Published in Nat Genet on April 15, 2007
Genome-wide association studies: potential next steps on a genetic journey. Hum Mol Genet (2008) 7.54
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet (2008) 5.23
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84
Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes (2009) 2.68
Gut microbiome-host interactions in health and disease. Genome Med (2011) 2.48
The functional impact of structural variation in humans. Trends Genet (2008) 2.03
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
Intestinal microbiota in human health and disease: the impact of probiotics. Genes Nutr (2011) 1.63
Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes. Diabetologia (2010) 1.60
Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice. PLoS One (2008) 1.23
Metabotyping of Caenorhabditis elegans reveals latent phenotypes. Proc Natl Acad Sci U S A (2007) 1.16
A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model. Genome Res (2011) 1.16
Systematic NMR analysis of stable isotope labeled metabolite mixtures in plant and animal systems: coarse grained views of metabolic pathways. PLoS One (2008) 1.11
MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes. BMC Med Genomics (2009) 1.10
The human gut microbiome and body metabolism: implications for obesity and diabetes. Clin Chem (2013) 1.07
Coordinated regulation of the metabolome and lipidome at the host-microbial interface. Biochim Biophys Acta (2009) 1.07
Getting biological about the genetics of diabetes. Nat Med (2010) 1.05
Body fat free mass is associated with the serum metabolite profile in a population-based study. PLoS One (2012) 1.04
Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ Health Perspect (2012) 1.00
Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells. PLoS Comput Biol (2011) 0.99
The challenges for molecular nutrition research 1: linking genotype to healthy nutrition. Genes Nutr (2008) 0.96
Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer. Genome Med (2012) 0.93
Correlation exploration of metabolic and genomic diversity in rice. BMC Genomics (2009) 0.92
Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links. PLoS Genet (2014) 0.91
Semi-quantitative and structural metabolic phenotyping by direct infusion ion trap mass spectrometry and its application in genetical metabolomics. Rapid Commun Mass Spectrom (2009) 0.89
Genetic basis of metabolome variation in yeast. PLoS Genet (2014) 0.87
Future of osteoporosis genetics: enhancing genome-wide association studies. J Bone Miner Res (2009) 0.86
Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations. Genome Med (2012) 0.83
Metabolic phenotyping and systems biology approaches to understanding neurological disorders. F1000Prime Rep (2013) 0.82
Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms. PLoS One (2016) 0.82
Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series. Genome Med (2016) 0.80
From integrative genomics to systems genetics in the rat to link genotypes to phenotypes. Dis Model Mech (2016) 0.79
Does our gut microbiome predict cardiovascular risk? A review of the evidence from metabolomics. Circ Cardiovasc Genet (2015) 0.77
Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks. Int J Epidemiol (2016) 0.76
Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat. Mamm Genome (2010) 0.76
Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression. G3 (Bethesda) (2016) 0.75
Systems mapping of metabolic genes through control theory. Adv Drug Deliv Rev (2013) 0.75
A Systematic Evaluation of Blood Serum and Plasma Pre-Analytics for Metabolomics Cohort Studies. Int J Mol Sci (2016) 0.75
Untargeted Metabotyping Lolium perenne Reveals Population-Level Variation in Plant Flavonoids and Alkaloids. Front Plant Sci (2017) 0.75
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Ensembl 2011. Nucleic Acids Res (2010) 14.68
Ensembl 2012. Nucleic Acids Res (2011) 14.55
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Ensembl 2014. Nucleic Acids Res (2013) 12.62
Ensembl 2013. Nucleic Acids Res (2012) 11.70
Ensembl's 10th year. Nucleic Acids Res (2009) 10.82
Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet (2006) 9.87
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Genomics (2002) 7.10
Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis. Nat Biotechnol (2002) 6.96
Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A (2008) 6.42
ENCODE data in the UCSC Genome Browser: year 5 update. Nucleic Acids Res (2012) 6.29
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet (2008) 6.06
Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc (2007) 5.92
Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet (2008) 5.55
Human metabolic phenotype diversity and its association with diet and blood pressure. Nature (2008) 5.41
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
Systems biology: Metabonomics. Nature (2008) 5.32
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A (2006) 5.19
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis. PLoS Med (2012) 4.37
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. Cell (2010) 4.34
Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets. Anal Chem (2005) 4.14
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med (2002) 3.91
Integrative annotation of chromatin elements from ENCODE data. Nucleic Acids Res (2012) 3.80
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Mol Syst Biol (2007) 3.68
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46
Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature (2006) 3.45
Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut (2011) 3.42
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Genetic and environmental effects on complex traits in mice. Genetics (2006) 3.27
Intraoperative tissue identification using rapid evaporative ionization mass spectrometry. Sci Transl Med (2013) 3.26
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem (2009) 3.23
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A (2009) 3.01
SNP and haplotype mapping for genetic analysis in the rat. Nat Genet (2008) 2.96
Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia. PLoS Med (2006) 2.95
Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol (2005) 2.90
E-learning in medical education in resource constrained low- and middle-income countries. Hum Resour Health (2013) 2.85
Metabolic phenotyping in health and disease. Cell (2008) 2.80
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov (2008) 2.59
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci U S A (2010) 2.52
Gut microbiome-host interactions in health and disease. Genome Med (2011) 2.48
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol (2008) 2.43
Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2010) 2.30
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat Genet (2009) 2.19
Global metabolic profiling procedures for urine using UPLC-MS. Nat Protoc (2010) 2.18
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Mol Syst Biol (2008) 2.17
UPLC/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation. Rapid Commun Mass Spectrom (2006) 2.17
NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed (2005) 2.15
Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification. Proc Natl Acad Sci U S A (2004) 2.11
Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J Proteome Res (2009) 2.10
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One (2010) 2.05
Colonization-induced host-gut microbial metabolic interaction. MBio (2011) 2.04
Optimized preprocessing of ultra-performance liquid chromatography/mass spectrometry urinary metabolic profiles for improved information recovery. Anal Chem (2011) 2.02
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
Global systems biology, personalized medicine and molecular epidemiology. Mol Syst Biol (2006) 1.99
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet (2003) 1.99
How has healthcare research performance been assessed?: a systematic review. J R Soc Med (2011) 1.97
Susceptibility of human metabolic phenotypes to dietary modulation. J Proteome Res (2006) 1.96
A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mamm Genome (2006) 1.96
High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J Proteome Res (2005) 1.93
Metabonomics in pharmaceutical R&D. FEBS J (2007) 1.93
The human gut microbiome: implications for future health care. Curr Gastroenterol Rep (2008) 1.84
Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A (2007) 1.84
Metabonomics in ulcerative colitis: diagnostics, biomarker identification, and insight into the pathophysiology. J Proteome Res (2010) 1.84
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
Scaling and normalization effects in NMR spectroscopic metabonomic data sets. Anal Chem (2006) 1.81
Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers (2004) 1.79
Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection. J Proteome Res (2008) 1.78
NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology. Chem Res Toxicol (2008) 1.77
Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study. Anal Chem (2006) 1.76
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues. Nat Protoc (2010) 1.76
Melamine-induced renal toxicity is mediated by the gut microbiota. Sci Transl Med (2013) 1.75
Understanding the role of gut microbiome-host metabolic signal disruption in health and disease. Trends Microbiol (2011) 1.72
A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies. Genome Biol (2015) 1.71