Published in Clin Epigenetics on October 26, 2011
Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. Oncogene (2013) 1.41
Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr (2011) 1.00
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics (2013) 0.98
Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants. Nutr Metab (Lond) (2012) 0.94
Health promoting effects of brassica-derived phytochemicals: from chemopreventive and anti-inflammatory activities to epigenetic regulation. Oxid Med Cell Longev (2013) 0.91
The strategies to control prostate cancer by chemoprevention approaches. Mutat Res (2014) 0.87
The interaction between epigenetics, nutrition and the development of cancer. Nutrients (2015) 0.87
Roles of microRNA-140 in stem cell-associated early stage breast cancer. World J Stem Cells (2014) 0.87
Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers. BMC Genomics (2014) 0.86
Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. Epigenetics (2012) 0.85
Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention. Cancer Lett (2014) 0.84
Medicinal chemistry of the epigenetic diet and caloric restriction. Curr Med Chem (2013) 0.83
Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition. Antioxid Redox Signal (2014) 0.83
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One (2014) 0.83
Considering maternal dietary modulators for epigenetic regulation and programming of the fetal epigenome. Nutrients (2015) 0.82
Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside. Curr Pharmacol Rep (2015) 0.81
SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells. Oncogenesis (2014) 0.81
Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS J (2013) 0.81
Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention. Curr Pharmacol Rep (2015) 0.81
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res (2014) 0.81
Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Semin Oncol (2015) 0.80
The Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA Methylation. Int J Mol Sci (2015) 0.80
Involvement of DNA methylation in the control of cell growth during heat stress in tobacco BY-2 cells. Protoplasma (2015) 0.80
Sulforaphane-induced transcription of thioredoxin reductase in lens: possible significance against cataract formation. Clin Ophthalmol (2013) 0.79
Epigenetic cancer prevention mechanisms in skin cancer. AAPS J (2013) 0.79
Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals. Curr Pharmacol Rep (2015) 0.78
Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells. Evid Based Complement Alternat Med (2015) 0.76
Methylation pattern analysis in prostate cancer tissue: identification of biomarkers using an MS-MLPA approach. J Transl Med (2016) 0.75
Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers. Curr Top Med Chem (2016) 0.75
Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals. Anticancer Agents Med Chem (2016) 0.75
DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer. Epigenomics (2016) 0.75
Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. J Nutr Biochem (2017) 0.75
The Silencing of CCND2 by Promoter Aberrant Methylation in Renal Cell Cancer and Analysis of the Correlation between CCND2 Methylation Status and Clinical Features. PLoS One (2016) 0.75
Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers. Sci Rep (2017) 0.75
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a co-activator of NQO1 in sulforaphane-treated colon cancer cells. Mol Nutr Food Res (2016) 0.75
Expression profiling of DNA methylation-mediated epigenetic gene-silencing factors in breast cancer. Clin Epigenetics (2014) 0.75
The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05
DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet (2000) 6.57
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet (2000) 5.09
Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science (1997) 5.05
Expression and amplification of cyclin genes in human breast cancer. Oncogene (1993) 3.79
Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J (1999) 3.41
The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation. Oncogene (1999) 3.17
DNA methylation and breast carcinogenesis. Oncogene (2002) 3.03
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A (2001) 3.02
Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J (2004) 2.94
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis (2003) 2.33
DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. Int J Cancer (2003) 2.18
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05
A prospective study of cruciferous vegetables and prostate cancer. Cancer Epidemiol Biomarkers Prev (2003) 2.04
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98
Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. J Biol Chem (2004) 1.88
Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer. J Mol Med (Berl) (2006) 1.72
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther (2007) 1.68
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One (2010) 1.61
Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci U S A (1984) 1.59
Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer (2002) 1.46
Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int J Oncol (2002) 1.39
Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme. Nucleic Acids Res (2010) 1.37
Histone deacetylase and DNA methyltransferase in human prostate cancer. Biochem Biophys Res Commun (2001) 1.30
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr (2009) 1.27
Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomas. Br J Cancer (2005) 1.25
Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. Nutr Cancer (2004) 1.24
Functional analysis of the human cyclin D2 and cyclin D3 promoters. J Biol Chem (1996) 1.24
Epigenomics and breast cancer. Pharmacogenomics (2008) 1.23
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res (2011) 1.22
Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues. Clin Cancer Res (2003) 1.22
Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases. Am J Pathol (2000) 1.16
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. Mol Cancer (2004) 1.14
Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int J Oncol (2004) 1.12
Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells. Prostate (2009) 1.04
Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane. J Nutr (2005) 1.03
Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis. J Pathol (1999) 1.02
Feedback regulation of DNA methyltransferase gene expression by methylation. Eur J Biochem (1999) 1.01
Dietary glucosinolate intake and risk of prostate cancer in the EPIC-Heidelberg cohort study. Int J Cancer (2009) 1.01
Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation. Clin Cancer Res (2003) 1.00
The cell cycle and development: redundant roles of cell cycle regulators. Curr Opin Cell Biol (1999) 0.98
Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers. Int J Cancer (2003) 0.93
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. Nutr Rev (2008) 0.93
Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells. Exp Biol Med (Maywood) (2009) 0.92
Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer. Br J Cancer (2003) 0.91
Restoration of cyclin D2 has an inhibitory potential on the proliferation of LNCaP cells. Biochem Biophys Res Commun (2009) 0.91
Fruit, vegetable, vitamin A intakes, and prostate cancer risk. Prostate Cancer Prostatic Dis (2007) 0.88
A new mode of transcriptional repression by c-myc: methylation. Oncogene (2006) 0.87
Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. Oral Oncol (2009) 0.85
The dynamic and static modification of the epigenome by hormones: a role in the developmental origin of hormone related cancers. Biochim Biophys Acta (2009) 0.84
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell (2010) 4.16
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res (2007) 3.43
Preceramic adoption of peanut, squash, and cotton in northern Peru. Science (2007) 3.23
Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study. Chem Res Toxicol (2009) 2.80
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res (2004) 2.71
Human hippocampal theta activity during virtual navigation. Hippocampus (2005) 2.37
Point of care diagnostics: status and future. Anal Chem (2011) 2.31
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther (2005) 2.30
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis (2005) 2.05
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
Peripheral leptin regulates bone formation. J Bone Miner Res (2013) 2.00
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood) (2007) 1.98
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J (2006) 1.98
Multi-targeted prevention of cancer by sulforaphane. Cancer Lett (2008) 1.98
B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol (2008) 1.96
Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol (2007) 1.93
Why stainless steel corrodes. Nature (2002) 1.90
Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression. Leuk Lymphoma (2011) 1.70
Enhanced recovery after surgery programs versus traditional care for colorectal surgery: a meta-analysis of randomized controlled trials. Dis Colon Rectum (2013) 1.69
Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout. Toxicol Sci (2005) 1.57
Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes. Immunotherapy (2009) 1.53
Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett (2006) 1.50
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? Carcinogenesis (2005) 1.46
Identification of sokotrasterol sulfate as a novel proangiogenic steroid. Circ Res (2006) 1.41
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. Curr Drug Targets (2006) 1.40
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31
Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood (2007) 1.28
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochem Biophys Res Commun (2002) 1.27
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr (2009) 1.27
A fine physical map of the rice chromosome 4. Genome Res (2002) 1.26
Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria. Curr Drug Metab (2003) 1.25
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res (2006) 1.24
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res (2011) 1.22
Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr (2009) 1.21
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res (2011) 1.21
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. Carcinogenesis (2003) 1.21
Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res (2010) 1.20
Spirastrellolide B reveals the absolute configuration of the spirastrellolide macrolide core. J Am Chem Soc (2007) 1.18
Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. J Pharmacol Exp Ther (2006) 1.16
Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species. J Nat Prod (2010) 1.15
Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells. Org Lett (2008) 1.15
Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games. Environ Sci Technol (2011) 1.15
Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett (2006) 1.15
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters. Genomics (2004) 1.15
Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets. Free Radic Biol Med (2005) 1.14
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. Mol Cancer (2011) 1.11
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen (2009) 1.11
Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour. Neuromolecular Med (2002) 1.11
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene (2004) 1.10
Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis (2006) 1.07
Should gum chewing be included in enhanced recovery after surgery programs for colorectal surgery? Dis Colon Rectum (2014) 1.07
Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione. Chem Res Toxicol (2004) 1.07
Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS One (2012) 1.06
Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene. Cancer Prev Res (Phila) (2008) 1.05
The natural history of dementia. Psychogeriatrics (2014) 1.04
Endurance exercise results in DNA damage as detected by the comet assay. Free Radic Biol Med (2004) 1.04
Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3'-diindolylmethane in sprague-dawley rats. Toxicol Sci (2003) 1.04
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinog (2011) 1.04
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis (2008) 1.04
Dietary manipulation of histone structure and function. Annu Rev Nutr (2008) 1.02
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells. Cancer Prev Res (Phila) (2009) 1.01
Effect of surface packing density of interfacially adsorbed monoclonal antibody on the binding of hormonal antigen human chorionic gonadotrophin. J Phys Chem B (2006) 1.01
Umbilical cord-derived mesenchymal stem cells isolated by a novel explantation technique can differentiate into functional endothelial cells and promote revascularization. Stem Cells Dev (2010) 1.01
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer (2010) 1.01
Aging is associated with altered dendritic cells subset distribution and impaired proinflammatory cytokine production. Exp Gerontol (2009) 1.00
Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent. Drug Metab Dispos (2004) 1.00
Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr (2011) 1.00
Induction of regulatory T cells by green tea polyphenol EGCG. Immunol Lett (2011) 0.99
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. J Biol Chem (2004) 0.99
Indole-3-carbinol is a negative regulator of estrogen. J Nutr (2003) 0.99
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res (2003) 0.98
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol (2012) 0.98
Liphagal, a Selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga: structure elucidation and biomimetic synthesis. Org Lett (2006) 0.98
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics (2013) 0.98
Vitamin D receptor gene polymorphisms and colorectal cancer risk: a systematic meta-analysis. World J Gastroenterol (2012) 0.98
Anti-fatigue effect of ginsenoside Rb1 on postoperative fatigue syndrome induced by major small intestinal resection in rat. Biol Pharm Bull (2013) 0.97