Published in PLoS Pathog on April 01, 2007
Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog (2010) 1.88
Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. Immunity (2013) 1.80
Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder. J Physiol (2015) 1.59
Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection. FEMS Microbiol Rev (2012) 1.55
Bacteria-induced uroplakin signaling mediates bladder response to infection. PLoS Pathog (2009) 1.53
TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe (2007) 1.47
Waging war against uropathogenic Escherichia coli: winning back the urinary tract. Infect Immun (2009) 1.46
Mechanisms of pain from urinary tract infection. Int J Urol (2014) 1.43
The role of Toll-like receptors in renal diseases. Nat Rev Nephrol (2010) 1.42
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D). Mol Psychiatry (2012) 1.41
TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. Proc Natl Acad Sci U S A (2009) 1.38
Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage. Int J Nephrol (2012) 1.31
Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest Ophthalmol Vis Sci (2008) 1.20
Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis. Infect Immun (2010) 1.19
The CTX-M-15-producing Escherichia coli clone O25b: H4-ST131 has high intestine colonization and urinary tract infection abilities. PLoS One (2012) 1.19
Molecular basis of uropathogenic Escherichia coli evasion of the innate immune response in the bladder. Infect Immun (2008) 1.17
TLR signaling in mast cells: common and unique features. Front Immunol (2012) 1.12
Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. FASEB J (2011) 1.01
TLR-mediated immune responses in the urinary tract. Curr Opin Microbiol (2008) 1.00
Microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways. J Immunol (2009) 0.97
Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence. Infect Immun (2010) 0.96
Regulation of TLR4-induced IL-6 response in bladder cancer cells by opposing actions of MAPK and PI3K signaling. J Cancer Res Clin Oncol (2008) 0.93
Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. J Immunol (2014) 0.91
Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. PLoS One (2011) 0.91
Vasoactive intestinal peptide downregulates proinflammatory TLRs while upregulating anti-inflammatory TLRs in the infected cornea. J Immunol (2012) 0.90
TLR4 mediates MAPK-STAT3 axis activation in bladder epithelial cells. Inflammation (2013) 0.87
The nature of immune responses to urinary tract infections. Nat Rev Immunol (2015) 0.86
Toll-like receptors in urothelial cells--targets for cancer immunotherapy. Nat Rev Urol (2013) 0.85
Moderate strength (0.23-0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells. BMC Genomics (2009) 0.83
Interleukin-6 and interleukin-8 levels in the urine of children with renal scarring. Pediatr Nephrol (2012) 0.83
Changes in the relative inflammatory responses in sheep cells overexpressing of toll-like receptor 4 when stimulated with LPS. PLoS One (2012) 0.83
Uropathogenic E. coli promote a paracellular urothelial barrier defect characterized by altered tight junction integrity, epithelial cell sloughing and cytokine release. J Comp Pathol (2011) 0.82
Interplay between vesicoureteric reflux and kidney infection in the development of reflux nephropathy in mice. Dis Model Mech (2013) 0.82
Subversion of Host Innate Immunity by Uropathogenic Escherichia coli. Pathogens (2016) 0.79
Transcriptional regulation of Tlr11 gene expression in epithelial cells. J Biol Chem (2009) 0.79
Protein kinase A enhances lipopolysaccharide-induced IL-6, IL-8, and PGE₂ production by human gingival fibroblasts. J Negat Results Biomed (2012) 0.78
Complete Genome Sequence of Uropathogenic Escherichia coli Strain CI5. Genome Announc (2015) 0.78
Impaired cytokine expression, neutrophil infiltration and bacterial clearance in response to urinary tract infection in diabetic mice. Pathog Dis (2015) 0.77
Who's really in control: microbial regulation of protein trafficking in the epithelium. Am J Physiol Cell Physiol (2013) 0.76
Dendrimers branch out to support mucosal integrity. EMBO Mol Med (2012) 0.76
Dual ligand/receptor interactions activate urothelial defenses against uropathogenic E. coli. Sci Rep (2015) 0.76
Regulation of cytotoxic T lymphocyte antigen 4 by cyclic AMP. Am J Respir Cell Mol Biol (2012) 0.76
The multiple antibacterial activities of the bladder epithelium. Ann Transl Med (2017) 0.75
Innate Immune Responses to Bladder Infection. Microbiol Spectr (2016) 0.75
Pathogen recognition and innate immunity. Cell (2006) 44.14
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest (2004) 11.05
Biological applications of ionophores. Annu Rev Biochem (1976) 9.81
TLR signaling. Cell Death Differ (2006) 9.24
Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science (1998) 8.16
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94
Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. EMBO J (2000) 5.03
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol (2002) 4.68
Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science (2000) 4.22
Interleukin-6 and chronic inflammation. Arthritis Res Ther (2006) 3.74
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A (2003) 3.21
Selective cytokine production by epithelial cells following exposure to Escherichia coli. Infect Immun (1993) 2.83
Identification and characterization of a gene product that regulates type 1 piliation in Escherichia coli. J Bacteriol (1984) 2.81
Sensing pathogens and tuning immune responses. Science (2001) 2.73
Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. J Immunol (2002) 2.70
Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene. Mol Cell Biol (1990) 2.41
Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism. J Immunol (2001) 2.27
Neutrophil recruitment and resistance to urinary tract infection. J Infect Dis (1999) 2.23
Bacterial virulence in urinary tract infection. Infect Dis Clin North Am (1997) 2.20
Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv (2002) 2.19
Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes. Circulation (1999) 1.98
Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor recognition and use of a domain-specific antibody to confer protection against experimental urinary tract infection. J Clin Invest (1997) 1.76
Bacterial penetration of bladder epithelium through lipid rafts. J Biol Chem (2004) 1.72
Protection against Escherichia coli-induced urinary tract infections with hybridoma antibodies directed against type 1 fimbriae or complementary D-mannose receptors. Infect Immun (1985) 1.71
Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cell Mol Neurobiol (2003) 1.69
Uropathogenic Escherichia coli potentiates type 1 pilus-induced apoptosis by suppressing NF-kappaB. Infect Immun (2001) 1.66
Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection. Infect Immun (2002) 1.65
Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli. Infect Immun (2005) 1.55
The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells. Invest Ophthalmol Vis Sci (2001) 1.55
The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. J Neurosci (2006) 1.51
Alpha-haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells. Nature (2000) 1.51
Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract. Cell Microbiol (2001) 1.50
Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa. Infect Immun (2004) 1.48
A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function. Am J Physiol Renal Physiol (2005) 1.46
Yersinia outer protein P of Yersinia enterocolitica simultaneously blocks the nuclear factor-kappa B pathway and exploits lipopolysaccharide signaling to trigger apoptosis in macrophages. J Immunol (2001) 1.41
Use of Mono Mac 6 human monocytic cell line and J774 murine macrophage cell line in parallel antimycobacterial drug studies. Antimicrob Agents Chemother (1996) 1.39
CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli. Infect Immun (2003) 1.38
Uropathogenic Escherichia coli as a model of host-parasite interaction. Curr Opin Microbiol (2006) 1.32
Interleukin-6 and disease severity in patients with bacteremic and nonbacteremic febrile urinary tract infection. J Infect Dis (1999) 1.29
Phenotypic and cytogenetic characterization of human bladder urothelia expanded in vitro. J Urol (1994) 1.20
Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J Recept Signal Transduct Res (2002) 1.18
Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin. Biochemistry (1992) 1.14
Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs. Mol Pharmacol (1999) 1.10
PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP. Cell Signal (2004) 1.09
Common errors in diagnosis and management of urinary tract infection. I: pathophysiology and diagnostic techniques. Nephrol Dial Transplant (1999) 1.08
Asymptomatic bacteriuria Escherichia coli strains: adhesins, growth and competition. FEMS Microbiol Lett (2006) 1.07
CREB-mediated transcriptional control. Crit Rev Eukaryot Gene Expr (1999) 1.07
Calcium channel blockers in the treatment of disease. J Neurosci Res (2004) 1.06
Pro-inflammatory cytokines up-regulate MUC1 gene expression in oral epithelial cells. J Dent Res (2003) 0.98
Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. Biochem Pharmacol (1998) 0.98
Fimbriae, transmembrane signaling, and cell activation. J Infect Dis (2001) 0.97
Molecular biology of cytokines. Artif Organs (1996) 0.95
A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines. Mol Cell Biol (1993) 0.95
Taurine blunts LPS-induced increases in intracellular calcium and TNF-alpha production by Kupffer cells. J Leukoc Biol (1998) 0.85
The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells. Biochem Pharmacol (2002) 0.83
Ca(2+)-sensitive adenylyl cyclases. Cell Signal (1994) 0.83
Bladder cancer. Human leukocyte antigen II, interleukin-6, and interleukin-6 receptor expression determined by the polymerase chain reaction. Cancer (1991) 0.80
1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i. Am J Physiol (1994) 0.79
Neurotensin stimulates both calcium mobilization from inositol trisphosphate-sensitive intracellular stores and calcium influx through membrane channels in frog pituitary melanotrophs. Endocrinology (2003) 0.79
Role of calcium during lipopolysaccharide stimulation of neutrophils. Infect Immun (1996) 0.78
Protease-activated receptor-2-mediated inhibition for Ca2+ response to lipopolysaccharide in Guinea pig tracheal epithelial cells. Am J Respir Cell Mol Biol (2004) 0.77
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Engineered antibody Fc variants with enhanced effector function. Proc Natl Acad Sci U S A (2006) 3.54
The genetic landscape of mutations in Burkitt lymphoma. Nat Genet (2012) 3.03
Topological structure analysis of the protein-protein interaction network in budding yeast. Nucleic Acids Res (2003) 2.90
Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med (2007) 2.72
Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol (2003) 2.68
Mast cell activators: a new class of highly effective vaccine adjuvants. Nat Med (2008) 2.27
Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. Eukaryot Cell (2006) 1.92
Concern c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice. Am J Respir Crit Care Med (2011) 1.91
Clonal analysis reveals high rate of structural mutations in fimbrial adhesins of extraintestinal pathogenic Escherichia coli. Mol Microbiol (2006) 1.82
Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. Immunity (2013) 1.80
Bacterial penetration of bladder epithelium through lipid rafts. J Biol Chem (2004) 1.72
Cell biology and physiology of the uroepithelium. Am J Physiol Renal Physiol (2009) 1.69
Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. Proc Natl Acad Sci U S A (2007) 1.64
Inactivation of TNF signaling by rationally designed dominant-negative TNF variants. Science (2003) 1.48
TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe (2007) 1.47
Microbial entry through caveolae: variations on a theme. Cell Microbiol (2002) 1.44
Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes. Genetics (2007) 1.44
Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med (2009) 1.42
Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. Proc Natl Acad Sci U S A (2011) 1.40
TLR4-mediated expulsion of bacteria from infected bladder epithelial cells. Proc Natl Acad Sci U S A (2009) 1.38
The role of lipid rafts in the pathogenesis of bacterial infections. Biochim Biophys Acta (2005) 1.23
The distinct binding specificities exhibited by enterobacterial type 1 fimbriae are determined by their fimbrial shafts. J Biol Chem (2005) 1.20
Innate immunity and its regulation by mast cells. J Immunol (2013) 1.19
Mast cell modulation of the vascular and lymphatic endothelium. Blood (2011) 1.19
Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues. Cell Host Microbe (2009) 1.17
Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. J Biol Chem (2004) 1.13
Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes. Nat Mater (2012) 1.12
Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli. Immunol Lett (2004) 1.10
Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage. Elife (2013) 1.10
The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen. Vaccine (2009) 1.09
The role of mast cells in host defense and their subversion by bacterial pathogens. Trends Immunol (2002) 1.06
Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. J Immunol (2003) 1.04
Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. J Biol Chem (2009) 1.02
Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata. G3 (Bethesda) (2012) 1.02
Development of a cytokine analog with enhanced stability using computational ultrahigh throughput screening. Protein Sci (2002) 1.01
TLR-mediated immune responses in the urinary tract. Curr Opin Microbiol (2008) 1.00
Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nat Med (2009) 0.99
Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice. PLoS One (2010) 0.99
Fibroblast growth factor-10 is a mitogen for urothelial cells. J Biol Chem (2002) 0.93
Bacterial penetration of the mucosal barrier by targeting lipid rafts. J Investig Med (2005) 0.92
Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. Crit Care Med (2013) 0.91
Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis. Nat Rev Microbiol (2013) 0.91
Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. J Clin Invest (2011) 0.91
Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits. PLoS One (2011) 0.91
The mast cell in innate and adaptive immunity. Adv Exp Med Biol (2011) 0.89
Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. J Immunol (2006) 0.89
Efficacy and safety of oxybutynin in children with detrusor hyperreflexia secondary to neurogenic bladder dysfunction. J Urol (2005) 0.88
Fibroblast growth factor-10 signals development of von Brunn's nests in the exstrophic bladder. Am J Physiol Renal Physiol (2010) 0.87
Antenatal hydronephrosis and the risk of pyelonephritis hospitalization during the first year of life. Urology (2007) 0.87
Computational stabilization of human growth hormone. Protein Sci (2002) 0.87
Stable dry powder formulation for nasal delivery of anthrax vaccine. J Pharm Sci (2011) 0.86
FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract. Am J Physiol Renal Physiol (2006) 0.85
Plasticity in mast cell responses during bacterial infections. Curr Opin Microbiol (2011) 0.85
Can a complete primary repair approach be applied to cloacal exstrophy? J Urol (2006) 0.85
Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation. Am J Physiol Lung Cell Mol Physiol (2005) 0.85
Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells. Cell Tissue Res (2009) 0.85
New roles for mast cells in modulating allergic reactions and immunity against pathogens. Curr Opin Immunol (2009) 0.83
The expanding roles of caveolin proteins in microbial pathogenesis. Commun Integr Biol (2009) 0.83
Interplay between vesicoureteric reflux and kidney infection in the development of reflux nephropathy in mice. Dis Model Mech (2013) 0.82
TNF ligands: is TALL-1 a trimer or a virus-like cluster? Nature (2004) 0.82
New roles for mast cells in pathogen defense and allergic disease. Discov Med (2010) 0.81
A comparison of non-toxin vaccine adjuvants for their ability to enhance the immunogenicity of nasally-administered anthrax recombinant protective antigen. Vaccine (2013) 0.81
A pilot study of the association between genetic polymorphisms involved in estrogen signaling and infant male genital phenotypes. Asian J Androl (2012) 0.79
Complete Genome Sequence of Uropathogenic Escherichia coli Strain CI5. Genome Announc (2015) 0.78
In vivo models for studying mast cell-dependent responses to bacterial infection. Methods Mol Biol (2006) 0.78
Renal and urologic manifestations of pediatric condition falsification/Munchausen by proxy. Pediatr Nephrol (2007) 0.77
Novel mechanism of P-fimbriated Escherichia coli virulence in pyelonephritis. J Am Soc Nephrol (2005) 0.77
A Mast Cell Degranulation Screening Assay for the Identification of Novel Mast Cell Activating Agents. Medchemcomm (2013) 0.77
Perineal reconstruction of female conjoined twins. J Pediatr Surg (2002) 0.76
Increased Nitric Oxide Production Prevents Airway Hyperresponsiveness in Caveolin-1 Deficient Mice Following Endotoxin Exposure. J Allergy Ther (2012) 0.76
Kidney α-intercalated cells and lipocalin 2: defending the urinary tract. J Clin Invest (2014) 0.76
A new candidate vaccine for Escherichia coli pyelonephritis. J Urol (2004) 0.76
Editorial comment. J Urol (2010) 0.75
Editorial comment. J Urol (2011) 0.75
Editorial comment. J Urol (2011) 0.75
Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)-/- mice. J Allergy Clin Immunol (2012) 0.75
How mast cells make decisions. J Clin Invest (2016) 0.75
Mast cell desensitization inhibits calcium flux and aberrantly remodels actin. J Clin Invest (2016) 0.75
Editorial comment. Urology (2010) 0.75
Editorial comment. J Urol (2010) 0.75
Editorial comment. J Urol (2011) 0.75
Editorial comment. J Urol (2009) 0.75
Modified bladder neck reconstruction in patients with incontinence after staged exstrophy/epispadias closures. J Urol (2006) 0.75
Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. J Clin Invest (2017) 0.75
[Quantitative assessment of left ventricular systolic dyssynchrony in relation to systolic function by real-time three-dimensional echocardiography-derived regional systolic dyssynchrony index in chronic heart failure patients]. Nan Fang Yi Ke Da Xue Xue Bao (2012) 0.75