Published in J Biol Chem on September 26, 2002
Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc Natl Acad Sci U S A (2004) 1.30
PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev (2005) 1.21
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Mol Biol Cell (2007) 1.10
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol (2007) 1.05
Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol (2010) 1.00
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One (2009) 0.98
Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Mol Syst Biol (2009) 0.94
Structural studies of human Naked2: a biologically active intrinsically unstructured protein. Biochem Biophys Res Commun (2006) 0.94
Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin. PLoS One (2011) 0.92
An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle. Genetics (2006) 0.89
Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis. BMC Cancer (2011) 0.86
Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling. Dev Biol (2008) 0.86
Wnt ligand-dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell (2015) 0.83
NKD1 down-regulation is associated with poor prognosis in breast invasive ductal carcinoma. Int J Clin Exp Pathol (2015) 0.80
Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd). Dev Biol (2007) 0.80
Gene expression during the life cycle of Drosophila melanogaster. Science (2002) 11.36
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
Communicating with Hedgehogs. Nat Rev Mol Cell Biol (2005) 5.01
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science (2010) 4.11
A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell (2004) 3.56
Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell (2002) 3.03
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc Natl Acad Sci U S A (2003) 2.72
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev (2010) 2.60
A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet (2008) 2.58
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A (2009) 2.47
Thirty-one flavors of Drosophila rab proteins. Genetics (2007) 2.46
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A (2006) 2.23
Twelve tips for teaching with ultrasound in the undergraduate curriculum. Med Teach (2013) 2.21
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J Cell Biol (2009) 2.10
Patching the gaps in Hedgehog signalling. Nat Cell Biol (2007) 2.01
The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. Proc Natl Acad Sci U S A (2003) 1.86
ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biol (2007) 1.82
Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Proc Natl Acad Sci U S A (2004) 1.82
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med (2010) 1.82
Assessing the conservation of mammalian gene expression using high-density exon arrays. Mol Biol Evol (2007) 1.81
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev (2003) 1.79
The Drosophila BRM complex facilitates global transcription by RNA polymerase II. EMBO J (2002) 1.78
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease. PLoS Genet (2005) 1.77
Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell (2010) 1.74
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer (2009) 1.72
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A (2006) 1.71
Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet (2011) 1.60
Microtubules enable the planar cell polarity of airway cilia. Curr Biol (2012) 1.59
Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci (2007) 1.57
Rab35 controls actin bundling by recruiting fascin as an effector protein. Science (2009) 1.51
Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J Neurosci (2011) 1.50
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. PLoS One (2010) 1.49
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol (2003) 1.44
Planar cell polarity and vertebrate organogenesis. Semin Cell Dev Biol (2006) 1.43
Incredible journey: how do developmental signals travel through tissue? Genes Dev (2004) 1.38
Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr Opin Neurobiol (2002) 1.38
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.28
Neuronal and epithelial cell rescue resolves chronic systemic inflammation in the lipid storage disorder Niemann-Pick C. Hum Mol Genet (2012) 1.26
Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Development (2007) 1.23
A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development (2005) 1.23
Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin Cancer Res (2005) 1.20
Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice. Cancer Res (2008) 1.18
Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis. Development (2003) 1.14
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev (2008) 1.14
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Dev Biol (2002) 1.14
Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens. Lab Chip (2006) 1.08
Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev (2011) 1.07
Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function. Development (2003) 1.04
Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging. Bioessays (2008) 1.04
Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol (2006) 1.04
Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts. J Biol Chem (2002) 1.03
Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genet (2009) 1.01
Complement is dispensable for neurodegeneration in Niemann-Pick disease type C. J Neuroinflammation (2012) 1.00
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol (2007) 1.00
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development (2005) 1.00
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One (2009) 0.98
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
Not lost in space: trafficking in the hedgehog signaling pathway. Sci Signal (2010) 0.94
Potential functional and survival benefit of double over single lung transplantation for selected patients with idiopathic pulmonary fibrosis. Transpl Int (2010) 0.93
Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling. Genetics (2004) 0.92
Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C. Dis Model Mech (2013) 0.91
Is sirolimus a therapeutic option for patients with progressive pulmonary lymphangioleiomyomatosis? Respir Res (2011) 0.89
Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Mol Cell Biol (2007) 0.89
Effect of inpatient rehabilitation on quality of life and exercise capacity in long-term lung transplant survivors: a prospective, randomized study. J Heart Lung Transplant (2011) 0.89
An unconventional nuclear localization motif is crucial for function of the Drosophila Wnt/wingless antagonist Naked cuticle. Genetics (2006) 0.89
Lung deposition of a liposomal cyclosporine A inhalation solution in patients after lung transplantation. J Aerosol Med Pulm Drug Deliv (2009) 0.88
The use of immunohistochemistry for biomarker assessment--can it compete with other technologies? Toxicol Pathol (2011) 0.88
Mes2, a MADF-containing transcription factor essential for Drosophila development. Dev Dyn (2006) 0.87
Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response. PLoS One (2009) 0.86
Apical-basal polarity, Wnt signaling and vertebrate organogenesis. Semin Cell Dev Biol (2006) 0.86
Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma. Proc Natl Acad Sci U S A (2013) 0.86
Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling. Dev Biol (2008) 0.86
Prognostic value of bronchoalveolar lavage neutrophilia in stable lung transplant recipients. J Heart Lung Transplant (2009) 0.86
Kif3a is necessary for initiation and maintenance of medulloblastoma. Carcinogenesis (2013) 0.85
Cell biology. Arrestin' movement in cilia. Science (2008) 0.83
Case studies of ends-out gene targeting in Drosophila. Genesis (2009) 0.83
The chromatin remodeling factor Chd1l is required in the preimplantation embryo. Biol Open (2012) 0.82
The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis. Dev Biol (2011) 0.82
Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila. Biol Open (2012) 0.82
Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila. Genetics (2013) 0.82
Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma. J Neurooncol (2013) 0.81
Cell-autonomous, myristyl-independent activity of the Drosophila Wnt/Wingless antagonist Naked cuticle (Nkd). Dev Biol (2007) 0.80
Cancer: a twist in a hedgehog's tale. Nature (2003) 0.79
Tail wags dog: primary cilia and tumorigenesis. Cancer Cell (2009) 0.79
WNTers in La Jolla. Development (2007) 0.79
Tacrolimus and mycophenolate mofetil as first line immunosuppression after lung transplantation. Transpl Int (2009) 0.78
Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila. Genetics (2014) 0.78
Nitrogen dioxide induces apoptosis and proliferation but not emphysema in rat lungs. Thorax (2007) 0.75
Comparing Azole Plasma Trough Levels in Lung Transplant Recipients: Percentage of Therapeutic Levels and Intrapatient Variability. Ther Drug Monit (2017) 0.75
Comment on letter by Nicholls et al.--Ultrasound: a hands-on and kinaesthetic approach to anatomy education. Med Teach (2014) 0.75
The Munich-LTX-Score: predictor for survival after lung transplantation. Clin Transplant (2011) 0.75