|
1
|
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.
|
Lancet
|
2012
|
56.72
|
|
2
|
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.
|
Lancet
|
2012
|
41.47
|
|
3
|
Heart disease and stroke statistics--2012 update: a report from the American Heart Association.
|
Circulation
|
2011
|
31.98
|
|
4
|
Heart disease and stroke statistics--2013 update: a report from the American Heart Association.
|
Circulation
|
2012
|
30.79
|
|
5
|
Heart disease and stroke statistics--2014 update: a report from the American Heart Association.
|
Circulation
|
2013
|
28.02
|
|
6
|
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.
|
Lancet
|
2012
|
26.95
|
|
7
|
Heart disease and stroke statistics--2015 update: a report from the American Heart Association.
|
Circulation
|
2014
|
22.74
|
|
8
|
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force.
|
J Am Coll Cardiol
|
2002
|
16.25
|
|
9
|
Multiple biomarkers for the prediction of first major cardiovascular events and death.
|
N Engl J Med
|
2006
|
15.60
|
|
10
|
Vitamin D deficiency and risk of cardiovascular disease.
|
Circulation
|
2008
|
13.39
|
|
11
|
Obesity and the risk of heart failure.
|
N Engl J Med
|
2002
|
12.58
|
|
12
|
Genome-wide association study of blood pressure and hypertension.
|
Nat Genet
|
2009
|
11.54
|
|
13
|
Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010.
|
Lancet
|
2012
|
11.32
|
|
14
|
The state of US health, 1990-2010: burden of diseases, injuries, and risk factors.
|
JAMA
|
2013
|
10.43
|
|
15
|
Long-term trends in the incidence of and survival with heart failure.
|
N Engl J Med
|
2002
|
10.37
|
|
16
|
Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association.
|
Circulation
|
2015
|
10.14
|
|
17
|
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination.
|
Am J Epidemiol
|
2007
|
9.90
|
|
18
|
Arterial stiffness and cardiovascular events: the Framingham Heart Study.
|
Circulation
|
2010
|
9.09
|
|
19
|
Lifetime risk for development of atrial fibrillation: the Framingham Heart Study.
|
Circulation
|
2004
|
8.80
|
|
20
|
Lifetime risk for developing congestive heart failure: the Framingham Heart Study.
|
Circulation
|
2002
|
8.49
|
|
21
|
Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study.
|
Hypertension
|
2004
|
8.27
|
|
22
|
2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.
|
J Am Coll Cardiol
|
2010
|
7.54
|
|
23
|
Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study.
|
Arterioscler Thromb Vasc Biol
|
2003
|
7.47
|
|
24
|
Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study.
|
Lancet
|
2009
|
7.27
|
|
25
|
Plasma natriuretic peptide levels and the risk of cardiovascular events and death.
|
N Engl J Med
|
2004
|
7.12
|
|
26
|
Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study.
|
Circulation
|
2003
|
6.83
|
|
27
|
Obesity and the risk of new-onset atrial fibrillation.
|
JAMA
|
2004
|
6.73
|
|
28
|
Executive summary: heart disease and stroke statistics--2014 update: a report from the American Heart Association.
|
Circulation
|
2014
|
6.55
|
|
29
|
C-reactive protein, fibrinogen, and cardiovascular disease prediction.
|
N Engl J Med
|
2012
|
6.39
|
|
30
|
Executive summary: heart disease and stroke statistics--2012 update: a report from the American Heart Association.
|
Circulation
|
2012
|
6.24
|
|
31
|
Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association.
|
Circulation
|
2013
|
6.13
|
|
32
|
Aortic stiffness, blood pressure progression, and incident hypertension.
|
JAMA
|
2012
|
6.01
|
|
33
|
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.
|
Lancet
|
2008
|
5.89
|
|
34
|
Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the american heart association.
|
Circulation
|
2011
|
5.26
|
|
35
|
Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block.
|
JAMA
|
2009
|
5.22
|
|
36
|
Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study.
|
Circulation
|
2007
|
5.10
|
|
37
|
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.
|
BMC Med Genet
|
2007
|
5.02
|
|
38
|
Serum aldosterone and the incidence of hypertension in nonhypertensive persons.
|
N Engl J Med
|
2004
|
4.92
|
|
39
|
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
|
Lancet
|
2012
|
4.87
|
|
40
|
Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring.
|
JAMA
|
2004
|
4.85
|
|
41
|
Multiple loci associated with indices of renal function and chronic kidney disease.
|
Nat Genet
|
2009
|
4.78
|
|
42
|
A risk score for predicting stroke or death in individuals with new-onset atrial fibrillation in the community: the Framingham Heart Study.
|
JAMA
|
2003
|
4.77
|
|
43
|
Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study.
|
Circulation
|
2008
|
4.69
|
|
44
|
Incidence and prognosis of syncope.
|
N Engl J Med
|
2002
|
4.69
|
|
45
|
AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients with Coronary and other Atherosclerotic Vascular Disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation.
|
Circulation
|
2011
|
4.65
|
|
46
|
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
|
Lancet
|
2012
|
4.63
|
|
47
|
A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study.
|
Ann Intern Med
|
2008
|
4.61
|
|
48
|
Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study.
|
Circulation
|
2013
|
4.60
|
|
49
|
Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study.
|
Hypertension
|
2004
|
4.56
|
|
50
|
2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.
|
Circulation
|
2010
|
4.56
|
|
51
|
Impact of obesity on plasma natriuretic peptide levels.
|
Circulation
|
2004
|
4.46
|
|
52
|
Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study.
|
Am J Respir Crit Care Med
|
2006
|
4.36
|
|
53
|
Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update.
|
Circulation
|
2007
|
4.16
|
|
54
|
Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study.
|
Circulation
|
2003
|
4.09
|
|
55
|
Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study.
|
Circulation
|
2005
|
4.08
|
|
56
|
Common variants in KCNN3 are associated with lone atrial fibrillation.
|
Nat Genet
|
2010
|
3.97
|
|
57
|
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure.
|
Nat Genet
|
2009
|
3.81
|
|
58
|
National study of physician awareness and adherence to cardiovascular disease prevention guidelines.
|
Circulation
|
2005
|
3.77
|
|
59
|
Genome-wide association study of PR interval.
|
Nat Genet
|
2010
|
3.73
|
|
60
|
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
|
Nat Genet
|
2012
|
3.71
|
|
61
|
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
|
Circulation
|
2011
|
3.68
|
|
62
|
Prevention of heart failure: a scientific statement from the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group.
|
Circulation
|
2008
|
3.56
|
|
63
|
Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute.
|
Circulation
|
2009
|
3.55
|
|
64
|
Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.
|
Arterioscler Thromb Vasc Biol
|
2006
|
3.48
|
|
65
|
Natural history of asymptomatic left ventricular systolic dysfunction in the community.
|
Circulation
|
2003
|
3.46
|
|
66
|
Evidence-based guidelines for cardiovascular disease prevention in women.
|
Circulation
|
2004
|
3.39
|
|
67
|
Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis.
|
JAMA
|
2011
|
3.34
|
|
68
|
C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study.
|
Arch Intern Med
|
2005
|
3.31
|
|
69
|
Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.
|
Circulation
|
2006
|
3.15
|
|
70
|
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
PLoS Genet
|
2011
|
3.07
|
|
71
|
Validation of an atrial fibrillation risk algorithm in whites and African Americans.
|
Arch Intern Med
|
2010
|
3.05
|
|
72
|
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
|
BMC Med Genet
|
2007
|
3.04
|
|
73
|
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.
|
BMC Med Genet
|
2007
|
2.93
|
|
74
|
Candidate gene association resource (CARe): design, methods, and proof of concept.
|
Circ Cardiovasc Genet
|
2010
|
2.91
|
|
75
|
Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the American Heart Association.
|
J Am Coll Cardiol
|
2011
|
2.89
|
|
76
|
Executive Summary: Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association.
|
Circulation
|
2016
|
2.87
|
|
77
|
Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study.
|
Stroke
|
2008
|
2.84
|
|
78
|
Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study.
|
Circulation
|
2003
|
2.80
|
|
79
|
Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.
|
Circulation
|
2017
|
2.76
|
|
80
|
Systemic inflammation and COPD: the Framingham Heart Study.
|
Chest
|
2007
|
2.74
|
|
81
|
Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study.
|
Circulation
|
2009
|
2.63
|
|
82
|
Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007.
|
Circ Cardiovasc Qual Outcomes
|
2012
|
2.61
|
|
83
|
2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.
|
Circulation
|
2010
|
2.58
|
|
84
|
Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study.
|
Eur Heart J
|
2004
|
2.58
|
|
85
|
Sleep apnea and markers of vascular endothelial function in a large community sample of older adults.
|
Am J Respir Crit Care Med
|
2003
|
2.51
|
|
86
|
Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study.
|
Circulation
|
2005
|
2.49
|
|
87
|
Simple risk model predicts incidence of atrial fibrillation in a racially and geographically diverse population: the CHARGE-AF consortium.
|
J Am Heart Assoc
|
2013
|
2.47
|
|
88
|
AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation endorsed by the World Heart Federation and the Preventive Cardiovascular Nurses Association.
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J Am Coll Cardiol
|
2011
|
2.45
|
|
89
|
Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study.
|
Circulation
|
2007
|
2.42
|
|
90
|
P wave duration and risk of longitudinal atrial fibrillation in persons ≥ 60 years old (from the Framingham Heart Study).
|
Am J Cardiol
|
2011
|
2.39
|
|
91
|
Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study.
|
Circulation
|
2003
|
2.39
|
|
92
|
Atrial fibrillation: current knowledge and future directions in epidemiology and genomics.
|
Circulation
|
2011
|
2.36
|
|
93
|
Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study.
|
JAMA
|
2002
|
2.33
|
|
94
|
Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community.
|
Circulation
|
2010
|
2.32
|
|
95
|
Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators.
|
Blood
|
2009
|
2.27
|
|
96
|
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
|
BMC Med Genet
|
2007
|
2.25
|
|
97
|
Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study.
|
Circulation
|
2008
|
2.22
|
|
98
|
Pulse pressure and risk of new-onset atrial fibrillation.
|
JAMA
|
2007
|
2.20
|
|
99
|
Resistin, adiponectin, and risk of heart failure the Framingham offspring study.
|
J Am Coll Cardiol
|
2008
|
2.18
|
|
100
|
Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060.
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Eur Heart J
|
2013
|
2.17
|
|
101
|
Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.
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Hypertension
|
2008
|
2.14
|
|
102
|
Impact of age and sex on plasma natriuretic peptide levels in healthy adults.
|
Am J Cardiol
|
2002
|
2.13
|
|
103
|
Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study.
|
Hypertension
|
2004
|
2.13
|
|
104
|
Does job strain increase the risk for coronary heart disease or death in men and women? The Framingham Offspring Study.
|
Am J Epidemiol
|
2004
|
2.12
|
|
105
|
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
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JAMA
|
2009
|
2.10
|
|
106
|
Uromodulin levels associate with a common UMOD variant and risk for incident CKD.
|
J Am Soc Nephrol
|
2009
|
2.10
|
|
107
|
Hemodynamic correlates of blood pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study.
|
Circulation
|
2010
|
2.07
|
|
108
|
Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation.
|
Eur Heart J
|
2009
|
2.06
|
|
109
|
Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community.
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Circulation
|
2009
|
2.05
|
|
110
|
Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.
|
Hum Mol Genet
|
2010
|
2.05
|
|
111
|
Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study.
|
Am J Epidemiol
|
2007
|
2.02
|
|
112
|
Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community.
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Circulation
|
2011
|
2.00
|
|
113
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Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation.
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Am J Cardiol
|
2010
|
1.97
|
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114
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QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study.
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Heart Rhythm
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2005
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1.96
|
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115
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Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality.
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Arterioscler Thromb Vasc Biol
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2010
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1.95
|
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116
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A multi-marker approach to predict incident CKD and microalbuminuria.
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J Am Soc Nephrol
|
2010
|
1.95
|
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117
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Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study.
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Circulation
|
2012
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1.95
|
|
118
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Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals.
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Circulation
|
2007
|
1.93
|
|
119
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Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample.
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Hypertension
|
2007
|
1.93
|
|
120
|
Characteristics of Framingham offspring participants with long-lived parents.
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Arch Intern Med
|
2007
|
1.91
|
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121
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Independent susceptibility markers for atrial fibrillation on chromosome 4q25.
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Circulation
|
2010
|
1.90
|
|
122
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Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts.
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Am J Hum Genet
|
2012
|
1.90
|
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123
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Relation of brachial and digital measures of vascular function in the community: the Framingham heart study.
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Hypertension
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2011
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1.90
|
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124
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European ancestry as a risk factor for atrial fibrillation in African Americans.
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Circulation
|
2010
|
1.90
|
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125
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Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study.
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Circulation
|
2004
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1.84
|
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126
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The epidemiology of "asymptomatic" left ventricular systolic dysfunction: implications for screening.
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Ann Intern Med
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2003
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1.84
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127
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Status of the epidemiology of atrial fibrillation.
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Med Clin North Am
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2008
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1.80
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128
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Multiple marker approach to risk stratification in patients with stable coronary artery disease.
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Eur Heart J
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2010
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1.80
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129
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Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function.
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Circulation
|
2006
|
1.78
|
|
130
|
CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study.
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Circulation
|
2005
|
1.76
|
|
131
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Longitudinal tracking of left ventricular mass over the adult life course: clinical correlates of short- and long-term change in the framingham offspring study.
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Circulation
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2009
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1.75
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132
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Association between familial atrial fibrillation and risk of new-onset atrial fibrillation.
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JAMA
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2010
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1.75
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133
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Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease.
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Am J Cardiol
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2008
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1.74
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134
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Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study.
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Circ Arrhythm Electrophysiol
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2010
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1.70
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135
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Association of parental heart failure with risk of heart failure in offspring.
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N Engl J Med
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2006
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1.69
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136
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Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update.
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J Am Coll Cardiol
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2007
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1.69
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137
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Assessment of endothelial function using digital pulse amplitude tonometry.
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Trends Cardiovasc Med
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2009
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1.69
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138
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Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants.
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J Am Geriatr Soc
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2005
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1.68
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139
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Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: the Framingham Heart Study.
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Circulation
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2005
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1.68
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140
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Symptoms and functional status of patients with atrial fibrillation: state of the art and future research opportunities.
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Circulation
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2012
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1.67
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141
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Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study.
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Stroke
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2009
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1.66
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142
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Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.
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Circulation
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2007
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1.65
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143
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