. J Immunol (2009) 0.90

Zinc transporter expression in zebrafish (Danio rerio) during development. Comp Biochem Physiol C Toxicol Pharmacol (2011) 0.89

A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells. Blood (2009) 0.89

NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J Immunol (2003) 0.89

CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Eur J Immunol (2009) 0.88

T-cell promiscuity in autoimmune diabetes. Diabetes (2008) 0.88

Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes. J Immunol (2011) 0.88

Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. J Immunol (2013) 0.86

B cell receptor affinity and B cell subset identity integrate to define the effectiveness, affinity threshold, and mechanism of anergy. J Immunol (2008) 0.86

Btk regulates multiple stages in the development and survival of B-1 cells. Mol Immunol (2007) 0.85

Consumption of green tea extract results in osteopenia in growing male mice. J Nutr (2009) 0.85

L-selectin is not required for T cell-mediated autoimmune diabetes. J Immunol (2002) 0.85

IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells. Eur J Immunol (2012) 0.84

Immunogenic versus tolerogenic dendritic cells: a matter of maturation. Int Rev Immunol (2010) 0.84

Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice. Clin Immunol (2008) 0.84

Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection. J Immunol (2007) 0.84

β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice. Diabetes (2013) 0.83

Diagnosis and clinical features of pemphigus foliaceus. Dermatol Clin (2011) 0.83

Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies. Diabetes (2012) 0.83

More stringent conditions of plasmid DNA vaccination are required to protect grafted versus endogenous islets in nonobese diabetic mice. J Immunol (2003) 0.83

CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes. Mol Immunol (2009) 0.82

Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc. Biometals (2009) 0.81

Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res (2014) 0.81

Kinetics of adeno-associated virus serotype 2 (AAV2) and AAV8 capsid antigen presentation in vivo are identical. Hum Gene Ther (2013) 0.81

Acute exposure to high dose γ-radiation results in transient activation of bone lining cells. Bone (2013) 0.80

Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage. PLoS One (2012) 0.79

Association of the pre-B cell receptor (BCR) expression level with the quality of pre-BII cell differentiation reveals hierarchical pre-BCR function. Mol Immunol (2006) 0.79

Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice. Eur J Immunol (2006) 0.78

Parameters influencing antigen-specific immunotherapy for type 1 diabetes. Immunol Res (2008) 0.78

Effect of reduced c-Kit signaling on bone marrow adiposity. Anat Rec (Hoboken) (2011) 0.77

Immunotherapy of type 1 diabetes. Arch Immunol Ther Exp (Warsz) (2008) 0.77

Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells. J Immunol (2012) 0.77

Mycobacterium bolletii/Mycobacterium massiliense furunculosis associated with pedicure footbaths: a report of 3 cases. Arch Dermatol (2011) 0.77

Maintenance of tolerance by regulation of anti-myeloperoxidase B cells. J Am Soc Nephrol (2008) 0.77

Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes. Hum Vaccin (2011) 0.77

Dysregulation of thymic clonal deletion and the escape of autoreactive T cells. Arch Immunol Ther Exp (Warsz) (2010) 0.76

Parameters influencing antigen-specific immunotherapy for Type 1 diabetes. Immunol Res (2008) 0.76

Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes. Arch Immunol Ther Exp (Warsz) (2015) 0.76

Regulation of hepatic suppressor of cytokine signaling 3 by zinc. J Nutr Biochem (2012) 0.76