PubRank

Arne Holmgren

Author PubWeight™ 133.10‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Thioredoxin and related molecules--from biology to health and disease. Antioxid Redox Signal 2007 3.50
2 From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 2007 3.49
3 Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. Antioxid Redox Signal 2004 3.04
4 Glutaredoxin systems. Biochim Biophys Acta 2008 2.65
5 The thioredoxin system in cancer. Semin Cancer Biol 2006 2.42
6 Probing the chemistry of thioredoxin catalysis with force. Nature 2007 2.17
7 Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A 2007 2.11
8 Selenoproteins. J Biol Chem 2008 2.02
9 Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems. Proc Natl Acad Sci U S A 2002 2.00
10 Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system. Am J Physiol Heart Circ Physiol 2006 1.99
11 Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers. Proc Natl Acad Sci U S A 2004 1.89
12 Thioredoxins and glutaredoxins as facilitators of protein folding. Biochim Biophys Acta 2008 1.85
13 Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis. Arch Biochem Biophys 2002 1.78
14 Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor. Proc Natl Acad Sci U S A 2005 1.68
15 Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. J Biol Chem 2005 1.64
16 Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase. J Biol Chem 2003 1.55
17 Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res 2006 1.48
18 Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity. J Biol Chem 2008 1.45
19 Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest 2010 1.33
20 Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase. J Biol Chem 2006 1.33
21 Thioredoxin system in cell death progression. Antioxid Redox Signal 2012 1.32
22 Regulation of the catalytic activity and structure of human thioredoxin 1 via oxidation and S-nitrosylation of cysteine residues. J Biol Chem 2008 1.32
23 Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. Nat Struct Mol Biol 2011 1.32
24 Chaperone properties of Escherichia coli thioredoxin and thioredoxin reductase. Biochem J 2003 1.30
25 Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo. J Am Chem Soc 2006 1.25
26 Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. PLoS One 2009 1.25
27 The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. Mol Cell Biol 2006 1.25
28 Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential. BMC Mol Biol 2007 1.24
29 Reversible silencing of CFTR chloride channels by glutathionylation. J Gen Physiol 2005 1.22
30 Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release. Biochem Biophys Res Commun 2005 1.21
31 Folate, vitamin B12, and homocysteine levels in South Asian women with growth-retarded fetuses. Acta Obstet Gynecol Scand 2005 1.20
32 Cellular and plasma levels of human glutaredoxin 1 and 2 detected by sensitive ELISA systems. Biochem Biophys Res Commun 2004 1.20
33 Molecular and structural basis for redox regulation of beta-actin. J Mol Biol 2007 1.20
34 Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. Hum Pathol 2004 1.19
35 A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase. J Biol Chem 2005 1.19
36 Protein folding drives disulfide formation. Cell 2012 1.18
37 Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase. J Biol Chem 2009 1.16
38 Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide. Proc Natl Acad Sci U S A 2004 1.16
39 A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase. J Biol Chem 2002 1.16
40 The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity. Biochem J 2011 1.15
41 Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant. Proc Natl Acad Sci U S A 2002 1.15
42 Truncated thioredoxin: physiological functions and mechanism. Antioxid Redox Signal 2004 1.13
43 Oxidation and S-nitrosylation of cysteines in human cytosolic and mitochondrial glutaredoxins: effects on structure and activity. J Biol Chem 2007 1.11
44 Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nat Struct Mol Biol 2009 1.11
45 Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione. FASEB J 2012 1.09
46 Selenium and selenoproteins in health and disease. Antioxid Redox Signal 2010 1.08
47 How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2? Antioxid Redox Signal 2007 1.08
48 Thioredoxin and glutaredoxin isoforms. Methods Enzymol 2002 1.07
49 The contributions of protein disulfide isomerase and its homologues to oxidative protein folding in the yeast endoplasmic reticulum. J Biol Chem 2004 1.06
50 Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose. J Biol Chem 2012 1.06
51 Streptomyces spp. contain class Ia and class II ribonucleotide reductases: expression analysis of the genes in vegetative growth. Microbiology 2002 1.03
52 Thioredoxin and thioredoxin reductase in relation to reversible S-nitrosylation. Antioxid Redox Signal 2012 1.01
53 A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins. Biochemistry 2007 1.00
54 Redox regulation of 3'-phosphoadenylylsulfate reductase from Escherichia coli by glutathione and glutaredoxins. J Biol Chem 2003 1.00
55 Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells. FASEB J 2002 0.98
56 Molecular mapping of functionalities in the solution structure of reduced Grx4, a monothiol glutaredoxin from Escherichia coli. J Biol Chem 2005 0.98
57 Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes. Free Radic Biol Med 2011 0.98
58 Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency. Biochem Biophys Res Commun 2002 0.97
59 The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina. Mol Cell Proteomics 2009 0.96
60 Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver. FASEB J 2009 0.96
61 Truncated thioredoxin (Trx80) exerts unique mitogenic cytokine effects via a mechanism independent of thiol oxido-reductase activity. FEBS Lett 2003 0.95
62 Expression pattern of human glutaredoxin 2 isoforms: identification and characterization of two testis/cancer cell-specific isoforms. Antioxid Redox Signal 2008 0.95
63 Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity. FASEB J 2008 0.94
64 Protein levels of Escherichia coli thioredoxins and glutaredoxins and their relation to null mutants, growth phase, and function. J Biol Chem 2002 0.94
65 The role of thioredoxin in the regulation of cellular processes by S-nitrosylation. Biochim Biophys Acta 2011 0.94
66 Thioredoxin 1 is inactivated due to oxidation induced by peroxiredoxin under oxidative stress and reactivated by the glutaredoxin system. J Biol Chem 2013 0.93
67 Characterization of Escherichia coli null mutants for glutaredoxin 2. J Biol Chem 2001 0.93
68 Catalysis of thiol/disulfide exchange. Glutaredoxin 1 and protein-disulfide isomerase use different mechanisms to enhance oxidase and reductase activities. J Biol Chem 2005 0.92
69 Bacillus anthracis thioredoxin systems, characterization and role as electron donors for ribonucleotide reductase. J Biol Chem 2012 0.92
70 The thioredoxin superfamily in oxidative protein folding. Antioxid Redox Signal 2014 0.92
71 Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radic Biol Med 2011 0.92
72 Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4-hydroxynonenal. Antioxid Redox Signal 2014 0.92
73 Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei. J Biol Chem 2013 0.91
74 Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. Free Radic Biol Med 2009 0.91
75 Redox properties and evolution of human glutaredoxins. Proteins 2007 0.90
76 Expression of the thioredoxin system in interstitial lung disease. J Pathol 2003 0.89
77 Vertebrate-specific glutaredoxin is essential for brain development. Proc Natl Acad Sci U S A 2011 0.89
78 A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase. Chem Res Toxicol 2012 0.89
79 Inhibition of the thioredoxin system in the brain and liver of zebra-seabreams exposed to waterborne methylmercury. Toxicol Appl Pharmacol 2010 0.88
80 Truncated thioredoxin (Trx80) induces differentiation of human CD14+ monocytes into a novel cell type (TAMs) via activation of the MAP kinases p38, ERK, and JNK. Blood 2004 0.88
81 Identification, expression pattern, and characterization of mouse glutaredoxin 2 isoforms. Antioxid Redox Signal 2009 0.88
82 Stimulation of Fe-S cluster insertion into apoFNR by Escherichia coli glutaredoxins 1, 2 and 3 in vitro. FEBS Lett 2004 0.88
83 Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction. Toxicol Appl Pharmacol 2005 0.87
84 The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins. Proteins 2009 0.87
85 Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase. Biochim Biophys Acta 2009 0.87
86 Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br J Haematol 2008 0.87
87 Proteomics in HepG2 hepatocarcinoma cells with stably silenced expression of PRDX1. J Proteomics 2012 0.86
88 Fifty years in the thioredoxin field and a bountiful harvest. Biochim Biophys Acta 2012 0.86
89 Inhibition of mammalian thioredoxin reductase by black tea and its constituents: implications for anticancer actions. Biochimie 2008 0.86
90 PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cells activated by the monocyte products IL-15 and IL-12. Blood 2004 0.86
91 SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Antioxid Redox Signal 2010 0.84
92 Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. FASEB J 2010 0.84
93 Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Proc Natl Acad Sci U S A 2013 0.84
94 High-resolution structures of oxidized and reduced thioredoxin reductase from Helicobacter pylori. Acta Crystallogr D Biol Crystallogr 2007 0.83
95 Characterization of the redox properties of poplar glutaredoxin. Antioxid Redox Signal 2003 0.83
96 Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma. APMIS 2004 0.83
97 Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun 2009 0.83
98 The thioredoxin system in cancer-introduction to a thematic volume of Seminars in Cancer Biology. Semin Cancer Biol 2006 0.82
99 Expression of Escherichia coli glutaredoxin 2 is mainly regulated by ppGpp and sigmaS. J Biol Chem 2002 0.82
100 The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43. Biochemistry 2007 0.82
101 Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability. Oncol Rep 2008 0.81
102 Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes. Acta Diabetol 2013 0.81
103 Requirements for the different cysteines in the chemotactic and desensitizing activity of human thioredoxin. Antioxid Redox Signal 2005 0.80
104 Real-time kinetics of the interaction between the two subunits, Escherichia coli thioredoxin and gene 5 protein of phage T7 DNA polymerase. J Biol Chem 2003 0.80
105 An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin. Biochem Biophys Res Commun 2013 0.79
106 Ebselen is a dehydroascorbate reductase mimic, facilitating the recycling of ascorbate via mammalian thioredoxin systems. Antioxid Redox Signal 2004 0.79
107 Ascorbate and endocytosed Motexafin gadolinium induce lysosomal rupture. Cancer Lett 2011 0.79
108 Biomarkers of adverse response to mercury: histopathology versus thioredoxin reductase activity. J Biomed Biotechnol 2012 0.78
109 Mammalian thioredoxin reductases as hydroperoxide reductases. Methods Enzymol 2002 0.78
110 Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity. FEBS Lett 2002 0.78
111 Solution structure and biophysical properties of MqsA, a Zn-containing antitoxin from Escherichia coli. Biochim Biophys Acta 2012 0.77
112 Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain. EMBO Mol Med 2012 0.76
113 Human glutaredoxin 2 affinity tag for recombinant peptide and protein purification. Protein Expr Purif 2005 0.76
114 Thioredoxin 80-activated-monocytes (TAMs) inhibit the replication of intracellular pathogens. PLoS One 2011 0.75