Published in Mol Biol Cell on July 18, 2012
Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol (2014) 1.54
Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics. Free Radic Biol Med (2014) 1.18
The conformational bases for the two functionalities of 2-cysteine peroxiredoxins as peroxidase and chaperone. J Exp Bot (2013) 1.06
Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress. Elife (2014) 0.92
A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep (2014) 0.91
Peroxiredoxin chaperone activity is critical for protein homeostasis in zinc-deficient yeast. J Biol Chem (2013) 0.88
Hierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast. J Biol Chem (2014) 0.87
Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise. Chem Res Toxicol (2012) 0.86
Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells. Cell Death Dis (2014) 0.83
The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response. Scientifica (Cairo) (2012) 0.81
Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. Br J Cancer (2013) 0.78
Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription. PLoS Genet (2013) 0.78
Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response. J Biol Chem (2016) 0.76
Reactive electrophilic oxylipins trigger a heat stress-like response through HSFA1 transcription factors. J Exp Bot (2016) 0.75
SGD: Saccharomyces Genome Database. Nucleic Acids Res (1998) 20.26
Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene (1995) 13.86
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell (2007) 8.84
HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16
Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell (1988) 7.06
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev (2008) 6.18
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell (1998) 5.52
Heat shock factor is regulated differently in yeast and HeLa cells. Nature (1987) 5.40
Heat shock factors: integrators of cell stress, development and lifespan. Nat Rev Mol Cell Biol (2010) 4.63
Is hsp70 the cellular thermometer? Trends Biochem Sci (1991) 4.53
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell (2006) 4.52
A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation. Cell (2002) 3.94
Mutations of the heat inducible 70 kilodalton genes of yeast confer temperature sensitive growth. Cell (1984) 3.83
Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev (1998) 3.72
Genome-wide analysis of the biology of stress responses through heat shock transcription factor. Mol Cell Biol (2004) 3.61
Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Mol Cell Biol (1988) 3.42
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res (2006) 3.10
The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev (1992) 3.04
Constitutive binding of yeast heat shock factor to DNA in vivo. Mol Cell Biol (1988) 2.98
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58
Transcriptional regulation of an hsp70 heat shock gene in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.52
Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor. EMBO J (2006) 2.45
Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem (2004) 2.45
A cyclophilin function in Hsp90-dependent signal transduction. Science (1996) 2.28
Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress. Genes Dev (2003) 2.27
Mutations in cognate genes of Saccharomyces cerevisiae hsp70 result in reduced growth rates at low temperatures. Mol Cell Biol (1985) 2.24
Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor. J Cell Biol (1992) 2.10
On mechanisms that control heat shock transcription factor activity in metazoan cells. Cell Stress Chaperones (2004) 2.03
Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. J Pharmacol Exp Ther (2005) 1.71
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell (2008) 1.69
Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p. Mol Cell Biol (2002) 1.62
Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock response. J Biol Chem (1998) 1.58
Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae. J Biol Chem (2002) 1.51
The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb. J Biol Chem (2005) 1.47
Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol (2010) 1.47
Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription. Genes Dev (1996) 1.41
The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone. J Biol Chem (1999) 1.39
Antiproliferative prostaglandins activate heat shock transcription factor. Proc Natl Acad Sci U S A (1992) 1.38
Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1. Biochemistry (2006) 1.34
Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal. Chem Res Toxicol (2004) 1.32
Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol (2011) 1.31
HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast. Proc Natl Acad Sci U S A (2008) 1.31
The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo. EMBO J (1999) 1.22
Geldanamycin restores a defective heat shock response in vivo. J Biol Chem (2001) 1.19
2-Cyclopenten-1-one, a new inducer of heat shock protein 70 with antiviral activity. J Biol Chem (1996) 1.19
A trans-activation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress. Mol Cell Biol (1999) 1.13
Reactive cysteines of the 90-kDa heat shock protein, Hsp90. Arch Biochem Biophys (2000) 1.05
pH profiles indicative of rate-limiting nucleophilic displacement in thioltransferase catalysis. Biochemistry (1997) 1.03
Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system. Mol Biol Cell (2010) 1.01
Determination of the pKa values of active-center cysteines, cysteines-32 and -35, in Escherichia coli thioredoxin by Raman spectroscopy. Biochemistry (1993) 0.99
N-Ethylmaleimide inactivates a nucleotide-free Hsp70 molecular chaperone. J Biol Chem (1996) 0.98
HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Chem Biol (2011) 0.96
Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast. Eur J Biochem (2003) 0.94
Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells. Mol Genet Genomics (2001) 0.93
Radicicol activates heat shock protein expression and cardioprotection in neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol (2004) 0.92
Arsenic oxide-induced thermotolerance in Saccharomyces cerevisiae. J Bacteriol (1989) 0.91
N-Ethylmaleimide-modified Hsp70 inhibits protein folding. Arch Biochem Biophys (1999) 0.83
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. J Clin Invest (2003) 2.41
Structure of the Hsp110:Hsc70 nucleotide exchange machine. Mol Cell (2008) 1.96
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell (2008) 1.69
Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system. Microbiol Mol Biol Rev (2012) 1.48
The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb. J Biol Chem (2005) 1.47
The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family. J Biol Chem (2004) 1.44
Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1. Biochemistry (2006) 1.34
All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity. Cell Stress Chaperones (2007) 1.31
The role of Sse1 in the de novo formation and variant determination of the [PSI+] prion. Genetics (2007) 1.28
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest (2014) 1.26
Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe. J Biol Chem (2002) 1.22
Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae. Mol Biol Cell (2011) 1.21
Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Pulm Circ (2012) 1.19
The molecular chaperone Sse1 and the growth control protein kinase Sch9 collaborate to regulate protein kinase A activity in Saccharomyces cerevisiae. Genetics (2005) 1.15
Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. J Biol Chem (2005) 1.09
Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ (2013) 1.09
Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med (2012) 1.09
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB J (2012) 1.01
Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system. Mol Biol Cell (2010) 1.01
Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins. Eukaryot Cell (2008) 0.99
SYM1 is the stress-induced Saccharomyces cerevisiae ortholog of the mammalian kidney disease gene Mpv17 and is required for ethanol metabolism and tolerance during heat shock. Eukaryot Cell (2004) 0.97
Hsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast. Mol Biol Cell (2009) 0.90
The Hsp110 protein chaperone Sse1 is required for yeast cell wall integrity and morphogenesis. Curr Genet (2008) 0.88
Hierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast. J Biol Chem (2014) 0.87
Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise. Chem Res Toxicol (2012) 0.86
The Hsp90 molecular chaperone complex regulates maltose induction and stability of the Saccharomyces MAL gene transcription activator Mal63p. J Biol Chem (2003) 0.85
TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae. Mol Biol Cell (2012) 0.84
Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension. Am J Respir Cell Mol Biol (2013) 0.84
Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae. Nucleic Acids Res (2014) 0.83
Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles. Chem Res Toxicol (2011) 0.81
A lysine-rich region within fungal BAG domain-containing proteins mediates a novel association with ribosomes. Eukaryot Cell (2012) 0.80
Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells. Chem Res Toxicol (2013) 0.80
Indirect immunofluorescence microscopy for direct detection of Xylella fastidiosa in xylem sap. Curr Microbiol (2004) 0.79
Coupled assays for monitoring protein refolding in Saccharomyces cerevisiae. J Vis Exp (2013) 0.77
Pronounced toxicity differences between homobifunctional protein cross-linkers and analogous monofunctional electrophiles. Chem Res Toxicol (2013) 0.76
Should radioiodine be the first-line treatment for paediatric Graves' disease? J Pediatr Endocrinol Metab (2015) 0.75