PubRank

Lawrence A Loeb

Author PubWeight™ 106.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Detection of ultra-rare mutations by next-generation sequencing. Proc Natl Acad Sci U S A 2012 5.53
2 Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet 2007 3.53
3 Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A 2006 3.11
4 Protein tolerance to random amino acid change. Proc Natl Acad Sci U S A 2004 3.07
5 Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation 2009 2.96
6 DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet 2008 2.77
7 Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol 2004 2.58
8 Environmental and chemical carcinogenesis. Semin Cancer Biol 2004 2.50
9 Mutational heterogeneity in human cancers: origin and consequences. Annu Rev Pathol 2010 2.02
10 Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem 2005 1.94
11 Quantification of random genomic mutations. Nat Methods 2005 1.88
12 Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol 2007 1.74
13 Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I. Proc Natl Acad Sci U S A 2003 1.67
14 Cancer genome sequencing--an interim analysis. Cancer Res 2009 1.52
15 On mitochondria, mutations, and methodology. Cell Metab 2009 1.52
16 Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet 2013 1.51
17 Genetic constraints on protein evolution. Crit Rev Biochem Mol Biol 2007 1.41
18 Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev 2011 1.39
19 Genetic instability in cancer: theory and experiment. Semin Cancer Biol 2005 1.34
20 Current advances in unraveling the function of the Werner syndrome protein. Mutat Res 2005 1.32
21 Optimization of DNA polymerase mutation rates during bacterial evolution. Proc Natl Acad Sci U S A 2009 1.28
22 Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Res 2002 1.27
23 Lethal mutagenesis of HIV. Virus Res 2005 1.26
24 Efficiency of carcinogenesis with and without a mutator mutation. Proc Natl Acad Sci U S A 2006 1.25
25 The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem 2002 1.22
26 High fidelity and lesion bypass capability of human DNA polymerase delta. Biochimie 2009 1.22
27 Generation of mutator mutants during carcinogenesis. DNA Repair (Amst) 2005 1.18
28 The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer. J Biol Chem 2008 1.18
29 Clonal expansions in ulcerative colitis identify patients with neoplasia. Proc Natl Acad Sci U S A 2009 1.17
30 Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I. J Biol Chem 2007 1.15
31 Werner syndrome protein interacts functionally with translesion DNA polymerases. Proc Natl Acad Sci U S A 2007 1.15
32 Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family. Nucleic Acids Res 2004 1.14
33 Quantification of random mutations in the mitochondrial genome. Methods 2008 1.14
34 Negative clonal selection in tumor evolution. Genetics 2005 1.13
35 APOBEC3B mutagenesis in cancer. Nat Genet 2013 1.09
36 An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Nat Genet 2013 1.09
37 The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C. J Biol Chem 2004 1.08
38 Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461. PLoS One 2011 1.08
39 Frameshift mutagenesis and microsatellite instability induced by human alkyladenine DNA glycosylase. Mol Cell 2010 1.07
40 Mutator phenotype in cancer: timing and perspectives. Environ Mol Mutagen 2005 1.06
41 Lethal mutagenesis: targeting the mutator phenotype in cancer. Semin Cancer Biol 2010 1.05
42 Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. J Biol Chem 2002 1.04
43 DNA polymerase delta in DNA replication and genome maintenance. Environ Mol Mutagen 2012 1.02
44 Implications of genetic heterogeneity in cancer. Ann N Y Acad Sci 2012 1.02
45 Critical role of R-loops in processing replication blocks. Front Biosci 2005 1.01
46 The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mech Ageing Dev 2003 1.01
47 The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst) 2004 0.99
48 Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression. J Biol Chem 2010 0.99
49 Incorporation of reporter-labeled nucleotides by DNA polymerases. Biotechniques 2005 0.98
50 Insertion of the T3 DNA polymerase thioredoxin binding domain enhances the processivity and fidelity of Taq DNA polymerase. Nucleic Acids Res 2003 0.98
51 Mutator phenotype in cancer: origin and consequences. Semin Cancer Biol 2010 0.98
52 Do mutator mutations fuel tumorigenesis? Cancer Metastasis Rev 2013 0.96
53 The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ. J Biol Chem 2012 0.96
54 The mutator phenotype in cancer: molecular mechanisms and targeting strategies. Curr Drug Targets 2010 0.95
55 Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication. Nucleic Acids Res 2011 0.94
56 Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea. J Biol Chem 2004 0.93
57 The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures. PLoS One 2012 0.92
58 Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases. DNA Repair (Amst) 2005 0.92
59 Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. J Biol Chem 2003 0.92
60 Ageing: mice and mitochondria. Nature 2004 0.88
61 Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers. Transl Oncol 2013 0.87
62 Mitochondrial DNA integrity is not dependent on DNA polymerase-beta activity. DNA Repair (Amst) 2005 0.87
63 A random mutation capture assay to detect genomic point mutations in mouse tissue. Nucleic Acids Res 2011 0.86
64 Tumbling down a different pathway to genetic instability. J Clin Invest 2003 0.86
65 When pol I goes into high gear: processive DNA synthesis by pol I in the cell. Cell Cycle 2004 0.84
66 Werner syndrome gene variants in human sarcomas. Mol Carcinog 2010 0.84
67 Use of Pol I-deficient E. coli for functional complementation of DNA polymerase. Methods Mol Biol 2003 0.83
68 Limits to the Human Cancer Genome Project? Science 2007 0.81
69 Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival. DNA Repair (Amst) 2008 0.80
70 LOH-proficient embryonic stem cells: a model of cancer progenitor cells? Trends Genet 2007 0.80
71 Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis. Inflamm Bowel Dis 2013 0.80
72 Accuracy of Next Generation Sequencing Platforms. Next Gener Seq Appl 2015 0.80
73 A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site. J Biol Chem 2013 0.80
74 Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin. Int J Cancer 2006 0.79
75 Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects. J Mol Med (Berl) 2010 0.79
76 The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum. J Mol Biol 2011 0.78
77 Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther 2006 0.78
78 Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells. Hum Gene Ther 2009 0.78
79 In vitro production and screening of DNA polymerase eta mutants for catalytic diversity. Biotechniques 2002 0.77
80 Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site. J Biol Chem 2003 0.77
81 Endogenous mutagenesis and cancer. Mutat Res 2002 0.77
82 Genetic complementation protocols. Methods Mol Biol 2003 0.76
83 Reply: Is There Any Genetic Instability in Human Cancer? DNA Repair (Amst) 2010 0.76
84 XPG and WRN: an unexpected partnership. Cell Cycle 2011 0.75
85 Random oligonucleotide mutagenesis. Methods Mol Biol 2003 0.75
86 The first US-Japan meeting on error-prone DNA synthesis, Maui, Hawaii, December 20-21, 2004. DNA Repair (Amst) 2005 0.75
87 Targeted mutagenesis in E. coli: A powerful tool for the generation of random mutant libraries. Discov Med 2003 0.75
88 The multiplicity of mutations in human cancers. Adv Exp Med Biol 2005 0.75
89 Selection of novel eukaryotic DNA polymerases by mutagenesis and genetic complementation of yeast. Methods Mol Biol 2003 0.75