Published in J Neurosci on March 21, 2007
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Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
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Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet (2011) 1.60
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. PLoS One (2010) 1.49
Planar cell polarity signaling, cilia and polarized ciliary beating. Curr Opin Cell Biol (2010) 1.37
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Mitotic internalization of planar cell polarity proteins preserves tissue polarity. Nat Cell Biol (2011) 1.28
Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development (2010) 1.26
Planar cell polarity: keeping hairs straight is not so simple. Cold Spring Harb Perspect Biol (2010) 1.24
Primary cilia in planar cell polarity regulation of the inner ear. Curr Top Dev Biol (2008) 1.23
Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One (2012) 1.22
The cell biology of planar cell polarity. J Cell Biol (2014) 1.19
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The plane facts of PCP in the CNS. Neuron (2008) 1.17
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Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development (2011) 1.10
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Over half the hair cells in the mouse utricle first appear after birth, with significant numbers originating from early postnatal mitotic production in peripheral and striolar growth zones. J Assoc Res Otolaryngol (2012) 1.04
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Wnt/PCP proteins regulate stereotyped axon branch extension in Drosophila. Development (2012) 1.00
Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci (2013) 0.97
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Planar cell polarity in Drosophila. Organogenesis (2011) 0.95
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Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol (2012) 0.91
Maintained expression of the planar cell polarity molecule Vangl2 and reformation of hair cell orientation in the regenerating inner ear. J Assoc Res Otolaryngol (2010) 0.90
Control of vertebrate core planar cell polarity protein localization and dynamics by Prickle 2. Development (2015) 0.89
Emx2 and early hair cell development in the mouse inner ear. Dev Biol (2010) 0.85
Distribution of high-conductance calcium-activated potassium channels in rat vestibular epithelia. J Comp Neurol (2009) 0.85
Rearrangements between differentiating hair cells coordinate planar polarity and the establishment of mirror symmetry in lateral-line neuromasts. Biol Open (2012) 0.84
Non-cell-autonomous planar cell polarity propagation in the auditory sensory epithelium of vertebrates. Dev Biol (2011) 0.82
Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice. Dev Dyn (2013) 0.82
Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis. Hum Mol Genet (2013) 0.81
Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear. Dev Biol (2014) 0.80
Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open (2014) 0.80
Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors. Semin Cell Dev Biol (2016) 0.77
Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation. JCI Insight (2016) 0.76
Otolaryngology-head and neck surgery at Johns Hopkins: The first 100 years (1914-2014). Laryngoscope (2015) 0.75
Establishment of planar cell polarity is coupled to regional cell cycle exit and cell differentiation in the mouse utricle. Sci Rep (2017) 0.75
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells. Elife (2017) 0.75
Planar cell polarity in moving cells: think globally, act locally. Development (2017) 0.75
Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development. Dev Biol (2017) 0.75
Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development (2016) 0.75
Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear. PLoS Genet (2017) 0.75
Gene expression during the life cycle of Drosophila melanogaster. Science (2002) 11.36
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell (2003) 7.93
Communicating with Hedgehogs. Nat Rev Mol Cell Biol (2005) 5.01
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science (2010) 4.11
A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell (2004) 3.56
Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Science (2005) 3.42
Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell (2002) 3.25
Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell (2002) 3.03
Fidelity in planar cell polarity signalling. Nature (2003) 2.74
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A (2003) 2.72
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev (2010) 2.60
A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet (2008) 2.58
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A (2009) 2.47
Thirty-one flavors of Drosophila rab proteins. Genetics (2007) 2.46
Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell (2008) 2.37
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A (2006) 2.23
Twelve tips for teaching with ultrasound in the undergraduate curriculum. Med Teach (2013) 2.21
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J Cell Biol (2009) 2.10
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Patching the gaps in Hedgehog signalling. Nat Cell Biol (2007) 2.01
The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. Proc Natl Acad Sci U S A (2003) 1.86
ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biol (2007) 1.82
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med (2010) 1.82
Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Proc Natl Acad Sci U S A (2004) 1.82
Assessing the conservation of mammalian gene expression using high-density exon arrays. Mol Biol Evol (2007) 1.81
A three-tiered mechanism for regulation of planar cell polarity. Semin Cell Dev Biol (2002) 1.80
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev (2003) 1.79
The Drosophila BRM complex facilitates global transcription by RNA polymerase II. EMBO J (2002) 1.78
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. J Cell Biol (2009) 1.77
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease. PLoS Genet (2005) 1.77
Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. Development (2007) 1.76
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci (2005) 1.74
Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell (2010) 1.74
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer (2009) 1.72
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A (2006) 1.71
Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol (2004) 1.66
Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet (2011) 1.60
Microtubules enable the planar cell polarity of airway cilia. Curr Biol (2012) 1.59
Rab35 controls actin bundling by recruiting fascin as an effector protein. Science (2009) 1.51
Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J Neurosci (2011) 1.50
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. PLoS One (2010) 1.49
Biology by numbers: mathematical modelling in developmental biology. Nat Rev Genet (2007) 1.49
Auditory neurons make stereotyped wiring decisions before maturation of their targets. J Neurosci (2007) 1.46
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol (2003) 1.44
Incredible journey: how do developmental signals travel through tissue? Genes Dev (2004) 1.38
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Pointing in the right direction: new developments in the field of planar cell polarity. Nat Rev Genet (2011) 1.28
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.28
Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C. Hum Mol Genet (2012) 1.26
Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci (2011) 1.26
Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Development (2007) 1.23
A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development (2005) 1.23
Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly. Prog Neurobiol (2011) 1.23
Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One (2012) 1.22
Control of neuronal morphology by the atypical cadherin Fat3. Neuron (2011) 1.19
Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice. Cancer Res (2008) 1.18
Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development (2013) 1.17
Regulation of PCP by the Fat signaling pathway. Genes Dev (2013) 1.17
Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. Development (2003) 1.14
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev (2008) 1.14
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Dev Biol (2002) 1.14
Gata3 is a critical regulator of cochlear wiring. J Neurosci (2013) 1.08
Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens. Lab Chip (2006) 1.08
Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development (2008) 1.07
Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev (2011) 1.07
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle. J Biol Chem (2002) 1.06
Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development (2003) 1.04
Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts. J Biol Chem (2002) 1.03
Cell packing influences planar cell polarity signaling. Proc Natl Acad Sci U S A (2008) 1.01
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Complement is dispensable for neurodegeneration in Niemann-Pick disease type C. J Neuroinflammation (2012) 1.00
Understanding biology by reverse engineering the control. Proc Natl Acad Sci U S A (2005) 1.00
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol (2007) 1.00
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development (2005) 1.00
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One (2009) 0.98
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
Not lost in space: trafficking in the hedgehog signaling pathway. Sci Signal (2010) 0.94
Changes in Sef levels influence auditory brainstem development and function. J Neurosci (2007) 0.93
Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling. Genetics (2004) 0.92
A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife (2013) 0.92
Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system. J Comp Neurol (2011) 0.92
Dishevelled links basal body docking and orientation in ciliated epithelial cells. Trends Cell Biol (2008) 0.91