Published in Cell on March 23, 2007
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Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. Dev Cell (2010) 3.72
Driving the cell cycle with a minimal CDK control network. Nature (2010) 2.79
Cell lineages and the logic of proliferative control. PLoS Biol (2009) 2.62
Unlimited multistability in multisite phosphorylation systems. Nature (2009) 2.57
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Protein sequestration generates a flexible ultrasensitive response in a genetic network. Mol Syst Biol (2009) 2.09
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Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes Dev (2012) 1.37
Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites. Proc Natl Acad Sci U S A (2007) 1.33
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Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery. Mol Cell (2011) 1.27
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The rational parameterization theorem for multisite post-translational modification systems. J Theor Biol (2009) 1.24
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The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update. Database (Oxford) (2013) 1.20
Multisite phosphorylation networks as signal processors for Cdk1. Nat Struct Mol Biol (2013) 1.19
A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast. Mol Biol Cell (2011) 1.17
Ultrasensitive response motifs: basic amplifiers in molecular signalling networks. Open Biol (2013) 1.16
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase. Proc Natl Acad Sci U S A (2012) 1.15
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Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback. Trends Biochem Sci (2014) 1.11
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Achieving optimal growth through product feedback inhibition in metabolism. PLoS Comput Biol (2010) 1.10
The cell cycle switch computes approximate majority. Sci Rep (2012) 1.09
Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity. Trends Biochem Sci (2014) 1.06
Distributivity and processivity in multisite phosphorylation can be distinguished through steady-state invariants. Biophys J (2007) 1.06
Non-transcriptional regulatory processes shape transcriptional network dynamics. Nat Rev Microbiol (2011) 1.04
Crosstalk and competition in signaling networks. Biophys J (2012) 1.03
Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation. Dev Cell (2012) 1.03
Multisite phosphorylation provides an effective and flexible mechanism for switch-like protein degradation. PLoS One (2010) 1.02
Human sirt-1: molecular modeling and structure-function relationships of an unordered protein. PLoS One (2008) 1.01
Sequestration-based bistability enables tuning of the switching boundaries and design of a latch. Mol Syst Biol (2012) 0.99
Cks confers specificity to phosphorylation-dependent CDK signaling pathways. Nat Struct Mol Biol (2013) 0.99
Ultrasensitivity part III: cascades, bistable switches, and oscillators. Trends Biochem Sci (2014) 0.98
Density-dependent lectin-glycan interactions as a paradigm for conditional regulation by posttranslational modifications. Mol Cell Proteomics (2013) 0.98
The Goodwin model: behind the Hill function. PLoS One (2013) 0.97
Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. Proc Natl Acad Sci U S A (2013) 0.94
Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model. BMC Syst Biol (2010) 0.94
Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response. Proc Natl Acad Sci U S A (2012) 0.94
Crosstalk and the evolution of specificity in two-component signaling. Proc Natl Acad Sci U S A (2014) 0.93
Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos. PLoS Biol (2014) 0.92
Ligand depletion in vivo modulates the dynamic range and cooperativity of signal transduction. PLoS One (2010) 0.92
Molecular mechanisms creating bistable switches at cell cycle transitions. Open Biol (2013) 0.92
Long signaling cascades tend to attenuate retroactivity. Biophys J (2011) 0.92
Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. J Cell Biol (2015) 0.91
Robust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of pins. Mol Cell (2011) 0.89
Stochastic modeling of stem-cell dynamics with control. Math Biosci (2012) 0.89
Feedback loops and reciprocal regulation: recurring motifs in the systems biology of the cell cycle. Curr Opin Cell Biol (2013) 0.89
Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches. Proc Natl Acad Sci U S A (2012) 0.89
14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis. PLoS One (2011) 0.88
How molecular competition influences fluxes in gene expression networks. PLoS One (2011) 0.88
Substrate-dependent control of ERK phosphorylation can lead to oscillations. Biophys J (2011) 0.86
Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation. Am J Physiol Cell Physiol (2012) 0.85
Employing the metabolic "branch point effect" to generate an all-or-none, digital-like response in enzymatic outputs and enzyme-based sensors. Anal Chem (2011) 0.85
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The Renaissance or the cuckoo clock. Philos Trans R Soc Lond B Biol Sci (2011) 0.85
Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. J Biol Chem (2015) 0.84
Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade. J Biol Chem (2013) 0.84
Reciprocal regulation as a source of ultrasensitivity in two-component systems with a bifunctional sensor kinase. PLoS Comput Biol (2014) 0.83
From quiescence to proliferation: Cdk oscillations drive the mammalian cell cycle. Front Physiol (2012) 0.83
A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain. PLoS Comput Biol (2014) 0.83
Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry. Cell Div (2010) 0.82
The biochemistry of mitosis. Cold Spring Harb Perspect Biol (2015) 0.82
The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks. Cell Rep (2016) 0.81
Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate. PLoS Comput Biol (2013) 0.81
MAP kinase modules: the excursion model and the steps that count. Biophys J (2014) 0.80
Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch. Front Physiol (2012) 0.80
Ultrasensitive synthetic protein regulatory networks using mixed decoys. ACS Synth Biol (2012) 0.80
Substrate Affinity Differentially Influences Protein Kinase C Regulation and Inhibitor Potency. J Biol Chem (2016) 0.80
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Compact modeling of allosteric multisite proteins: application to a cell size checkpoint. PLoS Comput Biol (2014) 0.79
CDK Substrate Phosphorylation and Ordering the Cell Cycle. Cell (2016) 0.79
Phosphatase specificity and pathway insulation in signaling networks. Biophys J (2015) 0.78
Robustness of cell cycle control and flexible orders of signaling events. Sci Rep (2015) 0.78
Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro. Biophys J (2011) 0.78
Minimal models for cell-cycle control based on competitive inhibition and multisite phosphorylations of Cdk substrates. Biophys J (2013) 0.78
A data-driven, mathematical model of mammalian cell cycle regulation. PLoS One (2014) 0.78
Encoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolution. PLoS One (2014) 0.78
Robust, tunable genetic memory from protein sequestration combined with positive feedback. Nucleic Acids Res (2015) 0.78
Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity. PLoS One (2016) 0.77
TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Sci Signal (2016) 0.76
Bistability, oscillations, and traveling waves in frog egg extracts. Bull Math Biol (2014) 0.76
Ultrasensitivity by molecular titration in spatially propagating enzymatic reactions. Biophys J (2013) 0.76
Triggering signaling pathways using F-actin self-organization. Sci Rep (2016) 0.76
Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora. Cell Cycle (2015) 0.75
A Synonymous Mutation Upstream of the Gene Encoding a Weak-Link Enzyme Causes an Ultrasensitive Response in Growth Rate. J Bacteriol (2016) 0.75
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science (2005) 6.88
A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature (2003) 6.25
Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol (2007) 6.11
Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol (2003) 5.86
Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc Natl Acad Sci U S A (2004) 4.63
Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science (2008) 4.45
Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA. PLoS Biol (2009) 4.32
Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS One (2008) 3.38
Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol (2003) 3.17
Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell (2005) 3.10
Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron (2003) 2.36
Ultrasensitivity in the Regulation of Cdc25C by Cdk1. Mol Cell (2011) 2.27
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Tuning the activation threshold of a kinase network by nested feedback loops. Science (2009) 2.03
The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses. Curr Biol (2003) 1.87
Tuning bulk electrostatics to regulate protein function. Cell (2007) 1.85
Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol (2004) 1.74
Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol (2007) 1.63
Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Curr Biol (2008) 1.57
A mechanism for the evolution of phosphorylation sites. Cell (2011) 1.47
The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch. Nat Cell Biol (2013) 1.46
Multisite M-phase phosphorylation of Xenopus Wee1A. Mol Cell Biol (2005) 1.37
The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell (2010) 1.29
Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF. Mol Biol Cell (2008) 1.27
Spatial positive feedback at the onset of mitosis. Cell (2012) 1.26
Minimizing off-target effects by using diced siRNAs for RNA interference. J RNAi Gene Silencing (2006) 1.20
Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy. Nat Protoc (2006) 1.16
Systems biology: On the cell cycle and its switches. Nature (2008) 1.02
Picking a winner: new mechanistic insights into the design of effective siRNAs. Trends Biotechnol (2004) 1.00
Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle. Nature (2013) 1.00
Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cell Cycle (2005) 0.99
Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes. Mol Biol Cell (2002) 0.97
Silencing gene expression with Dicer-generated siRNA pools. Methods Mol Biol (2005) 0.96
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res (2009) 0.92
Mos mediates the mitotic activation of p42 MAPK in Xenopus egg extracts. Curr Biol (2004) 0.86
Emi2 at the crossroads: where CSF meets MPF. Cell Cycle (2007) 0.84
Mechanistic studies of the mitotic activation of Mos. Mol Cell Biol (2006) 0.84
A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes. Dev Biol (2008) 0.83
A noisy 'Start' to the cell cycle. Mol Syst Biol (2006) 0.79
The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks. Cell Rep (2016) 0.78
Systems biology. A clock with a flip switch. Science (2007) 0.77
Bistability in one equation or fewer. Methods Mol Biol (2012) 0.77