Published in Pharmacol Res on May 05, 2007
Diabetic neuropathy: mechanisms to management. Pharmacol Ther (2008) 2.57
Crystal structure and allosteric activation of protein kinase C βII. Cell (2011) 2.19
Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. Rev Endocr Metab Disord (2010) 2.19
Retracted Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice. Circ Res (2008) 1.74
Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system. Am J Physiol Heart Circ Physiol (2008) 1.53
Mechanisms of disease: the oxidative stress theory of diabetic neuropathy. Rev Endocr Metab Disord (2008) 1.40
Protein kinase C pharmacology: refining the toolbox. Biochem J (2013) 1.27
Protein kinase Calpha: disease regulator and therapeutic target. Trends Pharmacol Sci (2009) 1.25
Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes. Int J Vasc Med (2012) 1.12
Endothelial cell metabolism in normal and diseased vasculature. Circ Res (2015) 1.09
MicroRNAs: potential mediators and biomarkers of diabetic complications. Free Radic Biol Med (2013) 1.08
Role of peroxynitrite in the redox regulation of cell signal transduction pathways. Front Biosci (Landmark Ed) (2009) 1.07
Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus. Cardiovasc Drugs Ther (2008) 1.07
Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications. Curr Med Chem (2013) 1.03
Molecular mechanisms of diabetic vascular complications. J Diabetes Investig (2010) 1.01
Mechanisms of distal axonal degeneration in peripheral neuropathies. Neurosci Lett (2015) 1.00
Decreased contractile response to endothelin-1 of peripheral microvasculature from diabetic patients. Surgery (2010) 1.00
Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction. Biochem J (2012) 1.00
Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis. Int J Mol Med (2008) 0.99
Myosin light chain kinase signaling in endothelial barrier dysfunction. Med Res Rev (2012) 0.98
Relationship between urinary sodium excretion and pioglitazone-induced edema. J Diabetes Investig (2010) 0.98
Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder. CNS Drugs (2009) 0.97
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res (2008) 0.96
Counter regulatory effects of PKCbetaII and PKCdelta on coronary endothelial permeability. Arterioscler Thromb Vasc Biol (2008) 0.96
The signal transduction pathway of PKC/NF-kappa B/c-fos may be involved in the influence of high glucose on the cardiomyocytes of neonatal rats. Cardiovasc Diabetol (2009) 0.96
Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats. Br J Pharmacol (2010) 0.95
Diabetic macular edema: new concepts in patho-physiology and treatment. Cell Biosci (2014) 0.95
High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Invest Ophthalmol Vis Sci (2011) 0.94
Angiotensin mediates renal fibrosis in the nephropathy of glycogen storage disease type Ia. Kidney Int (2007) 0.94
The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy. Int J Clin Exp Med (2013) 0.94
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol (2013) 0.92
Endoplasmic reticulum stress-mediated hippocampal neuron apoptosis involved in diabetic cognitive impairment. Biomed Res Int (2013) 0.92
Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain. Arterioscler Thromb Vasc Biol (2010) 0.92
Mechanisms by which diabetes increases cardiovascular disease. Drug Discov Today Dis Mech (2007) 0.91
Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling. Int J Biochem Cell Biol (2010) 0.91
Molecular mechanisms of diabetic retinopathy: potential therapeutic targets. Middle East Afr J Ophthalmol (2015) 0.88
Lipids: A Suitable Therapeutic Target in Diabetic Neuropathy? J Diabetes Res (2017) 0.87
Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Invest Ophthalmol Vis Sci (2011) 0.86
Tamoxifen use for the management of mania: a review of current preclinical evidence. Psychopharmacology (Berl) (2014) 0.85
Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression. Diabetologia (2009) 0.85
Left ventricular hypertrophy and geometry in type 2 diabetes patients with chronic kidney disease. An echocardiographic study. Cardiovasc J Afr (2012) 0.85
Breviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathway. Acta Pharmacol Sin (2009) 0.84
Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains. Am J Physiol Endocrinol Metab (2011) 0.84
Reactive metabolites and antioxidant gene polymorphisms in Type 2 diabetes mellitus. Redox Biol (2013) 0.84
Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes. Curr Diab Rep (2009) 0.84
Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. Acta Pharmacol Sin (2011) 0.84
Aldo-keto reductases in the eye. J Ophthalmol (2010) 0.84
Happy birthday protein kinase C: past, present and future of a superfamily. Pharmacol Res (2007) 0.83
Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BK(Ca) and Kir channels. Am J Physiol Heart Circ Physiol (2012) 0.83
Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility. Diabetes Care (2010) 0.83
Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3. Am J Physiol Cell Physiol (2008) 0.83
Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats. Br J Pharmacol (2011) 0.82
PCB 126 toxicity is modulated by cross-talk between caveolae and Nrf2 signaling. Toxicol Appl Pharmacol (2014) 0.82
Citrate treatment reduces endothelial death and inflammation under hyperglycaemic conditions. Diab Vasc Dis Res (2011) 0.82
The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration. Circ Res (2011) 0.81
Docetaxel Facilitates Endothelial Dysfunction through Oxidative Stress via Modulation of Protein Kinase C Beta: The Protective Effects of Sotrastaurin. Toxicol Sci (2015) 0.81
Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats. Pflugers Arch (2012) 0.81
Choosing preclinical study models of diabetic retinopathy: key problems for consideration. Drug Des Devel Ther (2014) 0.81
Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels. PLoS One (2014) 0.80
PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. Mol Vis (2011) 0.79
Binding of curcumin and its long chain derivatives to the activator binding domain of novel protein kinase C. Bioorg Med Chem (2010) 0.79
Berberine ameliorates cold and mechanical allodynia in a rat model of diabetic neuropathy. J Med Food (2013) 0.79
Protein kinase C in porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. Mol Vis (2009) 0.79
Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats. Evid Based Complement Alternat Med (2013) 0.79
Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. Int J Med Sci (2015) 0.79
The effect of lithospermic acid, an antioxidant, on development of diabetic retinopathy in spontaneously obese diabetic rats. PLoS One (2014) 0.78
Distinct expression and localization of diacylglycerol kinase isozymes in rat retina. J Histochem Cytochem (2013) 0.78
Promoting effects of the adipokine, apelin, on diabetic nephropathy. PLoS One (2013) 0.78
Advanced Glycation End Product (AGE)-AGE Receptor (RAGE) System Upregulated Connexin43 Expression in Rat Cardiomyocytes via PKC and Erk MAPK Pathways. Int J Mol Sci (2013) 0.78
Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats. Biomed Res Int (2015) 0.78
Monocytic adhesion molecule expression and monocyte-endothelial cell dysfunction are increased in patients with peripheral vascular disease versus patients with abdominal aortic aneurysms. J Surg Res (2012) 0.77
Carbohydrates and endothelial function: is a low-carbohydrate diet or a low-glycemic index diet favourable for vascular health? Clin Nutr Res (2015) 0.77
Effects of non-supervised low intensity aerobic excise training on the microvascular endothelial function of patients with type 1 diabetes: a non-pharmacological interventional study. BMC Cardiovasc Disord (2016) 0.76
Protein kinase C activation affects, via the mRNA-binding Hu-antigen R/ELAV protein, vascular endothelial growth factor expression in a pericytic/endothelial coculture model. Mol Vis (2012) 0.76
Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro: a potential therapeutic target. Clin Exp Metastasis (2008) 0.76
Intra- and extrarenal arteries exhibit different profiles of contractile responses in high glucose conditions. Br J Pharmacol (2008) 0.76
Distinct and complementary roles for α and β isoenzymes of PKC in mediating vasoconstrictor responses to acutely elevated glucose. Br J Pharmacol (2016) 0.76
Complex modulation of the expression of PKC isoforms in the rat brain during chronic type 1 diabetes mellitus. Brain Res (2012) 0.76
[Update on diabetic macroangiopathy]. Pathologe (2012) 0.76
Impairment of neurovascular coupling in Type 1 Diabetes Mellitus in rats is prevented by pancreatic islet transplantation and reversed by a semi-selective PKC inhibitor. Brain Res (2016) 0.75
PKCα signaling pathway involves in TNF-α-induced IP3R1 expression in human mesangial cells. World J Emerg Med (2012) 0.75
Presence and Risk Factors for Glaucoma in Patients with Diabetes. Curr Diab Rep (2016) 0.75
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. BMC Complement Altern Med (2016) 0.75
Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism. Eur J Nutr (2016) 0.75
PKC activation by resveratrol derivatives with unsaturated aliphatic chain. PLoS One (2012) 0.75
Effects of Hyperglycemia on Vascular Smooth Muscle Ca(2+) Signaling. Biomed Res Int (2017) 0.75
Nrf2: a potential therapeutic target for diabetic neuropathy. Inflammopharmacology (2017) 0.75
Metabolic Regulation of Angiogenesis in Diabetes and Aging. Physiology (Bethesda) (2017) 0.75
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab (2008) 7.97
Retinopathy in diabetes. Diabetes Care (2004) 4.25
Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA (2002) 4.18
Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes (2010) 2.94
Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res (2010) 2.87
Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab (2007) 2.48
Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem (2004) 2.35
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med (2009) 2.31
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest (2003) 2.11
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab (2010) 2.09
Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study. Diabetes Care (2011) 2.00
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes (2007) 1.99
Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation (2002) 1.84
Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes (2006) 1.71
Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A (2008) 1.70
Diabetic retinopathy. Diabetes Care (2003) 1.61
Diabetic retinopathy. Diabetes Care (2003) 1.52
Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab (2013) 1.51
Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care (2007) 1.46
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest (2003) 1.43
Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes (2002) 1.39
Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes (2006) 1.31
Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol (2005) 1.29
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes (2003) 1.21
Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications. Diabetes Care (2012) 1.21
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol (2006) 1.21
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A (2002) 1.19
Oxidative stress and antioxidant treatment in diabetes. Ann N Y Acad Sci (2004) 1.19
Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes. Diabetes (2012) 1.18
Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int (2011) 1.18
Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem (2005) 1.17
Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem (2005) 1.16
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest (2011) 1.15
Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J (2006) 1.14
Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes (2003) 1.12
Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem (2003) 1.09
Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol (2008) 1.09
The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients. Diabetes (2005) 1.05
Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem (2008) 1.05
Microvascular complications of diabetes. Endocrinol Metab Clin North Am (2004) 1.03
Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes. Diabetes Care (2006) 1.02
Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium. Circ Res (2013) 1.02
Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. Diabetes (2002) 1.00
Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci (2005) 1.00
New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia. Diabetes Metab J (2011) 0.98
Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes (2007) 0.98
Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem (2001) 0.98
Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications. J Am Soc Nephrol (2003) 0.96
Molecular targets of diabetic cardiovascular complications. Curr Drug Targets (2005) 0.96
Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications. Curr Diab Rep (2005) 0.94
Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem (2011) 0.93
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol (2013) 0.92
Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials (2010) 0.88
Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy. FASEB J (2012) 0.87
Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol (2012) 0.86
Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol (2009) 0.86
Kidney complications: factors that protect the diabetic vasculature. Nat Med (2010) 0.86
Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci (2012) 0.85
Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases. Circulation (2004) 0.85
Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med (2012) 0.84
Transforming growth factor beta-1 and incidence of heart failure in older adults: the Cardiovascular Health Study. Cytokine (2012) 0.84
A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes. PLoS One (2011) 0.83
Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin. Expert Opin Drug Saf (2006) 0.82
PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J Clin Invest (2016) 0.81
Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes. Diabetes Care (2004) 0.81
More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes. Arterioscler Thromb Vasc Biol (2008) 0.80
SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. PLoS One (2013) 0.79
Implications of treatment that target protective mechanisms against diabetic nephropathy. Semin Nephrol (2012) 0.79
Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J (2006) 0.79
Summary statement IV: Obesity and diabetes: opportunities for translation of basic research. Vascul Pharmacol (2006) 0.79
A complex interplay of factors causes diabetic nephropathy. Metabolism (2010) 0.78
Endothelium-dependent delivery of insulin to muscle interstitium. Cell Metab (2011) 0.78
Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients? Diabetes Care (2005) 0.77
Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2007) 0.77
Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes. Diabetes Care (2013) 0.77
Differential effects of bactericidal/permeability-increasing protein (BPI) analogues on retinal neovascularization and retinal pericyte growth. Invest Ophthalmol Vis Sci (2002) 0.76
Diabetes: Podocytes lose their footing. Nature (2010) 0.76
Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int (2008) 0.75
Characterization of factors affecting attainment of glycemic control in Asian Americans with diabetes in a culturally specific program. Diabetes Educ (2013) 0.75
Applications of inhibitors for protein kinase C and their isoforms. Methods Mol Biol (2003) 0.75
B-cell signaling: protein kinase Cdelta puts the brakes on. Curr Biol (2002) 0.75