PubRank

J J Skehel

Author PubWeight™ 397.69‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 1981 24.17
2 Atomic structure of the ectodomain from HIV-1 gp41. Nature 1997 16.31
3 Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 1981 15.85
4 Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 1994 14.61
5 The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu Rev Biochem 1987 11.99
6 Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature 1988 8.32
7 Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature 1983 8.28
8 The structure and receptor binding properties of the 1918 influenza hemagglutinin. Science 2004 7.74
9 Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion. Proc Natl Acad Sci U S A 1982 7.34
10 The molecular basis of the specific anti-influenza action of amantadine. EMBO J 1985 7.08
11 X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. Proc Natl Acad Sci U S A 2001 5.92
12 Crystalline antigen from the influenza virus envelope. Nat New Biol 1972 5.77
13 Fusion mutants of the influenza virus hemagglutinin glycoprotein. Cell 1985 4.84
14 Nucleotide sequences at the 5' termini of influenza virus RNAs and their transcripts. Nucleic Acids Res 1978 4.83
15 Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain. Mol Cell 1998 4.73
16 A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody. Proc Natl Acad Sci U S A 1984 4.37
17 Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A-strain specificity while infected cells confer cross-reactive cytotoxicity. Eur J Immunol 1977 4.05
18 Transcription of the influenza virus genome. Virology 1977 4.02
19 N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil. Proc Natl Acad Sci U S A 1999 3.90
20 The polypeptide composition of influenza A viruses. Virology 1971 3.79
21 Studies on the in vitro transcription of reovirus RNA catalyzed by reovirus cores. Virology 1969 3.79
22 Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol 1999 3.72
23 Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation. Cell 1998 3.69
24 Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses. Nature 1977 3.67
25 Analyses of the antigenicity of influenza haemagglutinin at the pH optimum for virus-mediated membrane fusion. J Gen Virol 1983 3.43
26 Structural basis for membrane fusion by enveloped viruses. Mol Membr Biol 1999 3.26
27 The receptor-binding and membrane-fusion properties of influenza virus variants selected using anti-haemagglutinin monoclonal antibodies. EMBO J 1987 3.03
28 Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography. Biochemistry 1992 3.03
29 Studies on the primary structure of the influenza virus hemagglutinin. Proc Natl Acad Sci U S A 1975 2.88
30 The influenza A virus nucleoprotein gene controls the induction of both subtype specific and cross-reactive cytotoxic T cells. J Exp Med 1984 2.81
31 Studies with crosslinking reagents on the oligomeric structure of the env glycoprotein of HIV. Virology 1989 2.74
32 Polypeptide synthesis in influenza virus-infected cells. Virology 1972 2.70
33 H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes. Virology 2004 2.67
34 Antigenic similarity of influenza A (H1N1) viruses from epidemics in 1977--1978 to "Scandinavian" strains isolated in epidemics of 1950--1951. Virology 1978 2.61
35 Refinement of the influenza virus hemagglutinin by simulated annealing. J Mol Biol 1990 2.61
36 An antibody that prevents the hemagglutinin low pH fusogenic transition. Virology 2002 2.56
37 Structure of influenza virus haemagglutinin complexed with a neutralizing antibody. Nature 1995 2.55
38 Binding of the influenza A virus to cell-surface receptors: structures of five hemagglutinin-sialyloligosaccharide complexes determined by X-ray crystallography. Virology 1997 2.51
39 On the mechanism of inhibition of influenza virus replication by amantadine hydrochloride. J Gen Virol 1978 2.50
40 Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease. Nature 1981 2.49
41 A complex of influenza hemagglutinin with a neutralizing antibody that binds outside the virus receptor binding site. Nat Struct Biol 1999 2.47
42 Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity. Cell 1992 2.47
43 The polypeptides of adenovirus-infected cells. J Gen Virol 1972 2.43
44 Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus. Nature 1998 2.41
45 Characterization of influenza virus RNA complete transcripts. Virology 1982 2.31
46 Influenza virus messenger RNAs are incomplete transcripts of the genome RNAs. Nucleic Acids Res 1977 2.26
47 A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation. Proc Natl Acad Sci U S A 1995 2.24
48 Hemagglutinins from two influenza virus variants bind to sialic acid derivatives with millimolar dissociation constants: a 500-MHz proton nuclear magnetic resonance study. Biochemistry 1989 2.24
49 The ectodomain of HIV-1 env subunit gp41 forms a soluble, alpha-helical, rod-like oligomer in the absence of gp120 and the N-terminal fusion peptide. EMBO J 1996 2.21
50 Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion. J Gen Virol 1988 2.21
51 Virus replication in enucleate cells: vesicular stomatitis virus and influenza virus. J Virol 1974 2.19
52 Conformational changes in the hemagglutinin of influenza virus which accompany heat-induced fusion of virus with liposomes. Virology 1986 2.13
53 Molecular basis of resistance of influenza A viruses to amantadine. J Antimicrob Chemother 1986 2.04
54 Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion. Proc Natl Acad Sci U S A 2001 2.04
55 Structural evidence for recognition of a single epitope by two distinct antibodies. Proteins 2000 1.99
56 Studies on the adaptation of influenza viruses to MDCK cells. EMBO J 1984 1.98
57 Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin. J Virol 1995 1.96
58 Studies of the binding properties of influenza hemagglutinin receptor-site mutants. Virology 1998 1.95
59 Evidence from studies with a cross-linking reagent that the haemagglutinin of influenza virus is a trimer. Virology 1977 1.93
60 Host-mediated selection of influenza virus receptor variants. Sialic acid-alpha 2,6Gal-specific clones of A/duck/Ukraine/1/63 revert to sialic acid-alpha 2,3Gal-specific wild type in ovo. J Biol Chem 1985 1.91
61 Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains. Proc Natl Acad Sci U S A 1983 1.88
62 Antigen distortion allows influenza virus to escape neutralization. Nat Struct Biol 1998 1.88
63 Electron microscopy of the human respiratory syncytial virus fusion protein and complexes that it forms with monoclonal antibodies. Virology 2000 1.87
64 Electron microscopy of the low pH structure of influenza virus haemagglutinin. EMBO J 1986 1.87
65 rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells. J Virol 1983 1.81
66 Mechanism of neutralization of influenza virus infectivity by antibodies. Virology 2002 1.80
67 Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles. Proc Natl Acad Sci U S A 1991 1.79
68 Studies of influenza haemagglutinin-mediated membrane fusion. Virology 1986 1.78
69 Electron microscopy of antibody complexes of influenza virus haemagglutinin in the fusion pH conformation. EMBO J 1995 1.74
70 Estimations of the molecular weight of the influenza virus genome. J Gen Virol 1971 1.74
71 Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin. Nature 1984 1.72
72 Receptor-binding characteristics of monoclonal antibody-selected antigenic variants of influenza virus. J Virol 1987 1.70
73 Membrane fusion by peptide analogues of influenza virus haemagglutinin. J Gen Virol 1988 1.69
74 Avian and human receptor binding by hemagglutinins of influenza A viruses. Glycoconj J 2006 1.66
75 Comparative analyses of the specificities of anti-influenza hemagglutinin antibodies in human sera. J Virol 1986 1.65
76 Antigenic analyses of influenza virus haemagglutinins with different receptor-binding specificities. Virology 1984 1.64
77 Nucleotide sequences at the terminal of La Crosse virus RNAs. Nucleic Acids Res 1980 1.61
78 The central structural feature of the membrane fusion protein subunit from the Ebola virus glycoprotein is a long triple-stranded coiled coil. Proc Natl Acad Sci U S A 1998 1.58
79 The matrix protein gene determines amantadine-sensitivity of influenza viruses. J Gen Virol 1979 1.54
80 Deacylation of the hemagglutinin of influenza A/Aichi/2/68 has no effect on membrane fusion properties. Virology 1991 1.50
81 Proteins synthesized in chick cells following infection with Semliki Forest virus. J Gen Virol 1968 1.50
82 The preparation and properties of adenovirus cores. J Gen Virol 1971 1.49
83 Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone. Virology 1984 1.48
84 Structure of the haemagglutinin of influenza virus. Br Med Bull 1979 1.47
85 Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity. Proc Natl Acad Sci U S A 1996 1.43
86 RNA-dependent RNA polymerase activity of the influenza virus. Virology 1971 1.43
87 The immune response of BALB/c mice to influenza hemagglutinin: commonality of the B cell and T cell repertoires and their relevance to antigenic drift. Eur J Immunol 1989 1.39
88 Influenza A specific cytotoxic T-cell clones that do not recognize viral glycoproteins. Nature 1982 1.38
89 Early polypeptide synthesis in influenza virus-infected cells. Virology 1973 1.38
90 Conformational-dependent recognition of influenza virus hemagglutinin by murine T helper clones. Eur J Immunol 1986 1.37
91 The size and shape of influenza virus neuraminidase. Virology 1973 1.36
92 Assembly of a rod-shaped chimera of a trimeric GCN4 zipper and the HIV-1 gp41 ectodomain expressed in Escherichia coli. Proc Natl Acad Sci U S A 1997 1.35
93 Structural basis for oseltamivir resistance of influenza viruses. Vaccine 2009 1.31
94 In vitro synthesis, glycosylation, and membrane insertion of influenza virus haemagglutinin. Virology 1979 1.31
95 A surface plasmon resonance assay for the binding of influenza virus hemagglutinin to its sialic acid receptor. Virology 1996 1.29
96 Crystallographic detection of a second ligand binding site in influenza virus hemagglutinin. Proc Natl Acad Sci U S A 1992 1.27
97 Antigenic and amino acid sequence variations in the haemagglutinins of type A influenza viruses recently isolated from human subjects. Bull World Health Organ 1983 1.26
98 Expression, purification, and characterization of gp160e, the soluble, trimeric ectodomain of the simian immunodeficiency virus envelope glycoprotein, gp160. J Biol Chem 2000 1.26
99 Amino acid sequences of haemagglutinins of influenza viruses of the H3 subtype isolated from horses. J Gen Virol 1985 1.26
100 Influenza virus. Amantadine blocks the channel. Nature 1992 1.24
101 Crystal structures of influenza virus hemagglutinin in complex with high-affinity receptor analogs. Structure 1994 1.24
102 Studies on influenza haemagglutinin fusion peptide mutants generated by reverse genetics. EMBO J 2001 1.23
103 Temperature dependence of fusion by sendai virus. Virology 2000 1.23
104 The polypeptide composition of mouse mammary tumor virus. Virology 1974 1.21
105 Antigenic and amino acid sequence analyses of influenza viruses of the H1N1 subtype isolated between 1982 and 1984. Bull World Health Organ 1985 1.21
106 Characterization of influenza virus RNA transcripts synthesized in vitro. J Gen Virol 1979 1.21
107 Adaptation of egg-grown and transfectant influenza viruses for growth in mammalian cells: selection of hemagglutinin mutants with elevated pH of membrane fusion. Virology 1997 1.20
108 Role of virion M2 protein in influenza virus uncoating: specific reduction in the rate of membrane fusion between virus and liposomes by amantadine. J Gen Virol 1994 1.20
109 Extensive diversity in the recognition of influenza virus hemagglutinin by murine T helper clones. J Exp Med 1986 1.18
110 Ribonucleic acid synthesis in chick embryo cells infected with fowl-plague virus. J Virol 1969 1.18
111 Characterization of temperature-sensitive mutants of adenovirus type 5: synthesis of polypeptides in infected cells. J Gen Virol 1974 1.16
112 Ligand recognition by influenza virus. The binding of bivalent sialosides. J Biol Chem 1991 1.15
113 Purification of virus glycoproteins by affinity chromatography using Lens culinaris phytohaemagglutinin. FEBS Lett 1973 1.15
114 Ground penetrating radar surveys to locate 1918 Spanish flu victims in permafrost. J Forensic Sci 2000 1.14
115 The structural requirements for class II (I-Ad)-restricted T cell recognition of influenza hemagglutinin: B cell epitopes define T cell epitopes. Eur J Immunol 1989 1.14
116 I-Ad restricted T cell recognition of influenza hemagglutinin. Synthetic peptides identify multiple epitopes corresponding to antibody-binding regions of the HA1 subunit. J Immunol 1989 1.13
117 The structure of a membrane fusion mutant of the influenza virus haemagglutinin. EMBO J 1990 1.11
118 Conformational aspects of the acid-induced fusion mechanism of influenza virus hemagglutinin. Circular dichroism and fluorescence studies. J Biol Chem 1988 1.11
119 Proton nuclear magnetic resonance studies of the binding of sialosides to intact influenza virus. Virology 1992 1.10
120 Influenza virus transcription. J Gen Virol 1978 1.09
121 Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides. Virus Res 1995 1.08
122 The characterization of subviral particles derived from influenza virus. Virology 1971 1.08
123 Characterization of virus-specific messenger RNAs from avian fibroblasts infected with fowl plague virus. J Gen Virol 1977 1.06
124 The structure and role of the carbohydrate moieties of influenza virus haemagglutinin. Biochem Soc Trans 1983 1.05
125 Fine specificity of murine class II-restricted T cell clones for synthetic peptides of influenza virus hemagglutinin. Heterogeneity of antigen interaction with the T cell and the Ia molecule. J Immunol 1988 1.01
126 Electron microscopy of influenza haemagglutinin-monoclonal antibody complexes. Virology 1983 1.01
127 Diversity of the class II (I-Ak/I-Ek)-restricted T cell repertoire for influenza hemagglutinin and antigenic drift. Six nonoverlapping epitopes on the HA1 subunit are defined by synthetic peptides. J Exp Med 1989 1.00
128 The conformation of influenza virus haemagglutinin. FEBS Lett 1977 0.98
129 Structure and synthesis of influenza virus complementary RNAs. Philos Trans R Soc Lond B Biol Sci 1980 0.97
130 Crystallization and x-ray diffraction studies on the haemagglutinin glycoprotein from the membrane of influenza virus. J Mol Biol 1977 0.97
131 Procedures for characterisation of the genetic material of candidate vaccine strains. Dev Biol Stand 1978 0.96
132 Analysis of antigenic variation in equine 2 influenza A viruses. Bull World Health Organ 1983 0.96
133 Interferon production and RNA inhibitors. J Gen Virol 1967 0.95
134 Antigenic and genetic characterization of current influenza strains. Eur J Epidemiol 1994 0.95
135 Effects of actinomycin D and 2-mercapto-1-(beta-4-pyridethyl) benzimidazole on the incorporation of [3H]uridine by chick embryo cells. Biochim Biophys Acta 1967 0.95
136 Electron microscopic evidence for the axial rotation and inter-domain flexibility of the Fab regions of immunoglobulin G. J Mol Biol 1983 0.94
137 The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core. Bioorg Med Chem 2000 0.93
138 A polar octapeptide fused to the N-terminal fusion peptide solubilizes the influenza virus HA2 subunit ectodomain. Biochemistry 1998 0.93
139 Crystals of a fragment of influenza haemagglutinin in the low pH induced conformation. J Mol Biol 1994 0.92
140 Structural studies on viral escape from antibody neutralization. Curr Top Microbiol Immunol 2001 0.92
141 [Epizootic swine influenza on animal farms in Brittany]. Rev Epidemiol Sante Publique 1983 0.91
142 Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus. Virus Res 2013 0.90
143 X-ray crystallographic determination of the structure of the influenza C virus haemagglutinin-esterase-fusion glycoprotein. Acta Crystallogr D Biol Crystallogr 1999 0.88
144 Refined three-dimensional structure of the Fab fragment of a murine IgGl,lambda antibody. Acta Crystallogr D Biol Crystallogr 1994 0.88
145 Interferon production and viral ribonucleic acid synthesis in chick embryo cells. J Gen Virol 1967 0.88
146 Interferon production by Semliki Forest virus inactivated with hydroxylamine. J Gen Virol 1968 0.87
147 Genetic composition and virulence of influenza virus: differences in facets of virulence in ferrets between two pairs of recombinants with RNA segments of the same parental origin. J Gen Virol 1982 0.87
148 Spontaneous and tryptic degradation of virus particles and structural components of adenoviruses. J Gen Virol 1971 0.87
149 Membrane fusion by surrogate receptor-bound influenza haemagglutinin. Virology 1999 0.86
150 The structure and role of the carbohydrate moieties of influenza virus haemagglutinin. Biochem Soc Trans 1983 0.86
151 Studies with monoclonal antibodies prepared against X-31 influenza virus haemagglutinin. Biochem Soc Trans 1985 0.85
152 Antigenic and amino acid sequence analysis of the variants of H1N1 influenza virus in 1986. Bull World Health Organ 1987 0.85
153 Differentiation of the haemagglutinin genes of variant influenza viruses by RNA-RNA hybridization. J Gen Virol 1979 0.85
154 Experimental influenza causes a non-permissive viral infection of brain, liver and muscle. J Neurovirol 2000 0.84
155 A single amino acid substitution in influenza hemagglutinin abrogates recognition by monoclonal antibody and a spectrum of subtype-specific L3T4+ T cell clones. Eur J Immunol 1987 0.83
156 Are peptides good antigens? Nature 1985 0.81
157 B- and T-cell recognition of influenza hemagglutinin. Cold Spring Harb Symp Quant Biol 1989 0.81
158 Influenza virus haemagglutinin signal sequence. FEBS Lett 1979 0.80
159 A neutralizing antibody Fab-influenza haemagglutinin complex with an unprecedented 2:1 stoichiometry: characterization and crystallization. Acta Crystallogr D Biol Crystallogr 2000 0.80
160 Suicide selection of murine T helper clones specific for variable regions of the influenza hemagglutinin molecule. Eur J Immunol 1986 0.80
161 The polypeptides of adenovirus type 12. J Gen Virol 1973 0.79
162 Crystallization and preliminary X-ray diffraction studies of complexes between an influenza hemagglutinin and Fab fragments of two different monoclonal antibodies. Proteins 1995 0.79
163 Crystallization and preliminary X-ray diffraction studies of a monoclonal antibody Fab fragment specific for an influenza virus haemagglutinin and of an escape mutant of that haemagglutinin. J Mol Biol 1990 0.78
164 Influenza virus transcription. Br Med Bull 1979 0.78
165 The immunotargeting approach to adjuvant-independent immunization with influenza haemagglutinin. Vaccine 1993 0.77
166 A temperature-sensitive event in interferon production. J Gen Virol 1968 0.77
167 Structural changes in influenza virus haemagglutinin at the pH of membrane fusion. Biochem Soc Trans 1986 0.77
168 Analysis of murine antibody responses to baculovirus-expressed human immunodeficiency virus type 1 envelope glycoproteins. J Gen Virol 1994 0.76
169 Use of molecular replacement in the solution of an immunoglobulin Fab fragment structure. Acta Crystallogr B 1991 0.76
170 Virus nucleic acid and interferon formation. Biochem J 1967 0.75
171 Protein components of fowl-plague virus. Biochem J 1968 0.75
172 Influenza virus infection of a cell-cycle mutant of Chinese hamster ovary cells. J Gen Virol 1977 0.75
173 Antigenic characterization of influenza A (H1N1) viruses recently isolated from pigs and turkeys in France. Bull World Health Organ 1985 0.75
174 Ribonucleic acid synthesis in fowl-plague virus-infected chick-embryo cells. Biochem J 1968 0.75
175 Infection of tumour cells by fowl plague virus in the presence of actinomycin D. Nat New Biol 1971 0.75
176 Studies on the structure of the haemagglutinin. Philos Trans R Soc Lond B Biol Sci 1980 0.75
177 Cryocrystallography of influenza virus hemagglutinin crystals. Acta Crystallogr D Biol Crystallogr 1995 0.75
178 Influenza A virus enhances IgE-mediated histamine release from human basophil leukocytes. Examination of the effect of viral neuraminidase and haemagglutinin. Agents Actions 1989 0.75
179 Crystallization and preliminary X-ray diffraction studies of the influenza C virus glycoprotein. Acta Crystallogr D Biol Crystallogr 1996 0.75
180 Interferons and other cell products influencing viral multiplication. Br Med Bull 1967 0.75
181 Characterization of avian influenza viruses isolated in Israel in 1978-1979. Comp Immunol Microbiol Infect Dis 1980 0.75