Published in Development on September 05, 2007
The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila. Cell Metab (2009) 2.23
The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Cell Host Microbe (2014) 1.47
Towards a semen proteome of the dengue vector mosquito: protein identification and potential functions. PLoS Negl Trop Dis (2011) 1.29
Transcriptional regulation of xenobiotic detoxification in Drosophila. Genes Dev (2011) 1.25
Methods for studying metabolism in Drosophila. Methods (2014) 1.19
The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. Genes Dev (2009) 1.19
Extensive differences in gene expression between symbiotic and aposymbiotic cnidarians. G3 (Bethesda) (2014) 1.09
Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration. J Neurosci (2008) 1.04
Nuclear receptor DHR96 acts as a sentinel for low cholesterol concentrations in Drosophila melanogaster. Mol Cell Biol (2009) 1.02
A Drosophila protein family implicated in pheromone perception is related to Tay-Sachs GM2-activator protein. J Biol Chem (2008) 0.94
Scavenger receptors mediate the role of SUMO and Ftz-f1 in Drosophila steroidogenesis. PLoS Genet (2013) 0.92
Transcriptional responses in honey bee larvae infected with chalkbrood fungus. BMC Genomics (2010) 0.91
Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish. J Lipid Res (2011) 0.90
Drosophila melanogaster as a model organism of brain diseases. Int J Mol Sci (2009) 0.90
Glycolipid trafficking in Drosophila undergoes pathway switching in response to aberrant cholesterol levels. Mol Biol Cell (2010) 0.89
Oral transfer of chemical cues, growth proteins and hormones in social insects. Elife (2016) 0.89
Genes of the ecdysone biosynthesis pathway are regulated by the dATAC histone acetyltransferase complex in Drosophila. Mol Cell Biol (2010) 0.89
The Fruit Fly Drosophila melanogaster as a Model System to Study Cholesterol Metabolism and Homeostasis. Cholesterol (2011) 0.88
Niemann-Pick type C2 protein mediating chemical communication in the worker ant. Proc Natl Acad Sci U S A (2014) 0.87
Aedes aegypti ML and Niemann-Pick type C family members are agonists of dengue virus infection. Dev Comp Immunol (2013) 0.86
Drosophila melanogaster NPC2 proteins bind bacterial cell wall components and may function in immune signal pathways. Insect Biochem Mol Biol (2012) 0.85
A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in Drosophila. Sci Rep (2014) 0.85
Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals. BMC Genomics (2015) 0.83
Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions. Nat Commun (2015) 0.83
How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group? Heredity (Edinb) (2015) 0.82
Population genomics of resource exploitation: insights from gene expression profiles of two Daphnia ecotypes fed alternate resources. Ecol Evol (2012) 0.79
A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster. BMC Genet (2014) 0.76
Invertebrate models of lysosomal storage disease: what have we learned so far? Invert Neurosci (2011) 0.76
A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline. Neurobiol Dis (2016) 0.75
DREF is involved in the steroidogenesis via regulation of shadow gene. Am J Cancer Res (2012) 0.75
TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior. Front Mol Neurosci (2016) 0.75
Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases. Dis Model Mech (2016) 0.75
Methods for studying the metabolic basis of Drosophila development. Wiley Interdiscip Rev Dev Biol (2017) 0.75
Gene expression during the life cycle of Drosophila melanogaster. Science (2002) 11.36
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
Communicating with Hedgehogs. Nat Rev Mol Cell Biol (2005) 5.01
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science (2010) 4.11
A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell (2004) 3.56
Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell (2002) 3.03
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A (2003) 2.72
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev (2010) 2.60
A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet (2008) 2.58
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A (2009) 2.47
Thirty-one flavors of Drosophila rab proteins. Genetics (2007) 2.46
Prothoracicotropic hormone regulates developmental timing and body size in Drosophila. Dev Cell (2007) 2.33
Control and biochemical nature of the ecdysteroidogenic pathway. Annu Rev Entomol (2002) 2.25
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A (2006) 2.23
Twelve tips for teaching with ultrasound in the undergraduate curriculum. Med Teach (2013) 2.21
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J Cell Biol (2009) 2.10
Patching the gaps in Hedgehog signalling. Nat Cell Biol (2007) 2.01
The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. Proc Natl Acad Sci U S A (2003) 1.86
The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis. Science (2009) 1.86
ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biol (2007) 1.82
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med (2010) 1.82
Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Proc Natl Acad Sci U S A (2004) 1.82
Assessing the conservation of mammalian gene expression using high-density exon arrays. Mol Biol Evol (2007) 1.81
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev (2003) 1.79
The Drosophila BRM complex facilitates global transcription by RNA polymerase II. EMBO J (2002) 1.78
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease. PLoS Genet (2005) 1.77
Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell (2010) 1.74
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer (2009) 1.72
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A (2006) 1.71
Discrete pulses of molting hormone, 20-hydroxyecdysone, during late larval development of Drosophila melanogaster: correlations with changes in gene activity. Dev Dyn (2006) 1.70
Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone. Proc Natl Acad Sci U S A (2003) 1.64
Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster. Proc Natl Acad Sci U S A (2002) 1.61
Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet (2011) 1.60
Microtubules enable the planar cell polarity of airway cilia. Curr Biol (2012) 1.59
Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci (2007) 1.57
Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis. Insect Biochem Mol Biol (2004) 1.57
The heat-inducible zebrafish hsp70 gene is expressed during normal lens development under non-stress conditions. Mech Dev (2002) 1.57
Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera. Dev Biol (2006) 1.57
The three-dimensional micro- and nanostructure of the aortic medial lamellar unit measured using 3D confocal and electron microscopy imaging. Matrix Biol (2007) 1.56
Rab35 controls actin bundling by recruiting fascin as an effector protein. Science (2009) 1.51
Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J Neurosci (2011) 1.50
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. PLoS One (2010) 1.49
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol (2003) 1.44
Incredible journey: how do developmental signals travel through tissue? Genes Dev (2004) 1.38
Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr Opin Neurobiol (2002) 1.38
Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila. Development (2009) 1.34
Neuroendocrine regulation of Drosophila metamorphosis requires TGFbeta/Activin signaling. Development (2011) 1.33
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.28
Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C. Hum Mol Genet (2012) 1.26
A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development (2005) 1.23
Developmental toxicology of cadmium in living embryos of a stable transgenic zebrafish line. Environ Health Perspect (2002) 1.23
Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice. Cancer Res (2008) 1.18
Molecular evolution of the insect Halloween family of cytochrome P450s: phylogeny, gene organization and functional conservation. Insect Biochem Mol Biol (2007) 1.18
A phosphoproteomics approach to elucidate neuropeptide signal transduction controlling insect metamorphosis. Insect Biochem Mol Biol (2009) 1.16
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Dev Biol (2002) 1.14
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev (2008) 1.14
Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. Development (2003) 1.14
Daphnia Halloween genes that encode cytochrome P450s mediating the synthesis of the arthropod molting hormone: evolutionary implications. BMC Evol Biol (2008) 1.10
New players in the regulation of ecdysone biosynthesis. J Genet Genomics (2008) 1.10
The finished DNA sequence of human chromosome 12. Nature (2006) 1.08
Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens. Lab Chip (2006) 1.08
Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev (2011) 1.07
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle. J Biol Chem (2002) 1.06
Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development (2003) 1.04
A molecular genetic approach to the biosynthesis of the insect steroid molting hormone. Vitam Horm (2005) 1.03
Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts. J Biol Chem (2002) 1.03
Complement is dispensable for neurodegeneration in Niemann-Pick disease type C. J Neuroinflammation (2012) 1.00
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development (2005) 1.00
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol (2007) 1.00
Identification, characterization and developmental expression of Halloween genes encoding P450 enzymes mediating ecdysone biosynthesis in the tobacco hornworm, Manduca sexta. Insect Biochem Mol Biol (2006) 0.99
molting defective is required for ecdysone biosynthesis. Dev Biol (2005) 0.97
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
Not lost in space: trafficking in the hedgehog signaling pathway. Sci Signal (2010) 0.94
Germline-dependent gene expression in distant non-gonadal somatic tissues of Drosophila. BMC Genomics (2010) 0.93
MET is required for the maximal action of 20-hydroxyecdysone during Bombyx metamorphosis. PLoS One (2012) 0.92
Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling. Genetics (2004) 0.92
Developmental expression of Manduca shade, the P450 mediating the final step in molting hormone synthesis. Mol Cell Endocrinol (2006) 0.92
Drosophila is an inclusive model for human diseases, growth and development. Mol Cell Endocrinol (2008) 0.91
Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C. Dis Model Mech (2013) 0.91
Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-κB transcription factor Relish. PLoS One (2012) 0.88
Mes2, a MADF-containing transcription factor essential for Drosophila development. Dev Dyn (2006) 0.87
Studies on the Black Box: incorporation of 3-oxo-7-dehydrocholesterol into ecdysteroids by Drosophila melanogaster and Manduca sexta. Insect Biochem Mol Biol (2009) 0.86
Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response. PLoS One (2009) 0.86
Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma. Proc Natl Acad Sci U S A (2013) 0.86
Global identification of bursicon-regulated genes in Drosophila melanogaster. BMC Genomics (2008) 0.86
Kif3a is necessary for initiation and maintenance of medulloblastoma. Carcinogenesis (2013) 0.85
Profiling of ecdysteroids in complex biological samples using liquid chromatography/ion trap mass spectrometry. Rapid Commun Mass Spectrom (2006) 0.84
Hsc70 binds to ultraspiracle resulting in the upregulation of 20-hydroxyecdsone-responsive genes in Helicoverpa armigera. Mol Cell Endocrinol (2009) 0.83