Published in J Biol Chem on March 12, 2007
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci (2008) 3.30
Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov (2009) 2.88
Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) (2008) 2.51
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain (2008) 2.32
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol (2007) 2.26
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08
TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci (2009) 2.07
The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem (2008) 2.03
Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J (2008) 1.93
Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol (2008) 1.85
A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst (2008) 1.70
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel. J Biol Chem (2010) 1.63
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A (2011) 1.56
TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci (2009) 1.53
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol (2009) 1.51
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain (2009) 1.42
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
Irritating channels: the case of TRPA1. J Physiol (2010) 1.32
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins. Nat Commun (2014) 1.30
TRPA1 and cold transduction: an unresolved issue? J Gen Physiol (2009) 1.30
TRPA1 mediates mechanical sensitization in nociceptors during inflammation. PLoS One (2012) 1.29
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest (2008) 1.27
Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification. Proc Natl Acad Sci U S A (2009) 1.25
TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons. PLoS One (2010) 1.25
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci (2014) 1.21
A TRPA1-dependent mechanism for the pungent sensation of weak acids. J Gen Physiol (2011) 1.19
Mice left out in the cold: commentary on the phenotype of TRPM8-nulls. Mol Pain (2007) 1.19
Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. Proc Am Thorac Soc (2010) 1.18
Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy. J Biol Chem (2011) 1.17
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch (2009) 1.16
Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice. Arthritis Res Ther (2016) 1.15
Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake. Proc Natl Acad Sci U S A (2013) 1.14
Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1. Biophys J (2010) 1.12
Burning cold: involvement of TRPA1 in noxious cold sensation. J Gen Physiol (2009) 1.11
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Proc Natl Acad Sci U S A (2013) 1.06
Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies. J Biol Chem (2012) 1.06
Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. Neuron (2014) 1.05
Thymol and related alkyl phenols activate the hTRPA1 channel. Br J Pharmacol (2008) 1.04
Direct evidence for functional TRPV1/TRPA1 heteromers. Pflugers Arch (2014) 1.03
Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate. Am J Physiol Cell Physiol (2008) 1.00
TRPA1 is a polyunsaturated fatty acid sensor in mammals. PLoS One (2012) 0.99
TRPA1 channels: molecular sentinels of cellular stress and tissue damage. J Physiol (2016) 0.98
Polymodal ligand sensitivity of TRPA1 and its modes of interactions. J Gen Physiol (2009) 0.98
Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4. PLoS One (2010) 0.98
Activation of TRPA1 by membrane permeable local anesthetics. Mol Pain (2011) 0.96
Transient receptor potential A1 channels: insights into cough and airway inflammatory disease. Chest (2011) 0.96
TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells. J Assoc Res Otolaryngol (2011) 0.94
Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate. Br J Pharmacol (2012) 0.94
Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am J Physiol Cell Physiol (2011) 0.93
Transient receptor potential V1 regulates activation and modulation of transient receptor potential A1 by Ca2+. Neuroscience (2010) 0.93
The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression. Biophys J (2010) 0.93
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol (2008) 0.93
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1. Biochem J (2011) 0.92
Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics. Br J Pharmacol (2014) 0.91
1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain (2012) 0.90
Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons. J Neurosci (2012) 0.90
TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis. J Neurophysiol (2011) 0.89
New strategies to develop novel pain therapies: addressing thermoreceptors from different points of view. Pharmaceuticals (Basel) (2011) 0.87
Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain. J Mol Model (2012) 0.87
C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel. J Biol Chem (2012) 0.87
The TRPM8 ion channel comprises direct Gq protein-activating capacity. Pflugers Arch (2012) 0.86
ThermoTRPs and Pain. Neuroscientist (2015) 0.86
The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings. Biochim Biophys Acta (2010) 0.85
Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner. Pflugers Arch (2012) 0.84
Perceptual mapping of chemesthetic stimuli in naïve assessors. Chemosens Percept (2015) 0.84
Species-specific temperature sensitivity of TRPA1. Temperature (Austin) (2015) 0.84
The dynamic TRPA1 channel: a suitable pharmacological pain target? Curr Pharm Biotechnol (2011) 0.84
C. elegans TRP channels. Adv Exp Med Biol (2011) 0.83
Trafficking of ThermoTRP Channels. Membranes (Basel) (2014) 0.83
A synergistic effect of simultaneous TRPA1 and TRPV1 activations on vagal pulmonary C-fiber afferents. J Appl Physiol (1985) (2014) 0.83
Benzoquinone reveals a cysteine-dependent desensitization mechanism of TRPA1. Mol Pharmacol (2013) 0.82
Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity. J Physiol Sci (2014) 0.82
Mechanical force and cytoplasmic Ca(2+) activate yeast TRPY1 in parallel. J Membr Biol (2009) 0.82
2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2). Front Pharmacol (2013) 0.82
TRPA1 as a drug target--promise and challenges. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.82
Transient receptor potential channel A1 and noxious cold responses in rat cutaneous nociceptors. Neuroscience (2009) 0.82
Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation. Pflugers Arch (2013) 0.82
Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation. J Biol Chem (2012) 0.81
In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model. J Pain Res (2013) 0.81
Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1. Pflugers Arch (2012) 0.80
How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy. Bioessays (2015) 0.80
Dose-dependent effects of icilin on thermal preference in the hindpaw and face of rats. J Pain (2009) 0.80
Role of calcium ions in the positive interaction between TRPA1 and TRPV1 channels in bronchopulmonary sensory neurons. J Appl Physiol (1985) (2015) 0.79
Heat and AITC activate green anole TRPA1 in a membrane-delimited manner. Pflugers Arch (2014) 0.79
Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil. J Biol Chem (2014) 0.79
A temperature-sensitive TRP ion channel, Painless, functions as a noxious heat sensor in fruit flies. Commun Integr Biol (2009) 0.79
An astrocyte TRP switch for inhibition. Nat Neurosci (2011) 0.78
Agonist-induced sensitisation of the irritant receptor ion channel TRPA1. J Physiol (2016) 0.78
Involvement of TRPV1 and TRPA1 in incisional intraoral and extraoral pain. J Dent Res (2015) 0.78
Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science (2003) 4.39
Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster. Nat Neurosci (2004) 2.49
Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. J Biol Chem (2009) 1.67
Dual capacity of a human olfactory receptor. Curr Biol (2004) 1.67
Expression profile of ectopic olfactory receptors determined by deep sequencing. PLoS One (2013) 1.29
Tmem16b is specifically expressed in the cilia of olfactory sensory neurons. Chem Senses (2010) 1.26
Two cDNAs coding for histamine-gated ion channels in D. melanogaster. Nat Neurosci (2002) 1.26
3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron (2002) 1.25
The stimulatory Gα(s) protein is involved in olfactory signal transduction in Drosophila. PLoS One (2011) 1.21
Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping. J Biol Chem (2006) 1.20
Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm. Mol Cell Endocrinol (2006) 1.08
Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. J Cell Sci (2006) 1.07
Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. J Biol Chem (2004) 1.06
A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins. Chem Senses (2006) 1.06
Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia. PLoS One (2013) 1.06
Beta-arrestin2-mediated internalization of mammalian odorant receptors. J Neurosci (2006) 1.05
Arachidonic acid plays a role in rat vomeronasal signal transduction. J Neurosci (2002) 1.05
Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. PLoS One (2013) 1.01
Direct activation of transient receptor potential V1 by nickel ions. Pflugers Arch (2010) 1.00
Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis. J Gen Physiol (2011) 0.99
Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J Biol Chem (2008) 0.99
Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling. Angew Chem Int Ed Engl (2011) 0.98
Chemosensory properties of murine nasal and cutaneous trigeminal neurons identified by viral tracing. BMC Neurosci (2006) 0.98
A novel chloride channel in Drosophila melanogaster is inhibited by protons. J Biol Chem (2005) 0.97
Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors. J Biol Chem (2010) 0.94
Chondroitin sulfate proteoglycans regulate astrocyte-dependent synaptogenesis and modulate synaptic activity in primary embryonic hippocampal neurons. Eur J Neurosci (2011) 0.93
Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. J Pharm Pharm Sci (2010) 0.93
Odorant-receptor interactions and odor percept: a chemical perspective. Chem Biodivers (2008) 0.92
Overexpression of a hyperpolarization-activated cation current (Ih) channel gene modifies the firing activity of identified motor neurons in a small neural network. J Neurosci (2003) 0.92
Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J Biol Chem (2011) 0.91
GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies. Pflugers Arch (2011) 0.90
Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels. Br J Pharmacol (2004) 0.90
Anti-ganglioside antibodies alter presynaptic release and calcium influx. Neurobiol Dis (2007) 0.89
Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channels. J Pharm Pharm Sci (2009) 0.89
Identification of RL-TGR, a coreceptor involved in aversive chemical signaling. Proc Natl Acad Sci U S A (2010) 0.88
Prediction of perception: probing the hOR17-4 olfactory receptor model with silicon analogues of bourgeonal and lilial. Angew Chem Int Ed Engl (2007) 0.88
Subunit-specific P2X-receptor expression defines chemosensory properties of trigeminal neurons. Eur J Neurosci (2004) 0.87
G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. J Biol Chem (2011) 0.87
hOR17-4 as a potential therapeutic target. Drug News Perspect (2004) 0.87
Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS One (2012) 0.86
Go α is involved in sugar perception in Drosophila. Chem Senses (2010) 0.86
In-depth characterisation of Retinal Pigment Epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC). Neuromolecular Med (2014) 0.86
The TRPM8 ion channel comprises direct Gq protein-activating capacity. Pflugers Arch (2012) 0.86
Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation. J Neurosci (2013) 0.85
Molecular and functional characterization of an I(h)-channel from lobster olfactory receptor neurons. Eur J Neurosci (2005) 0.84
Advanced tracing tools: functional neuronal expression of virally encoded fluorescent calcium indicator proteins. J Neurovirol (2009) 0.84
Camphor modulates TRPV3 cation channels activity by interacting with critical pore-region cysteine residues. Pak J Pharm Sci (2013) 0.84
The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK. Front Pharmacol (2013) 0.84
Expression and distribution of the intermediate filament protein nestin and other stem cell related molecules in the human olfactory epithelium. Histol Histopathol (2010) 0.83
Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carcinoma cells: a comparison with leukocytes. Mol Cancer Res (2006) 0.83
Amiloride derivatives are effective blockers of insect odorant receptors. Chem Senses (2013) 0.83
Suppression of soft tissue sarcoma growth by a host defense-like lytic peptide. PLoS One (2011) 0.82
Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses. J Neurosci Res (2002) 0.82
Purinergic signalling mobilizes mitochondrial Ca²⁺ in mouse Sertoli cells. J Physiol (2011) 0.82
2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2). Front Pharmacol (2013) 0.82
Inhibition of TRPV1 for the treatment of sensitive skin. Exp Dermatol (2010) 0.82
New insights in endogenous modulation of ligand-gated ion channels: histamine is an inverse agonist at strychnine sensitive glycine receptors. Eur J Pharmacol (2013) 0.81
Oncolytic designer host defense peptide suppresses growth of human liposarcoma. Int J Cancer (2010) 0.81
Olfaction in three genetic and two MPTP-induced Parkinson's disease mouse models. PLoS One (2013) 0.80
Nasal chemosensory-stimulation evoked activity patterns in the rat trigeminal ganglion visualized by in vivo voltage-sensitive dye imaging. PLoS One (2011) 0.80
Odorant-dependent generation of nitric oxide in Mammalian olfactory sensory neurons. PLoS One (2009) 0.80
Variants of the Drosophila melanogaster Ih-channel are generated by different splicing. Insect Biochem Mol Biol (2005) 0.80
Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1. FEBS J (2009) 0.80
Anterograde transsynaptic tracing in the murine somatosensory system using Pseudorabies virus (PrV): a "live-cell"-tracing tool for analysis of identified neurons in vitro. J Neurovirol (2007) 0.80
New insight into stimulus-induced plasticity of the olfactory epithelium in Mus musculus by quantitative proteomics. J Proteome Res (2008) 0.79
Characterization of recombinant and native Ih-channels from Apis mellifera. Insect Biochem Mol Biol (2003) 0.79
Unusual functional properties of homo- and heteromultimeric histamine-gated chloride channels of Drosophila melanogaster: spontaneous currents and dual gating by GABA and histamine. Neurosci Lett (2004) 0.79