Published in Am J Physiol Endocrinol Metab on August 16, 2011
A metabolic prosurvival role for PML in breast cancer. J Clin Invest (2012) 1.57
Post-translational modifications of PML: consequences and implications. Front Oncol (2013) 0.88
Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a Western diet. J Biol Chem (2013) 0.85
Microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (PML) and tumor necrosis factor alpha (TNFα) signaling in endothelial cells. BMC Genomics (2012) 0.83
Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity. Mol Biol Cell (2014) 0.77
Dual oncogenic and tumor suppressor roles of the promyelocytic leukemia gene in hepatocarcinogenesis associated with hepatitis B virus surface antigen. Oncotarget (2016) 0.75
The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis. Int J Biol Sci (2015) 0.75
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
Cancer-related inflammation. Nature (2008) 34.21
Nuclear factor-kappaB in cancer development and progression. Nature (2006) 18.31
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer (2004) 16.69
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature (1995) 11.53
Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol (2006) 11.36
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mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev (1994) 10.44
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature (1997) 9.71
Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem (2008) 9.56
Transcriptional regulation of adipogenesis. Genes Dev (2000) 8.52
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell (2010) 8.04
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature (2004) 7.64
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev (2003) 5.91
Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem (1995) 5.75
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med (1994) 5.28
Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med (2000) 4.92
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90
Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care (2003) 4.23
AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem (2004) 3.84
Role of PML in cell growth and the retinoic acid pathway. Science (1998) 3.82
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76
PML is essential for multiple apoptotic pathways. Nat Genet (1998) 3.75
Identification of a tumour suppressor network opposing nuclear Akt function. Nature (2006) 3.68
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol (2006) 3.67
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med (2007) 3.66
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
The role of PML in tumor suppression. Cell (2002) 3.28
CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev (1996) 3.27
Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J Natl Cancer Inst (2004) 3.17
A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes (2010) 3.04
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature (2006) 3.01
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab (2002) 2.98
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest (2007) 2.86
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell (2007) 2.70
regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes (2004) 2.64
Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). EMBO J (1995) 2.58
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One (2009) 2.54
The function of PML in p53-dependent apoptosis. Nat Cell Biol (2000) 2.24
Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML. Mol Cell Biol (1998) 2.21
Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad Sci U S A (1995) 2.03
Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation. Biochem Biophys Res Commun (1999) 1.99
A role for PML and the nuclear body in genomic stability. Oncogene (1999) 1.97
Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J Biol Chem (1999) 1.96
Toward a more complete (and less controversial) understanding of energy expenditure and its role in obesity pathogenesis. Diabetes (2011) 1.92
Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats. Diabetes (1988) 1.86
Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc Natl Acad Sci U S A (1999) 1.82
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes (2001) 1.80
S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol (2001) 1.70
Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol (1992) 1.70
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol Cell Biol (1998) 1.69
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology (2010) 1.65
Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women. Diabetes Care (2001) 1.58
BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI. Mol Cell Biol (2004) 1.57
Mitotic clonal expansion during preadipocyte differentiation: calpain-mediated turnover of p27. J Biol Chem (2000) 1.55
Prevalence of fatty liver in a general population of Okinawa, Japan. Jpn J Med (1988) 1.54
SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell (2008) 1.48
The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology (2009) 1.43
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Eur J Biochem (2002) 1.38
Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion. J Cell Physiol (2001) 1.38
Efficacy of troglitazone on body fat distribution in type 2 diabetes. Diabetes Care (2000) 1.29
Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Mol Cell (2001) 1.29
On raising energy expenditure in ob/ob mice. Science (1997) 1.26
Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes. Metabolism (2003) 1.21
A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr Opin Genet Dev (2009) 1.20
DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J Biol Chem (2001) 1.18
Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. Proc Natl Acad Sci U S A (2002) 1.16
Effects of age on body fat distribution and cardiovascular risk factors in women. Am J Clin Nutr (1997) 1.15
SIRT1 stabilizes PML promoting its sumoylation. Cell Death Differ (2010) 1.10
Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis. Oncogene (1998) 1.08
Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation. J Biol Chem (2006) 0.94
Ciglitazone, a new hypoglycemic agent. II. Effect on glucose and lipid metabolisms and insulin binding in the adipose tissue of C57BL/6J-ob/ob and -+/? mice. Diabetes (1983) 0.87
Fat cell adrenoceptors: inter- and intraspecific differences and hormone regulation. Int J Obes (1985) 0.86
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell (2012) 5.71
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol (2004) 2.67
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem (2002) 2.06
Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins. J Biol Chem (2004) 1.86
Optical coherence tomography today: speed, contrast, and multimodality. J Biomed Opt (2014) 1.79
Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol (2002) 1.73
Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin. J Biol Chem (2006) 1.52
Anesthetic effects of clove oil and lidocaine-HCl on marine medaka (Oryzias dancena). Lab Anim (NY) (2011) 1.50
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One (2009) 1.43
The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology (2009) 1.43
Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res (2006) 1.38
Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2. J Biol Chem (2007) 1.35
Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression. Pharmacol Res (2002) 1.27
Peptide switch is essential for Sirt1 deacetylase activity. Mol Cell (2011) 1.26
AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS One (2011) 1.11
Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation. Cancer Res (2004) 1.04
Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation. Cell Cycle (2008) 1.03
Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Cell Cycle (2013) 1.03
Robotic modified radical neck dissection by bilateral axillary breast approach for papillary thyroid carcinoma with lateral neck metastasis. Head Neck (2014) 1.02
Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis. Biochemistry (2006) 1.01
ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem (2006) 1.01
53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage. Oncogene (2005) 0.99
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase. PLoS One (2009) 0.99
Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion. Cancer Res (2003) 0.99
Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif. Exp Mol Med (2007) 0.98
Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1. Oncogene (2004) 0.97
PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology (2007) 0.96
Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation. J Biol Chem (2006) 0.94
Enzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2. Nucleic Acids Res (2005) 0.92
Identification of reassortant pandemic H1N1 influenza virus in Korean pigs. J Microbiol Biotechnol (2012) 0.92
Spectroscopic photoacoustic microscopy using a photonic crystal fiber supercontinuum source. Opt Express (2010) 0.90
Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α. J Nutr Biochem (2011) 0.90
Breast-conserving surgery after tumor downstaging by neoadjuvant chemotherapy is oncologically safe for stage III breast cancer patients. Ann Surg Oncol (2013) 0.90
Appropriate timing for thyroidectomy scar treatment using a 1,550-nm fractional erbium-glass laser. Dermatol Surg (2013) 0.89
Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase. Exp Cell Res (2003) 0.88
Cytoplasmic localization of Jab1 and p27 Kip1 might be associated with invasiveness of papillary thyroid carcinoma. Endocr J (2009) 0.88
Motility analysis of bacteria-based microrobot (bacteriobot) using chemical gradient microchamber. Biotechnol Bioeng (2013) 0.87
Decreased prefrontal CaMKII alpha mRNA in bipolar illness. Neuroreport (2002) 0.87
Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3K-dependent signaling pathway in a human vascular endothelial cell line. FEBS Lett (2005) 0.86
Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity. FEBS Lett (2006) 0.86
Postoperative-stimulated serum thyroglobulin measured at the time of 131I ablation is useful for the prediction of disease status in patients with differentiated thyroid carcinoma. Surgery (2013) 0.86
Genetic characterization of canine rotavirus isolated from a puppy in Korea and experimental reproduction of disease. J Vet Diagn Invest (2007) 0.85
Sentinel lymph node identification with radiopharmaceuticals in patients with breast cancer: a comparison of 99mTc-tin colloid and 99mTc-phytate efficiency. Breast Cancer Res Treat (2010) 0.84
Metabolic effects of resveratrol: addressing the controversies. Cell Mol Life Sci (2014) 0.83
Sarcoidosis mimicking metastatic breast cancer in Korean woman with breast cancer. Breast J (2014) 0.83
Central neck dissection using a bilateral axillo-breast approach for robotic thyroidectomy: comparison with conventional open procedure after propensity score matching. Surg Laparosc Endosc Percutan Tech (2014) 0.83
Dendritic cells loaded with exogenous antigen by electroporation can enhance MHC class I-mediated antitumor immunity. Cancer Immunol Immunother (2003) 0.83
Danhong injection inhibits the development of atherosclerosis in both Apoe⁻/⁻ and Ldlr⁻/⁻ mice. J Cardiovasc Pharmacol (2014) 0.82
Development of bacteria-based microrobot using biocompatible poly(ethylene glycol). Biomed Microdevices (2012) 0.82
Involvement of matrix metalloproteinase-9 in platelet-activating factor-induced angiogenesis. FEBS Lett (2005) 0.82
Case of small bowel perforation due to enteropathy-type T-cell lymphoma. Yonsei Med J (2009) 0.82
Synthesis and biological evaluation of novel T-type calcium channel blockers. Bioorg Med Chem Lett (2006) 0.82
Comparison of ex vivo and in vivo injection of blue dye in sentinel lymph node mapping for colorectal cancer. World J Surg (2009) 0.81
Oxygen tension regulates the stability of insulin receptor substrate-1 (IRS-1) through caspase-mediated cleavage. J Biol Chem (2006) 0.81
Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression. Schizophr Res (2002) 0.81
Retroperitoneal desmoplastic small round cell tumor: pediatric patient treated with multimodal therapy. World J Gastroenterol (2009) 0.81
Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination. Proc Natl Acad Sci U S A (2013) 0.81
Euthyroid status after total thyroidectomy due to functioning lung metastases from a clear cell variant of papillary thyroid carcinoma. Thyroid (2012) 0.81
Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. Int J Cancer (2007) 0.81
Alkylating agent methyl methanesulfonate (MMS) induces a wave of global protein hyperacetylation: implications in cancer cell death. Biochem Biophys Res Commun (2007) 0.80
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism. Biochim Biophys Acta (2013) 0.79
Impairment of p38 MAPK-mediated cytosolic phospholipase A2 activation in the kidneys is associated with pathogenicity of Candida albicans. Immunology (2006) 0.79
Clinical factors for distinguishing perforated from nonperforated appendicitis: a comparison using multidetector computed tomography in 528 laparoscopic appendectomies. Surg Laparosc Endosc Percutan Tech (2011) 0.79
Synthesis and SAR studies of a novel series of T-type calcium channel blockers. Bioorg Med Chem (2006) 0.78
Killian-Jamieson diverticulum mimicking a suspicious thyroid nodule: sonographic diagnosis. J Clin Ultrasound (2009) 0.78
CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving tumor necrosis factor-alpha-dependent interleukin-12 induction. FEMS Immunol Med Microbiol (2007) 0.78
Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma. Arch Virol (2011) 0.78
Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers. Bioorg Med Chem Lett (2006) 0.78
Kaposiform hemangioendothelioma of the breast in an adult female. Clin Breast Cancer (2011) 0.77
Nomogram for predicting positive resection margins after breast-conserving surgery. Breast Cancer Res Treat (2012) 0.77
Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks. Biochim Biophys Acta (2011) 0.77
Toxoplasma gondii protects against H(2)O(2) -induced apoptosis in ARPE-19 cells through the transcriptional regulation of apoptotic elements and downregulation of the p38 MAPK pathway. Acta Ophthalmol (2011) 0.77
Anti-proliferative effect and action mechanism of dexamethasone in human medullary thyroid cancer cell line. Endocr Res (2011) 0.77
Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations. Acta Diabetol (2009) 0.76
The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study. Am J Hypertens (2009) 0.75
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab (2017) 0.75
Fate of Polycyclic Aromatic Hydrocarbons in Seawater from the Western Pacific to the Southern Ocean (17.5°N to 69.2°S) and Their Inventories on the Antarctic Shelf. Environ Sci Technol (2016) 0.75
Eyes of beautiful women and femme fatales depicted in Western portraits. J Craniofac Surg (2015) 0.75
A novel approach to classify significant ECG data based on heart instantaneous frequency and ECG-derived respiration using conductive textiles. Conf Proc IEEE Eng Med Biol Soc (2007) 0.75
Macrophage migration inhibitory factor levels correlate with an infection in trauma patients. Ulus Travma Acil Cerrahi Derg (2017) 0.75
Dual modality reflection mode optical coherence and photoacoustic microscopy using an akinetic sensor. Opt Lett (2017) 0.75
Endovascular treatment of a distal splenic artery aneurysm with use of a stent-graft. J Vasc Interv Radiol (2009) 0.75