Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.

PubWeight™: 3.22‹?› | Rank: Top 1%

🔗 View Article (PMC 398335)

Published in EMBO J on May 15, 1995

Authors

B C Freeman1, M P Myers, R Schumacher, R I Morimoto

Author Affiliations

1: Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.

Articles citing this

(truncated to the top 100)

Structural analysis of substrate binding by the molecular chaperone DnaK. Science (1996) 6.13

GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J (1997) 4.68

Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev (1998) 3.72

Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol (1997) 3.39

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. EMBO J (1996) 3.23

BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91

The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol (2000) 2.69

The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. EMBO J (1999) 2.67

Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo. Mol Cell Biol (1996) 2.53

A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates. EMBO J (1996) 2.33

Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions. Protein Sci (2005) 2.10

A small heat shock protein cooperates with heat shock protein 70 systems to reactivate a heat-denatured protein. Plant Physiol (2000) 2.08

Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest (2005) 2.06

The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors. Mol Cell Biol (1998) 2.05

T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis. Microbiol Mol Biol Rev (2002) 1.92

Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J (2001) 1.79

Genomic analysis of the Hsp70 superfamily in Arabidopsis thaliana. Cell Stress Chaperones (2001) 1.73

Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate binding. Mol Cell Biol (2004) 1.55

Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system. Microbiol Mol Biol Rev (2012) 1.48

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J (1998) 1.48

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J (2001) 1.42

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochim Biophys Acta (2011) 1.42

Chaperone networks: tipping the balance in protein folding diseases. Neurobiol Dis (2010) 1.42

Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol (2000) 1.41

Mechanism of clathrin basket dissociation: separate functions of protein domains of the DnaJ homologue auxilin. J Cell Biol (1996) 1.40

Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast. Proc Natl Acad Sci U S A (1996) 1.39

Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal (2011) 1.37

Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol (2002) 1.35

All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity. Cell Stress Chaperones (2007) 1.31

Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins. EMBO J (1996) 1.28

The human DnaJ homologue dj2 facilitates mitochondrial protein import and luciferase refolding. J Cell Biol (1997) 1.28

Stress genes and proteins in the archaea. Microbiol Mol Biol Rev (1999) 1.27

Mutations in the C-terminal fragment of DnaK affecting peptide binding. Proc Natl Acad Sci U S A (1996) 1.24

Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1. J Biol Chem (2000) 1.24

FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity. EMBO J (2001) 1.22

Mutation of the ATP-binding pocket of SSA1 indicates that a functional interaction between Ssa1p and Ydj1p is required for post-translational translocation into the yeast endoplasmic reticulum. Genetics (2000) 1.20

p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity. Mol Cell Biol (2008) 1.20

Identification of a Hsp70 recognition domain within the rubisco small subunit transit peptide. Plant Physiol (2000) 1.18

Divergent functional properties of the ribosome-associated molecular chaperone Ssb compared with other Hsp70s. Mol Biol Cell (2001) 1.17

Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol (2002) 1.17

Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40: yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1. Biochem J (2002) 1.15

Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol (2012) 1.15

Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly. Biochemistry (2008) 1.11

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor. Proc Natl Acad Sci U S A (2013) 1.10

Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly. Mol Cell Biol (1998) 1.10

Heat shock protein 40: structural studies and their functional implications. Protein Pept Lett (2009) 1.10

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus. Ann Rheum Dis (2010) 1.10

Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae. Genetics (2005) 1.08

Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Proc Natl Acad Sci U S A (2001) 1.08

The hsp90 molecular chaperone modulates multiple telomerase activities. Mol Cell Biol (2007) 1.08

Hsc70 protein interaction with soluble and fibrillar alpha-synuclein. J Biol Chem (2011) 1.07

Primate chaperones Hsc70 (constitutive) and Hsp70 (induced) differ functionally in supporting growth and prion propagation in Saccharomyces cerevisiae. Genetics (2005) 1.05

Keep the traffic moving: mechanism of the Hsp70 motor. Traffic (2006) 1.04

Different combinations of the heat-shock cognate protein 70 (hsc70) C-terminal functional groups are utilized to interact with distinct tetratricopeptide repeat-containing proteins. Biochem J (2001) 1.03

ATP-dependent simian virus 40 T-antigen-Hsc70 complex formation. J Virol (2001) 1.02

Hsp70 structure, function, regulation and influence on yeast prions. Protein Pept Lett (2009) 1.01

Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complex. Biochem J (2006) 1.00

The refolding activity of the yeast heat shock proteins Ssa1 and Ssa2 defines their role in protein translocation. J Cell Biol (1996) 1.00

Allosteric coupling between the lid and interdomain linker in DnaK revealed by inhibitor binding studies. J Bacteriol (2008) 0.98

The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation. J Cell Biol (1999) 0.98

The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1. BMC Struct Biol (2008) 0.97

Induced levels of heat shock proteins in a dnaK mutant of Lactococcus lactis. J Bacteriol (1998) 0.97

Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol (1999) 0.96

Molecular identification and expression of heat shock cognate 70 (hsc70) and heat shock protein 70 (hsp70) genes in the Pacific oyster Crassostrea gigas. Cell Stress Chaperones (2003) 0.96

Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2. Cell Stress Chaperones (2001) 0.96

Topology and dynamics of the 10 kDa C-terminal domain of DnaK in solution. Protein Sci (1999) 0.96

Interference between proteins Hap46 and Hop/p60, which bind to different domains of the molecular chaperone hsp70/hsc70. Mol Cell Biol (1998) 0.95

Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones. Trends Biochem Sci (2009) 0.92

Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress Chaperones (2004) 0.91

The second metal-binding site of 70 kDa heat-shock protein is essential for ADP binding, ATP hydrolysis and ATP synthesis. Biochem J (2004) 0.90

Molecular cloning and characterization of a cytosolic heat shock protein 70 from Naegleria fowleri. Parasitol Res (2007) 0.90

Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis. Cell Stress Chaperones (2008) 0.89

Hsp40 proteins modulate humoral and cellular immune response in rheumatoid arthritis patients. Cell Stress Chaperones (2010) 0.87

Induction of stress response renders human tumor cell lines resistant to curcumin-mediated apoptosis: role of reactive oxygen intermediates. Cell Stress Chaperones (2001) 0.87

Isolation and characterization of a DnaJ-like protein in rats: the C-terminal 10-kDa domain of hsc70 is not essential for stimulating the ATP-hydrolytic activity of hsc70 by a DnaJ-like protein. Protein Sci (1998) 0.87

In vivo and in vitro interaction of DnaK and a chloroplast transit peptide. Cell Stress Chaperones (2000) 0.86

ATP-driven molecular chaperone machines. Biopolymers (2013) 0.86

Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2. Blood (2007) 0.86

Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway. Cell Death Dis (2011) 0.86

Molecular chaperones: guardians of the proteome in normal and disease states. F1000Res (2015) 0.85

What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor? J Zhejiang Univ Sci B (2007) 0.84

The cellular chaperone hsc70 is specifically recruited to reovirus viral factories independently of its chaperone function. J Virol (2011) 0.84

Heat shock protein 70 (Hsp70) inhibits oxidative phosphorylation and compensates ATP balance through enhanced glycolytic activity. J Appl Physiol (1985) (2012) 0.84

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide. Autophagy (2015) 0.83

Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function. Biochem J (2003) 0.83

Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells. Cell Stress Chaperones (2002) 0.83

C-terminal amino acids are essential for human heat shock protein 70 dimerization. Cell Stress Chaperones (2014) 0.83

Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survival. Cell Stress Chaperones (2004) 0.81

The lid domain of Caenorhabditis elegans Hsc70 influences ATP turnover, cofactor binding and protein folding activity. PLoS One (2012) 0.80

A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of Pluripotency. Stem Cell Reports (2015) 0.80

Characterization of a molecular chaperone present in the eukaryotic flagellum. Eukaryot Cell (2005) 0.80

Structural variants of yeast prions show conformer-specific requirements for chaperone activity. Mol Microbiol (2014) 0.80

The substrate binding domain of DnaK facilitates slow protein refolding. Proc Natl Acad Sci U S A (2002) 0.80

Genome-wide identification of hsp40 genes in channel catfish and their regulated expression after bacterial infection. PLoS One (2014) 0.80

Characterization of the anti-DnaJ monoclonal antibodies and their use to compare immunological properties of DnaJ and its human homologue HDJ-1. Cell Stress Chaperones (2003) 0.79

HSP70 and heat shock factor 1 cooperate to repress Ras-induced transcriptional activation of the c-fos gene. Cell Stress Chaperones (2000) 0.79

The crystal structure of the human co-chaperone P58(IPK). PLoS One (2011) 0.79

Dissection of structural and functional requirements that underlie the interaction of ERdj3 protein with substrates in the endoplasmic reticulum. J Biol Chem (2014) 0.78

Roles of intramolecular and intermolecular interactions in functional regulation of the Hsp70 J-protein co-chaperone Sis1. J Mol Biol (2015) 0.78

Cycloheximide- and puromycin-induced heat resistance: different effects on cytoplasmic and nuclear luciferases. Cell Stress Chaperones (2000) 0.78

Articles cited by this

An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell (1986) 10.38

70K heat shock related proteins stimulate protein translocation into microsomes. Nature (1988) 9.60

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature (1990) 6.45

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proc Natl Acad Sci U S A (1985) 6.45

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK. Proc Natl Acad Sci U S A (1991) 5.96

Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. Science (1990) 5.88

Peptide binding and release by proteins implicated as catalysts of protein assembly. Science (1989) 5.84

The dnaK protein modulates the heat-shock response of Escherichia coli. Cell (1983) 5.53

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature (1990) 5.12

Structure and expression of the human gene encoding major heat shock protein HSP70. Mol Cell Biol (1985) 4.79

A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science (1989) 4.58

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature (1989) 4.57

The translation machinery and 70 kd heat shock protein cooperate in protein synthesis. Cell (1992) 4.39

The structure and expression of maize genes encoding the major heat shock protein, hsp70. EMBO J (1986) 3.71

TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature (1992) 3.52

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner. Cell (1990) 3.51

A cytoplasmic chaperonin that catalyzes beta-actin folding. Cell (1992) 3.50

Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock. Proc Natl Acad Sci U S A (1982) 3.23

T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. Nature (1992) 3.12

70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria. J Cell Biol (1988) 3.04

The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev (1992) 3.04

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles. EMBO J (1985) 2.96

The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate. Mol Cell Biol (1992) 2.85

Purification and properties of the dnaJ replication protein of Escherichia coli. J Biol Chem (1985) 2.84

Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci U S A (1986) 2.83

ATP-induced protein-Hsp70 complex dissociation requires K+ but not ATP hydrolysis. Nature (1993) 2.77

Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein. Mol Cell Biol (1985) 2.51

The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein. J Biol Chem (1991) 2.47

Regulation of Hsp70 function by a eukaryotic DnaJ homolog. J Biol Chem (1992) 2.46

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding. Proc Natl Acad Sci U S A (1991) 2.41

Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses. J Biol Chem (1992) 2.37

The ATPase core of a clathrin uncoating protein. J Biol Chem (1987) 2.28

Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation. DNA (1988) 2.23

Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins. Mol Biol Cell (1993) 2.15

Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. Nucleic Acids Res (1987) 2.05

Mutations altering heat shock specific subunit of RNA polymerase suppress major cellular defects of E. coli mutants lacking the DnaK chaperone. EMBO J (1990) 1.97

Developmental control of the heat shock response in Xenopus. Proc Natl Acad Sci U S A (1984) 1.95

Self-regulation of 70-kilodalton heat shock proteins in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.82

Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines. Gene (1990) 1.80

Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. J Cell Biol (1989) 1.78

A conserved loop in the ATPase domain of the DnaK chaperone is essential for stable binding of GrpE. Nat Struct Biol (1994) 1.64

A role for a eukaryotic GrpE-related protein, Mge1p, in protein translocation. Proc Natl Acad Sci U S A (1994) 1.51

Cloning and subcellular localization of human mitochondrial hsp70. J Biol Chem (1995) 1.50

Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins. J Biol Chem (1990) 1.50

A head-to-tail tandem organization of hsp70 genes in Trypanosoma cruzi. Nucleic Acids Res (1988) 1.47

Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange. Biochemistry (1992) 1.47

Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis. Cell (1990) 1.42

The SSA1 and SSA2 genes of the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1989) 1.24

Organization, nucleotide sequence, and transcription of the chicken HSP70 gene. J Biol Chem (1986) 1.23

Which came first, MHC class I or class II? Immunogenetics (1991) 1.22

Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. Dev Biol (1988) 1.20

A human homologue of the Escherichia coli DnaJ heat-shock protein. Nucleic Acids Res (1991) 1.06

The heat shock cognate protein from Dictyostelium affects actin polymerization through interaction with the actin-binding protein cap32/34. EMBO J (1993) 1.05

Thermodynamic and structural analysis of the folding/unfolding transitions of the Escherichia coli molecular chaperone DnaK. J Mol Biol (1993) 1.02

Uncoupling of peptide-stimulated ATPase and clathrin-uncoating activity in deletion mutant of hsc70. J Biol Chem (1994) 0.94

Relationship between glucocorticoid receptor steroid-binding capacity and association of the Mr 90,000 heat shock protein with the unliganded receptor. J Steroid Biochem (1988) 0.84

Articles by these authors

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proc Natl Acad Sci U S A (1985) 6.45

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol (2000) 5.24

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol (1993) 5.11

Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst (2000) 4.54

Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev (1998) 3.72

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Mol Cell Biol (1988) 3.42

Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci U S A (1986) 3.27

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. EMBO J (1996) 3.23

The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev (1992) 3.04

Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev (1991) 2.95

BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J (1997) 2.91

Effect of sodium salicylate on the human heat shock response. Science (1992) 2.88

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation. Science (1995) 2.87

Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL. Science (1995) 2.87

Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23. Science (1996) 2.84

A light-entrainment mechanism for the Drosophila circadian clock. Nature (1996) 2.84

Expression of human HSP70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci U S A (1986) 2.83

Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Mol Cell Biol (1987) 2.77

Transcription of the human hsp70 gene is induced by serum stimulation. Proc Natl Acad Sci U S A (1985) 2.76

The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol (2000) 2.69

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2000) 2.63

Phagocytic function of polymorphonuclear leukocytes in rheumatic diseases. J Clin Invest (1973) 2.51

Classification of community hospitals by scope of service: four indexes. Health Serv Res (1972) 2.48

Complex regulation of heat shock- and glucose-responsive genes in human cells. Mol Cell Biol (1988) 2.40

Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol (1997) 2.32

The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Res (1998) 2.32

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell (2000) 2.32

In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proc Natl Acad Sci U S A (1990) 2.28

The phenomenon of treatment failures in Human African Trypanosomiasis. Trop Med Int Health (2001) 2.18

Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Mol Cell Biol (1987) 2.17

Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Mol Cell Biol (1992) 2.14

Effects of two rescue doses of a synthetic surfactant on mortality rate and survival without bronchopulmonary dysplasia in 700- to 1350-gram infants with respiratory distress syndrome. The American Exosurf Neonatal Study Group I. J Pediatr (1991) 2.09

Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J (2001) 1.97

HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol (1997) 1.96

Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol (2001) 1.95

Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. J Biol Chem (1996) 1.88

Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes Dev (1997) 1.88

E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Mol Cell Biol (1989) 1.83

The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene. Mol Cell Biol (1986) 1.81

Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Mol Cell Biol (1993) 1.81

Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. J Cell Biol (1989) 1.78

Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes. Mol Cell Biol (1984) 1.76

Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway. Mol Cell Biol (1998) 1.74

Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes Dev (1991) 1.74

Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Mol Cell Biol (1994) 1.71

Binding of polyomavirus large T antigen to the human hsp70 promoter is not required for trans activation. Mol Cell Biol (1986) 1.68

Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting. Mol Cell Biol (1991) 1.65

Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling. J Mol Biol (1999) 1.65

Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors. Biochem Soc Symp (1999) 1.64

The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive. Mol Cell Biol (1995) 1.63

PTEN controls tumor-induced angiogenesis. Proc Natl Acad Sci U S A (2001) 1.62

Negative regulation of the heat shock transcriptional response by HSBP1. Genes Dev (1998) 1.61

Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein. Proc Natl Acad Sci U S A (1987) 1.60

Toxicity of polybrominated biphenyls Firemaster BP-6 in rodents. Environ Res (1975) 1.53

Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biol Reprod (1994) 1.51

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. EMBO J (2001) 1.50

Cloning and subcellular localization of human mitochondrial hsp70. J Biol Chem (1995) 1.50

Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Mol Cell Biol (1990) 1.48

Improved infarct-related arterial patency after high dose, weight-adjusted, rapid infusion of tissue-type plasminogen activator in myocardial infarction: results of a multicenter randomized trial of two dosage regimens. J Am Coll Cardiol (1990) 1.48

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J (1998) 1.48

Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element. Mol Cell Biol (1993) 1.47

Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity. Mol Cell Biol (1994) 1.45

The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. J Biol Chem (1999) 1.43

Safety and efficacy of repeated shockwave lithotripsy of gallstones with and without adjuvant bile acid therapy. Gastroenterology (1997) 1.41

Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol Cell Biol (2000) 1.41

Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response. Mol Cell Biol (1989) 1.38

[Intracranial hemorrhage: cause, diagnosis and significance]. Gynakologe (1987) 1.38

Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. J Biol Chem (1994) 1.38

Antiproliferative prostaglandins activate heat shock transcription factor. Proc Natl Acad Sci U S A (1992) 1.38

Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc Natl Acad Sci U S A (1999) 1.37

Stress-specific activation and repression of heat shock factors 1 and 2. Mol Cell Biol (2001) 1.37

Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element. Mol Cell Biol (1994) 1.35

Arachidonate is a potent modulator of human heat shock gene transcription. Proc Natl Acad Sci U S A (1994) 1.34

PTEN: sometimes taking it off can be better than putting it on. Am J Hum Genet (1997) 1.32

Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes. Proc Natl Acad Sci U S A (1988) 1.31

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. Biochemistry (2001) 1.30

Molecular and phenotypic variability in the congenital alveolar proteinosis syndrome associated with inherited surfactant protein B deficiency. J Pediatr (1994) 1.30

Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. EMBO J (1998) 1.29

Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage. Proc Natl Acad Sci U S A (1995) 1.29

Intron-independent association of splicing factors with active genes. J Cell Biol (1999) 1.29

Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses. J Virol (1991) 1.28

Cell cycle-dependent association of HSP70 with specific cellular proteins. J Cell Biol (1989) 1.25

Organization, nucleotide sequence, and transcription of the chicken HSP70 gene. J Biol Chem (1986) 1.23

Role of the heat-shock response in the life and death of proteins. Ann N Y Acad Sci (1998) 1.21

Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells. Mol Cell Biol (1987) 1.19

Chromosomal location of human genes encoding major heat-shock protein HSP70. Somat Cell Mol Genet (1987) 1.17

The pathogenesis of esophageal dysfunction in scleroderma and Raynaud's disease. J Clin Invest (1972) 1.12

Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. EMBO J (1998) 1.11

Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15. J Virol (1999) 1.10

Heat shock factor 2-like activity in mouse blastocysts. Dev Biol (1994) 1.09

The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J Biol Chem (1999) 1.07

Biochemical characterization and localization of the dual specificity kinase CLK1. J Cell Sci (2000) 1.07

Progressive calcifications of lung and liver in neonatal herpes simplex virus infection. Pediatr Radiol (1991) 1.07

Erythroid lineage-specific expression and inducibility of the major heat shock protein HSP70 during avian embryogenesis. Genes Dev (1987) 1.07

Glycosylation increases potassium channel stability and surface expression in mammalian cells. J Biol Chem (2001) 1.06

Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1. Proc Natl Acad Sci U S A (1994) 1.06

Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science (1997) 1.06

Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene. J Virol (1991) 1.05