Published in Cell Stress Chaperones on January 01, 2007
Heat shock protein 70 (hsp70) as an emerging drug target. J Med Chem (2010) 2.21
The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics (2011) 2.16
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev (2012) 1.95
Hsp90 and co-chaperones twist the functions of diverse client proteins. Biopolymers (2010) 1.67
An interdomain sector mediating allostery in Hsp70 molecular chaperones. Mol Syst Biol (2010) 1.42
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med (2007) 1.41
The activities and function of molecular chaperones in the endoplasmic reticulum. Semin Cell Dev Biol (2007) 1.16
Selective targeting of the stress chaperome as a therapeutic strategy. Trends Pharmacol Sci (2014) 1.12
Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells. Cell Stress Chaperones (2010) 1.10
Unique peptide substrate binding properties of 110-kDa heat-shock protein (Hsp110) determine its distinct chaperone activity. J Biol Chem (2011) 1.07
Quality control and fate determination of Hsp90 client proteins. Biochim Biophys Acta (2011) 1.04
Multiple hsp70 isoforms in the eukaryotic cytosol: mere redundancy or functional specificity? Curr Genomics (2008) 1.03
The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery? Br J Pharmacol (2011) 1.02
Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system. Mol Biol Cell (2010) 1.01
Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase. J Biol Chem (2013) 0.98
RDJ2 (DNAJA2) chaperones neural G protein signaling pathways. Cell Stress Chaperones (2008) 0.93
Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis. J Biol Chem (2013) 0.93
The endoplasmic reticulum Grp170 acts as a nucleotide exchange factor of Hsp70 via a mechanism similar to that of the cytosolic Hsp110. J Biol Chem (2010) 0.92
Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B', in differentiated human neuronal cells. Cell Stress Chaperones (2010) 0.92
A protective Hsp70-TLR4 pathway in lethal oxidant lung injury. J Immunol (2013) 0.91
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer. ACS Chem Biol (2014) 0.91
The complex evolutionary dynamics of Hsp70s: a genomic and functional perspective. Genome Biol Evol (2013) 0.90
J domain co-chaperone specificity defines the role of BiP during protein translocation. J Biol Chem (2010) 0.90
A functional DnaK dimer is essential for the efficient interaction with Hsp40 heat shock protein. J Biol Chem (2015) 0.89
The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel. J Biol Chem (2013) 0.89
Swapping nucleotides, tuning Hsp70. Cell (2008) 0.88
The Hsp110 protein chaperone Sse1 is required for yeast cell wall integrity and morphogenesis. Curr Genet (2008) 0.88
Hierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast. J Biol Chem (2014) 0.87
Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturation. Mol Cell Biol (2008) 0.86
The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s. J Biol Chem (2013) 0.86
Large-Scale Conformational Transitions and Dimerization Are Encoded in the Amino-Acid Sequences of Hsp70 Chaperones. PLoS Comput Biol (2015) 0.83
Expression of a malarial Hsp70 improves defects in chaperone-dependent activities in ssa1 mutant yeast. PLoS One (2011) 0.82
Ssz1 restores endoplasmic reticulum-associated protein degradation in cells expressing defective cdc48-ufd1-npl4 complex by upregulating cdc48. Genetics (2009) 0.81
Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother (2015) 0.80
The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog (2014) 0.78
Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes. Biomed Res Int (2015) 0.78
Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication. PLoS Comput Biol (2017) 0.77
HSP70s: From Tumor Transformation to Cancer Therapy. Clin Med Oncol (2008) 0.77
Direct association of heat shock protein 20 (HSPB6) with phosphoinositide 3-kinase (PI3K) in human hepatocellular carcinoma: regulation of the PI3K activity. PLoS One (2013) 0.76
The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics. Front Oncol (2015) 0.76
HSPA4, the "Evil Chaperone" of the HSP Family, Delays Gastric Ulcer Healing. Dig Dis Sci (2015) 0.75
The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization. J Biol Chem (2016) 0.75
HSP110 promotes colorectal cancer growth through STAT3 activation. Oncogene (2016) 0.75
Global analysis of protein expression in yeast. Nature (2003) 34.15
The Hsp70 and Hsp60 chaperone machines. Cell (1998) 13.79
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature (1990) 6.45
GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J (1997) 4.68
Heat-shock protein 90, a chaperone for folding and regulation. Cell Mol Life Sci (2002) 4.24
Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast. J Cell Biol (1990) 4.19
Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function. Cell Stress Chaperones (1998) 3.94
Kinetics of molecular chaperone action. Science (1994) 3.91
Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK. Science (1997) 3.31
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science (2001) 3.27
Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO J (1995) 3.22
Molecular evolution of the HSP70 multigene family. J Mol Evol (1994) 3.00
Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein. J Cell Biol (1991) 2.63
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58
Nucleotide-induced conformational changes in the ATPase and substrate binding domains of the DnaK chaperone provide evidence for interdomain communication. J Biol Chem (1995) 2.53
Regulation of Hsp70 function by a eukaryotic DnaJ homolog. J Biol Chem (1992) 2.46
Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor. EMBO J (2006) 2.45
Functional specificity among Hsp70 molecular chaperones. Science (1997) 2.45
Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy. Nat Genet (2005) 2.38
The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1. Nat Struct Mol Biol (2005) 2.28
The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct. J Biol Chem (1999) 2.17
The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s. Cell Stress Chaperones (2000) 2.05
The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone. Nat Genet (2005) 2.05
Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70. J Cell Biol (1993) 2.02
Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. Mol Cell (2005) 1.94
RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin. Proc Natl Acad Sci U S A (2001) 1.94
Coordinated activation of Hsp70 chaperones. Science (2004) 1.85
A novel Hsp70 of the yeast ER lumen is required for the efficient translocation of a number of protein precursors. EMBO J (1996) 1.70
Investigation of the interaction between DnaK and DnaJ by surface plasmon resonance spectroscopy. J Mol Biol (1999) 1.69
Hsp70 chaperone machines. Adv Protein Chem (2001) 1.67
Heat shock proteins and thermotolerance; a comparison of induction kinetics. Br J Radiol (1982) 1.64
A functional chaperone triad on the yeast ribosome. Proc Natl Acad Sci U S A (2002) 1.63
Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p. Mol Cell Biol (2002) 1.62
LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum. EMBO J (2000) 1.55
Hsp110 protects heat-denatured proteins and confers cellular thermoresistance. J Biol Chem (1997) 1.53
Isolation and characterization of SSE1 and SSE2, new members of the yeast HSP70 multigene family. Gene (1993) 1.52
The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain. Proc Natl Acad Sci U S A (2002) 1.48
The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb. J Biol Chem (2005) 1.47
Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous. Science (2005) 1.44
Overexpression of yeast Hsp110 homolog Sse1p suppresses ydj1-151 thermosensitivity and restores Hsp90-dependent activity. Mol Biol Cell (2002) 1.44
The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family. J Biol Chem (2004) 1.44
The chaperoning activity of hsp110. Identification of functional domains by use of targeted deletions. J Biol Chem (1999) 1.44
The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone. J Biol Chem (1999) 1.39
Hsp110 cooperates with different cytosolic HSP70 systems in a pathway for de novo folding. J Biol Chem (2005) 1.39
Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1. Biochemistry (2006) 1.34
Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase. Mol Biol Cell (2004) 1.30
SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae endoplasmic reticulum. Mol Cell Biol (1996) 1.27
Human and yeast Hsp110 chaperones exhibit functional differences. FEBS Lett (2005) 1.22
HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc70 nucleotide exchange factor. FEBS Lett (2002) 1.21
The 170 kDa glucose regulated stress protein is a large HSP70-, HSP110-like protein of the endoplasmic reticulum. FEBS Lett (1996) 1.20
Purification and characterization of BiP/Kar2 protein from Saccharomyces cerevisiae. J Biol Chem (1992) 1.20
Regulation of transcription factor Pdr1p function by an Hsp70 protein in Saccharomyces cerevisiae. Mol Cell Biol (1998) 1.17
The molecular chaperone Sse1 and the growth control protein kinase Sch9 collaborate to regulate protein kinase A activity in Saccharomyces cerevisiae. Genetics (2005) 1.15
Cer1p, a novel Hsp70-related protein required for posttranslational endoplasmic reticulum translocation in yeast. J Biol Chem (1996) 1.14
Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae. J Biol Chem (2002) 1.07
Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity. J Biol Chem (2003) 0.98
Characterization of native interaction of hsp110 with hsp25 and hsc70. FEBS Lett (2000) 0.90
Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells. Biochem Biophys Res Commun (1998) 0.88
Functional analysis of a conserved amino-terminal region of HSP70 by site-directed mutagenesis. Yeast (1991) 0.85
The distribution and localization of hsp110 in brain. Brain Res (2000) 0.80
Structure of the Hsp110:Hsc70 nucleotide exchange machine. Mol Cell (2008) 1.96
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell (2008) 1.69
Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system. Microbiol Mol Biol Rev (2012) 1.48
The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb. J Biol Chem (2005) 1.47
The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family. J Biol Chem (2004) 1.44
Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1. Biochemistry (2006) 1.34
The role of Sse1 in the de novo formation and variant determination of the [PSI+] prion. Genetics (2007) 1.28
Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe. J Biol Chem (2002) 1.22
The molecular chaperone Sse1 and the growth control protein kinase Sch9 collaborate to regulate protein kinase A activity in Saccharomyces cerevisiae. Genetics (2005) 1.15
Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. J Biol Chem (2005) 1.09
Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system. Mol Biol Cell (2010) 1.01
Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins. Eukaryot Cell (2008) 0.99
SYM1 is the stress-induced Saccharomyces cerevisiae ortholog of the mammalian kidney disease gene Mpv17 and is required for ethanol metabolism and tolerance during heat shock. Eukaryot Cell (2004) 0.97
The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds. Mol Biol Cell (2012) 0.90
Hsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast. Mol Biol Cell (2009) 0.90
The Hsp110 protein chaperone Sse1 is required for yeast cell wall integrity and morphogenesis. Curr Genet (2008) 0.88
Hierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast. J Biol Chem (2014) 0.87
Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise. Chem Res Toxicol (2012) 0.86
The Hsp90 molecular chaperone complex regulates maltose induction and stability of the Saccharomyces MAL gene transcription activator Mal63p. J Biol Chem (2003) 0.85
Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles. Chem Res Toxicol (2011) 0.81
A lysine-rich region within fungal BAG domain-containing proteins mediates a novel association with ribosomes. Eukaryot Cell (2012) 0.80
Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells. Chem Res Toxicol (2013) 0.80
Indirect immunofluorescence microscopy for direct detection of Xylella fastidiosa in xylem sap. Curr Microbiol (2004) 0.79
Coupled assays for monitoring protein refolding in Saccharomyces cerevisiae. J Vis Exp (2013) 0.77