Published in Development on September 01, 2009
The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81
Principles of planar polarity in animal development. Development (2011) 2.94
Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat Cell Biol (2011) 2.40
Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia. Science (2009) 2.25
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev (2011) 1.94
A role for primary cilia in glutamatergic synaptic integration of adult-born neurons. Nat Neurosci (2012) 1.90
Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev Cell (2009) 1.83
Cilia organize ependymal planar polarity. J Neurosci (2010) 1.80
Intraflagellar transport proteins are essential for cilia formation and for planar cell polarity. J Am Soc Nephrol (2010) 1.74
Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity. Dev Cell (2011) 1.64
Cilia in the CNS: the quiet organelle claims center stage. Neuron (2011) 1.59
Mechanism and evolution of cytosolic Hedgehog signal transduction. Development (2010) 1.58
Cilia in vertebrate development and disease. Development (2012) 1.50
Role of primary cilia in brain development and cancer. Curr Opin Neurobiol (2010) 1.49
Cilia in the nervous system: linking cilia function and neurodevelopmental disorders. Curr Opin Neurol (2011) 1.43
Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion. Development (2009) 1.42
The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. Dev Biol (2009) 1.38
BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes. Hum Mol Genet (2012) 1.33
Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis. Cilia (2013) 1.28
Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. J Biol Chem (2010) 1.28
Kinocilia mediate mechanosensitivity in developing zebrafish hair cells. Dev Cell (2012) 1.27
Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. Mol Biol Cell (2010) 1.20
Trafficking in and to the primary cilium. Cilia (2012) 1.20
Wnt/β-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development (2011) 1.20
Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects. Hum Mol Genet (2013) 1.13
A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation. PLoS One (2012) 1.11
The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet (2011) 1.11
miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish. Development (2012) 1.10
Cystic kidney disease: the role of Wnt signaling. Trends Mol Med (2010) 1.10
Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development (2011) 1.10
Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development (2011) 1.10
Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish. BMC Biol (2010) 1.09
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. J Clin Invest (2014) 1.00
Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol (2010) 1.00
Cilia, Wnt signaling, and the cytoskeleton. Cilia (2012) 0.99
Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genet (2012) 0.98
Keeping the balance between proliferation and differentiation: the primary cilium. Curr Genomics (2011) 0.96
Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity. J Cell Biol (2012) 0.96
The emerging face of primary cilia. Genesis (2011) 0.94
Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep (2014) 0.94
Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS Genet (2013) 0.93
Primary cilia and kidney injury: current research status and future perspectives. Am J Physiol Renal Physiol (2013) 0.90
The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development (2012) 0.90
Vertebrate Hedgehog signaling: cilia rule. BMC Biol (2010) 0.88
Hedgehog signaling is required at multiple stages of zebrafish tooth development. BMC Dev Biol (2010) 0.87
The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper retinal development and lamination. PLoS One (2012) 0.87
The intraflagellar transport protein ift80 is essential for photoreceptor survival in a zebrafish model of jeune asphyxiating thoracic dystrophy. Invest Ophthalmol Vis Sci (2010) 0.86
Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. PLoS One (2014) 0.86
Zebrafish assays of ciliopathies. Methods Cell Biol (2011) 0.85
Morphogenesis and cell fate determination within the adaxial cell equivalence group of the zebrafish myotome. PLoS Genet (2012) 0.85
What are those cilia doing in the neural tube? Cilia (2012) 0.85
Endothelial cilia are essential for developmental vascular integrity in zebrafish. J Am Soc Nephrol (2014) 0.85
Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea. Development (2015) 0.84
Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons. Development (2011) 0.84
Cilia in cell signaling and human disorders. Protein Cell (2010) 0.83
The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. Dev Biol (2013) 0.82
Hedgehog signaling requires motile cilia in the sea urchin. Mol Biol Evol (2013) 0.82
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Mol Biol Cell (2014) 0.82
Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. J Biol Chem (2011) 0.81
N-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube. Mol Biol Cell (2011) 0.81
Zebrafish arl6ip1 is required for neural crest development during embryogenesis. PLoS One (2012) 0.80
A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. PLoS Genet (2014) 0.80
Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Biol Open (2013) 0.80
IFT46 plays an essential role in cilia development. Dev Biol (2015) 0.79
Primary Cilia and Mammalian Hedgehog Signaling. Cold Spring Harb Perspect Biol (2016) 0.78
miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development (2016) 0.77
Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms. Dev Biol (2014) 0.77
Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biol Open (2015) 0.77
Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish. G3 (Bethesda) (2016) 0.76
Microtubule Motors Drive Hedgehog Signaling in Primary Cilia. Trends Cell Biol (2016) 0.76
Genetic screening reveals a link between Wnt signaling and antitubulin drugs. Pharmacogenomics J (2015) 0.75
The medaka dhc2 mutant reveals conserved and distinct mechanisms of Hedgehog signaling in teleosts. BMC Dev Biol (2015) 0.75
Centrosomes in the zebrafish (Danio rerio): a review including the related basal body. Cilia (2012) 0.75
ATR promotes cilia signalling: links to developmental impacts. Hum Mol Genet (2016) 0.75
Opportunities lost and gained: Changes in progenitor competence during nervous system development. Neurogenesis (Austin) (2017) 0.75
Nuclear roles for cilia-associated proteins. Cilia (2017) 0.75
RAPAMYCIN INCREASES LENGTH AND MECHANOSENSORY FUNCTION OF PRIMARY CILIA IN RENAL EPITHELIAL AND VASCULAR ENDOTHELIAL CELLS. Int Educ Res J (2016) 0.75
Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. PLoS Biol (2017) 0.75
Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24
Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21
Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38
p53 activation by knockdown technologies. PLoS Genet (2007) 6.85
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15
Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature (2000) 5.52
The graded response to Sonic Hedgehog depends on cilia architecture. Dev Cell (2007) 5.35
Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol (2007) 5.09
Cilia and developmental signaling. Annu Rev Cell Dev Biol (2007) 4.88
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development (2002) 4.80
Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet (2005) 4.76
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development (2005) 4.32
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24
Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. Curr Top Dev Biol (2008) 4.10
PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol (2005) 4.04
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. Nat Genet (2006) 3.97
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney. Development (2004) 3.97
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development (2000) 3.91
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol (2005) 3.63
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development (2006) 3.39
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet (2008) 3.19
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nat Genet (2007) 2.98
Ciliary dysfunction in developmental abnormalities and diseases. Curr Top Dev Biol (2008) 2.88
Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Dev Cell (2001) 2.39
Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat Neurosci (2000) 2.36
Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts. Dev Dyn (2008) 2.30
Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons. Neuron (2004) 2.27
Ftm is a novel basal body protein of cilia involved in Shh signalling. Development (2007) 2.25
Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet (2005) 2.24
Evolution of eukaryotic transcription circuits. Science (2008) 2.24
Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo. Curr Biol (2003) 2.17
Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr Biol (2003) 2.06
Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev Cell (2008) 1.87
Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Genes Dev (1999) 1.77
Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development (2003) 1.76
Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Dev Biol (2005) 1.69
Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature (2009) 1.69
Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proc Natl Acad Sci U S A (2002) 1.62
Convergent extension movements and ciliary function are mediated by ofd1, a zebrafish orthologue of the human oral-facial-digital type 1 syndrome gene. Hum Mol Genet (2008) 1.46
The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Development (2009) 1.45
The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling. Genes Dev (2006) 1.42
The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr Biol (2009) 1.39
Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev Biol (2005) 1.38
iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev (2004) 1.36
The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development (2004) 1.34
Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria. PLoS Genet (2008) 1.30
C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development (2008) 1.18
Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling. Dev Dyn (2009) 1.18
Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. Development (2004) 1.12
Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev Biol (2000) 1.12
Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Mol Cell Neurosci (2007) 1.02
Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube. Gene Expr Patterns (2007) 0.96
Gsk3beta/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity. Development (2008) 0.82
Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science (2006) 18.14
MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science (2007) 4.72
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development (2005) 4.64
Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis. Genome Res (2011) 3.81
Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature (2006) 3.80
Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (2010) 3.60
Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430. Curr Biol (2006) 3.51
Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36
Brain-wide neuronal dynamics during motor adaptation in zebrafish. Nature (2012) 3.17
Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. J Neurosci (2006) 2.86
Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Curr Biol (2008) 2.69
Chromatin signature of embryonic pluripotency is established during genome activation. Nature (2010) 2.64
Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system. Science (2012) 2.57
Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors. Curr Biol (2005) 2.33
Monitoring neural activity with bioluminescence during natural behavior. Nat Neurosci (2010) 2.24
Morphogen gradients: from generation to interpretation. Annu Rev Cell Dev Biol (2011) 2.19
Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron (2008) 2.07
CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nat Genet (2012) 1.99
Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development (2003) 1.76
Lefty proteins are long-range inhibitors of squint-mediated nodal signaling. Curr Biol (2002) 1.67
Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science (2014) 1.66
Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proc Natl Acad Sci U S A (2002) 1.62
Stat3 Controls Cell Movements during Zebrafish Gastrulation. Dev Cell (2002) 1.57
Ribosome profiling reveals resemblance between long non-coding RNAs and 5' leaders of coding RNAs. Development (2013) 1.54
Polycystin-2 immunolocalization and function in zebrafish. J Am Soc Nephrol (2006) 1.50
Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci (2008) 1.48
Bivalent histone modifications in early embryogenesis. Curr Opin Cell Biol (2012) 1.48
A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome Res (2013) 1.48
Optical control of metabotropic glutamate receptors. Nat Neurosci (2013) 1.45
Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish. Development (2013) 1.43
Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev Biol (2005) 1.38
EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1. Genes Dev (2003) 1.37
Targeted mutagenesis in zebrafish. Nat Biotechnol (2008) 1.35
The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm. Development (2003) 1.31
Assembly of trigeminal sensory ganglia by chemokine signaling. Neuron (2005) 1.29
Specified neural progenitors sort to form sharp domains after noisy Shh signaling. Cell (2013) 1.24
Nodal stability determines signaling range. Curr Biol (2005) 1.21
Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors. PLoS Biol (2004) 1.19
Morphogen transport. Development (2013) 1.16
Neuropeptidergic signaling partitions arousal behaviors in zebrafish. J Neurosci (2014) 1.14
Multicolor Brainbow imaging in zebrafish. Cold Spring Harb Protoc (2011) 1.14
Extracellular movement of signaling molecules. Dev Cell (2011) 1.13
In vivo birthdating by BAPTISM reveals that trigeminal sensory neuron diversity depends on early neurogenesis. Development (2008) 1.10
A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects. Hum Genet (2002) 1.09
Canonical nucleosome organization at promoters forms during genome activation. Genome Res (2013) 1.05
Nodal signaling activates differentiation genes during zebrafish gastrulation. Dev Biol (2007) 1.03
Behavioral screening for neuroactive drugs in zebrafish. Dev Neurobiol (2012) 1.01
Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Dev Cell (2012) 0.98
Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genet (2012) 0.98
Whole-brain activity mapping onto a zebrafish brain atlas. Nat Methods (2015) 0.97
The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex. Curr Biol (2012) 0.94
no tail integrates two modes of mesoderm induction. Development (2010) 0.94
A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. J Am Chem Soc (2002) 0.93
The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development (2012) 0.90
Developmental biology: Rise of the source-sink model. Nature (2009) 0.90
Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction. Development (2003) 0.89
Genomics: Zebrafish earns its stripes. Nature (2013) 0.89
Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish. Dev Dyn (2008) 0.88
Identifying (non-)coding RNAs and small peptides: challenges and opportunities. Bioessays (2014) 0.87
Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons. Development (2011) 0.85
Sites of action of sleep and wake drugs: insights from model organisms. Curr Opin Neurobiol (2013) 0.85
Monitoring sleep and arousal in zebrafish. Methods Cell Biol (2010) 0.84
Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b. J Neurophysiol (2012) 0.83
Maternal nodal and zebrafish embryogenesis. Nature (2007) 0.81
Neuropeptidergic control of sleep and wakefulness. Annu Rev Neurosci (2014) 0.79
Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development. Cell Rep (2016) 0.77
Clearing the path for germ cells. Cell (2008) 0.77
Mesoderm induction and patterning. Results Probl Cell Differ (2002) 0.76
Developmental biology: tail of decay. Nature (2004) 0.76
Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development (2016) 0.75
BAPTI and BAPTISM birthdating of neurons in zebrafish. Cold Spring Harb Protoc (2012) 0.75