Published in Proc Natl Acad Sci U S A on February 26, 2007
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev (2011) 2.38
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 1.86
Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development (2013) 1.17
Identification and regulation of c-Myb target genes in MCF-7 cells. BMC Cancer (2011) 1.13
In vitro and in vivo analysis of B-Myb in basal-like breast cancer. Oncogene (2008) 1.13
Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved. Proc Natl Acad Sci U S A (2010) 1.06
One-step preservation of phosphoproteins and tissue morphology at room temperature for diagnostic and research specimens. PLoS One (2011) 1.03
Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance. Carcinogenesis (2012) 1.00
Myb proteins: angels and demons in normal and transformed cells. Front Biosci (Landmark Ed) (2011) 0.96
Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer. PLoS One (2010) 0.95
Myb permits multilineage airway epithelial cell differentiation. Stem Cells (2014) 0.90
Dramatic repositioning of c-Myb to different promoters during the cell cycle observed by combining cell sorting with chromatin immunoprecipitation. PLoS One (2011) 0.89
A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets. Oncotarget (2014) 0.88
Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis. Cancers (Basel) (2014) 0.85
The CSF-1 receptor fashions the intestinal stem cell niche. Stem Cell Res (2012) 0.85
A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding. Mol Cancer (2008) 0.84
CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response. PLoS One (2013) 0.84
Human Vav1 expression in hematopoietic and cancer cell lines is regulated by c-Myb and by CpG methylation. PLoS One (2012) 0.83
MYBL2 is an independent prognostic marker that has tumor-promoting functions in colorectal cancer. Am J Cancer Res (2015) 0.83
Delayed development of specific thyroid hormone-regulated events in transthyretin null mice. Am J Physiol Endocrinol Metab (2012) 0.82
Mouse models of intestinal cancer. J Pathol (2015) 0.81
Duplication and maintenance of the Myb genes of vertebrate animals. Biol Open (2012) 0.80
Intestinal-specific activatable Myb initiates colon tumorigenesis in mice. Oncogene (2015) 0.79
The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis. Cell Death Dis (2013) 0.79
Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice. J Lipid Res (2012) 0.78
c-Myb inhibits myoblast fusion. PLoS One (2013) 0.77
Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas. Sci Rep (2017) 0.75
The Expression of c-Myb Correlates with the Levels of Rhabdomyosarcoma-specific Marker Myogenin. Sci Rep (2015) 0.75
The Myb-p300 Interaction Is a Novel Molecular Pharmacologic Target. Mol Cancer Ther (2015) 0.75
Exploiting induced senescence in intestinal organoids to drive enteroendocrine cell expansion. Stem Cell Investig (2017) 0.75
MYB deregulation from a EWSR1-MYB fusion at leukemic evolution of a JAK2 (V617F) positive primary myelofibrosis. Mol Cytogenet (2016) 0.75
Regulation of Cancer Cell Responsiveness to Ionizing Radiation Treatment by Cyclic AMP Response Element Binding Nuclear Transcription Factor. Front Oncol (2017) 0.75
miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb. Cell Rep (2017) 0.75
DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening. Sci Rep (2017) 0.75
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol (1992) 34.17
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell (1996) 8.41
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell (1991) 6.14
Cyclin E ablation in the mouse. Cell (2003) 5.58
Expression of the c-myb proto-oncogene during cellular proliferation. Nature (1986) 3.45
Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos Trans R Soc Lond B Biol Sci (1998) 2.92
Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J (2003) 2.61
Differentiation and self-renewal in the mouse gastrointestinal epithelium. Curr Opin Cell Biol (1994) 2.51
c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell (2005) 2.30
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A (2004) 1.81
c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium. Mol Cell Biol (2005) 1.70
c-Myb is essential for early T cell development. Genes Dev (1999) 1.70
B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis. Am J Pathol (2003) 1.68
Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma. Proc Natl Acad Sci U S A (1984) 1.59
A method for the isolation and culture of human colonic crypts in collagen gels. In Vitro Cell Dev Biol (1987) 1.54
Transcriptional activation of the c-myc gene by the c-myb and B-myb gene products. Oncogene (1992) 1.36
p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line. Exp Cell Res (1996) 1.34
Targeting c-Myb expression in human disease. Expert Opin Ther Targets (2003) 1.24
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis. Oncogene (1999) 1.23
Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers. Genes Chromosomes Cancer (2006) 1.13
c-Myb down-regulation is associated with human colon cell differentiation, apoptosis, and decreased Bcl-2 expression. Cancer Res (1998) 1.04
c-Myb a stem-progenitor cell regulator in multiple tissue compartments. Growth Factors (2005) 1.00
Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression. J Biol Chem (2002) 0.97
p27 expression in inflammatory bowel disease-associated neoplasia. Further evidence of a unique molecular pathogenesis. Am J Pathol (1999) 0.92
c-Myb is critical for murine colon development. Oncogene (1999) 0.91
Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS. DNA Cell Biol (2005) 0.88
c-myb Heterozygous mice are hypersensitive to 5-fluorouracil and ionizing radiation. Mol Cancer Res (2004) 0.85
Colonic expression of c-myb is initiated in utero and continues throughout adult life. Cell Growth Differ (1996) 0.85
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature (2010) 18.69
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet (2006) 12.98
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell (2010) 12.23
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science (2012) 8.42
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol (2006) 7.89
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Coexistence of quiescent and active adult stem cells in mammals. Science (2010) 7.54
Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 7.29
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell (2009) 7.08
FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (2012) 6.55
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell (2009) 6.26
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature (2011) 6.09
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 5.99
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol (2006) 5.83
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44
Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42
Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov (2006) 5.29
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell (2011) 4.79
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell (2007) 4.59
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The Intestinal Wnt/TCF Signature. Gastroenterology (2006) 4.48
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (2004) 4.39
Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol (2005) 4.34
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med (2002) 4.28
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27
The intestinal stem cell. Genes Dev (2008) 4.21
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology (2009) 4.16
Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09
Correlation of structural elements and infectivity of the HET-s prion. Nature (2005) 4.01
Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol (2004) 4.00
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97
Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol (2006) 3.85
Transcriptome profile of human colorectal adenomas. Mol Cancer Res (2007) 3.82
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (2013) 3.43
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology (2009) 3.39
Strategies for homeostatic stem cell self-renewal in adult tissues. Cell (2011) 3.33
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol (2012) 3.30
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol (2004) 3.24
Isolation and in vitro expansion of human colonic stem cells. Nat Med (2011) 3.20
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat Med (2012) 3.17
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med (2006) 3.11
STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology (2006) 3.05
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 3.03
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol (2008) 3.02
The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans. Proc Natl Acad Sci U S A (2004) 2.80
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Res Treat (2009) 2.76
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature (2012) 2.76
Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol (2011) 2.72
Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J (2003) 2.61
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology (2012) 2.57
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology (2010) 2.55
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci U S A (2002) 2.55
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A (2004) 2.46
Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40
Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Dev Biol (2005) 2.38
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest (2009) 2.28
Survivin and molecular pathogenesis of colorectal cancer. Lancet (2003) 2.25
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol (2011) 2.21
Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell (2010) 2.15
STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. Gastroenterology (2006) 2.13
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell (2010) 2.13
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10