Published in EMBO J on June 14, 2007
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Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Mol Cell Biol (2009) 1.12
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p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1. Proc Natl Acad Sci U S A (2016) 0.76
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The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest. Cancer Biol Ther (2004) 1.05
Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells. J Biol Chem (2002) 1.01
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p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol (2011) 3.70
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer Discov (2014) 2.79
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal (2007) 2.30
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Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Mol Cell Biol (2006) 2.02
New fibrate use and acute renal outcomes in elderly adults: a population-based study. Ann Intern Med (2012) 1.91
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Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release. Kidney Int (2013) 1.71
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature (2010) 1.71
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TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Biol (2013) 1.61
DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J Biol Chem (2007) 1.59
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence. Cancer Res (2014) 1.55
The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Mol Cell Biol (2006) 1.50
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol (2008) 1.48
Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res (2011) 1.48
COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae. J Biol Chem (2005) 1.39
No increase in adverse events during aliskiren use among ontario patients receiving angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers. Can J Cardiol (2013) 1.39
MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma. Proc Natl Acad Sci U S A (2011) 1.39
Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem (2004) 1.38
The comet assay: a sensitive method for detecting DNA damage in individual cells. Methods (2009) 1.35
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia (2009) 1.27
MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression. PLoS One (2012) 1.27
Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. J Natl Cancer Inst (2004) 1.27
Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1. Oncogene (2005) 1.26
Surf the post-translational modification network of p53 regulation. Int J Biol Sci (2012) 1.25
Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc Natl Acad Sci U S A (2013) 1.24
Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription. Genes Dev (2012) 1.21
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17
Global dissection of alternative splicing in paleopolyploid soybean. Plant Cell (2014) 1.15
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules. Proc Natl Acad Sci U S A (2011) 1.14
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling. EMBO Rep (2012) 1.12
Regulation of L-threonine dehydrogenase in somatic cell reprogramming. Stem Cells (2013) 1.09
Noxa/Mcl-1 balance regulates susceptibility of cells to camptothecin-induced apoptosis. Neoplasia (2007) 1.09
Bone morphogenetic protein 3B silencing in non-small-cell lung cancer. Oncogene (2004) 1.06
FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway. Autophagy (2012) 1.05
Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3. J Biol Chem (2004) 1.03
Regulation of the pentose phosphate pathway in cancer. Protein Cell (2014) 1.03
XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling. EMBO J (2013) 1.02
Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells. Cell Signal (2012) 0.99
Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation. Oncogene (2005) 0.99
HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells. PLoS One (2008) 0.98
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells. Cell Res (2013) 0.98
DEAD-box helicase DP103 defines metastatic potential of human breast cancers. J Clin Invest (2014) 0.97
An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem (2007) 0.97
PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Nat Commun (2013) 0.97
Risk of acute kidney injury from oral acyclovir: a population-based study. Am J Kidney Dis (2013) 0.96
Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice. Oncogene (2002) 0.96
Endometriosis is associated with a decreased risk of pre-eclampsia. Hum Reprod (2007) 0.96
Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study. BMC Genomics (2013) 0.96
p53 and Bad: remote strangers become close friends. Cell Res (2007) 0.95
Characterization and prediction of lysine (K)-acetyl-transferase specific acetylation sites. Mol Cell Proteomics (2011) 0.95
Bcl-rambo beta, a special splicing variant with an insertion of an Alu-like cassette, promotes etoposide- and Taxol-induced cell death. FEBS Lett (2003) 0.94
Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1. Nucleic Acids Res (2006) 0.93
Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. J Biol Chem (2009) 0.92
p53-facilitated miR-199a-3p regulates somatic cell reprogramming. Stem Cells (2012) 0.92
Sumoylation is critical for DJ-1 to repress p53 transcriptional activity. FEBS Lett (2008) 0.92
A single amino acid change (Asp 53 --> Ala53) converts Survivin from anti-apoptotic to pro-apoptotic. Mol Biol Cell (2003) 0.90
c-Myc modulates microRNA processing via the transcriptional regulation of Drosha. Sci Rep (2013) 0.90
5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins. FASEB J (2011) 0.90
A new role of p53 in regulating lipid metabolism. J Mol Cell Biol (2012) 0.90
Deficiency of hepatocystin induces autophagy through an mTOR-dependent pathway. Autophagy (2011) 0.89
Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins. J Biol Chem (2007) 0.89
HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors. FEBS Lett (2002) 0.89
Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase. Nat Commun (2013) 0.87
p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells. PLoS One (2011) 0.86
Concerted evolution of D1 and D2 to regulate chlorophyll degradation in soybean. Plant J (2014) 0.86
E2F1 represses beta-catenin/TCF activity by direct up-regulation of Siah1. J Cell Mol Med (2009) 0.85
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Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1. J Biol Chem (2008) 0.84
Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity. J Biol Chem (2010) 0.84
Retinoic acid-induced HOXA5 expression is co-regulated by HuR and miR-130a. Cell Signal (2013) 0.84
Upper gastrointestinal bleeding in elderly adults with dementia receiving cholinesterase inhibitors: a population-based cohort study. J Am Geriatr Soc (2014) 0.83
The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage. DNA Repair (Amst) (2011) 0.83
Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death. Autophagy (2010) 0.83
Triphenyl tin benzimidazolethiol, a novel antitumor agent, induces mitochondrial-mediated apoptosis in human cervical cancer cells via suppression of HPV-18 encoded E6. J Biochem (2003) 0.83
Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling. Int J Oncol (2007) 0.83
p53-dependent apoptotic mechanism of a new designer bimetallic compound tri-phenyl tin benzimidazolethiol copper chloride (TPT-CuCl2): in vivo studies in Wistar rats as well as in vitro studies in human cervical cancer cells. J Pharmacol Exp Ther (2004) 0.82
The regulation of the autophagic network and its implications for human disease. Int J Biol Sci (2013) 0.82
RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. Biochem Biophys Res Commun (2005) 0.81
Increased expression of neutrophil gelatinase-associated lipocalin receptor by interleukin-1β in human mesangial cells via MAPK/ERK activation. Int J Mol Med (2011) 0.81
Multiple roles for nuclear localization signal (NLS, aa 442-472) of receptor interacting protein 3 (RIP3). Biochem Biophys Res Commun (2008) 0.81
Structural changes in exon 11 of MEF2A are not related to sporadic coronary artery disease in Han Chinese population. Eur J Clin Invest (2010) 0.81
Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703. Eur J Biochem (2003) 0.80