Published in J Neurosci on March 21, 2007
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med (2009) 4.11
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2009) 3.31
Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis. J Neurosci (2010) 1.78
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol (2010) 1.71
Age-related changes in Arc transcription and DNA methylation within the hippocampus. Neurobiol Aging (2010) 1.61
Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J Neurosci (2009) 1.52
Sex-dependent modulation of age-related cognitive decline by the L-type calcium channel gene Cacna1c (Cav 1.2). Eur J Neurosci (2015) 1.39
Stem cell review series: role of neurogenesis in age-related memory disorders. Aging Cell (2008) 1.36
Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice. Neurobiol Aging (2008) 1.22
Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease. Adv Drug Deliv Rev (2008) 1.21
Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci (2010) 1.17
Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline. Neurobiol Dis (2011) 1.14
Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment. Mol Neurodegener (2007) 1.13
Prominent hippocampal CA3 gene expression profile in neurocognitive aging. Neurobiol Aging (2009) 1.12
An epigenetic hypothesis of aging-related cognitive dysfunction. Front Aging Neurosci (2010) 1.11
Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome. J Neurochem (2010) 1.08
Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways. PLoS One (2012) 1.07
Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Biochim Biophys Acta (2010) 1.06
Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment. J Neuroinflammation (2011) 1.05
Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging. J Mol Neurosci (2012) 1.03
Differential expression of Wnts after spinal cord contusion injury in adult rats. PLoS One (2011) 1.03
Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. J Alzheimers Dis (2012) 1.03
The genomic response of the ipsilateral and contralateral cortex to stroke in aged rats. J Cell Mol Med (2008) 1.02
A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. PLoS One (2008) 0.99
Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging. Neurobiol Aging (2010) 0.98
Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats. Neurobiol Aging (2013) 0.95
Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. J Neurosci (2011) 0.95
Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. PLoS One (2011) 0.94
Porcine muscle sensory attributes associate with major changes in gene networks involving CAPZB, ANKRD1, and CTBP2. Funct Integr Genomics (2009) 0.94
Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease. Adv Pharmacol (2012) 0.93
Mechanisms of age-related cognitive change and targets for intervention: epigenetics. J Gerontol A Biol Sci Med Sci (2012) 0.93
Cognitive performance and age-related changes in the hippocampal proteome. Neuroscience (2008) 0.93
Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury. J Neurotrauma (2014) 0.92
Region-specific genetic alterations in the aging hippocampus: implications for cognitive aging. Front Aging Neurosci (2010) 0.92
Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats. Proc Natl Acad Sci U S A (2014) 0.91
High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging. Neurobiol Aging (2014) 0.90
Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates. Neuropharmacology (2012) 0.90
Effects of long-term pioglitazone treatment on peripheral and central markers of aging. PLoS One (2010) 0.90
Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. BMC Genomics (2013) 0.89
Gene expression profiling in the rhesus macaque: methodology, annotation and data interpretation. Methods (2009) 0.89
Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention. PLoS One (2013) 0.88
Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory. J Neurochem (2012) 0.88
The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiol Aging (2015) 0.87
Enhanced calcium buffering in F344 rat cholinergic basal forebrain neurons is associated with age-related cognitive impairment. J Neurophysiol (2009) 0.87
Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. J Gerontol A Biol Sci Med Sci (2014) 0.86
The hippocampal neuroproteome with aging and cognitive decline: past progress and future directions. Front Aging Neurosci (2011) 0.86
Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities. Front Cell Neurosci (2013) 0.86
White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease. EBioMedicine (2015) 0.86
Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One (2012) 0.85
Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain. Front Pharmacol (2012) 0.85
Local amplification of glucocorticoids in the aging brain and impaired spatial memory. Front Aging Neurosci (2012) 0.85
Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age. PLoS One (2011) 0.85
Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Adv Pharmacol Sci (2011) 0.85
Glucocorticoid-dependent hippocampal transcriptome in male rats: pathway-specific alterations with aging. Endocrinology (2013) 0.84
Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging Cell (2013) 0.84
Alzheimer's disease and age-related memory decline (preclinical). Pharmacol Biochem Behav (2011) 0.83
Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging. J Gerontol A Biol Sci Med Sci (2015) 0.83
CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging. Neurobiol Aging (2012) 0.83
Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. Eur J Pharmacol (2013) 0.82
Influence of aging on Bmal1 and Per2 expression in extra-SCN oscillators in hamster brain. Brain Res (2012) 0.82
Homer-1a immediate early gene expression correlates with better cognitive performance in aging. Age (Dordr) (2012) 0.81
Spatial behavior and seizure-induced changes in c-fos mRNA expression in young and old rats. Neurobiol Aging (2012) 0.80
Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats. Biogerontology (2013) 0.80
The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseases. Curr Neuropharmacol (2013) 0.80
Age-dependent variability in gene expression in male Fischer 344 rat retina. Toxicol Sci (2008) 0.80
Age-related changes in Egr1 transcription and DNA methylation within the hippocampus. Hippocampus (2016) 0.80
Characterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparation. J Neurophysiol (2013) 0.79
Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: dynamic responses to depolarization and sensitivity to pioglitazone. Cell Calcium (2011) 0.79
Age-changes in gene expression in primary mixed glia cultures from young vs. old rat cerebral cortex are modified by interactions with neurons. Brain Behav Immun (2011) 0.79
Hippocampal gene expression meta-analysis identifies aging and age-associated spatial learning impairment (ASLI) genes and pathways. PLoS One (2013) 0.79
Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. J Neuroinflammation (2012) 0.79
The effects of aging vs. α7 nAChR subunit deficiency on the mouse brain transcriptome: aging beats the deficiency. Age (Dordr) (2010) 0.79
P2Y receptors in Alzheimer's disease. Biol Cell (2014) 0.79
Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole. Mol Psychiatry (2016) 0.78
FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? Eur J Pharmacol (2013) 0.78
DNA methylation and cognitive aging. Oncotarget (2015) 0.78
Environmental enrichment reverses histone methylation changes in the aged hippocampus and restores age-related memory deficits. Biology (Basel) (2015) 0.78
Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain. Oncotarget (2015) 0.78
Hippocampal CA1 transcriptional profile of sleep deprivation: relation to aging and stress. PLoS One (2012) 0.77
Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome. Neurobiol Aging (2016) 0.77
The effects of aging and genotype on NMDA receptor expression in growth hormone receptor knockout (GHRKO) mice. J Gerontol A Biol Sci Med Sci (2011) 0.77
Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice. J Neuroendocrinol (2016) 0.77
Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus. J Neurosci (2015) 0.77
Epigenetic contributions to cognitive aging: disentangling mindspan and lifespan. Learn Mem (2014) 0.77
Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer's disease? J Neural Transm (Vienna) (2010) 0.76
Aging-related gene signature regulated by Nlrp3 predicts glioma progression. Am J Cancer Res (2014) 0.76
Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy aging. Front Aging Neurosci (2014) 0.76
The Brain Metabolome of Male Rats across the Lifespan. Sci Rep (2016) 0.76
Wnt Signaling in Neurogenesis during Aging and Physical Activity. Brain Sci (2012) 0.76
Age and High-Fat Diet Effects on Glutamine Synthetase Immunoreactivity in Liver and Hippocampus and Recognition Memory in Mice. Curr Aging Sci (2016) 0.75
Integrative Transcriptome Profiling of Cognitive Aging and Its Preservation through Ser/Thr Protein Phosphatase Regulation. PLoS One (2015) 0.75
Higher levels of phosphorylated Y1472 on GluN2B subunits in the frontal cortex of aged mice are associated with good spatial reference memory, but not cognitive flexibility. Age (Dordr) (2016) 0.75
Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline. Oncotarget (2015) 0.75
Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex. Front Aging Neurosci (2016) 0.75
A novel mouse model of the aged brain: Over-expression of the L-type voltage-gated calcium channel CaV1.3. Behav Brain Res (2016) 0.75
Transcriptome profiling and pathway analysis of genes expressed differentially in participants with or without a positive response to topiramate treatment for methamphetamine addiction. BMC Med Genomics (2014) 0.75
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A (2004) 5.65
Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci (2003) 3.33
Statistical implications of pooling RNA samples for microarray experiments. BMC Bioinformatics (2003) 2.52
Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell (2007) 1.90
The entorhinal cortex of the mouse: organization of the projection to the hippocampal formation. Hippocampus (2003) 1.80
The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats. J Neurosci (2005) 1.57
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. J Neurosci (2005) 1.55
Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J Neurosci (2009) 1.52
Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. J Neurosci (2006) 1.48
Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice. Neurobiol Dis (2003) 1.48
Ca2+ regulation and gene expression in normal brain aging. Trends Neurosci (2004) 1.32
Hydrazide oligonucleotides: new chemical modification for chip array attachment and conjugation. Nucleic Acids Res (2002) 1.29
Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: Implications for depressive disorders and future therapies. J Neurosci Res (2004) 1.23
Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Gastroenterology (2008) 1.23
Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol (2012) 1.21
DNA methylation impacts on learning and memory in aging. Neurobiol Aging (2007) 1.20
Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci (2010) 1.17
Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503. Brain Res (2006) 1.15
Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats. J Neurosci (2002) 1.14
Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology (Berl) (2011) 1.14
Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels. Brain Res (2007) 1.14
MicroRNA modulation in complex regional pain syndrome. J Transl Med (2011) 1.14
A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease. Curr Alzheimer Res (2007) 1.10
Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease. J Chem Neuroanat (2011) 1.10
Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. J Med Chem (2011) 1.08
Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice. Neurobiol Dis (2006) 1.08
Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy. Epilepsia (2008) 1.07
Central mechanisms of menthol-induced analgesia. J Pharmacol Exp Ther (2012) 1.05
Reduction of Alzheimer's disease amyloid plaque load in transgenic mice by D3, A D-enantiomeric peptide identified by mirror image phage display. ChemMedChem (2008) 1.04
Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes. J Gerontol A Biol Sci Med Sci (2012) 1.03
Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease. Neurobiol Dis (2009) 1.03
WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A novel 5-hydroxytryptamine 2C receptor-selective agonist with preclinical antipsychotic-like activity. J Pharmacol Exp Ther (2006) 1.03
Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. J Alzheimers Dis (2012) 1.03
Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons. J Neurochem (2009) 1.02
Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice. ACS Chem Neurosci (2010) 0.98
Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats. Psychopharmacology (Berl) (2005) 0.98
Role of the anterodorsal and anteroventral nuclei of the thalamus in spatial memory in the rat. Behav Brain Res (2002) 0.98
Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging. Neurobiol Aging (2010) 0.98
Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. J Med Chem (2012) 0.96
Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats. Neurobiol Aging (2013) 0.95
Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. J Neurosci (2011) 0.95
Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice. PLoS One (2011) 0.94
Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents. Psychopharmacology (Berl) (2007) 0.94
Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats. Psychopharmacology (Berl) (2006) 0.94
Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology. Brain Res Brain Res Rev (2005) 0.94
Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the rat. Behav Brain Res (2004) 0.94
Age-related decline in spatial learning and memory: attenuation by captopril. Clin Exp Hypertens (2003) 0.94
Species differences in the projections from the entorhinal cortex to the hippocampus. Brain Res Bull (2002) 0.94
Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depression. J Am Board Fam Pract (2003) 0.94
Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging. Cell Calcium (2006) 0.93
The 13- and 20-item Hopkins Symptom Checklist Depression Scale: psychometric properties in primary care patients with minor depression or dysthymia. Int J Psychiatry Med (2004) 0.93
In vitro and in vivo staining characteristics of small, fluorescent, Abeta42-binding D-enantiomeric peptides in transgenic AD mouse models. ChemMedChem (2009) 0.93
Neurodevelopmental impairment following neonatal hyperoxia in the mouse. Neurobiol Dis (2012) 0.92
Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology. Neurobiol Aging (2009) 0.92
Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders. J Psychiatr Res (2009) 0.91
P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. J Psychiatr Res (2010) 0.91