Published in Proc Natl Acad Sci U S A on April 09, 2007
Integrating physical and genetic maps: from genomes to interaction networks. Nat Rev Genet (2007) 2.77
Models from experiments: combinatorial drug perturbations of cancer cells. Mol Syst Biol (2008) 2.33
Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Syst Biol (2009) 1.63
Towards genome-scale signalling network reconstructions. Nat Rev Genet (2010) 1.39
High-order combination effects and biological robustness. Mol Syst Biol (2008) 1.24
Reverse phase protein microarrays advance to use in clinical trials. Mol Oncol (2010) 1.23
Serial dilution curve: a new method for analysis of reverse phase protein array data. Bioinformatics (2009) 1.17
Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network. Genome Res (2009) 1.17
Akt2 kinase suppresses glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation. J Biol Chem (2011) 1.14
Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society. Mol Cell Proteomics (2014) 1.11
Deterministic Effects Propagation Networks for reconstructing protein signaling networks from multiple interventions. BMC Bioinformatics (2009) 1.03
MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer. J Pathol (2014) 0.96
RNAi-based validation of antibodies for reverse phase protein arrays. Proteome Sci (2010) 0.92
Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis. BMC Cancer (2008) 0.87
A network-based method to assess the statistical significance of mild co-regulation effects. PLoS One (2013) 0.86
Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplification. Proteome Sci (2010) 0.86
Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. PLoS One (2011) 0.84
Structure-Based Design of Dendritic Peptide Bolaamphiphiles for siRNA Delivery. ACS Cent Sci (2015) 0.80
Microarray-integrated optoelectrofluidic immunoassay system. Biomicrofluidics (2016) 0.77
Anticipatory activation of the unfolded protein response by epidermal growth factor is required for immediate early gene expression and cell proliferation. Mol Cell Endocrinol (2015) 0.77
Reno: regularized non-parametric analysis of protein lysate array data. Bioinformatics (2012) 0.76
Untangling the ErbB signalling network. Nat Rev Mol Cell Biol (2001) 28.05
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA (2006) 7.06
Insulin-like growth factors and neoplasia. Nat Rev Cancer (2004) 6.29
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 4.85
Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J Biol Chem (2004) 4.32
Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A (2004) 2.81
Integrin signaling in epithelial cells. Cancer Lett (2006) 1.72
ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients. Cancer Res (2001) 1.48
Molecular basis for Rho GTPase signaling specificity. Breast Cancer Res Treat (2004) 1.28
Infrared-based protein detection arrays for quantitative proteomics. Proteomics (2007) 1.25
Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes. Biotechniques (2006) 1.21
Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway. Cell Cycle (2006) 1.03
Precision and variance components in quantitative gel electrophoresis. Electrophoresis (2005) 0.98
Intraductal spread of invasive breast carcinoma has a positive correlation with c-erb B-2 overexpression and vascular invasion. Cancer (1999) 0.83
The signaling network of tumor invasion. Histol Histopathol (2005) 0.82
Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics (2002) 20.59
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol (2008) 12.96
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Dissecting the genomic complexity underlying medulloblastoma. Nature (2012) 4.77
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
The first RSBI (ISA-TAB) workshop: "can a simple format work for complex studies?". OMICS (2008) 4.15
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell (2013) 3.08
Circulating miRNAs are correlated with tumor progression in prostate cancer. Int J Cancer (2011) 3.02
Serum microRNAs as non-invasive biomarkers for cancer. Mol Cancer (2010) 2.95
GOSim--an R-package for computation of information theoretic GO similarities between terms and gene products. BMC Bioinformatics (2007) 2.86
Identification of a common gene expression signature in dilated cardiomyopathy across independent microarray studies. J Am Coll Cardiol (2006) 2.73
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res (2007) 2.54
Marked gene transcript level alterations occur early during radical prostatectomy. Eur Urol (2007) 2.41
KEGGgraph: a graph approach to KEGG PATHWAY in R and bioconductor. Bioinformatics (2009) 2.31
Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization. Anal Biochem (2004) 2.28
Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. BMC Med Genomics (2011) 2.24
Yes and PI3K bind CD95 to signal invasion of glioblastoma. Cancer Cell (2008) 2.21
The completion of the Mammalian Gene Collection (MGC). Genome Res (2009) 2.21
A 15q13.3 microdeletion segregating with autism. Eur J Hum Genet (2008) 2.12
The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Res (2007) 2.07
A microscope-based screening platform for large-scale functional protein analysis in intact cells. FEBS Lett (2003) 2.04
arrayMagic: two-colour cDNA microarray quality control and preprocessing. Bioinformatics (2004) 2.02
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol (2012) 1.88
Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes. Lung Cancer (2008) 1.71
Parameter estimation for the calibration and variance stabilization of microarray data. Stat Appl Genet Mol Biol (2003) 1.70
Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol (2012) 1.69
Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Syst Biol (2009) 1.63
Circulating microRNAs in plasma as early detection markers for breast cancer. Int J Cancer (2012) 1.61
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. PLoS Med (2007) 1.61
Molecular cancer phenotype in normal prostate tissue. Eur Urol (2008) 1.58
Identification of aberrant chromosomal regions from gene expression microarray studies applied to human breast cancer. Bioinformatics (2007) 1.50
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. Mol Cell Biol (2011) 1.49
A compendium to ensure computational reproducibility in high-dimensional classification tasks. Stat Appl Genet Mol Biol (2004) 1.48
Estimating large-scale signaling networks through nested effect models with intervention effects from microarray data. Bioinformatics (2008) 1.46
A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. J Cell Sci (2003) 1.46
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet (2011) 1.43
Effects of infiltrating lymphocytes and estrogen receptor on gene expression and prognosis in breast cancer. Breast Cancer Res Treat (2008) 1.42
LIFEdb: a database for functional genomics experiments integrating information from external sources, and serving as a sample tracking system. Nucleic Acids Res (2004) 1.41
ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction. Clin Cancer Res (2010) 1.41
Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion. J Immunol (2007) 1.40
SMART amplification combined with cDNA size fractionation in order to obtain large full-length clones. BMC Genomics (2004) 1.37
Identification of the bacteria-binding peptide domain on salivary agglutinin (gp-340/DMBT1), a member of the scavenger receptor cysteine-rich superfamily. J Biol Chem (2002) 1.37
Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage. Gynecol Oncol (2011) 1.37
Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31. J Pathol (2010) 1.36
Dynamic deterministic effects propagation networks: learning signalling pathways from longitudinal protein array data. Bioinformatics (2010) 1.35
Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAs. Nucleic Acids Res (2006) 1.34
Large scale statistical inference of signaling pathways from RNAi and microarray data. BMC Bioinformatics (2007) 1.33
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol (2011) 1.30
CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D. Eur J Immunol (2003) 1.29
RPPanalyzer: Analysis of reverse-phase protein array data. Bioinformatics (2010) 1.29
On target: a public repository for large-scale RNAi experiments. Nat Cell Biol (2012) 1.27
TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling. BMC Cancer (2011) 1.26
Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains. J Biol Chem (2004) 1.26
Systematic analysis of T7 RNA polymerase based in vitro linear RNA amplification for use in microarray experiments. BMC Genomics (2004) 1.25
Infrared-based protein detection arrays for quantitative proteomics. Proteomics (2007) 1.25
The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer. J Mol Med (Berl) (2012) 1.23
Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation. Cancer Discov (2012) 1.21
Prognostic role of E2F1 and members of the CDKN2A network in gastrointestinal stromal tumors. Clin Cancer Res (2005) 1.19
Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma. Oncotarget (2014) 1.18
A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome. Am J Hum Genet (2002) 1.18
Large-scale protein expression for proteome research. Proteomics (2005) 1.18
DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. Gastroenterology (2007) 1.18
EZH2 depletion blocks the proliferation of colon cancer cells. PLoS One (2011) 1.15
Integration of pathway knowledge into a reweighted recursive feature elimination approach for risk stratification of cancer patients. Bioinformatics (2010) 1.15
MicroRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon (PKCepsilon). J Biol Chem (2013) 1.13
Gene expression in kidney cancer is associated with cytogenetic abnormalities, metastasis formation, and patient survival. Clin Cancer Res (2005) 1.13
Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer Res (2005) 1.12
The full-ORF clone resource of the German cDNA Consortium. BMC Genomics (2007) 1.11