Published in Neuroscientist on January 21, 2015
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An HSV-based library screen identifies PP1α as a negative TRPV1 regulator with analgesic activity in models of pain. Mol Ther Methods Clin Dev (2016) 0.75
Toluene diisocyanate exposure induces airway inflammation of bronchial epithelial cells via the activation of transient receptor potential melastatin 8. Exp Mol Med (2017) 0.75
4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities. Sci Rep (2017) 0.75
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A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
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The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
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An ion channel essential for sensing chemical damage. J Neurosci (2007) 3.03
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A (2003) 2.95
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High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nat Neurosci (2006) 2.83
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Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol (2006) 2.34
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain (2008) 2.32
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Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol (2007) 2.21
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron (2004) 2.19
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Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc Natl Acad Sci U S A (2010) 2.15
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Visualizing cold spots: TRPM8-expressing sensory neurons and their projections. J Neurosci (2008) 1.92
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Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. J Neurosci (2007) 1.82
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75
TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron (2013) 1.73
Uncoupling proton activation of vanilloid receptor TRPV1. J Neurosci (2007) 1.69
TRPM8 mechanism of cold allodynia after chronic nerve injury. J Neurosci (2007) 1.69
TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain (2005) 1.69
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem (2003) 1.68
Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J Neurosci (2010) 1.66
Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc Natl Acad Sci U S A (2011) 1.65
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Ann Rheum Dis (2013) 1.64
The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation. Pain (2009) 1.55
Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2. J Neurosci (2008) 1.53
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans. Pain (2007) 1.53
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol (2006) 1.48
Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis. Gastroenterology (2007) 1.44
Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800. Pain (2006) 1.41
TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. Mol Pain (2011) 1.38
Localization of the PIP2 sensor of TRPV1 ion channels. J Biol Chem (2011) 1.38
A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia. J Neurosci (2013) 1.38
TRPV1 is activated by both acidic and basic pH. J Neurosci (2009) 1.37
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Pain (2011) 1.35
TRPA1 and substance P mediate colitis in mice. Gastroenterology (2011) 1.35
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain (2011) 1.34
Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS One (2011) 1.34
Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol (2009) 1.34