Published in Nature on April 20, 2008
Worlds within worlds: evolution of the vertebrate gut microbiota. Nat Rev Microbiol (2008) 12.16
Phenomics: the next challenge. Nat Rev Genet (2010) 4.20
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc (2011) 4.13
Systems medicine: the future of medical genomics and healthcare. Genome Med (2009) 3.85
Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci U S A (2010) 3.51
Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut (2011) 3.42
An atlas of genetic influences on human blood metabolites. Nat Genet (2014) 3.21
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84
Metabolite profiling identifies pathways associated with metabolic risk in humans. Circulation (2012) 2.51
Gut microbiome-host interactions in health and disease. Genome Med (2011) 2.48
Metabolomics reveals metabolic biomarkers of Crohn's disease. PLoS One (2009) 2.35
The human intestinal microbiome: a new frontier of human biology. DNA Res (2009) 2.30
Global metabolic profiling procedures for urine using UPLC-MS. Nat Protoc (2010) 2.18
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A (2013) 2.10
Effects of cis and trans genetic ancestry on gene expression in African Americans. PLoS Genet (2008) 2.09
Metabolic phenotyping in clinical and surgical environments. Nature (2012) 2.09
Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics (2009) 2.03
Diet-induced metabolic improvements in a hamster model of hypercholesterolemia are strongly linked to alterations of the gut microbiota. Appl Environ Microbiol (2009) 2.02
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
Exposure science and the exposome: an opportunity for coherence in the environmental health sciences. Environ Health Perspect (2011) 1.80
Biomarkers in nutritional epidemiology: applications, needs and new horizons. Hum Genet (2009) 1.68
Application of OMICS technologies in occupational and environmental health research; current status and projections. Occup Environ Med (2009) 1.67
Intestinal microbiota in human health and disease: the impact of probiotics. Genes Nutr (2011) 1.63
Human metabolic profiles are stably controlled by genetic and environmental variation. Mol Syst Biol (2011) 1.60
Metabolomics as a tool for cardiac research. Nat Rev Cardiol (2011) 1.51
Metabolomic study of carotid-femoral pulse-wave velocity in women. J Hypertens (2015) 1.49
Enhanced hypertension prevalence in non-Han Chinese minorities from Xinjiang Province, China. Hypertens Res (2009) 1.49
A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice. ISME J (2013) 1.42
Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model. J Proteome Res (2012) 1.41
Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study. PLoS One (2008) 1.40
Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol Cell Proteomics (2012) 1.36
The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability. Environ Health (2009) 1.31
Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis. Curr Bioinform (2012) 1.31
The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia. Eur J Epidemiol (2009) 1.31
Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology. J Clin Epidemiol (2010) 1.31
Toxicogenomic profiling of chemically exposed humans in risk assessment. Mutat Res (2010) 1.30
Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol (2013) 1.29
The blood exposome and its role in discovering causes of disease. Environ Health Perspect (2014) 1.27
Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits. Metabolomics (2010) 1.24
Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review. Metabolomics (2014) 1.24
Biomarkers intersect with the exposome. Biomarkers (2012) 1.22
Environmental exposure measurement in cancer epidemiology. Mutagenesis (2008) 1.19
Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. PLoS One (2009) 1.18
Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies. Genes Nutr (2010) 1.18
Comparison of the gut microbiotas of healthy adult twins living in South Korea and the United States. Appl Environ Microbiol (2011) 1.18
Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification. J Proteome Res (2010) 1.16
Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? J Obes (2012) 1.16
Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study. J Proteome Res (2010) 1.15
Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks. J Biomol NMR (2011) 1.15
Workflow4Metabolomics: a collaborative research infrastructure for computational metabolomics. Bioinformatics (2014) 1.14
Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes. Diabetes (2011) 1.14
Bioactivity enhancement of herbal supplements by intestinal microbiota focusing on ginsenosides. Am J Chin Med (2011) 1.13
Multidimensional approaches to NMR-based metabolomics. Anal Chem (2013) 1.12
Metabotyping of long-lived mice using 1H NMR spectroscopy. J Proteome Res (2012) 1.11
Systematic NMR analysis of stable isotope labeled metabolite mixtures in plant and animal systems: coarse grained views of metabolic pathways. PLoS One (2008) 1.11
Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children. Sci Rep (2016) 1.10
More than 9,000,000 unique genes in human gut bacterial community: estimating gene numbers inside a human body. PLoS One (2009) 1.09
The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med (2016) 1.08
Genetic Determinants of the Gut Microbiome in UK Twins. Cell Host Microbe (2016) 1.08
The human gut microbiome and body metabolism: implications for obesity and diabetes. Clin Chem (2013) 1.07
Coordinated regulation of the metabolome and lipidome at the host-microbial interface. Biochim Biophys Acta (2009) 1.07
The human milk metabolome reveals diverse oligosaccharide profiles. J Nutr (2013) 1.07
Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption. Am J Clin Nutr (2010) 1.04
Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population. BMC Med (2012) 1.03
Metabolomics of neural progenitor cells: a novel approach to biomarker discovery. Cold Spring Harb Symp Quant Biol (2008) 1.02
Molecular phenotyping of a UK population: defining the human serum metabolome. Metabolomics (2014) 1.02
In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart. Cardiovasc Res (2012) 1.01
From differentiating metabolites to biomarkers. Anal Bioanal Chem (2009) 1.01
The marriage of nutrigenomics with the microbiome: the case of infant-associated bifidobacteria and milk. Am J Clin Nutr (2014) 1.00
Statistical methods for the analysis of high-throughput metabolomics data. Comput Struct Biotechnol J (2013) 1.00
Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease. Mol Vis (2009) 0.99
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: the normal gut microbiota in health and disease. Clin Exp Immunol (2010) 0.98
Gallic acid ameliorated impaired glucose and lipid homeostasis in high fat diet-induced NAFLD mice. PLoS One (2014) 0.97
Genomic approaches to coronary artery disease. Indian J Med Res (2010) 0.96
Genetic regulation of mouse liver metabolite levels. Mol Syst Biol (2014) 0.95
Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics? Genes Nutr (2009) 0.95
A rendezvous with our microbes. Proc Natl Acad Sci U S A (2011) 0.95
Volatile compound fingerprinting of mixed-culture fermentations. Appl Environ Microbiol (2011) 0.94
Opportunities and challenges for selected emerging technologies in cancer epidemiology: mitochondrial, epigenomic, metabolomic, and telomerase profiling. Cancer Epidemiol Biomarkers Prev (2012) 0.94
Hepatocellular carcinoma: Review of disease and tumor biomarkers. World J Hepatol (2016) 0.94
Unbiased approaches to biomarker discovery in neurodegenerative diseases. Neuron (2014) 0.93
Development of an integrated metabolomic profiling approach for infectious diseases research. Analyst (2011) 0.92
Association of raw fruit and fruit juice consumption with blood pressure: the INTERMAP Study. Am J Clin Nutr (2013) 0.92
Metabolic profiles of male meat eaters, fish eaters, vegetarians, and vegans from the EPIC-Oxford cohort. Am J Clin Nutr (2015) 0.92
Can we trust untargeted metabolomics? Results of the metabo-ring initiative, a large-scale, multi-instrument inter-laboratory study. Metabolomics (2014) 0.91
Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression. Malar J (2010) 0.90
Development and validation of a standardized protocol to monitor human dietary exposure by metabolite fingerprinting of urine samples. Metabolomics (2011) 0.90
Semi-quantitative and structural metabolic phenotyping by direct infusion ion trap mass spectrometry and its application in genetical metabolomics. Rapid Commun Mass Spectrom (2009) 0.89
Magnetic resonance spectroscopy detectable metabolomic fingerprint of response to antineoplastic treatment. PLoS One (2011) 0.89
Metabolomics for Biomarker Discovery: Moving to the Clinic. Biomed Res Int (2015) 0.89
The gut microbiota, environment and diseases of modern society. Gut Microbes (2012) 0.88
NMR/MS Translator for the Enhanced Simultaneous Analysis of Metabolomics Mixtures by NMR Spectroscopy and Mass Spectrometry: Application to Human Urine. J Proteome Res (2015) 0.88
The impact of eating frequency and time of intake on nutrient quality and Body Mass Index: the INTERMAP Study, a Population-Based Study. J Acad Nutr Diet (2015) 0.87
Metabolomic analysis of human disease and its application to the eye. J Ocul Biol Dis Infor (2009) 0.87
Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation. Anal Chem (2009) 0.87
Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study. BMC Med (2014) 0.86
Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids. Genome Med (2014) 0.86
Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice. Proc Natl Acad Sci U S A (2012) 0.86
Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer. Mol Nutr Food Res (2013) 0.85
Metabolic phenotyping for enhanced mechanistic stratification of chronic hepatitis C-induced liver fibrosis. Am J Gastroenterol (2014) 0.85
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. JAMA (2003) 7.35
Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies. PLoS Genet (2008) 6.66
Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A (2008) 6.42
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
Electron-beam tomography coronary artery calcium and cardiac events: a 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults. Circulation (2003) 6.13
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet (2008) 6.06
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc (2007) 5.92
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Effect of lower sodium intake on health: systematic review and meta-analyses. BMJ (2013) 5.78
Aircraft noise and cardiovascular disease near Heathrow airport in London: small area study. BMJ (2013) 5.74
Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet (2008) 5.55
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
Systems biology: Metabonomics. Nature (2008) 5.32
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009). Hypertens Res (2009) 5.24
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A (2006) 5.19
Salt intakes around the world: implications for public health. Int J Epidemiol (2009) 5.05
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
Design and implementation of the Hispanic Community Health Study/Study of Latinos. Ann Epidemiol (2010) 4.61
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53
Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet (2016) 4.49
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (2008) 4.38
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Psychosocial factors and risk of hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. JAMA (2003) 4.07
Sequence-level population simulations over large genomic regions. Genetics (2007) 4.04
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med (2002) 3.91
Interpreting posterior relative risk estimates in disease-mapping studies. Environ Health Perspect (2004) 3.81
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Mol Syst Biol (2007) 3.68
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46
Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature (2006) 3.45
Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation (2004) 3.44
Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut (2011) 3.42
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature (2012) 3.41
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Genome-wide significance for dense SNP and resequencing data. Genet Epidemiol (2008) 3.26
Intraoperative tissue identification using rapid evaporative ionization mass spectrometry. Sci Transl Med (2013) 3.26
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations. Circulation (2012) 3.14
Blood pressure and the global burden of disease 2000. Part II: estimates of attributable burden. J Hypertens (2006) 3.12
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A (2009) 3.01
Pulse pressure and cardiovascular disease-related mortality: follow-up study of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA (2002) 2.96
Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia. PLoS Med (2006) 2.95
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol (2005) 2.90
SLC2A9 is a high-capacity urate transporter in humans. PLoS Med (2008) 2.87
Body-mass index and cancer mortality in the Asia-Pacific Cohort Studies Collaboration: pooled analyses of 424,519 participants. Lancet Oncol (2010) 2.81
Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-ethnic Study of Atherosclerosis (MESA). Environ Health Perspect (2008) 2.80
Metabolic phenotyping in health and disease. Cell (2008) 2.80
Maintaining a high physical activity level over 20 years and weight gain. JAMA (2010) 2.78
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study. J Am Coll Cardiol (2008) 2.74
Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J Hepatol (2002) 2.70
Dietary sources of sodium in China, Japan, the United Kingdom, and the United States, women and men aged 40 to 59 years: the INTERMAP study. J Am Diet Assoc (2010) 2.60
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov (2008) 2.59
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature (2011) 2.59
MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS. PLoS One (2012) 2.56
Status of cardiovascular health in US adults: prevalence estimates from the National Health and Nutrition Examination Surveys (NHANES) 2003-2008. Circulation (2011) 2.54
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci U S A (2010) 2.52
Gut microbiome-host interactions in health and disease. Genome Med (2011) 2.48
Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality. JAMA (2004) 2.45
Association of acculturation levels and prevalence of diabetes in the multi-ethnic study of atherosclerosis (MESA). Diabetes Care (2008) 2.44
Blood pressure and the global burden of disease 2000. Part 1: estimates of blood pressure levels. J Hypertens (2006) 2.43
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol (2008) 2.43
Healthy lifestyle through young adulthood and the presence of low cardiovascular disease risk profile in middle age: the Coronary Artery Risk Development in (Young) Adults (CARDIA) study. Circulation (2012) 2.40
Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study. Hypertension (2010) 2.37
Midlife body mass index and hospitalization and mortality in older age. JAMA (2006) 2.36