Published in Curr Biol on February 22, 2007
Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One (2010) 3.50
Mechanisms of chromosomal instability. Curr Biol (2010) 3.21
Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell (2010) 2.45
Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep (2012) 1.81
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov (2014) 1.69
Illicit survival of cancer cells during polyploidization and depolyploidization. Cell Death Differ (2010) 1.57
Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc Natl Acad Sci U S A (2009) 1.45
Cell Fusion Connects Oncogenesis with Tumor Evolution. Am J Pathol (2015) 1.44
Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci (2014) 1.26
Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells. Cell Cycle (2012) 1.20
Spontaneous formation of tumorigenic hybrids between breast cancer and multipotent stromal cells is a source of tumor heterogeneity. Am J Pathol (2012) 1.14
Mechanisms of ploidy increase in human cancers: a new role for cell cannibalism. Cancer Res (2012) 1.04
Mechanisms of aneuploidy. Curr Opin Cell Biol (2011) 1.01
Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology (2008) 0.99
Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo. Int J Cancer (2011) 0.95
Cell fusions in mammals. Histochem Cell Biol (2008) 0.93
Characterization of the plasma membrane localization and orientation of HPV16 E5 for cell-cell fusion. Virology (2009) 0.92
Abrogation of the postmitotic checkpoint contributes to polyploidization in human papillomavirus E7-expressing cells. J Virol (2009) 0.91
Linking JNK Activity to the DNA Damage Response. Genes Cancer (2013) 0.89
Chromosome mis-segregation and cytokinesis failure in trisomic human cells. Elife (2015) 0.88
Targeting the Mitotic Catastrophe Signaling Pathway in Cancer. Mediators Inflamm (2015) 0.86
p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells. PLoS One (2011) 0.86
Spontaneous cell fusion of acute leukemia cells and macrophages observed in cells with leukemic potential. Neoplasia (2012) 0.85
Chromosomal gain promotes formation of a steep RanGTP gradient that drives mitosis in aneuploid cells. J Cell Biol (2013) 0.85
Human papillomavirus E7 induces rereplication in response to DNA damage. J Virol (2012) 0.85
Tissue Regeneration in the Chronically Inflamed Tumor Environment: Implications for Cell Fusion Driven Tumor Progression and Therapy Resistant Tumor Hybrid Cells. Int J Mol Sci (2015) 0.85
How virus persistence can initiate the tumorigenesis process. World J Virol (2013) 0.84
Genomic Instability Induced By Human Papillomavirus Oncogenes. N Am J Med Sci (Boston) (2010) 0.84
High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer. Virol J (2010) 0.83
Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer. Future Oncol (2009) 0.82
Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy. Int J Mol Sci (2016) 0.81
Telomeres in cancer: tumour suppression and genome instability. Nat Rev Mol Cell Biol (2017) 0.80
Tetraploid cancer cell precursors in ovarian carcinoma. Cell Cycle (2012) 0.80
Transgenerational cell fate profiling: a method for the graphical presentation of complex cell cycle alterations. Cell Cycle (2012) 0.79
Rho'ing in and out of cells: viral interactions with Rho GTPase signaling. Small GTPases (2014) 0.78
Genome management and mismanagement-cell-level opportunities and challenges of whole-genome duplication. Genes Dev (2015) 0.78
Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition. Oncotarget (2016) 0.77
Cancer Cell Fusion: Mechanisms Slowly Unravel. Int J Mol Sci (2016) 0.77
A non-invasive technique for quantifying and isolating fused cells. Cytotechnology (2009) 0.77
Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replication. Cell Cycle (2016) 0.76
Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells. Oncotarget (2016) 0.75
Generation and Purification of Tetraploid Cells. Methods Mol Biol (2016) 0.75
Occurrence of cancer at multiple sites: towards distinguishing multigenesis from metastasis. Biol Direct (2008) 0.75
From silencing to gene expression: real-time analysis in single cells. Cell (2004) 7.73
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol (2007) 6.54
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res (2009) 5.99
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science (2002) 4.80
Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol (2007) 4.35
An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother (2011) 4.02
Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood (2004) 3.76
Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant. Clin Cancer Res (2002) 3.54
Comparison of Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS mutations: diagnostic and clinical implications. J Mol Diagn (2010) 3.12
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
Actin-dependent intranuclear repositioning of an active gene locus in vivo. J Cell Biol (2007) 2.93
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med (2011) 2.86
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J Biol Chem (2001) 2.71
Silence of chromosomal amplifications in colon cancer. Cancer Res (2002) 2.58
Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells (2005) 2.52
Development of ipilimumab: contribution to a new paradigm for cancer immunotherapy. Semin Oncol (2010) 2.51
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. Blood (2009) 2.44
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas. Proc Natl Acad Sci U S A (2005) 2.38
Can a biologist fix a radio?--Or, what I learned while studying apoptosis. Cancer Cell (2002) 2.28
Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A (2009) 2.12
Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol Cell Biol (2003) 2.12
Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. J Clin Oncol (2005) 2.07
Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood. Clin Cancer Res (2012) 2.07
UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genet Cytogenet (2010) 2.06
The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell (2007) 2.00
Cell fusion: a hidden enemy? Cancer Cell (2003) 1.95
Cell-to-cell fusion as a link between viruses and cancer. Nat Rev Cancer (2007) 1.93
Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer. Genes Chromosomes Cancer (2009) 1.91
Pre-processing Agilent microarray data. BMC Bioinformatics (2007) 1.84
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer Res (2005) 1.83
Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location. Hum Mutat (2004) 1.78
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (2009) 1.75
Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res (2004) 1.74
Increased serum levels of complement C3a anaphylatoxin indicate the presence of colorectal tumors. Gastroenterology (2006) 1.72
The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequence. Genes Chromosomes Cancer (2005) 1.70
Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling. PLoS Genet (2013) 1.69
Retracted A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities. Proc Natl Acad Sci U S A (2008) 1.69
Clonal cytogenetic abnormalities and BCL2 rearrangement in interdigitating dendritic cell sarcoma. Leuk Lymphoma (2006) 1.68
The rectal cancer microRNAome--microRNA expression in rectal cancer and matched normal mucosa. Clin Cancer Res (2012) 1.61
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers. Cancer Res (2003) 1.58
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol (2005) 1.56
The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines. Cancer Res (2003) 1.56
Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. Cancer Res (2007) 1.53
Spectral karyotyping analysis of human and mouse chromosomes. Nat Protoc (2006) 1.52
Combined breast ductal lavage and ductal endoscopy for the evaluation of the high-risk breast: a feasibility study. J Surg Oncol (2006) 1.51
Identification of der(1;19)(q10;p10) in five oligodendrogliomas suggests mechanism of concurrent 1p and 19q loss. J Neuropathol Exp Neurol (2006) 1.50
Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. Genes Chromosomes Cancer (2010) 1.50
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res (2013) 1.47
A sequence-based survey of the complex structural organization of tumor genomes. Genome Biol (2008) 1.45
Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome. Cancer Res (2008) 1.44
LGR5 positivity defines stem-like cells in colorectal cancer. Carcinogenesis (2013) 1.41
The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. J Cell Biol (2004) 1.37
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. J Exp Med (2007) 1.37
Isolation and solubilization of proteins after TRIzol extraction of RNA and DNA from patient material following prolonged storage. Biotechniques (2007) 1.36
Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu. Oncogene (2002) 1.36
Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase. Carcinogenesis (2011) 1.35
Safety and clinical activity of ipilimumab in melanoma patients with brain metastases: retrospective analysis of data from a phase 2 trial. Melanoma Res (2011) 1.35
The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome. Int J Cancer (2009) 1.34
Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia. Am J Pathol (2003) 1.33
Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer. Am J Pathol (2005) 1.32
Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene. Blood (2007) 1.32
Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res (2013) 1.31
Aneuploidy-dependent massive deregulation of the cellular transcriptome and apparent divergence of the Wnt/beta-catenin signaling pathway in human rectal carcinomas. Cancer Res (2006) 1.31
DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma. PLoS One (2012) 1.30
Stage-specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesis. Genes Chromosomes Cancer (2007) 1.26
Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Mol Cell Biol (2003) 1.24
The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dubé gene pathway. Cancer Genet Cytogenet (2008) 1.24
Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol (2007) 1.21
Internal tandem duplications of the FLT3 gene are present in leukemia stem cells. Blood (2005) 1.18
A primate virus generates transformed human cells by fusion. J Cell Biol (2005) 1.17
Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus-positive and -negative tumors. Int J Cancer (2003) 1.17
Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability. Oncogene (2004) 1.16
Tanespimycin with bortezomib: activity in relapsed/refractory patients with multiple myeloma. Br J Haematol (2010) 1.14
Ipilimumab increases activated T cells and enhances humoral immunity in patients with advanced melanoma. J Immunother (2012) 1.14
Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2. Mol Cancer Ther (2009) 1.14
High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter. Carcinogenesis (2002) 1.13
Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. J Clin Invest (2013) 1.13
Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study. Br J Haematol (2011) 1.12
SMC1 involvement in fragile site expression. Hum Mol Genet (2005) 1.11
RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors. Cancer Genet Cytogenet (2007) 1.10
Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags. Cancer Biol Ther (2004) 1.10
Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J (2012) 1.09
Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression. Am J Pathol (2012) 1.09
KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy. Radiother Oncol (2009) 1.09
Interstitial microduplication of Xp22.31: Causative of intellectual disability or benign copy number variant? Eur J Med Genet (2010) 1.08
Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability. Oncogene (2004) 1.08
Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation study. Br J Haematol (2010) 1.07
Confirming specificity of RNAi in mammalian cells. Sci STKE (2002) 1.07