It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.

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Published in Genes Cancer on March 01, 2012

Authors

Ian M Love1, Steven R Grossman

Author Affiliations

1: Division of Hematology, Oncology, and Palliative Care, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.

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Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26

Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87

Regulation of p53 stability by Mdm2. Nature (1997) 18.20

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell (1993) 12.41

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell (1997) 12.41

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell (2000) 10.90

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science (2004) 9.52

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science (1996) 9.48

p53 regulates mitochondrial respiration. Science (2006) 9.06

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell (1998) 8.99

p53 has a direct apoptogenic role at the mitochondria. Mol Cell (2003) 8.98

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68

Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol (2001) 8.68

mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature (1993) 7.90

DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell (2004) 7.22

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell (2005) 6.86

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet (2003) 6.46

Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell (2004) 6.12

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell (1999) 6.04

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell (2004) 6.00

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer (2009) 5.86

Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol (1999) 5.78

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev (1994) 5.68

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell (2004) 5.08

The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature (2004) 5.05

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell (2003) 4.96

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J (1996) 4.65

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature (2007) 4.63

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature (2006) 4.57

Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A (1995) 3.86

The emerging complexity of protein ubiquitination. Biochem Soc Trans (2009) 3.85

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc Natl Acad Sci U S A (1999) 3.78

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev (2001) 3.67

In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res (1996) 3.50

Delivery of ubiquitinated substrates to protein-unfolding machines. Nat Cell Biol (2005) 3.38

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science (2004) 3.28

A subset of p53-deficient embryos exhibit exencephaly. Nat Genet (1995) 3.24

Yin Yang 1 is a negative regulator of p53. Cell (2004) 3.24

Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science (2003) 3.21

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep (2001) 3.19

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J (2004) 3.10

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene (1993) 3.08

INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res (2005) 3.08

Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol (2006) 2.99

CHIP: a link between the chaperone and proteasome systems. Cell Stress Chaperones (2003) 2.98

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors. Nat Chem Biol (2011) 2.94

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature (1986) 2.94

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell (1999) 2.93

NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem (2003) 2.92

TRIM proteins and cancer. Nat Rev Cancer (2011) 2.84

A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol Cell (1998) 2.81

Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. J Biol Chem (2003) 2.57

High-frequency developmental abnormalities in p53-deficient mice. Curr Biol (1995) 2.57

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol Cell Biol (1993) 2.55

Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nat Cell Biol (2006) 2.52

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. Mol Cell (2010) 2.52

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene (2002) 2.50

E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50

Dissecting p53-dependent apoptosis. Cell Death Differ (2006) 2.44

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell (2007) 2.42

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol Cell Biol (1997) 2.41

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol Cell Biol (2000) 2.34

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation. Mol Cell Biol (2003) 2.32

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell (2006) 2.32

Arabidopsis DREB2A-interacting proteins function as RING E3 ligases and negatively regulate plant drought stress-responsive gene expression. Plant Cell (2008) 2.29

p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res (2008) 2.27

Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol (2006) 2.27

Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Mol Cell Biol (2001) 2.27

Temporal dissection of p53 function in vitro and in vivo. Nat Genet (2005) 2.19

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. Proc Natl Acad Sci U S A (1996) 2.18

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells. J Biol Chem (1998) 2.07

The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation. J Biol Chem (2005) 2.01

Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A (2009) 2.00

The proteasome and proteasome inhibitors in cancer therapy. Annu Rev Pharmacol Toxicol (2006) 1.99

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96

Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J (1997) 1.96

Mdm2 association with p53 targets its ubiquitination. Oncogene (1998) 1.94

The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53. Cancer Cell (2005) 1.90

The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol (2007) 1.83

Ubiquitination and degradation of mutant p53. Mol Cell Biol (2007) 1.77

Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. Mol Cancer Res (2011) 1.77

Constructing and decoding unconventional ubiquitin chains. Nat Struct Mol Biol (2011) 1.76

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ (2011) 1.76

CHIP: a quality-control E3 ligase collaborating with molecular chaperones. Int J Biochem Cell Biol (2003) 1.72

Localization to the proteasome is sufficient for degradation. J Biol Chem (2004) 1.72

ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice. Cancer Cell (2012) 1.70

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2. Nat Cell Biol (2007) 1.70

The central region of HDM2 provides a second binding site for p53. Proc Natl Acad Sci U S A (2006) 1.67

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J Biol Chem (2004) 1.66

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