Published in Trends Pharmacol Sci on September 15, 2009
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Examination of sex and minocycline treatment on acute morphine-induced analgesia and inflammatory gene expression along the pain pathway in Sprague-Dawley rats. Biol Sex Differ (2015) 0.78
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Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model. J Neuroinflammation (2015) 0.77
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Changes in the NMR metabolic profile of human microglial cells exposed to lipopolysaccharide or morphine. J Neuroimmune Pharmacol (2010) 0.76
Morphine attenuates apically-directed cytokine secretion from intestinal epithelial cells in response to enteric pathogens. Pathogens (2014) 0.76
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain Behav Immun (2016) 0.76
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The protective effect of hydromorphone to ischemia in rat glial cells. Springerplus (2016) 0.75
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P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain. J Pain Res (2017) 0.75
Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys. Biochim Biophys Acta (2016) 0.75
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Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain. Mol Pain (2017) 0.75
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Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J Pharmacol Exp Ther (2003) 3.69
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Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
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Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal (2007) 2.43
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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci (2004) 2.14
A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J Biol Chem (2007) 2.05
The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats. J Neurosci (2002) 2.02
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain Behav Immun (2008) 1.92
The involvement of glial cells in the development of morphine tolerance. Neurosci Res (2001) 1.87
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Role of spinal microglia in rat models of peripheral nerve injury and inflammation. Eur J Pain (2006) 1.70
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun (2006) 1.67
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Supraspinal glial-neuronal interactions contribute to descending pain facilitation. J Neurosci (2008) 1.61
Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats. Neuropsychopharmacology (2004) 1.61
Microglia and neuropathic pain. Glia (2009) 1.59
IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats. Pain (2007) 1.59
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain Behav Immun (2008) 1.58
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. J Nucl Med (2009) 1.58
PET of glial metabolism using 2-18F-fluoroacetate. J Nucl Med (2009) 1.56
Neuroimmune interactions and pain: focus on glial-modulating targets. Curr Opin Investig Drugs (2008) 1.50
Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance. Brain Res (2006) 1.50
Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opin Investig Drugs (2007) 1.45
The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats. Brain Res (2008) 1.45
Spinal glial activation contributes to pathological pain states. Neurosci Biobehav Rev (2008) 1.44
Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain. Eur J Pharmacol (2007) 1.44
The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain. Neuron Glia Biol (2006) 1.43
Effects of Etanercept and Minocycline in a rat model of spinal cord injury. Eur J Pain (2008) 1.43
Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse. Neuropsychopharmacology (2006) 1.39
Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury. Anesthesiology (2008) 1.39
Morphine enhances microglial migration through modulation of P2X4 receptor signaling. J Neurosci (2009) 1.38
The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain. Neuroscience (2008) 1.37
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Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav Immun (2008) 1.34
Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology (2007) 1.30
Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness. Pharmacol Rep (2008) 1.29
Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat. Pain (2008) 1.29
Opioid tolerance and hyperalgesia. Med Clin North Am (2007) 1.28
A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia. Brain Behav Immun (2007) 1.28
Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance. Pain (2005) 1.27
Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur J Pharmacol (2008) 1.27
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Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J (2005) 1.15
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Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome. Eur J Pain (2008) 1.13
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Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2. Biochem Biophys Res Commun (2008) 1.10
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Peroxynitrite: a strategic linchpin of opioid analgesic tolerance. Trends Pharmacol Sci (2009) 0.94
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A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats. J Neurosci Methods (2009) 0.94
dextro- and levo-morphine attenuate opioid delta and kappa receptor agonist produced analgesia in mu-opioid receptor knockout mice. Eur J Pharmacol (2006) 0.93
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Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun (2006) 2.89
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Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol Aging (2006) 2.37
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Morphine activates neuroinflammation in a manner parallel to endotoxin. Proc Natl Acad Sci U S A (2012) 1.80
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The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology (Berl) (2007) 1.74
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In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity. Neuropsychopharmacology (2012) 1.61
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5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress. Biol Psychiatry (2009) 1.55
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Neonatal infection induces memory impairments following an immune challenge in adulthood. Behav Neurosci (2005) 1.53
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Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology (2002) 1.45
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress. Behav Neurosci (2004) 1.44
Peripheral and central proinflammatory cytokine response to a severe acute stressor. Brain Res (2003) 1.42
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Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology (Berl) (2006) 1.37
Synthesis and pharmacological effects of the enantiomers of the N-phenethyl analogues of the ortho and para e- and f-oxide-bridged phenylmorphans. Org Biomol Chem (2008) 1.36
Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun (2009) 1.36
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The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration. Behav Brain Res (2008) 1.36
Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav Immun (2008) 1.34
Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine (2003) 1.30
Central proinflammatory cytokines and pain enhancement. Neurosignals (2005) 1.30
Toll-like receptors in chronic pain. Exp Neurol (2011) 1.29
Effects of prior stress on LPS-induced cytokine and sickness responses. Am J Physiol Regul Integr Comp Physiol (2002) 1.26
Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther (2004) 1.25
Synthesis of rac-(1R,4aR,9aR)-2-methyl-1,3,4,9a-tetrahydro-2H-1,4a-propanobenzofuro[2,3-c]pyridin-6-ol. An unusual double rearrangement leading to the ortho- and para-f oxide-bridged phenylmorphan isomers. Org Biomol Chem (2004) 1.25
A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats. Behav Brain Res (2006) 1.25
The cortical innate immune response increases local neuronal excitability leading to seizures. Brain (2009) 1.25
Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. J Pharmacol Exp Ther (2004) 1.24
The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress. J Neurosci (2002) 1.24
Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain Behav Immun (2011) 1.23
A method for measuring multiple cytokines from small samples. Brain Behav Immun (2004) 1.23
Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Addict Biol (2009) 1.23
Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. J Neurosci (2011) 1.22
Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress. Eur J Neurosci (2009) 1.22
Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception. J Pharmacol Exp Ther (2003) 1.21
The consequences of uncontrollable stress are sensitive to duration of prior wheel running. Brain Res (2005) 1.20
BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration. J Neuroimmunol (2004) 1.19
Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. Brain Behav Immun (2007) 1.19
Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes. J Neurosci (2011) 1.19
Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur J Neurosci (2005) 1.19
Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain (2010) 1.19
Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats. Psychopharmacology (Berl) (2002) 1.18
Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biol (2006) 1.18
Patterns of nicotinic receptor antagonism: nicotine discrimination studies. J Pharmacol Exp Ther (2011) 1.18
Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain. Brain Behav Immun (2009) 1.17
Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat. Stress (2009) 1.17
Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice. Psychopharmacology (Berl) (2003) 1.17
Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biol Psychiatry (2013) 1.16