Common variants at 19p13 are associated with susceptibility to ovarian cancer.

Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer (2011) 5.28

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet (2011) 3.37

Mutations in BRIP1 confer high risk of ovarian cancer. Nat Genet (2011) 3.06

Current status of genome-wide association studies in cancer. Hum Genet (2011) 2.14

The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. Clin Cancer Res (2011) 2.09

The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection. J Biol Chem (2011) 1.91

19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res (2012) 1.81

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. J Natl Cancer Inst (2015) 1.70

Common breast cancer susceptibility loci are associated with triple-negative breast cancer. Cancer Res (2011) 1.65

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas. Gynecol Oncol (2013) 1.61

Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet (2015) 1.47

Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients. Clin Cancer Res (2011) 1.47

Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst (2010) 1.41

Genetic architecture of cancer and other complex diseases: lessons learned and future directions. Carcinogenesis (2011) 1.39

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Res (2012) 1.38

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nat Commun (2013) 1.36

The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population. Hum Mol Genet (2014) 1.21

Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLoS One (2011) 1.20

GWAS identifies a common breast cancer risk allele among BRCA1 carriers. Nat Genet (2010) 1.19

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev (2012) 1.17

NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes. J Biol Chem (2011) 1.14

Assessment of hepatocyte growth factor in ovarian cancer mortality. Cancer Epidemiol Biomarkers Prev (2011) 1.14

A role for XRCC2 gene polymorphisms in breast cancer risk and survival. J Med Genet (2011) 1.10

Comprehensive functional annotation of seventy-one breast cancer risk Loci. PLoS One (2013) 1.10

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet (2014) 1.09

Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions. Sci Transl Med (2012) 1.07

Primary culture and immortalization of human fallopian tube secretory epithelial cells. Nat Protoc (2012) 1.03

BRCA1 tumor suppressor network: focusing on its tail. Cell Biosci (2012) 1.03

Most common 'sporadic' cancers have a significant germline genetic component. Hum Mol Genet (2014) 1.03

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer. Cancer Epidemiol Biomarkers Prev (2013) 1.02

PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov (2014) 1.02

Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status. Sci Rep (2014) 1.02

Genetic variants in TGF-β pathway are associated with ovarian cancer risk. PLoS One (2011) 1.01

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. J Clin Oncol (2015) 1.01

Hereditary breast cancer: ever more pieces to the polygenic puzzle. Hered Cancer Clin Pract (2013) 0.99

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. Hum Genet (2013) 0.99

Population distribution of lifetime risk of ovarian cancer in the United States. Cancer Epidemiol Biomarkers Prev (2015) 0.99

Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Hum Mutat (2012) 0.98

Ovarian cancer risk associated with inherited inflammation-related variants. Cancer Res (2012) 0.98

Distinct and competitive regulatory patterns of tumor suppressor genes and oncogenes in ovarian cancer. PLoS One (2012) 0.96

Discovery analysis of TCGA data reveals association between germline genotype and survival in ovarian cancer patients. PLoS One (2013) 0.95

The new face of ovarian cancer modeling: better prospects for detection and treatment. F1000 Med Rep (2011) 0.94

Inherited variants in regulatory T cell genes and outcome of ovarian cancer. PLoS One (2013) 0.93

Genomics of the NF-κB signaling pathway: hypothesized role in ovarian cancer. Cancer Causes Control (2011) 0.91

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discov (2016) 0.90

Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development. BMC Med Genet (2011) 0.90

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer. Carcinogenesis (2015) 0.88

Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci. Hum Mol Genet (2015) 0.88

An analysis of polymorphisms within the Wnt signaling pathway in relation to ovarian cancer risk in a Polish population. Mol Diagn Ther (2014) 0.88

Germline copy number variation and ovarian cancer survival. Front Genet (2012) 0.88

Reproducibility and concordance of differential DNA methylation and gene expression in cancer. PLoS One (2012) 0.87

In vitro three-dimensional modeling of fallopian tube secretory epithelial cells. BMC Cell Biol (2013) 0.87

The immune system in the pathogenesis of ovarian cancer. Crit Rev Immunol (2013) 0.86

The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility. PLoS One (2012) 0.86

Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk. Mol Carcinog (2010) 0.86

Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer. BMC Med Genomics (2014) 0.86

Regulatory T cells, inherited variation, and clinical outcome in epithelial ovarian cancer. Cancer Immunol Immunother (2015) 0.86

The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. Oncotarget (2014) 0.85

Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes. Cancer Epidemiol Biomarkers Prev (2012) 0.85

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk. Hum Mol Genet (2011) 0.85

Functional annotation signatures of disease susceptibility loci improve SNP association analysis. BMC Genomics (2014) 0.85

Breast Cancer Update 2014 - Focus on the Patient and the Tumour. Geburtshilfe Frauenheilkd (2015) 0.85

Retracted Targeted immune therapy of ovarian cancer. Cancer Metastasis Rev (2015) 0.84

Analyzing association of the XRCC3 gene polymorphism with ovarian cancer risk. Biomed Res Int (2014) 0.84

Genome-wide significant risk associations for mucinous ovarian carcinoma. Nat Genet (2015) 0.83

Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer. Carcinogenesis (2012) 0.83

Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology. Adv Exp Med Biol (2014) 0.83

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Commun (2016) 0.82

Genome-wide association study for ovarian cancer susceptibility using pooled DNA. Twin Res Hum Genet (2012) 0.82

Genome-wide investigation of regional blood-based DNA methylation adjusted for complete blood counts implicates BNC2 in ovarian cancer. Genet Epidemiol (2014) 0.82

A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects. J Med Genet (2015) 0.82

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer. Nat Commun (2015) 0.82

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer. Hum Mol Genet (2015) 0.81

DNA methylation changes in epithelial ovarian cancer histotypes. Genomics (2015) 0.80

Assessing disease risk in genome-wide association studies using family history. Epidemiology (2012) 0.80

Common variation in Nemo-like kinase is associated with risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev (2012) 0.80

Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies. PLoS One (2012) 0.80

Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium. BMC Cancer (2013) 0.80

Variation in NF-κB signaling pathways and survival in invasive epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev (2014) 0.80

MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy. Cell Rep (2015) 0.80

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study. Gynecol Oncol (2014) 0.80

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk. Cancer Epidemiol Biomarkers Prev (2015) 0.80

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium. Clin Cancer Res (2015) 0.79

Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk. PLoS Genet (2017) 0.79

Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome. Clin Chem (2013) 0.79

Evidence of differential effects of vitamin d receptor variants on epithelial ovarian cancer risk by predicted vitamin d status. Front Oncol (2014) 0.79

Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network. Geburtshilfe Frauenheilkd (2015) 0.78

Genomic/Epigenomic Alterations in Ovarian Carcinoma: Translational Insight into Clinical Practice. J Cancer (2016) 0.78

MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. Genes Dev (2015) 0.78

Prediction of potential cancer-risk regions based on transcriptome data: towards a comprehensive view. PLoS One (2014) 0.78

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes. Hum Genet (2016) 0.77

Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. Mol Nutr Food Res (2014) 0.77

A targeted genetic association study of epithelial ovarian cancer susceptibility. Oncotarget (2016) 0.77

Evidence of a genetic link between endometriosis and ovarian cancer. Fertil Steril (2015) 0.76

The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis. PLoS One (2016) 0.76

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci. Br J Cancer (2017) 0.76

Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families. Biomark Insights (2012) 0.76

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk. Hum Mol Genet (2016) 0.75

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95

A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68

A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. Am J Hum Genet (2006) 28.32

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet (2007) 11.62

Estimating local ancestry in admixed populations. Am J Hum Genet (2008) 5.90

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet (2010) 4.96

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38

Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA (2000) 3.69

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev (2009) 3.23

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Genes Dev (2009) 2.67

MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev (2009) 2.49

Pathology of ovarian cancers in BRCA1 and BRCA2 carriers. Clin Cancer Res (2004) 2.17

A set of BAC clones spanning the human genome. Nucleic Acids Res (2004) 2.00

Prevalent cases in observational studies of cancer survival: do they bias hazard ratio estimates? Br J Cancer (2009) 1.96

Phylogeny of the TMEM16 protein family: some members are overexpressed in cancer. Int J Mol Med (2005) 1.46

Prognostic impact of BRCA1 pathogenic and BRCA1/BRCA2 unclassified variant mutations in patients with ovarian carcinoma. Cancer (2005) 1.45

A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro. Lab Invest (2004) 1.31

Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast. Breast Cancer Res (2009) 1.16

Regulation of aromatase promoter activity in human breast tissue by nuclear receptors. Oncogene (2002) 1.05

Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells. Int J Cancer (2009) 1.02

Finding the missing heritability of complex diseases. Nature (2009) 67.95

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41

Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med (2012) 35.24

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A (2004) 33.85

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA (2006) 24.01

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Genetics of gene expression and its effect on disease. Nature (2008) 21.35

International network of cancer genome projects. Nature (2010) 20.35

Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71

Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature (2005) 19.56

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03

Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst (2004) 19.00

A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res (2007) 16.79

The Genome sequence of the SARS-associated coronavirus. Science (2003) 16.68

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10

Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43

Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet (2007) 14.37

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31

Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29

A common inversion under selection in Europeans. Nat Genet (2005) 13.66

A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47

Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol (2010) 13.25

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Many sequence variants affecting diversity of adult human height. Nat Genet (2008) 12.80

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet (2008) 12.43

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19

Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet (2011) 12.13

Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol (2011) 12.10

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Rate of de novo mutations and the importance of father's age to disease risk. Nature (2012) 11.92

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet (2007) 11.62

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A (2005) 10.89

Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87

Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet (2007) 10.81

Common variants conferring risk of schizophrenia. Nature (2009) 10.37

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A (2006) 10.32

Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med (2012) 10.16

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature (2011) 9.71

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet (2002) 9.71

Detection of sharing by descent, long-range phasing and haplotype imputation. Nat Genet (2008) 9.69

Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med (2008) 9.64