Published in PLoS One on February 02, 2010
Principles of planar polarity in animal development. Development (2011) 2.94
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev (2011) 1.94
Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity. Dev Cell (2011) 1.64
Microtubules enable the planar cell polarity of airway cilia. Curr Biol (2012) 1.59
Planar cell polarity signaling, cilia and polarized ciliary beating. Curr Opin Cell Biol (2010) 1.37
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacol Rev (2015) 1.29
Understanding ciliated epithelia: the power of Xenopus. Genesis (2011) 1.23
The cell biology of planar cell polarity. J Cell Biol (2014) 1.19
Planar cell polarity signaling: coordination of cellular orientation across tissues. Wiley Interdiscip Rev Dev Biol (2013) 1.11
Cystic kidney disease: the role of Wnt signaling. Trends Mol Med (2010) 1.10
A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality. Dev Biol (2013) 1.10
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B. Hum Mol Genet (2010) 1.07
The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish. Development (2010) 1.06
RTTN mutations link primary cilia function to organization of the human cerebral cortex. Am J Hum Genet (2012) 1.01
Asymmetric protein localization in planar cell polarity: mechanisms, puzzles, and challenges. Curr Top Dev Biol (2012) 1.01
Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol (2010) 1.00
Cilia, Wnt signaling, and the cytoskeleton. Cilia (2012) 0.99
SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing. Genome Biol (2011) 0.99
Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt). Annu Rev Cell Dev Biol (2015) 0.98
Disruption of planar cell polarity activity leads to developmental biliary defects. Dev Biol (2011) 0.97
Regional cell shape changes control form and function of Kupffer's vesicle in the zebrafish embryo. Dev Biol (2012) 0.92
Regulation of basal body and ciliary functions by Diversin. Mech Dev (2011) 0.91
Diversity and convergence in the mechanisms establishing L/R asymmetry in metazoa. EMBO Rep (2014) 0.90
Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning. Hum Mol Genet (2013) 0.89
Left-right asymmetry: cilia stir up new surprises in the node. Open Biol (2013) 0.88
Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development. Semin Cell Dev Biol (2015) 0.87
Planar polarization of Vangl2 in the vertebrate neural plate is controlled by Wnt and Myosin II signaling. Biol Open (2015) 0.87
Micropatterning of cells reveals chiral morphogenesis. Stem Cell Res Ther (2013) 0.87
Physical association between a novel plasma-membrane structure and centrosome orients cell division. Elife (2016) 0.86
It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry. Commun Integr Biol (2013) 0.85
Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos. Cell Mol Life Sci (2013) 0.85
What are those cilia doing in the neural tube? Cilia (2012) 0.85
An essential and highly conserved role for Zic3 in left-right patterning, gastrulation and convergent extension morphogenesis. Dev Biol (2012) 0.85
Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development. Stem Cells Dev (2012) 0.85
Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development. PLoS One (2013) 0.84
Salient features of the ciliated organ of asymmetry. Bioarchitecture (2014) 0.84
Genome-wide view of TGFβ/Foxh1 regulation of the early mesendoderm program. Development (2014) 0.82
Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ (2012) 0.81
Embryonic exposure to propylthiouracil disrupts left-right patterning in Xenopus embryos. FASEB J (2012) 0.80
Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation. Development (2014) 0.80
Polarity proteins are required for left-right axis orientation and twin-twin instruction. Genesis (2011) 0.80
Cilia self-organize in response to planar cell polarity and flow. Nat Cell Biol (2010) 0.79
ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled. Nat Commun (2015) 0.78
Laterality defects are influenced by timing of treatments and animal model. Differentiation (2011) 0.78
Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors. Semin Cell Dev Biol (2016) 0.77
Cilia in vertebrate left-right patterning. Philos Trans R Soc Lond B Biol Sci (2016) 0.77
Drosophila Dachsous and Fat polarize actin-based protrusions over a restricted domain of the embryonic denticle field. Dev Biol (2013) 0.77
Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms. Dev Biol (2014) 0.77
TGF-β Signaling Regulates the Differentiation of Motile Cilia. Cell Rep (2015) 0.77
Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right. Dev Cell (2010) 0.77
Wnt proteins can direct planar cell polarity in vertebrate ectoderm. Elife (2016) 0.76
Chirality of the cytoskeleton in the origins of cellular asymmetry. Philos Trans R Soc Lond B Biol Sci (2016) 0.76
Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth. Sci Rep (2016) 0.76
Requirement of DLG1 for cardiovascular development and tissue elongation during cochlear, enteric, and skeletal development: possible role in convergent extension. PLoS One (2015) 0.75
Establishment of lateral organ asymmetries in the invertebrate chordate, Ciona intestinalis. Evodevo (2017) 0.75
Effective targeted gene 'knockdown' in zebrafish. Nat Genet (2000) 14.40
In situ hybridization: an improved whole-mount method for Xenopus embryos. Methods Cell Biol (1991) 8.31
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell (2003) 7.93
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature (2003) 4.56
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet (2008) 4.28
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet (2007) 3.88
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. Nat Genet (2008) 3.84
Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature (2006) 3.80
Tissue/planar cell polarity in vertebrates: new insights and new questions. Development (2007) 3.66
Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell (2001) 3.65
Nodal flow and the generation of left-right asymmetry. Cell (2006) 3.52
The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci (2006) 3.36
Planar cell polarization: an emerging model points in the right direction. Annu Rev Cell Dev Biol (2005) 3.10
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (2006) 2.96
Morpholino oligos: making sense of antisense? Dev Biol (2002) 2.95
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci (2006) 2.73
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development (2002) 2.71
Ascidian prickle regulates both mediolateral and anterior-posterior cell polarity of notochord cells. Curr Biol (2005) 2.57
De novo formation of left-right asymmetry by posterior tilt of nodal cilia. PLoS Biol (2005) 2.42
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. Nat Genet (2008) 2.31
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
The left-right axis in the mouse: from origin to morphology. Development (2006) 2.27
Cilia-driven leftward flow determines laterality in Xenopus. Curr Biol (2007) 1.97
Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell (1998) 1.93
Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci U S A (2008) 1.90
Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation. J Cell Biol (2008) 1.87
The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin. Curr Biol (2009) 1.87
Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol (2010) 1.83
Progress and challenges in understanding planar cell polarity signaling. Semin Cell Dev Biol (2009) 1.64
Cilia orientation and the fluid mechanics of development. Curr Opin Cell Biol (2008) 1.62
Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci (2007) 1.57
Cilia multifunctional organelles at the center of vertebrate left-right asymmetry. Curr Top Dev Biol (2008) 1.52
Asymmetric localisation of planar polarity proteins: Mechanisms and consequences. Semin Cell Dev Biol (2009) 1.45
Radial intercalation of ciliated cells during Xenopus skin development. Development (2006) 1.36
The key to left-right asymmetry. Cell (2006) 1.34
Flow on the right side of the gastrocoel roof plate is dispensable for symmetry breakage in the frog Xenopus laevis. Dev Biol (2009) 1.26
Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice. Dev Biol (2001) 1.13
Xenopus, an ideal model system to study vertebrate left-right asymmetry. Dev Dyn (2009) 1.13
Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues. Dev Dyn (2007) 1.01
Gene expression during the life cycle of Drosophila melanogaster. Science (2002) 11.36
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell (2003) 7.93
Communicating with Hedgehogs. Nat Rev Mol Cell Biol (2005) 5.01
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science (2010) 4.11
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. Nat Genet (2008) 3.84
A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell (2004) 3.56
Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Science (2005) 3.42
Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell (2002) 3.25
Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell (2002) 3.03
Fidelity in planar cell polarity signalling. Nature (2003) 2.74
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A (2003) 2.72
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev (2002) 2.64
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev (2010) 2.60
A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet (2008) 2.58
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A (2009) 2.47
Thirty-one flavors of Drosophila rab proteins. Genetics (2007) 2.46
A positive feedback mechanism governs the polarity and motion of motile cilia. Nature (2007) 2.44
Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell (2008) 2.37
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. Nat Genet (2008) 2.31
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A (2006) 2.23
Twelve tips for teaching with ultrasound in the undergraduate curriculum. Med Teach (2013) 2.21
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J Cell Biol (2009) 2.10
Planar cell polarity signaling: the developing cell's compass. Cold Spring Harb Perspect Biol (2009) 2.02
Patching the gaps in Hedgehog signalling. Nat Cell Biol (2007) 2.01
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol (2005) 1.88
The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin. Curr Biol (2009) 1.87
The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. Proc Natl Acad Sci U S A (2003) 1.86
ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biol (2007) 1.82
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med (2010) 1.82
Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Proc Natl Acad Sci U S A (2004) 1.82
Assessing the conservation of mammalian gene expression using high-density exon arrays. Mol Biol Evol (2007) 1.81
A three-tiered mechanism for regulation of planar cell polarity. Semin Cell Dev Biol (2002) 1.80
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev (2003) 1.79
The Drosophila BRM complex facilitates global transcription by RNA polymerase II. EMBO J (2002) 1.78
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. J Cell Biol (2009) 1.77
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease. PLoS Genet (2005) 1.77
Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell (2010) 1.74
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci (2005) 1.74
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer (2009) 1.72
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A (2006) 1.71
Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet (2011) 1.60
Microtubules enable the planar cell polarity of airway cilia. Curr Biol (2012) 1.59
Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci (2007) 1.57
Rab35 controls actin bundling by recruiting fascin as an effector protein. Science (2009) 1.51
Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J Neurosci (2011) 1.50
Biology by numbers: mathematical modelling in developmental biology. Nat Rev Genet (2007) 1.49
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol (2003) 1.44
A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl (2005) 1.44
Incredible journey: how do developmental signals travel through tissue? Genes Dev (2004) 1.38
Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis. Dev Cell (2004) 1.38
Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr Opin Neurobiol (2002) 1.38
Radial intercalation of ciliated cells during Xenopus skin development. Development (2006) 1.36
Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators. Development (2003) 1.35
Pointing in the right direction: new developments in the field of planar cell polarity. Nat Rev Genet (2011) 1.28
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.28
Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C. Hum Mol Genet (2012) 1.26
The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. Genes Dev (2009) 1.23
Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Development (2007) 1.23
A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development (2005) 1.23
Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice. Cancer Res (2008) 1.18
Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development (2013) 1.17
Regulation of PCP by the Fat signaling pathway. Genes Dev (2013) 1.17
Modulation of notch signaling during somitogenesis. Annu Rev Cell Dev Biol (2003) 1.15
Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. Development (2003) 1.14
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev (2008) 1.14
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Dev Biol (2002) 1.14
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Proc Natl Acad Sci U S A (2005) 1.11
Specification of ion transport cells in the Xenopus larval skin. Development (2011) 1.08
Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens. Lab Chip (2006) 1.08
A novel mechanism for the transcriptional regulation of Wnt signaling in development. Genes Dev (2011) 1.07
Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev (2011) 1.07
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle. J Biol Chem (2002) 1.06
Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development (2003) 1.04
Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts. J Biol Chem (2002) 1.03
Thyroid hormone promotes neurogenesis in the Xenopus spinal cord. Dev Dyn (2002) 1.02
Cell packing influences planar cell polarity signaling. Proc Natl Acad Sci U S A (2008) 1.01
Asymmetric protein localization in planar cell polarity: mechanisms, puzzles, and challenges. Curr Top Dev Biol (2012) 1.01
Complement is dispensable for neurodegeneration in Niemann-Pick disease type C. J Neuroinflammation (2012) 1.00
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development (2005) 1.00
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol (2007) 1.00
Understanding biology by reverse engineering the control. Proc Natl Acad Sci U S A (2005) 1.00
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One (2009) 0.98
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors. Development (2005) 0.95