Published in J Gerontol A Biol Sci Med Sci on May 08, 2012
Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative Magnetic Resonance Imaging studies. Diabetes Care (2012) 1.10
Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study. Sleep (2014) 0.97
Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. J Gerontol A Biol Sci Med Sci (2012) 0.95
Neuroinflammation in the normal aging hippocampus. Neuroscience (2015) 0.95
Type 2 diabetes and cognitive impairment: contributions from neuroimaging. J Geriatr Psychiatry Neurol (2014) 0.92
Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. J Gerontol A Biol Sci Med Sci (2012) 0.92
Associations between sleep-disordered breathing, nocturnal hypoxemia, and subsequent cognitive decline in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc (2015) 0.86
Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. J Gerontol A Biol Sci Med Sci (2014) 0.86
Beneficial effects of multisensory and cognitive stimulation on age-related cognitive decline in long-term-care institutions. Clin Interv Aging (2014) 0.85
Does the brain shrink as the waist expands? Ageing Res Rev (2014) 0.82
Younger age of dementia diagnosis in a Hispanic population in southern California. Int J Geriatr Psychiatry (2014) 0.82
Nutraceutical intervention improves older adults' cognitive functioning. Rejuvenation Res (2014) 0.81
The Expression Changes of Inflammasomes in the Aging Rat Kidneys. J Gerontol A Biol Sci Med Sci (2015) 0.80
Three midlife strategies to prevent cognitive impairment due to Alzheimer's disease. Climacteric (2014) 0.80
Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men. Antivir Ther (2015) 0.79
A novel approach to rapidly prevent age-related cognitive decline. Aging Cell (2013) 0.78
How predictive of dementia are peripheral inflammatory markers in the elderly? Neurodegener Dis Manag (2012) 0.78
What Metabolic Syndrome Contributes to Brain Outcomes in African American & Caucasian Cohorts. Curr Alzheimer Res (2015) 0.76
Brain MRI Volume Findings in Diabetic Adults With Albuminuria: The ACCORD-MIND Study. J Gerontol A Biol Sci Med Sci (2015) 0.75
Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans? Front Pharmacol (2016) 0.75
In vivo and in vitro attenuation of naloxone-precipitated experimental opioid withdrawal syndrome by insulin and selective KATP channel modulator. Psychopharmacology (Berl) (2014) 0.75
Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA (2002) 25.68
Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron (2004) 5.44
The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA (2004) 4.73
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci (2008) 4.04
Food combination and Alzheimer disease risk: a protective diet. Arch Neurol (2010) 3.99
Prevalence of dementia in older latinos: the influence of type 2 diabetes mellitus, stroke and genetic factors. J Am Geriatr Soc (2003) 3.60
Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci (2003) 3.33
The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged. Arch Neurol (2009) 3.13
Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation (2004) 2.90
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab (2003) 2.51
Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell (2007) 1.78
Differential contribution of NMDA receptors in hippocampal subregions to spatial working memory. Nat Neurosci (2002) 1.56
Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim Biophys Acta (2008) 1.56
The metabolic syndrome and development of cognitive impairment among older women. Arch Neurol (2009) 1.54
Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento Area Latino Study of Aging study. J Am Geriatr Soc (2007) 1.52
Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment. J Neurosci (2009) 1.52
Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II. J Neurosci (2010) 1.24
Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair. Eur J Pharmacol (2008) 1.18
Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci (2010) 1.17
Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Arch Neurol (2011) 1.15
PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus. J Neurochem (2010) 1.02
Redox sensitive calcium stores underlie enhanced after hyperpolarization of aged neurons: role for ryanodine receptor mediated calcium signaling. J Neurophysiol (2010) 1.00
Gene expression in the hippocampus: regionally specific effects of aging and caloric restriction. Mech Ageing Dev (2010) 0.96
Insulin resistance, diabetes and cognitive function: consequences for preventative strategies. Diabetes Metab (2010) 0.94
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 24.02
The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol (2011) 8.15
Effects of Testosterone Treatment in Older Men. N Engl J Med (2016) 6.66
Functional status of elderly adults before and after initiation of dialysis. N Engl J Med (2009) 6.45
Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA (2005) 6.20
Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA (2009) 5.75
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A (2004) 5.65
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ (2005) 5.34
Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA (2003) 5.23
The NIH Cognitive and Emotional Health Project. Report of the Critical Evaluation Study Committee. Alzheimers Dement (2006) 5.05
Hearing loss and incident dementia. Arch Neurol (2011) 4.65
Hearing loss and cognitive decline in older adults. JAMA Intern Med (2013) 4.25
Kidney function and cognitive impairment in US adults: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Am J Kidney Dis (2008) 3.87
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry (2006) 3.61
Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci (2007) 3.61
A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc (2009) 3.58
Limited literacy and mortality in the elderly: the health, aging, and body composition study. J Gen Intern Med (2006) 3.51
Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Arch Intern Med (2007) 3.50
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci (2003) 3.33
Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging. Neurobiol Aging (2006) 3.26
Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. Am J Geriatr Psychiatry (2006) 3.22
Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease. J Int Neuropsychol Soc (2008) 3.21
Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study. J Am Soc Nephrol (2005) 3.14
Patient and caregiver characteristics associated with depression in caregivers of patients with dementia. J Gen Intern Med (2003) 3.13
Morphological classification of brains via high-dimensional shape transformations and machine learning methods. Neuroimage (2004) 3.13
A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. J Am Geriatr Soc (2003) 3.09
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci (2009) 3.06
The association between physical function and lifestyle activity and exercise in the health, aging and body composition study. J Am Geriatr Soc (2004) 2.93
Structural and functional biomarkers of prodromal Alzheimer's disease: a high-dimensional pattern classification study. Neuroimage (2008) 2.93
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun (2006) 2.89
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci (2003) 2.87
Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults. J Gerontol A Biol Sci Med Sci (2003) 2.82
Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study. Arch Intern Med (2009) 2.82
Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry (2003) 2.77
Longitudinal changes in cerebral blood flow in the older hypertensive brain. Stroke (2007) 2.75
Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev (2002) 2.75
Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci (2006) 2.73
Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71
Simple paradigm for extra-cerebral tissue removal: algorithm and analysis. Neuroimage (2011) 2.69
Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly. Ann Neurol (2006) 2.68
Contribution of Alzheimer disease to mortality in the United States. Neurology (2014) 2.67
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci (2008) 2.65
Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development Program. Clin Transl Sci (2009) 2.60
Hearing loss and cognition in the Baltimore Longitudinal Study of Aging. Neuropsychology (2011) 2.54
Statistical implications of pooling RNA samples for microarray experiments. BMC Bioinformatics (2003) 2.52
Cognitive impairment in chronic kidney disease. J Am Geriatr Soc (2004) 2.50
Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Ann Neurol (2011) 2.46
High occurrence of mood and anxiety disorders among older adults: The National Comorbidity Survey Replication. Arch Gen Psychiatry (2010) 2.43
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal (2007) 2.43
Association between physical and cognitive function in healthy elderly: the health, aging and body composition study. Neuroepidemiology (2005) 2.39
Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med (2013) 2.38
Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37
Depression and risk of developing dementia. Nat Rev Neurol (2011) 2.31
"Brain-specific" nutrients: a memory cure? Nutrition (2003) 2.29
Adverse oral health and cognitive decline: the health, aging and body composition study. J Am Geriatr Soc (2013) 2.27
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis. Mol Ther (2005) 2.27
Body mass index in midlife and risk of Alzheimer disease and vascular dementia. Curr Alzheimer Res (2007) 2.19
Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun (2009) 2.19
Hormone therapy and risk of Alzheimer disease: a critical time. JAMA (2002) 2.16
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci (2004) 2.14
Promising strategies for the prevention of dementia. Arch Neurol (2009) 2.14
Effect of infarcts on dementia in the Baltimore longitudinal study of aging. Ann Neurol (2008) 2.10
ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology (2007) 2.09
Activity energy expenditure and incident cognitive impairment in older adults. Arch Intern Med (2011) 2.07
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex. J Neurosci (2006) 2.07
Limited literacy in older people and disparities in health and healthcare access. J Am Geriatr Soc (2006) 2.06
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging (2006) 2.06
Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index. Brain (2009) 2.05
The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults. JAMA Intern Med (2013) 2.05
Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing. Brain (2010) 2.04
Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study. Am J Med (2002) 2.02
Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun (2006) 2.00
Executive function, more than global cognition, predicts functional decline and mortality in elderly women. J Gerontol A Biol Sci Med Sci (2007) 1.97
Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults. J Am Geriatr Soc (2012) 1.96
Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort. Arch Intern Med (2004) 1.95
Circulating 25-hydroxyvitamin D levels and frailty status in older women. J Clin Endocrinol Metab (2010) 1.93
Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats. J Neurosci (2012) 1.93
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci (2003) 1.91
Chronic kidney disease and cognitive impairment in menopausal women. Am J Kidney Dis (2005) 1.91
Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell (2007) 1.90
Vision impairment and combined vision and hearing impairment predict cognitive and functional decline in older women. J Am Geriatr Soc (2004) 1.88
Depressive symptoms in middle age and the development of later-life functional limitations: the long-term effect of depressive symptoms. J Am Geriatr Soc (2010) 1.88
Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. J Neurosci (2007) 1.86
Glia: novel counter-regulators of opioid analgesia. Trends Neurosci (2005) 1.86
Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol (2003) 1.84
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection. Brain Behav Immun (2008) 1.82
Prior stressor exposure sensitizes LPS-induced cytokine production. Brain Behav Immun (2002) 1.82
Glial activation and pathological pain. Neurochem Int (2004) 1.80
A meta-analysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology (2005) 1.79
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy. Neuron (2012) 1.78
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One (2011) 1.78
Physical activity over the life course and its association with cognitive performance and impairment in old age. J Am Geriatr Soc (2010) 1.76
Cognitive impairment, depressive symptoms, and functional decline in older people. J Am Geriatr Soc (2002) 1.76
The last 2 years of life: functional trajectories of frail older people. J Am Geriatr Soc (2003) 1.74
Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). J Neuropathol Exp Neurol (2005) 1.74
Long-term cognitive and functional effects of potentially inappropriate medications in older women. J Gerontol A Biol Sci Med Sci (2013) 1.74