Published in Cell on February 09, 2007
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STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
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A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature (2003) 6.25
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Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol (2003) 5.86
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Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science (2008) 4.45
Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA. PLoS Biol (2009) 4.32
Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS One (2008) 3.38
Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol (2003) 3.17
Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell (2005) 3.10
Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell (2007) 2.88
Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron (2003) 2.36
Ultrasensitivity in the Regulation of Cdc25C by Cdk1. Mol Cell (2011) 2.27
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Tuning the activation threshold of a kinase network by nested feedback loops. Science (2009) 2.03
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Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol (2004) 1.74
Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol (2007) 1.63
Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Curr Biol (2008) 1.57
A mechanism for the evolution of phosphorylation sites. Cell (2011) 1.47
The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch. Nat Cell Biol (2013) 1.46
Multisite M-phase phosphorylation of Xenopus Wee1A. Mol Cell Biol (2005) 1.37
The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell (2010) 1.29
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Spatial positive feedback at the onset of mitosis. Cell (2012) 1.26
Minimizing off-target effects by using diced siRNAs for RNA interference. J RNAi Gene Silencing (2006) 1.20
Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy. Nat Protoc (2006) 1.16
Systems biology: On the cell cycle and its switches. Nature (2008) 1.02
Picking a winner: new mechanistic insights into the design of effective siRNAs. Trends Biotechnol (2004) 1.00
Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle. Nature (2013) 1.00
Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cell Cycle (2005) 0.99
Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes. Mol Biol Cell (2002) 0.97
Silencing gene expression with Dicer-generated siRNA pools. Methods Mol Biol (2005) 0.96
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res (2009) 0.92
Mos mediates the mitotic activation of p42 MAPK in Xenopus egg extracts. Curr Biol (2004) 0.86
Emi2 at the crossroads: where CSF meets MPF. Cell Cycle (2007) 0.84
Mechanistic studies of the mitotic activation of Mos. Mol Cell Biol (2006) 0.84
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A noisy 'Start' to the cell cycle. Mol Syst Biol (2006) 0.79
The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks. Cell Rep (2016) 0.78
Systems biology. A clock with a flip switch. Science (2007) 0.77
Bistability in one equation or fewer. Methods Mol Biol (2012) 0.77