Human immunodeficiency virus infection induces both polyclonal and virus-specific B cell activation.

PubWeight™: 1.84‹?› | Rank: Top 3%

🔗 View Article (PMC 442888)

Published in J Clin Invest on February 01, 1992

Authors

A Shirai1, M Cosentino, S F Leitman-Klinman, D M Klinman

Author Affiliations

1: Laboratory of Retrovirus Research, Food and Drug Administration, Bethesda, Maryland 20892.

Articles citing this

Pathogenesis of human immunodeficiency virus infection. Microbiol Rev (1993) 5.88

B cells in HIV infection and disease. Nat Rev Immunol (2009) 4.73

Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies. J Virol (2008) 3.83

Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults. Science (2010) 2.91

Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1. J Virol (1997) 2.60

HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals. Proc Natl Acad Sci U S A (2001) 2.54

HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy. J Exp Med (1998) 2.50

Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses. J Virol (2006) 2.50

Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. PLoS Med (2009) 2.11

Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease. J Allergy Clin Immunol (2008) 2.01

Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J Exp Med (2004) 2.00

Persistence of HIV-1 structural proteins and glycoproteins in lymph nodes of patients under highly active antiretroviral therapy. Proc Natl Acad Sci U S A (2005) 1.54

Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individuals. Proc Natl Acad Sci U S A (2003) 1.53

Antibodies to the Cryptococcus neoformans capsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV- individuals. Clin Exp Immunol (1995) 1.45

Critical issues in mucosal immunity for HIV-1 vaccine development. J Allergy Clin Immunol (2008) 1.41

Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS. Cell Host Microbe (2008) 1.31

How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development? AIDS Res Hum Retroviruses (2011) 1.30

Antigen-dependent and -independent mechanisms of T and B cell hyperactivation during chronic HIV-1 infection. J Virol (2011) 1.17

A B lymphocyte mitogen is a Brucella abortus virulence factor required for persistent infection. Proc Natl Acad Sci U S A (2006) 1.13

Murine AIDS protects mice against experimental cerebral malaria: down-regulation by interleukin 10 of a T-helper type 1 CD4+ cell-mediated pathology. Proc Natl Acad Sci U S A (1994) 1.12

SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination. Blood (2011) 1.11

Effect of B-cell depletion on viral replication and clinical outcome of simian immunodeficiency virus infection in a natural host. J Virol (2009) 1.09

Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment. J Virol (2010) 1.07

Characterization of plasmablasts in the blood of HIV-infected viremic individuals: evidence for nonspecific immune activation. J Virol (2013) 1.06

Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection. J Immunol (2010) 1.04

IL-10-producing B cells are induced early in HIV-1 infection and suppress HIV-1-specific T cell responses. PLoS One (2014) 0.98

Rotavirus-specific intestinal immune response in mice assessed by enzyme-linked immunospot assay and intestinal fragment culture. Clin Diagn Lab Immunol (1994) 0.96

Immunoglobulin V(H) usage during primary infection of rhesus monkeys with chimeric simian-human immunodeficiency viruses. J Virol (1997) 0.93

Complement-mediated binding of naturally glycosylated and glycosylation-modified human immunodeficiency virus type 1 to human CR2 (CD21). J Virol (1993) 0.92

Role of IL-21 and IL-21 receptor on B cells in HIV infection. Crit Rev Immunol (2012) 0.90

B-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth. J Virol (2012) 0.89

B cell responses to HIV antigen are a potent correlate of viremia in HIV-1 infection and improve with PD-1 blockade. PLoS One (2013) 0.89

Immune reconstitution and vaccination outcome in HIV-1 infected children: present knowledge and future directions. Hum Vaccin Immunother (2012) 0.89

Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms. Biomark Res (2013) 0.89

Suboptimal immune reconstitution in vertically HIV infected children: a view on how HIV replication and timing of HAART initiation can impact on T and B-cell compartment. Clin Dev Immunol (2012) 0.86

High frequency of virus-specific B lymphocytes in germinal centers of simian-human immunodeficiency virus-infected rhesus monkeys. J Virol (2002) 0.85

Evolution of broadly cross-reactive HIV-1-neutralizing activity: therapy-associated decline, positive association with detectable viremia, and partial restoration of B-cell subpopulations. J Virol (2013) 0.84

Bacterial and viral superantigens: roles in autoimmunity? Ann Rheum Dis (1993) 0.83

Emergence of exhausted B cells in asymptomatic HIV-1-infected patients naïve for HAART is related to reduced immune surveillance. Clin Dev Immunol (2012) 0.82

Alterations in peripheral blood B-cell populations in SHIV89.6P-infected macaques (Macacca fascicularis). Comp Med (2011) 0.81

Antibody-secreting B cells in HIV infection. Curr Opin HIV AIDS (2009) 0.80

Serologic responses to recombinant Pneumocystis jirovecii major surface glycoprotein among Ugandan patients with respiratory symptoms. PLoS One (2012) 0.80

Reduced IgM levels and elevated IgG levels against oxidized low-density lipoproteins in HIV-1 infection. BMC Infect Dis (2014) 0.79

Transgenic dissection of HIV genes involved in lymphoid depletion. J Clin Invest (1997) 0.79

The complication of coinfection. Yale J Biol Med (2012) 0.79

Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection. PLoS Pathog (2016) 0.78

Pseudohyponatremia in a patient with HIV and hepatitis C coinfection. J Gen Intern Med (2007) 0.77

In vitro anti-HIV-1 antibody production in subjects in different stages of HIV-1 infection. Clin Exp Immunol (1995) 0.75

Blockade of immunoregulatory Fc-signalling by HIV peptides: oligopeptides from HIV gp120 and gp41 bind the Fc portion of IgG and increase the in vitro anti-ssDNA response. Clin Exp Immunol (1993) 0.75

Elevated granzyme B(+) B-cell level in SIV-infection correlate with viral load and low CD4 T-cell count. Immunol Cell Biol (2016) 0.75

Cellular Architecture of Spinal Granulomas and the Immunological Response in Tuberculosis Patients Coinfected with HIV. Front Immunol (2017) 0.75

Morphological and immunological changes in the skin of autopsied women with AIDS. Virchows Arch (2012) 0.75

Articles cited by this

Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med (1981) 14.62

Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes. Science (1984) 10.38

Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med (1983) 10.09

Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III. Science (1985) 8.53

NIH conference. Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann Intern Med (1984) 6.45

HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex. Nature (1985) 5.10

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells. J Immunol Methods (1983) 4.39

Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients. Science (1985) 3.81

Seroepidemiological studies of human T-lymphotropic retrovirus type III in acquired immunodeficiency syndrome. Lancet (1984) 3.77

Opportunistic infections and immune deficiency in homosexual men. Ann Intern Med (1982) 3.29

Antibodies to HTLV-III in Swiss patients with AIDS and pre-AIDS and in groups at risk for AIDS. N Engl J Med (1985) 2.95

Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J Exp Med (1985) 2.87

Possible role of a B-cell mitogen in hypergammaglobulinaemia in malaria and trypanosomiasis. Lancet (1974) 2.83

Systemic autoimmune disease arises from polyclonal B cell activation. J Exp Med (1987) 2.71

Immunologic abnormalities in homosexual men. Relationship to Kaposi's sarcoma. Am J Med (1982) 2.71

B-cell immunodeficiency in acquired immune deficiency syndrome. JAMA (1984) 2.63

Quantitative changes in T helper or T suppressor/cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders. Am J Med (1984) 2.60

Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro. Nature (1977) 2.58

Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus. Science (1986) 2.57

Detection of IgG antibodies to lymphadenopathy-associated virus in patients with AIDS or lymphadenopathy syndrome. Lancet (1984) 2.56

Immunoregulatory subsets of the T helper and T suppressor cell populations in homosexual men with chronic unexplained lymphadenopathy. J Clin Invest (1984) 2.07

Influence of the human T-lymphotropic virus/lymphadenopathy-associated virus on functions of human lymphocytes: evidence for immunosuppressive effects and polyclonal B-cell activation by banded viral preparations. Proc Natl Acad Sci U S A (1985) 2.04

B-cell activation and HIV-1 infection: deeds and misdeeds. Immunol Today (1990) 1.95

Mechanisms of B cell activation in patients with acquired immunodeficiency syndrome and related disorders. Contribution of antibody-producing B cells, of Epstein-Barr virus-infected B cells, and of immunoglobulin production induced by human T cell lymphotropic virus, type III/lymphadenopathy-associated virus. J Clin Invest (1986) 1.70

HIV-1-specific B cell activation. A major constituent of spontaneous B cell activation during HIV-1 infection. J Immunol (1989) 1.66

Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease. J Immunol (1987) 1.64

Characteristics of B cell proliferation and activation in murine AIDS. J Immunol (1989) 1.61

Autoimmune response to DNA, red blood cells, and thymocyte antigens in association with polyclonal antibody synthesis during experimental African trypanosomiasis. J Immunol (1979) 1.60

Stimulatory and inhibitory influences of human immunodeficiency virus on normal B lymphocytes. Proc Natl Acad Sci U S A (1986) 1.54

Lymphadenopathy-associated viral antibody in AIDS. Immune correlations and definition of a carrier state. N Engl J Med (1984) 1.51

Depressed interleukin 2 receptor expression in acquired immune deficiency and lymphadenopathy syndromes. J Immunol (1984) 1.49

Shared idiotypes and restricted immunoglobulin variable region heavy chain genes characterize murine autoantibodies of various specificities. J Clin Invest (1986) 1.48

Activated B lymphocytes from human immunodeficiency virus-infected individuals induce virus expression in infected T cells and a promonocytic cell line, U1. J Exp Med (1991) 1.45

Anti-lymphocyte antibodies in patients with the acquired immune deficiency syndrome. Am J Med (1985) 1.38

Hypothesis: AIDS is an autoimmune disease directed at the immune system and triggered by a lymphotropic retrovirus. Clin Immunol Immunopathol (1986) 1.31

Spontaneous in vitro production of virus-specific antibody by lymphocytes from HIV-infected subjects. Clin Immunol Immunopathol (1988) 1.30

Neutralizing antibodies in HIV (HTLV-III) infection: correlation with clinical outcome and antibody response against different viral proteins. Clin Exp Immunol (1987) 1.30

Detection of native and denatured DNA antibody forming cells by the enzyme-linked immunospot assay. A clinical study of (New Zealand black x New Zealand white)F1 mice. Arthritis Rheum (1986) 1.24

B cell activation by cytomegalovirus. J Exp Med (1983) 1.24

In-vitro production of HIV-specific antibody in children at risk of AIDS. Lancet (1988) 1.22

Acquired immunodeficiency syndrome, opportunistic infections, and malignancies in male homosexuals. A hypothesis of etiologic factors in pathogenesis. JAMA (1983) 1.20

Anti-DNA antibody production by CD5+ and CD5- B cells of patients with systemic lupus erythematosus. J Clin Invest (1990) 1.17

B-cell activation in HIV infection: relationship of spontaneous immunoglobulin secretion to various immunological parameters. Clin Exp Immunol (1988) 1.16

Antibody response to human immunodeficiency virus in homosexual men. Relation of antibody specificity, titer, and isotype to clinical status, severity of immunodeficiency, and disease progression. J Clin Invest (1987) 1.09

Graft-vs-host reaction limited to a class II MHC difference results in a selective deficiency in L3T4+ but not in Lyt-2+ T helper cell function. J Immunol (1987) 1.08

In vitro synthesis of human immunodeficiency virus-specific antibodies in peripheral blood lymphocytes of infants. Proc Natl Acad Sci U S A (1989) 1.06

Altered immunoregulation and autoimmune aspects of HIV infection: relevant murine models. Immunol Today (1990) 1.04

Development of the autoimmune B cell repertoire in MRL-lpr/lpr mice. J Immunol (1990) 1.00

Localization of B-cell stimulatory activity of HIV-1 to the carboxyl terminus of gp41. AIDS Res Hum Retroviruses (1990) 0.96

Functional heterogeneity of L3T4+ T cells in MRL-lpr/lpr mice. L3T4+ T cells suppress major histocompatibility complex-self-restricted L3T4+ T helper cell function in association with autoimmunity. J Exp Med (1988) 0.95

Antigen-specific and polyclonal immunoglobulin production induced by a cloned tetanus toxoid-specific T cell line. J Immunol (1983) 0.93

Novel ELISA and ELISA-spot assays used to quantitate B cells and serum antibodies specific for T cell and bromelated mouse red blood cell autoantigens. J Immunol Methods (1987) 0.93

Distribution of antibodies against denatured collagen in AIDS risk groups and homosexual AIDS patients suggests a link between autoimmunity and the immunopathogenesis of AIDS. J Immunol (1990) 0.92

Polyclonal activation of B cells in homosexual men. N Engl J Med (1984) 0.89

Clinical implications of positive tests for antibodies to human immunodeficiency virus type 1 in asymptomatic blood donors. N Engl J Med (1989) 0.87

Specificity of anti-lymphocyte antibodies in sera from patients with AIDS-related complex (ARC) and healthy homosexuals. Clin Exp Immunol (1988) 0.87

Allogeneic leukocytes as a possible factor in induction of aids in homosexual men. N Engl J Med (1983) 0.87

Spontaneous antibody-secreting cells against DNA and common environmental antigens in systemic lupus erythematosus. J Autoimmun (1990) 0.86

Sequential immunizations with rgp120s from independent isolates of human immunodeficiency virus type 1 induce the preferential expansion of broadly crossreactive B cells. J Exp Med (1991) 0.85

Lymphocytotoxic antibodies against peripheral blood B and T lymphocytes in homosexuals with AIDS and ARC. AIDS Res (1986) 0.83

Assessment of responses of normal human B lymphocytes to different isolates of human immunodeficiency virus: role of normal donor and of cell line used to prepare viral isolate. AIDS Res Hum Retroviruses (1989) 0.82

Quantitation of autoantibody-secreting B cells in systemic lupus erythematosus. Autoimmunity (1989) 0.80

Multiple dysfunctions in developmental and activational stages of T lymphocytes, B lymphocytes and monocytes in ARC and AIDS patients. Immunol Lett (1987) 0.78

Analysis of autoantibody reactivities in hybridoma collections derived from normal adult BALB/c mice. Ann Inst Pasteur Immunol (1986) 0.77

Articles by these authors

CpG motifs in bacterial DNA trigger direct B-cell activation. Nature (1995) 12.24

DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol (2000) 4.51

Varicella vaccination: evidence for frequent reactivation of the vaccine strain in healthy children. Nat Med (2000) 3.07

Systemic autoimmune disease arises from polyclonal B cell activation. J Exp Med (1987) 2.71

Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J Immunol (2001) 2.61

Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J Immunol (2001) 2.49

Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol (1999) 2.23

Genomic DNA released by dying cells induces the maturation of APCs. J Immunol (2001) 2.03

Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J Exp Med (1997) 1.73

Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J Immunol (1999) 1.58

Distinct patterns of cytokine secretion characterize new onset synovitis versus chronic rheumatoid arthritis. J Rheumatol (1998) 1.55

A plasmid encoding murine granulocyte-macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine. J Immunol (1998) 1.54

Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc Natl Acad Sci U S A (1999) 1.48

Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J Immunol (1996) 1.46

Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol (1985) 1.44

Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J Immunol (2001) 1.33

Autoimmunity and increased c-myb transcription. Science (1984) 1.27

Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA. J Immunol (1995) 1.24

Microbial products induce autoimmune disease by an IL-12-dependent pathway. J Immunol (1997) 1.21

Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen. Vaccine (1999) 1.20

CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis. Infect Immun (2000) 1.19

Proliferation of anti-DNA-producing NZB B cells in a non-autoimmune environment. J Immunol (1986) 1.17

Oncogene expression in autoimmune and normal peripheral blood mononuclear cells. J Exp Med (1986) 1.15

Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids. Infect Immun (1998) 1.09

Induction of neonatal tolerance by plasmid DNA vaccination of mice. J Clin Invest (1996) 1.08

Efficacy, immunogenicity, safety, and use of live attenuated chickenpox vaccine. J Pediatr (1995) 1.08

Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides. Bioorg Med Chem (1994) 1.07

Sequence analysis and expression of an X-linked, lymphocyte-regulated gene family (XLR). J Exp Med (1987) 1.07

Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo. Immunology (2000) 1.06

NIH conference. Systemic lupus erythematosus. Ann Intern Med (1991) 1.06

Theoretical and experimental approaches to generalized autoimmunity. Immunol Rev (1990) 1.03

Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. J Clin Invest (1998) 1.03

Heterogeneous expression and coordinate regulation of endogenous retroviral sequences in human peripheral blood mononuclear cells. AIDS Res Hum Retroviruses (1992) 1.02

Pathogenesis of systemic lupus erythematosus. Rheum Dis Clin North Am (1988) 1.02

CpG motifs of DNA vaccines induce the expression of chemokines and MHC class II molecules on myocytes. Eur J Immunol (2001) 1.01

Plasticity in the enteric nervous system. Gastroenterology (1999) 1.01

Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies. Blood (1997) 1.00

CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell Immunol (2000) 0.99

IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice. Proc Natl Acad Sci U S A (1995) 0.98

Individual cells simultaneously produce both IL-4 and IL-6 in vivo. Cytokine (1994) 0.98

A suppressive oligodeoxynucleotide inhibits ocular inflammation. Clin Exp Immunol (2009) 0.98

Disassociation of sex hormone levels and cytokine production in SLE patients. Lupus (2001) 0.96

Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion. Int Immunol (1999) 0.96

Identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa. J Nat Prod (1996) 0.96

Toward clinical trials of DNA vaccines against malaria. Immunol Cell Biol (1997) 0.95

Do DNA vaccines induce autoimmune disease? Hum Gene Ther (1997) 0.95

Autoantibody production is associated with polyclonal B cell activation in autoimmune mice which express the lpr or gld genes. Eur J Immunol (1988) 0.95

Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides. Rheumatology (Oxford) (2003) 0.95

The interaction of the xid and me genes. J Immunol (1987) 0.95

Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism. Neurology (2005) 0.95

Activation of microglia and astrocytes by CpG oligodeoxynucleotides. Neuroreport (2001) 0.95

NIH conference. Angioimmunoblastic lymphadenopathy with dysproteinemia. Ann Intern Med (1988) 0.93

Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFN and TNF-alpha in human peripheral blood. Cytokine (1995) 0.93

Neural and endogenous catecholamines in the bone marrow. Circadian association of norepinephrine with hematopoiesis? Exp Hematol (1998) 0.93

Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV. Gene Ther (2005) 0.92

Murine cytomegalovirus infection-induced polyclonal B cell activation is independent of CD4+ T cells and CD40. Virology (1998) 0.92

Immune responses in asymptomatic HIV-1-infected patients after HIV-DNA immunization followed by highly active antiretroviral treatment. J Immunol (1999) 0.90

Increased activation and altered ratio of interferon-gamma: interleukin-4 secreting cells in MRL-lpr/lpr mice. Autoimmunity (1995) 0.90

DNAse treatment does not improve the survival of lupus prone (NZB x NZW)F1 mice. Lupus (1998) 0.90

Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome. J Rheumatol (1998) 0.90

Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood. AIDS Res Hum Retroviruses (1996) 0.90

The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice. J Immunol (1996) 0.89

IFN-gamma is a potent inducer of Ig secretion by sort-purified murine B cells activated through the mIg, but not the CD40, signaling pathway. Int Immunol (1996) 0.89

Endogenous catecholamine synthesis, metabolism storage, and uptake in human peripheral blood mononuclear cells. Exp Hematol (1999) 0.89

Factors associated with the development of neonatal tolerance after the administration of a plasmid DNA vaccine. J Immunol (1999) 0.88

Adrenergic mechanisms in the control of gastrointestinal motility: from basic science to clinical applications. Pharmacol Ther (1996) 0.88

Selling androgenic anabolic steroids by the pound: identification and analysis of popular websites on the Internet. Scand J Med Sci Sports (2011) 0.87

Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice. J Immunol (1998) 0.87

Peripheral markers of apoptosis in Parkinson's disease: the effect of dopaminergic drugs. Ann N Y Acad Sci (2003) 0.86

Idiotypy and autoimmunity. Arthritis Rheum (1986) 0.85

Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides. Vet Microbiol (2001) 0.84

Genetic studies in NZB mice. VI. Association of autoimmune traits in recombinant inbred lines. J Immunol (1984) 0.84

Contribution of interleukin-3 to antigen-induced Th2 cytokine production. Eur J Immunol (1996) 0.84

Components of arterial systolic pressure and RR-interval oscillation spectra in a case of baroreflex failure, a human open-loop model of vascular control. J Hum Hypertens (2009) 0.83

Positive and negative regulatory elements contribute to CpG oligonucleotide-mediated regulation of human IL-6 gene expression. Eur J Immunol (2000) 0.83

Activity and safety of DNA plasmids encoding IL-4 and IFN gamma. Gene Ther (1999) 0.83

Measurement of catecholamines in mouse bone marrow by means of HPLC with electrochemical detection. Haematologica (1997) 0.83

CpG ODN-mediated regulation of IL-12 p40 transcription. Eur J Immunol (2000) 0.83

Abnormal numbers of cytokine producing cells in patients with polymyositis and dermatomyositis. Clin Exp Rheumatol (1997) 0.82

The regulation of DNA vaccines. Curr Opin Biotechnol (2001) 0.82

Calcium-channel blockers and gastrointestinal motility: basic and clinical aspects. Pharmacol Ther (1993) 0.82

Differential effects of antimuscarinic agents on intestinal motility in the conscious dog. J Pharmacol Exp Ther (1993) 0.81

Diazepam stimulates migration and phagocytosis of human neutrophils: possible contribution of peripheral-type benzodiazepine receptors and intracellular calcium. Pharmacology (2001) 0.81

[A second transurethral resection could be not necessary in all high grade non-muscle-invasive bladder tumors]. Actas Urol Esp (2012) 0.80

Quantitation of autoantibody-secreting B cells in systemic lupus erythematosus. Autoimmunity (1989) 0.80

Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of beta 3-adrenoceptors. Br J Pharmacol (1995) 0.80

Ultrasound guided fine-needle aspiration biopsy of thyroid nodules: Guidelines and recommendations vs clinical practice; a 12-month study of 89 patients. J Ultrasound (2012) 0.80

Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor. Vaccine (1999) 0.80

Mouse monoclonal antibodies to human immunodeficiency virus glycoprotein 120 generated by repeated immunization with glycoprotein 120 from a single isolate, or by sequential immunization with glycoprotein 120 from three isolates. Hybridoma (1995) 0.80

Long-term effect of primary immunization on subsequent immune responsiveness. Cell Immunol (1997) 0.79

Modulation of c-myb transcription in autoimmune disease by cyclophosphamide. J Immunol (1985) 0.79

Changes in autonomic modulation to the heart and intracellular catecholamines. A longitudinal study in differentiated thyroid carcinoma during short-term hypothyroidism and thyroid hormone replacement. Horm Res (2006) 0.79

Preserving primary cDNA libraries. Anal Biochem (1987) 0.79

Analysis of B-cell subpopulations. I. Relationships among splenic xid, Ly 1+, and Lyb 5+ B cells. Cell Immunol (1985) 0.78

Effect of anti-Ia treatment on the production of anti-DNA antibody by NZB mice. Eur J Immunol (1986) 0.78

Dialyzable serum components can support the growth of hybridoma cell lines in vitro. J Immunol Methods (1981) 0.78

Modulation of enteric cholinergic neurons by hetero- and autoreceptors: cooperation among inhibitory inputs. Life Sci (1999) 0.78

Immunization with recombinant gp160 prolongs the survival of HIV-1 transgenic mice. AIDS Res Hum Retroviruses (1993) 0.78

Modifications of apoptosis-related protein levels in lymphocytes of patients with Parkinson's disease. The effect of dopaminergic treatment. J Neural Transm (Vienna) (2004) 0.78