A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors.

PubWeight™: 1.98‹?› | Rank: Top 2%

🔗 View Article (PMID 17324405)

Published in Gastroenterology on December 16, 2006

Authors

Georgina L Hold1, Charles S Rabkin, Wong-Ho Chow, Malcolm G Smith, Marilie D Gammon, Harvey A Risch, Thomas L Vaughan, Kenneth E L McColl, Jolanta Lissowska, Witold Zatonski, Janet B Schoenberg, William J Blot, N Ashley G Mowat, Joseph F Fraumeni, Emad M El-Omar

Author Affiliations

1: Department of Medicine and Therapeutics, Aberdeen University, Aberdeen, Scotland.

Articles citing this

Gastric cancer. Lancet (2009) 7.27

Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29

Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res (2008) 2.08

Nature meets nurture: molecular genetics of gastric cancer. Hum Genet (2009) 1.87

Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Physiol Rev (2010) 1.73

Cancer and inflammation: promise for biologic therapy. J Immunother (2010) 1.72

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses. Hepatology (2009) 1.72

Role of Toll-like receptors in gastrointestinal malignancies. Oncogene (2008) 1.69

Helicobacter Pylori associated global gastric cancer burden. Front Biosci (Landmark Ed) (2009) 1.33

Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease. Infect Immun (2009) 1.19

Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals. Gastroenterology (2010) 1.18

Pathogen recognition receptors, cancer and inflammation in the gut. Curr Opin Pharmacol (2009) 1.14

SOCS, inflammation, and cancer. JAKSTAT (2013) 1.13

Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis. Fibrogenesis Tissue Repair (2010) 1.09

CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations. Eur J Cancer Prev (2009) 1.07

Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes. Clin Exp Immunol (2008) 1.07

Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer. Gastroenterology (2011) 1.05

Role of bacteria in oncogenesis. Clin Microbiol Rev (2010) 1.05

TLR4 polymorphisms and disease susceptibility. Inflamm Res (2012) 1.05

Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population. World J Gastroenterol (2012) 1.02

The role of viral and bacterial pathogens in gastrointestinal cancer. J Cell Physiol (2008) 1.02

Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection. J Hepatol (2009) 1.02

β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ (2014) 1.00

Gastric cancer, Helicobacter pylori infection and other risk factors. World J Gastrointest Oncol (2010) 0.96

Association of gastric disease with polymorphisms in the inflammatory-related genes IL-1B, IL-1RN, IL-10, TNF and TLR4. Eur J Gastroenterol Hepatol (2009) 0.95

Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma. PLoS One (2011) 0.95

Pattern-recognition receptors and gastric cancer. Front Immunol (2014) 0.95

Should a Toll-like receptor 4 (TLR-4) agonist or antagonist be designed to treat cancer? TLR-4: its expression and effects in the ten most common cancers. Onco Targets Ther (2013) 0.94

Virulence Factors of Helicobacter pylori: A Review. Clin Med Insights Gastroenterol (2014) 0.93

Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis. Mol Carcinog (2009) 0.92

The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta-analysis. PLoS One (2013) 0.91

Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer. Dig Dis Sci (2012) 0.91

Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine. Front Immunol (2013) 0.91

Toll-like receptor-4 deficiency enhances repair of UVR-induced cutaneous DNA damage by nucleotide excision repair mechanism. J Invest Dermatol (2013) 0.90

Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. Genes Dis (2014) 0.90

Molecular cross-talk between Helicobacter pylori and human gastric mucosa. World J Gastroenterol (2011) 0.90

Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas. J Transl Med (2011) 0.89

Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy. Infect Immun (2013) 0.89

Toll-like receptors in esophageal cancer. Front Immunol (2014) 0.88

MyD88 and its divergent toll in carcinogenesis. Trends Immunol (2013) 0.88

Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer. Gut Liver (2014) 0.88

Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. World J Gastrointest Oncol (2010) 0.87

Helicobacter pylori-Induced Signaling Pathways Contribute to Intestinal Metaplasia and Gastric Carcinogenesis. Biomed Res Int (2015) 0.87

Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients. Biomed Res Int (2013) 0.86

TLR3 and TLR4 expression in healthy and diseased human endometrium. Reprod Biol Endocrinol (2008) 0.86

Toll-like receptor 4 polymorphisms and their haplotypes modulate the risk of developing diabetic retinopathy in type 2 diabetes patients. Mol Vis (2014) 0.85

Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors. Biomed Res Int (2015) 0.84

Helicobacter pylori infection and disease: from humans to animal models. Dis Model Mech (2008) 0.84

Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis. Mol Cancer (2009) 0.83

TLR9 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis. PLoS One (2013) 0.83

Macrophages, PPARs, and Cancer. PPAR Res (2008) 0.83

A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. Neoplasia (2009) 0.83

Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients. PLoS One (2016) 0.83

Biomarkers of Helicobacter pylori-associated gastric cancer. Gut Microbes (2013) 0.82

Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer. Curr Mol Med (2013) 0.81

Atrophic gastritis: risk factor for esophageal squamous cell carcinoma in a Latin-American population. World J Gastroenterol (2013) 0.81

Innate immune sensors and gastrointestinal bacterial infections. Clin Dev Immunol (2011) 0.81

A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population. J Biomed Res (2010) 0.81

Association of TLR2 and TLR4 polymorphisms with risk of cancer: a meta-analysis. PLoS One (2013) 0.80

The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium. Oncoimmunology (2013) 0.80

Effects of polymorphisms of innate immunity genes and environmental factors on the risk of noncardia gastric cancer. Cancer Res Treat (2013) 0.80

Helicobacter pylori in gastric carcinogenesis. World J Gastrointest Oncol (2015) 0.80

Cyclooxygenase-2 polymorphisms and the risk of gastric cancer in various degrees of relationship in the Chinese Han population. Oncol Lett (2011) 0.79

Polymorphisms in chemokine and receptor genes and gastric cancer risk and survival in a high risk Polish population. Scand J Gastroenterol (2010) 0.79

At the bedside: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. J Leukoc Biol (2014) 0.78

Novel role of toll-like receptors in Helicobacter pylori - induced gastric malignancy. World J Gastroenterol (2014) 0.77

Mouse models for gastric cancer: Matching models to biological questions. J Gastroenterol Hepatol (2016) 0.77

Prevention of Gastric Cancer: When is Treatment of Helicobacter Pylori Warranted? Therap Adv Gastroenterol (2008) 0.77

The influence of cytokine gene polymorphisms on the risk of developing gastric cancer in patients with Helicobacter pylori infection. Radiol Oncol (2015) 0.77

The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes. PLoS One (2014) 0.77

Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent. Genes Immun (2013) 0.76

Association between TLR4 (+896A/G and +1196C/T) polymorphisms and gastric cancer risk: an updated meta-analysis. PLoS One (2014) 0.76

NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression. Aliment Pharmacol Ther (2009) 0.75

Molecular alterations in gastric cancer with special reference to the early-onset subtype. World J Gastroenterol (2016) 0.75

Association between CD14 SNP -159 C/T and gastric cancer: an independent case-control study and an updated meta-analysis. Onco Targets Ther (2016) 0.75

Bronchoalveolar Lavage Fluid Utilized Ex Vivo to Validate In Vivo Findings: Inhibition of Gap Junction Activity in Lung Tumor Promotion is Toll-Like Receptor 4-Dependent. J Mol Biomark Diagn (2013) 0.75

Correlation of Asp299Gly and Thr399Ile polymorphisms in toll-like receptor 4 gene with digestive cancer risk: A meta-analysis. Biomed Rep (2012) 0.75

Surveillance for gastrointestinal malignancies. World J Gastroenterol (2012) 0.75

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis. PLoS One (2017) 0.75

Toll-like receptor gene polymorphisms and susceptibility to Epstein-Barr virus-associated and -negative gastric carcinoma in Northern China. Saudi J Gastroenterol (2015) 0.75

Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract. Front Genet (2017) 0.75

Articles by these authors

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18

Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65

Replicating genotype-phenotype associations. Nature (2007) 16.11

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10

Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report. Gut (2012) 12.62

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39

Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24

A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30

Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. JAMA Intern Med (2013) 7.30

Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys. Lancet (2012) 6.49

The Shanghai Women's Health Study: rationale, study design, and baseline characteristics. Am J Epidemiol (2005) 6.44

Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst (2003) 6.28

Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22

Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med (2010) 6.04

Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst (2008) 6.00

Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99

Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey. Lancet (2011) 5.95

Performance of common genetic variants in breast-cancer risk models. N Engl J Med (2010) 5.79

Social inequalities in male mortality, and in male mortality from smoking: indirect estimation from national death rates in England and Wales, Poland, and North America. Lancet (2006) 5.70

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14

Spectrum of cancer risk among US solid organ transplant recipients. JAMA (2011) 4.99

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89

Merging and emerging cohorts: not worth the wait. Nature (2007) 4.66

Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst (2007) 4.55

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst (2010) 4.54

Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet (2010) 4.51

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38

Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. Am J Respir Crit Care Med (2010) 4.35

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35

Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk. JAMA (2004) 4.31

Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev (2007) 4.23

Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer Res (2008) 4.02

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet (2010) 3.93

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86

Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81

Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet (2009) 3.76

False-positive results in cancer epidemiology: a plea for epistemological modesty. J Natl Cancer Inst (2008) 3.72

Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69

Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68

Southern community cohort study: establishing a cohort to investigate health disparities. J Natl Med Assoc (2005) 3.67

Investigation of the fine structure of European populations with applications to disease association studies. Eur J Hum Genet (2008) 3.65

Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology (2003) 3.58

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet (2010) 3.53

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet (2011) 3.37

Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst (2006) 3.36

Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis. Nat Rev Cancer (2010) 3.27

Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology (2008) 3.25

Peptic ulcer disease. Lancet (2009) 3.23

Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe (2013) 3.21

Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20

Epidemiology and pathogenesis of esophageal cancer. Semin Radiat Oncol (2007) 3.18

Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst (2003) 3.07

The landscape of recombination in African Americans. Nature (2011) 3.06

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet (2010) 2.96

Use of 5-alpha-reductase inhibitors for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline. J Clin Oncol (2009) 2.95

Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst (2009) 2.88

Environmental causes of esophageal cancer. Gastroenterol Clin North Am (2009) 2.80

Age-specific trends in incidence of noncardia gastric cancer in US adults. JAMA (2010) 2.78

A combined analysis of North American case-control studies of residential radon and lung cancer. J Toxicol Environ Health A (2006) 2.78

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 2.72

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet (2011) 2.70

Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. Am J Epidemiol (2007) 2.64

Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control (2006) 2.64