Published in Aging Cell on April 10, 2015
Molecular pathology endpoints useful for aging studies. Ageing Res Rev (2016) 0.89
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab (2016) 0.85
Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise. Aging Cell (2016) 0.77
Dietary Restriction and Nutrient Balance in Aging. Oxid Med Cell Longev (2015) 0.77
Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy. Front Physiol (2016) 0.76
Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle. Ageing Res Rev (2017) 0.75
Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats. Sci Rep (2016) 0.75
Fat mass and obesity associated (FTO) gene influences skeletal muscle phenotypes in non-resistance trained males and elite rugby playing position. BMC Genet (2017) 0.75
Exercise capacity, physical activity, and morbidity. Heart Fail Rev (2017) 0.75
Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Biogerontology (2016) 0.75
Acanthoic Acid Can Partially Prevent Alcohol Exposure-Induced Liver Lipid Deposition and Inflammation. Front Pharmacol (2017) 0.75
Live strong and prosper: the importance of skeletal muscle strength for healthy ageing. Biogerontology (2016) 0.75
Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers. PLoS One (2017) 0.75
Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging. Front Cell Neurosci (2017) 0.75
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application. Aging Cell (2017) 0.75
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases. Nat Rev Mol Cell Biol (2017) 0.75
Murine myoblast migration: influence of replicative ageing and nutrition. Biogerontology (2017) 0.75
Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity. Eur J Appl Physiol (2017) 0.75
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab (2017) 0.75
Tissue-specific gene expression and fasting regulation of sirtuin family in gilthead sea bream (Sparus aurata). J Comp Physiol B (2016) 0.75
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med (2009) 12.38
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell (2004) 11.33
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature (2002) 10.52
Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. Point: IGF is the major physiological regulator of muscle mass. J Appl Physiol (1985) (2009) 10.48
Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet (1998) 10.11
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol (2004) 9.96
The TOR pathway: a target for cancer therapy. Nat Rev Cancer (2004) 9.02
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet (2004) 8.77
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
The endocrine regulation of aging by insulin-like signals. Science (2003) 8.10
Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80
Genetics: influence of TOR kinase on lifespan in C. elegans. Nature (2003) 7.55
FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene (2005) 7.50
Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev (2006) 6.62
Insulin-like growth factors and neoplasia. Nat Rev Cancer (2004) 6.29
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell (2009) 6.09
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell (2012) 5.71
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell (2003) 5.23
Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem (2008) 5.22
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science (2004) 4.70
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J (2004) 4.41
Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature (1993) 4.33
The sirtuin SIRT6 regulates lifespan in male mice. Nature (2012) 4.07
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell (2005) 4.02
Sarcopenia: origins and clinical relevance. J Nutr (1997) 3.88
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J (2007) 3.83
Rapamycin slows aging in mice. Aging Cell (2012) 3.76
Signaling in muscle atrophy and hypertrophy. Physiology (Bethesda) (2008) 3.68
Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc (2003) 3.30
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet (1999) 3.27
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell (2009) 3.16
Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. J Gerontol A Biol Sci Med Sci (2001) 3.15
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci U S A (1994) 3.09
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun (2010) 2.97
The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab (2014) 2.97
Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology (2005) 2.84
TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. FASEB J (2005) 2.81
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol (2005) 2.80
Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am (2003) 2.73
Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression 1. Am J Clin Nutr (2006) 2.70
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell (2007) 2.70
Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol (2009) 2.64
Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol (2008) 2.62
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature (2011) 2.60
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab (2012) 2.59
A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Natl Acad Sci U S A (2002) 2.53
Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol Rev (1996) 2.52
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab (2003) 2.51
Life extension in the dwarf mouse. Curr Top Dev Biol (2004) 2.48
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab (2014) 2.48
Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev (1994) 2.42
Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell (2008) 2.41
Mechanisms regulating skeletal muscle growth and atrophy. FEBS J (2013) 2.40
Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr (2008) 2.39
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. J Cell Biol (2009) 2.30
Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. Cancer Epidemiol Biomarkers Prev (2003) 2.26
Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23
Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol (2010) 2.22
Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol (2007) 2.22
Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? J Intern Med (2008) 2.12
Aging of human muscle: structure, function and adaptability. Scand J Med Sci Sports (1995) 2.12
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12
Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J (1994) 2.08
A population of myogenic stem cells that survives skeletal muscle aging. Stem Cells (2007) 2.03
Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J Clin Invest (2004) 2.01
Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial. Am J Clin Nutr (2012) 1.96
S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. Cell Metab (2007) 1.92
Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell (2012) 1.92
NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest (2012) 1.91
Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J (2001) 1.88
NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am J Physiol Regul Integr Comp Physiol (2000) 1.87
Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J (2001) 1.83
Mechanisms underlying the transcriptional regulation of skeletal myogenesis. Curr Opin Genet Dev (2005) 1.82
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab (2013) 1.74
Regenerative potential of human skeletal muscle during aging. Aging Cell (2002) 1.73
Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr (2012) 1.73
Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology (1988) 1.72
Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis (2009) 1.72
Role of insulin-like signalling in Drosophila lifespan. Trends Biochem Sci (2007) 1.70
Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci (2009) 1.69
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci Signal (2011) 1.69