Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.

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Published in Chem Res Toxicol on July 31, 2012

Authors

James D West1, Yanyu Wang, Kevin A Morano

Author Affiliations

1: Biochemistry and Molecular Biology Program, Departments of Biology and Chemistry, The College of Wooster, Wooster, Ohio 44691, USA. jwest@wooster.edu

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ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol (2007) 8.10

HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16

Heat shock transcription factors: structure and regulation. Annu Rev Cell Dev Biol (1995) 6.16

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Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit. Cell (1989) 4.11

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The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacol Ther (1998) 3.66

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Varying patterns of protein synthesis in Drosophila during heat shock: implications for regulation. Dev Biol (1980) 3.35

Heat shock regulatory elements function as an inducible enhancer in the Xenopus hsp70 gene and when linked to a heterologous promoter. Cell (1986) 3.34

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Constitutive binding of yeast heat shock factor to DNA in vivo. Mol Cell Biol (1988) 2.98

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Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells. Biochim Biophys Acta (1980) 2.75

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