PubRank

Robert H Singer

Author PubWeight™ 221.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 From silencing to gene expression: real-time analysis in single cells. Cell 2004 7.73
2 Transcriptional pulsing of a developmental gene. Curr Biol 2006 6.35
3 In vivo dynamics of RNA polymerase II transcription. Nat Struct Mol Biol 2007 6.10
4 Single-RNA counting reveals alternative modes of gene expression in yeast. Nat Struct Mol Biol 2008 6.09
5 Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature 2005 5.29
6 Single-cell gene expression profiling. Science 2002 5.07
7 Dynamics of single mRNPs in nuclei of living cells. Science 2004 4.58
8 Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res 2004 4.04
9 Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res 2002 3.95
10 Gene expression and the myth of the average cell. Trends Cell Biol 2003 3.78
11 Real-time observation of transcription initiation and elongation on an endogenous yeast gene. Science 2011 3.67
12 Fluorescence in situ hybridization: past, present and future. J Cell Sci 2003 3.20
13 The great escape: when cancer cells hijack the genes for chemotaxis and motility. Annu Rev Cell Dev Biol 2005 2.97
14 Single-molecule mRNA decay measurements reveal promoter- regulated mRNA stability in yeast. Cell 2011 2.92
15 Visualization of single molecules of mRNA in situ. Methods Enzymol 2003 2.62
16 A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev Cell 2008 2.51
17 How and why does beta-actin mRNA target? Biol Cell 2005 2.38
18 Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition. Mol Biol Cell 2005 2.36
19 Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons. J Neurosci 2003 2.34
20 Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization. J Neurosci 2003 2.28
21 A transgenic mouse for in vivo detection of endogenous labeled mRNA. Nat Methods 2011 2.27
22 The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Mol Biol Cell 2008 2.25
23 Single β-actin mRNA detection in neurons reveals a mechanism for regulating its translatability. Science 2014 2.23
24 Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment. J Cell Biol 2002 2.20
25 Visualization of dynamics of single endogenous mRNA labeled in live mouse. Science 2014 2.20
26 In vivo imaging of labelled endogenous β-actin mRNA during nucleocytoplasmic transport. Nature 2010 2.16
27 Stepwise RNP assembly at the site of H/ACA RNA transcription in human cells. J Cell Biol 2006 2.09
28 Asymmetric sorting of ash1p in yeast results from inhibition of translation by localization elements in the mRNA. Mol Cell 2002 2.08
29 A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization. Genes Dev 2004 2.05
30 Real-time visualization of ZBP1 association with beta-actin mRNA during transcription and localization. Curr Biol 2003 2.04
31 Visualization of mRNA translation in living cells. J Cell Biol 2006 2.03
32 Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts. J Cell Sci 2005 1.95
33 Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells. Curr Biol 2004 1.91
34 ZBP1 regulates mRNA stability during cellular stress. J Cell Biol 2006 1.84
35 Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons. J Neurosci 2006 1.80
36 Transcription of functionally related constitutive genes is not coordinated. Nat Struct Mol Biol 2010 1.78
37 A predominantly nuclear protein affecting cytoplasmic localization of beta-actin mRNA in fibroblasts and neurons. J Cell Biol 2002 1.77
38 Imaging transcription in living cells. Annu Rev Biophys 2009 1.76
39 Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses. J Neurosci 2003 1.74
40 Structural basis for the coevolution of a viral RNA-protein complex. Nat Struct Mol Biol 2007 1.71
41 A single molecule view of gene expression. Trends Cell Biol 2009 1.69
42 The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing. EMBO J 2003 1.68
43 Pathways for mRNA localization in the cytoplasm. Trends Biochem Sci 2006 1.66
44 Nuclear export dynamics of RNA-protein complexes. Nature 2011 1.63
45 Variegated gene expression caused by cell-specific long-range DNA interactions. Nat Cell Biol 2011 1.63
46 ZBP1 recognition of beta-actin zipcode induces RNA looping. Genes Dev 2010 1.63
47 Single-molecule analysis of gene expression using two-color RNA labeling in live yeast. Nat Methods 2012 1.62
48 Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions. Mol Biol Cell 2002 1.60
49 Eukaryotic transcriptional dynamics: from single molecules to cell populations. Nat Rev Genet 2013 1.57
50 Modern fluorescent proteins and imaging technologies to study gene expression, nuclear localization, and dynamics. Curr Opin Cell Biol 2011 1.55
51 A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain. Nat Struct Mol Biol 2006 1.52
52 Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation. Genes Dev 2008 1.50
53 Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate. Proc Natl Acad Sci U S A 2010 1.44
54 Gene expression profiling in single cells within tissue. Nat Methods 2005 1.43
55 YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNA. Mol Cell 2007 1.43
56 Imaging gene expression in single living cells. Nat Rev Mol Cell Biol 2004 1.39
57 RNA localization. J Cell Sci 2005 1.39
58 Fluorescence fluctuation spectroscopy enables quantitative imaging of single mRNAs in living cells. Biophys J 2012 1.37
59 She2p is a novel RNA binding protein with a basic helical hairpin motif. Cell 2004 1.37
60 ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. Mol Cell Biol 2007 1.35
61 Dynamics of transcription and mRNA export. Curr Opin Cell Biol 2005 1.35
62 The life of an mRNA in space and time. J Cell Sci 2010 1.31
63 Mechanisms and cellular roles of local protein synthesis in mammalian cells. Curr Opin Cell Biol 2008 1.31
64 Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control. Genes Dev 2012 1.26
65 The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons. J Neurosci 2011 1.25
66 Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. J Cell Biol 2005 1.23
67 Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis. PLoS Pathog 2013 1.23
68 RNA processing and export. Cold Spring Harb Perspect Biol 2010 1.22
69 Measurement of barbed ends, actin polymerization, and motility in live carcinoma cells after growth factor stimulation. Cell Motil Cytoskeleton 2004 1.21
70 IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev 2012 1.20
71 The nuclear connection in RNA transport and localization. Trends Cell Biol 2002 1.20
72 Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell 2012 1.19
73 Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev 2013 1.18
74 Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cells. PLoS One 2010 1.17
75 Imaging mRNA movement from transcription sites to translation sites. Semin Cell Dev Biol 2007 1.17
76 Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase. Dev Biol 2006 1.15
77 Single-mRNA counting using fluorescent in situ hybridization in budding yeast. Nat Protoc 2012 1.15
78 β-Actin mRNA compartmentalization enhances focal adhesion stability and directs cell migration. Genes Dev 2012 1.13
79 ZBP1 enhances cell polarity and reduces chemotaxis. J Cell Sci 2007 1.11
80 Analyzing mRNA expression using single mRNA resolution fluorescent in situ hybridization. Methods Enzymol 2010 1.11
81 Gene expression within a dynamic nuclear landscape. EMBO J 2006 1.10
82 Rrp17p is a eukaryotic exonuclease required for 5' end processing of Pre-60S ribosomal RNA. Mol Cell 2009 1.10
83 The fate of the messenger is pre-determined: a new model for regulation of gene expression. Biochim Biophys Acta 2013 1.08
84 Assembling an intermediate filament network by dynamic cotranslation. J Cell Biol 2006 1.08
85 Asymmetric distribution of nuclear pore complexes and the cytoplasmic localization of beta2-tubulin mRNA in Chlamydomonas reinhardtii. Dev Cell 2003 1.07
86 Single mRNA tracking in live cells. Methods Enzymol 2010 1.07
87 Transcription goes digital. EMBO Rep 2012 1.06
88 Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1. J Cell Sci 2012 1.05
89 Feedback regulation between zipcode binding protein 1 and beta-catenin mRNAs in breast cancer cells. Mol Cell Biol 2008 1.04
90 An unbiased analysis method to quantify mRNA localization reveals its correlation with cell motility. Cell Rep 2012 1.03
91 Direct observation of frequency modulated transcription in single cells using light activation. Elife 2013 1.03
92 Cell biology of mRNA decay. Methods Enzymol 2008 1.02
93 Cotranscriptional effect of a premature termination codon revealed by live-cell imaging. RNA 2011 1.02
94 An active precursor in assembly of yeast nuclear ribonuclease P. RNA 2002 1.01
95 Dynamic association and localization of human H/ACA RNP proteins. RNA 2006 1.01
96 Imaging of single mRNAs in the cytoplasm of living cells. Prog Mol Subcell Biol 2004 0.99
97 mRNA on the move: the road to its biological destiny. J Biol Chem 2013 0.99
98 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res 2002 0.97
99 RNA asymmetric distribution and daughter/mother differentiation in yeast. Curr Opin Microbiol 2003 0.97
100 The dynamic range of transcription. Mol Cell 2008 0.95
101 Imaging translation in single cells using fluorescent microscopy. Cold Spring Harb Perspect Biol 2012 0.93
102 Blocking beta-catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells. J Cell Sci 2009 0.93
103 Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body. RNA 2008 0.91
104 QNQKE targeting motif for the SMN-Gemin multiprotein complexin neurons. J Neurosci Res 2007 0.90
105 A nucleoporin, Nup60p, affects the nuclear and cytoplasmic localization of ASH1 mRNA in S. cerevisiae. RNA 2010 0.90
106 The cytoplasmic fate of an mRNP is determined cotranscriptionally: exception or rule? Genes Dev 2010 0.89
107 Multiscale dynamics in nucleocytoplasmic transport. Curr Opin Cell Biol 2011 0.89
108 Yeast mitochondrial transcriptomics. Methods Mol Biol 2007 0.88
109 Calibrating excitation light fluxes for quantitative light microscopy in cell biology. Nat Protoc 2008 0.86
110 Molecular restoration of archived transcriptional profiles by complementary-template reverse-transcription (CT-RT). Nucleic Acids Res 2007 0.86
111 The spatial order of transcription in mammalian cells. J Cell Biochem 2007 0.85
112 Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Cancer Res 2008 0.83
113 Altered dynamics of intestinal cell maturation in Apc1638N/+ mice. Cancer Res 2010 0.82
114 Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells. J Cell Physiol 2009 0.82
115 Single cell analysis of RNA-mediated histone H3.3 recruitment to a cytomegalovirus promoter-regulated transcription site. J Biol Chem 2013 0.78
116 Role of the parafusin orthologue, PRP1, in microneme exocytosis and cell invasion in Toxoplasma gondii. Cell Microbiol 2003 0.78
117 Nuclear microenvironment in cancer diagnosis and treatment. J Cell Biochem 2008 0.77
118 A der(8)t(8;11) chromosome in the Karpas-620 myeloma cell line expresses only cyclin D1: yet both cyclin D1 and MYC are repositioned in close proximity to the 3'IGH enhancer. DNA Repair (Amst) 2008 0.77
119 Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning. Learn Mem 2012 0.77
120 Imaging real-time gene expression in living yeast. CSH Protoc 2007 0.77
121 Time-integrated fluorescence cumulant analysis and its application in living cells. Methods Enzymol 2013 0.77
122 Transcription, one allele at a time. Genome Biol 2010 0.76
123 Imaging real-time gene expression in Mammalian cells with single-transcript resolution. CSH Protoc 2007 0.75
124 Imaging real-time gene expression in living systems with single-transcript resolution: construct design and imaging system setup. CSH Protoc 2007 0.75
125 Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single mRNA Particle Tracking with ImageJ-Based Analysis. CSH Protoc 2007 0.75
126 Imaging real-time gene expression in living systems with single-transcript resolution: image analysis of single mRNA transcripts. CSH Protoc 2007 0.75
127 Nucleus and gene regulation. Curr Opin Cell Biol 2006 0.75
128 Cellular Levels of Signaling Factors Are Sensed by β-actin Alleles to Modulate Transcriptional Pulse Intensity. Cell Rep 2015 0.75