PubRank

Jennifer A Doudna

Author PubWeight™ 264.85‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012 48.17
2 RNA-guided genetic silencing systems in bacteria and archaea. Nature 2012 17.12
3 Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 2013 13.43
4 CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 2013 9.55
5 High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat Biotechnol 2013 8.40
6 Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science 2010 6.79
7 A three-dimensional view of the molecular machinery of RNA interference. Nature 2009 6.31
8 Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nat Struct Mol Biol 2011 6.02
9 Structural basis for double-stranded RNA processing by Dicer. Science 2006 5.86
10 Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science 2014 5.13
11 RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc Natl Acad Sci U S A 2011 4.58
12 Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell 2009 4.57
13 Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science 2005 3.91
14 Adaptive strategies of the influenza virus polymerase for replication in humans. Proc Natl Acad Sci U S A 2009 3.89
15 Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. Structure 2009 3.47
16 In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci U S A 2008 3.43
17 Multiplexed RNA structure characterization with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq). Proc Natl Acad Sci U S A 2011 3.30
18 An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. Cell Host Microbe 2008 2.81
19 Mechanism of substrate selection by a highly specific CRISPR endoribonuclease. RNA 2012 2.78
20 Mechanism of foreign DNA selection in a bacterial adaptive immune system. Mol Cell 2012 2.77
21 Structural determinants of RNA recognition and cleavage by Dicer. Nat Struct Mol Biol 2007 2.67
22 Autoinhibition of human dicer by its internal helicase domain. J Mol Biol 2008 2.62
23 Molecular mechanisms of RNA interference. Annu Rev Biophys 2013 2.58
24 A conformational switch controls hepatitis delta virus ribozyme catalysis. Nature 2004 2.57
25 Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc Natl Acad Sci U S A 2008 2.50
26 An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Mol Biol 2011 2.49
27 Ribonuclease revisited: structural insights into ribonuclease III family enzymes. Curr Opin Struct Biol 2006 2.28
28 Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics 2013 2.22
29 Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proc Natl Acad Sci U S A 2004 2.22
30 Structural insights into RNA processing by the human RISC-loading complex. Nat Struct Mol Biol 2009 2.19
31 Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nat Struct Biol 2002 2.14
32 Cap-independent translation is required for starvation-induced differentiation in yeast. Science 2007 2.05
33 An essential GTPase promotes assembly of preribosomal RNA processing complexes. Mol Cell 2005 2.04
34 Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep 2013 1.96
35 RNA processing enables predictable programming of gene expression. Nat Biotechnol 2012 1.92
36 Structural and mechanistic insights into hepatitis C viral translation initiation. Nat Rev Microbiol 2006 1.87
37 eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol Cell 2007 1.78
38 Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol Cell Proteomics 2007 1.71
39 Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nat Struct Mol Biol 2010 1.66
40 Direct link between RACK1 function and localization at the ribosome in vivo. Mol Cell Biol 2008 1.61
41 Structural insights into group II intron catalysis and branch-site selection. Science 2002 1.58
42 The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. J Biol Chem 2003 1.57
43 CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proc Natl Acad Sci U S A 2014 1.53
44 dsRNA with 5' overhangs contributes to endogenous and antiviral RNA silencing pathways in plants. EMBO J 2009 1.52
45 Modeling and automation of sequencing-based characterization of RNA structure. Proc Natl Acad Sci U S A 2011 1.49
46 Crystallization of RNA and RNA-protein complexes. Methods 2004 1.48
47 Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning. Structure 2011 1.44
48 Assembly of an active group II intron-maturase complex by protein dimerization. Biochemistry 2004 1.42
49 The crystal structure of the signal recognition particle in complex with its receptor. Science 2011 1.41
50 Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa. Mol Cell Proteomics 2012 1.40
51 Substrate-specific kinetics of Dicer-catalyzed RNA processing. J Mol Biol 2010 1.39
52 Specificity of RNA-RNA helix recognition. Proc Natl Acad Sci U S A 2002 1.38
53 Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. Mol Cell 2011 1.36
54 Structural insights into RNA interference. Curr Opin Struct Biol 2010 1.34
55 siRNA repositioning for guide strand selection by human Dicer complexes. Mol Cell 2011 1.31
56 Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies. Mol Cell 2011 1.31
57 Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proc Natl Acad Sci U S A 2011 1.30
58 TRBP alters human precursor microRNA processing in vitro. RNA 2012 1.28
59 Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. J Virol 2011 1.28
60 Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA. EMBO J 2012 1.27
61 Structural roles of monovalent cations in the HDV ribozyme. Structure 2007 1.27
62 Biotechnology: Rewriting a genome. Nature 2013 1.27
63 RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle. Nat Struct Mol Biol 2005 1.24
64 Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. Protein Sci 2005 1.23
65 Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Res 2013 1.22
66 Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly. Biochemistry 2002 1.22
67 Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae. PLoS One 2010 1.21
68 The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nat Struct Mol Biol 2009 1.18
69 The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit. RNA 2010 1.17
70 SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting. RNA 2006 1.16
71 Substrate-specific structural rearrangements of human Dicer. Nat Struct Mol Biol 2013 1.08
72 Coordinated activities of human dicer domains in regulatory RNA processing. J Mol Biol 2012 1.07
73 GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. J Mol Biol 2005 1.07
74 Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases. Nucleic Acids Res 2013 1.06
75 Multiple sensors ensure guide strand selection in human RNAi pathways. RNA 2013 1.04
76 Conserved but nonessential interaction of SRP RNA with translation factor EF-G. RNA 2004 1.03
77 Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure. Nucleic Acids Res 2013 1.02
78 Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Res 2013 1.02
79 RNA-protein analysis using a conditional CRISPR nuclease. Proc Natl Acad Sci U S A 2013 1.00
80 ATP-independent diffusion of double-stranded RNA binding proteins. Proc Natl Acad Sci U S A 2012 0.99
81 Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. Nucleic Acids Res 2013 0.93
82 Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein. RNA 2006 0.93
83 An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer. Acta Crystallogr D Biol Crystallogr 2007 0.92
84 A host of factors regulating influenza virus replication. Viruses 2010 0.90
85 Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry 2010 0.90
86 Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron. Nucleic Acids Res 2004 0.86
87 Identification and analysis of U5 snRNA variants in Drosophila. RNA 2005 0.84
88 Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. Methods Enzymol 2014 0.84
89 Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules. RNA 2013 0.83
90 Ro's role in RNA reconnaissance. Cell 2005 0.82
91 A fast and efficient procedure to produce scFvs specific for large macromolecular complexes. J Immunol Methods 2006 0.81
92 Optimized high-throughput screen for hepatitis C virus translation inhibitors. J Biomol Screen 2011 0.80
93 Quantitative studies of ribosome conformational dynamics. Q Rev Biophys 2007 0.78
94 Biochemistry. Guided tour to the heart of RISC. Science 2012 0.78
95 eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature 2016 0.78
96 RNAs regulate biology. ACS Chem Biol 2006 0.76
97 RNA: primed for packing? Chem Biol 2004 0.75
98 Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System. PLoS One 2017 0.75
99 Activating silent argonautes. Nat Struct Mol Biol 2013 0.75
100 A higher degree of difficulty. ACS Chem Biol 2007 0.75
101 Nucleic acids and their protein partners. Curr Opin Struct Biol 2008 0.75