Activation of protein kinase C isoforms and its impact on diabetic complications.

PubWeight™: 2.87‹?› | Rank: Top 1%

🔗 View Article (PMC 2877591)

Published in Circ Res on April 30, 2010

Authors

Pedro Geraldes1, George L King

Author Affiliations

1: Dianne Nunnally Hoppes Laboratory for Diabetes Complications, Harvard Medical School, Boston, MA, USA.

Associated clinical trials:

Effect of HMP on Diabetic Microangiopaemia in T2DM | NCT05095922

Articles citing this

(truncated to the top 100)

Oxidative stress and diabetic complications. Circ Res (2010) 9.37

Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab (2011) 2.47

Protein kinase C, an elusive therapeutic target? Nat Rev Drug Discov (2012) 2.33

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Eur Heart J (2013) 2.02

Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation (2012) 1.88

Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis. Circ Res (2012) 1.78

A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes. Sci Signal (2014) 1.67

Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab (2013) 1.51

Epigenetic mechanisms in diabetic vascular complications. Cardiovasc Res (2011) 1.43

Inflammation and diabetic retinal microvascular complications. J Cardiovasc Dis Res (2011) 1.33

Novel roles of nuclear angiotensin receptors and signaling mechanisms. Am J Physiol Regul Integr Comp Physiol (2011) 1.26

Mechanism of diabetic neuropathy: Where are we now and where to go? J Diabetes Investig (2011) 1.25

Epigenetic mechanisms in diabetic complications and metabolic memory. Diabetologia (2014) 1.22

Oxidative stress and metabolic pathologies: from an adipocentric point of view. Oxid Med Cell Longev (2014) 1.16

Protein kinase C and toll-like receptor signaling. Enzyme Res (2011) 1.14

Oxidative stress in diabetes: implications for vascular and other complications. Int J Mol Sci (2013) 1.13

Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9. J Cell Physiol (2012) 1.12

Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes. Int J Vasc Med (2012) 1.12

Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev Endocr Metab Disord (2013) 1.08

Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes. Circulation (2012) 1.05

The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an update. Basic Res Cardiol (2011) 1.03

Vascular pathology and blood-brain barrier disruption in cognitive and psychiatric complications of type 2 diabetes mellitus. Cardiovasc Psychiatry Neurol (2011) 1.02

Diabetic retinopathy, superoxide damage and antioxidants. Curr Pharm Biotechnol (2011) 1.02

Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium. Circ Res (2013) 1.02

Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy. World J Diabetes (2012) 1.00

A1c variability can predict coronary artery disease in patients with type 2 diabetes with mean a1c levels greater than 7. Endocrinol Metab (Seoul) (2013) 0.99

Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach? Pharmacol Rev (2012) 0.99

Hyperglycemia-induced protein kinase C β2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling. Diabetes (2013) 0.98

Anti-inflammatory therapy for diabetic retinopathy. Immunotherapy (2011) 0.98

Mechanisms of lipotoxicity in the cardiovascular system. Curr Hypertens Rep (2012) 0.98

Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response. J Transl Med (2015) 0.97

Vascular dysfunction associated with type 2 diabetes and Alzheimer's disease: a potential etiological linkage. Med Sci Monit Basic Res (2014) 0.96

A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation (2012) 0.96

Conserved modular domains team up to latch-open active protein kinase Cα. J Biol Chem (2014) 0.94

Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes. Vasc Health Risk Manag (2013) 0.94

Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem (2011) 0.93

Role of microangiopathy in diabetic cardiomyopathy. Heart Fail Rev (2014) 0.92

Reactivation of fetal splicing programs in diabetic hearts is mediated by protein kinase C signaling. J Biol Chem (2013) 0.92

Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circ Res (2016) 0.92

Regulation of NADPH oxidase 5 by protein kinase C isoforms. PLoS One (2014) 0.91

Protein kinase Cβ deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling. J Lipid Res (2011) 0.91

Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats. J Cereb Blood Flow Metab (2012) 0.90

Beta-adrenergic receptor agonist decreases VEGF levels through altered eNOS and PKC signaling in diabetic retina. Growth Factors (2015) 0.90

Novel drugs and their targets in the potential treatment of diabetic retinopathy. Med Sci Monit (2013) 0.90

The genetics of diabetic nephropathy. Genes (Basel) (2013) 0.90

Ten-year longitudinal changes in retinal microvascular lesions: the atherosclerosis risk in communities study. Ophthalmology (2011) 0.90

Renal endothelial dysfunction in diabetic nephropathy. Cardiovasc Hematol Disord Drug Targets (2014) 0.90

Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targets. Biomed Res Int (2014) 0.89

Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ. J Lipid Res (2011) 0.89

Taurine attenuates oxidative stress and alleviates cardiac failure in type I diabetic rats. Croat Med J (2013) 0.87

Common mechanisms of Alzheimer's disease and ischemic stroke: the role of protein kinase C in the progression of age-related neurodegeneration. J Alzheimers Dis (2015) 0.86

Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochem Pharmacol (2012) 0.86

Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-α activation and disruption of the p120-vascular endothelial cadherin interaction. Arterioscler Thromb Vasc Biol (2013) 0.86

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. Invest Ophthalmol Vis Sci (2013) 0.86

Top-down Proteomics: Technology Advancements and Applications to Heart Diseases. Expert Rev Proteomics (2016) 0.86

Tamoxifen use for the management of mania: a review of current preclinical evidence. Psychopharmacology (Berl) (2014) 0.85

Aldose reductase modulates cardiac glycogen synthase kinase-3β phosphorylation during ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2012) 0.85

Molecular mechanisms of vascular dysfunction and cardiovascular biomarkers in type 2 diabetes. Cardiovasc Diagn Ther (2014) 0.85

Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ. Diabetes (2011) 0.85

Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats. Cardiovasc Diabetol (2011) 0.84

The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta. BMC Cell Biol (2014) 0.84

Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin-induced type I diabetic nephropathy. PLoS One (2013) 0.84

Decreased coronary microvascular reactivity after cardioplegic arrest in patients with uncontrolled diabetes mellitus. Surgery (2012) 0.84

Mouse models of diabetic neuropathy. ILAR J (2014) 0.84

Type 2 Diabetes: Endothelial dysfunction and Exercise. J Exerc Nutrition Biochem (2014) 0.84

Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart. World J Diabetes (2014) 0.84

Diabetes, Endothelial Dysfunction, and Vascular Repair: What Should a Diabetologist Keep His Eye on? Int J Endocrinol (2015) 0.83

Protective effect and mechanism of Ginkgo biloba extract-EGb 761 on STZ-induced diabetic cardiomyopathy in rats. Pharmacogn Mag (2014) 0.83

The Role of AGE/RAGE Signaling in Diabetes-Mediated Vascular Calcification. J Diabetes Res (2016) 0.83

Endothelial NO and O₂·⁻ production rates differentially regulate oxidative, nitroxidative, and nitrosative stress in the microcirculation. Free Radic Biol Med (2013) 0.83

Intravitreal injection of ranibizumab and CTGF shRNA improves retinal gene expression and microvessel ultrastructure in a rodent model of diabetes. Int J Mol Sci (2014) 0.82

Dynamics and Membrane Interactions of Protein Kinase C. Biochemistry (2015) 0.82

Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cβ in mice. PLoS One (2013) 0.82

Preconditioning diabetic mesenchymal stem cells with myogenic medium increases their ability to repair diabetic heart. Stem Cell Res Ther (2013) 0.82

Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress. Endocrinology (2012) 0.82

PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J Clin Invest (2016) 0.81

Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss. J Clin Invest (2015) 0.81

myo-Inositol Oxygenase Overexpression Accentuates Generation of Reactive Oxygen Species and Exacerbates Cellular Injury following High Glucose Ambience: A NEW MECHANISM RELEVANT TO THE PATHOGENESIS OF DIABETIC NEPHROPATHY. J Biol Chem (2016) 0.81

Protein kinase Cβ2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase 8-triggered apoptotic pathway. Am J Obstet Gynecol (2011) 0.81

Blood glucose management in the patient undergoing cardiac surgery: A review. World J Cardiol (2014) 0.81

Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy. J Am Heart Assoc (2014) 0.81

Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504. Arterioscler Thromb Vasc Biol (2016) 0.81

Kinase-SUMO networks in diabetes-mediated cardiovascular disease. Metabolism (2016) 0.80

Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels. PLoS One (2014) 0.80

Effect of short-term hyperglycemia on protein kinase C alpha activation in human erythrocytes. Rev Diabet Stud (2012) 0.80

PKCβ positively regulates RANKL-induced osteoclastogenesis by inactivating GSK-3β. Mol Cells (2014) 0.80

Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study. J Am Chem Soc (2014) 0.80

Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy. Br J Pharmacol (2014) 0.80

Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy. World J Diabetes (2015) 0.80

Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion. Biosci Rep (2017) 0.80

Everolimus-eluting stents improve vascular response in a diabetic animal model. Circ Cardiovasc Interv (2014) 0.79

The C-terminal V5 domain of Protein Kinase Cα is intrinsically disordered, with propensity to associate with a membrane mimetic. PLoS One (2013) 0.79

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. Cell Rep (2016) 0.79

Low molecular weight fucoidan alleviates cardiac dysfunction in diabetic Goto-Kakizaki rats by reducing oxidative stress and cardiomyocyte apoptosis. J Diabetes Res (2014) 0.79

Activation of protein kinase C-α and Src kinase increases urea transporter A1 α-2, 6 sialylation. J Am Soc Nephrol (2014) 0.79

C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells. PLoS One (2011) 0.79

Role of impaired endothelial cell Ca(2+) signaling in uteroplacental vascular dysfunction during diabetic rat pregnancy. Am J Physiol Heart Circ Physiol (2013) 0.79

IL-33 attenuates anoxia/reoxygenation-induced cardiomyocyte apoptosis by inhibition of PKCβ/JNK pathway. PLoS One (2013) 0.79

Exercise-induced cardiac performance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylglycerol. J Appl Physiol (1985) (2012) 0.79

In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. Inflammation (2015) 0.79

Articles cited by this

(truncated to the top 100)

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med (1993) 102.56

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet (1998) 95.79

Atherosclerosis--an inflammatory disease. N Engl J Med (1999) 59.28

Inflammation in atherosclerosis. Nature (2002) 28.92

Biochemistry and molecular cell biology of diabetic complications. Nature (2001) 25.43

Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care (1998) 24.53

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature (2000) 12.33

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (1992) 12.18

Atherosclerosis. the road ahead. Cell (2001) 11.88

Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus. N Engl J Med (2003) 5.87

Diabetic retinopathy. N Engl J Med (2004) 5.12

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest (1996) 4.98

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J (2003) 4.65

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes (2000) 4.55

Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med (1989) 4.40

Structural basis of protein kinase C isoform function. Physiol Rev (2008) 4.00

Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res (2001) 3.89

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest (2000) 3.79

The changing natural history of nephropathy in type I diabetes. Am J Med (1985) 3.50

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest (1994) 3.49

Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia (1992) 3.43

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Circulation (1999) 3.35

Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes (2003) 3.20

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest (1999) 3.18

Effect of diabetes mellitus on formation of coronary collateral vessels. Circulation (1999) 3.16

Protein kinase C activation and the development of diabetic complications. Diabetes (1998) 2.93

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science (1996) 2.80

Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway. Diabetes (2007) 2.51

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A (1992) 2.48

Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab (2007) 2.48

High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species. Circulation (2003) 2.44

Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease. J Am Coll Cardiol (2005) 2.42

Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A (1997) 2.42

Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). J Biol Chem (2001) 2.42

Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy. Ophthalmology (2006) 2.39

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res (2002) 2.37

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest (1996) 2.36

Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int (1981) 2.36

Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med (2009) 2.31

Role of monocytes in atherogenesis. Physiol Rev (2003) 2.30

Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest (2001) 2.29

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest (1992) 2.26

Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta. Trends Pharmacol Sci (2007) 2.24

High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes (2008) 2.23

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation (2000) 2.18

Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci (1996) 2.01

Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia (2001) 1.98

Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav (2007) 1.94

Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation (2005) 1.93

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J (2000) 1.93

VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci (2006) 1.86

Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation (2002) 1.84

The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis. The MILIS Study Group. J Am Coll Cardiol (1989) 1.80

Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial. Arch Ophthalmol (2007) 1.77

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. J Med Chem (1996) 1.77

Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes (1994) 1.75

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest (1997) 1.75

Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest (1999) 1.72

Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes (2006) 1.71

RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes. Atherosclerosis (2005) 1.67

The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. Diabetes (2005) 1.59

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circ Res (2009) 1.58

Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care (2007) 1.46

Protein kinase C and the development of diabetic vascular complications. Diabet Med (2001) 1.42

Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation (2002) 1.42

Increased endothelial albumin permeability mediated by protein kinase C activation. J Clin Invest (1990) 1.39

Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes (2002) 1.39

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol (1993) 1.36

The effect of ruboxistaurin on nephropathy in type 2 diabetes. Diabetes Care (2005) 1.36

Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes (2003) 1.34

Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes (1990) 1.33

Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes. Prevention by aldose reductase inhibitors and castration. Diabetes (1987) 1.32

Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes (2006) 1.31

Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol (2005) 1.29

Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus. Am J Physiol (1989) 1.26

Diabetic cardiomyopathy. A unique entity or a complication of coronary artery disease? Diabetes Care (1995) 1.26

Protein kinase C regulatory domains: the art of decoding many different signals in membranes. Biochim Biophys Acta (2006) 1.25

Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocin-induced diabetic rats. J Pharmacol Exp Ther (1989) 1.24

Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial. Clin Ther (2005) 1.23

Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol (2006) 1.21

A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy. Diabetes Care (2007) 1.21

Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A (2002) 1.19

A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats. Diabetes (1999) 1.18

Rationally designed peptide regulators of protein kinase C. Trends Endocrinol Metab (2008) 1.17

Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation. Circ Res (2004) 1.17

The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury. Biochem Soc Trans (2007) 1.17

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures. Am J Physiol (1991) 1.16

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy. Circ Heart Fail (2009) 1.16

Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem (2005) 1.16

Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice. Diabetes (2004) 1.15

The immunohistopathology of glomerular antigens. II. The glomerular basement membrane, actomyosin, and fibroblast surface antigens in normal, diseased, and transplanted human kidneys. Am J Pathol (1978) 1.14

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes (2000) 1.13

Vascular smooth muscle cells exhibit increased growth in response to elevated glucose. Biochem Biophys Res Commun (1992) 1.13

Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes (2003) 1.12

Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis. FASEB J (2008) 1.12

Specific protein kinase C isoforms as transducers and modulators of insulin signaling. Mol Genet Metab (2006) 1.11

Hyperglycemia inhibits vascular smooth muscle cell apoptosis through a protein kinase C-dependent pathway. Circ Res (2000) 1.11

Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression. Am J Physiol Endocrinol Metab (2000) 1.10

Mesangial cell protein kinase C isozyme activation in the diabetic milieu. Am J Physiol Renal Physiol (2002) 1.10

High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha. Circ Res (1997) 1.10

Articles by these authors

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab (2008) 7.97

Retinopathy in diabetes. Diabetes Care (2004) 4.25

Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA (2002) 4.18

Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes (2010) 2.94

Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab (2007) 2.48

Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem (2004) 2.35

Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med (2009) 2.31

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest (2003) 2.11

Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab (2010) 2.09

The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res (2007) 2.06

Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study. Diabetes Care (2011) 2.00

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes (2007) 1.99

Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation (2002) 1.84

Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes (2006) 1.71

Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A (2008) 1.70

Diabetic retinopathy. Diabetes Care (2003) 1.61

Diabetic retinopathy. Diabetes Care (2003) 1.52

Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab (2013) 1.51

Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care (2007) 1.46

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest (2003) 1.43

Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes. Diabetes (2002) 1.39

Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes (2006) 1.31

Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol (2005) 1.29

Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes (2003) 1.21

Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications. Diabetes Care (2012) 1.21

Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol (2006) 1.21

Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A (2002) 1.19

Oxidative stress and antioxidant treatment in diabetes. Ann N Y Acad Sci (2004) 1.19

Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes. Diabetes (2012) 1.18

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int (2011) 1.18

Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation. J Biol Chem (2005) 1.17

Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem (2005) 1.16

PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest (2011) 1.15

Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J (2006) 1.14

Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes (2003) 1.12

Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem (2003) 1.09

Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol (2008) 1.09

The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients. Diabetes (2005) 1.05

Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem (2008) 1.05

Microvascular complications of diabetes. Endocrinol Metab Clin North Am (2004) 1.03

Identification of linguistic barriers to diabetes knowledge and glycemic control in Chinese Americans with diabetes. Diabetes Care (2006) 1.02

Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium. Circ Res (2013) 1.02

Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy. Diabetes (2002) 1.00

Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci (2005) 1.00

New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia. Diabetes Metab J (2011) 0.98

Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes (2007) 0.98

Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem (2001) 0.98

Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications. J Am Soc Nephrol (2003) 0.96

Molecular targets of diabetic cardiovascular complications. Curr Drug Targets (2005) 0.96

Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications. Curr Diab Rep (2005) 0.94

Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem (2011) 0.93

Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol (2013) 0.92

Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways. J Biol Chem (2001) 0.91

Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials (2010) 0.88

Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy. FASEB J (2012) 0.87

Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol (2012) 0.86

Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. Am J Physiol Heart Circ Physiol (2009) 0.86

Kidney complications: factors that protect the diabetic vasculature. Nat Med (2010) 0.86

Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci (2012) 0.85

Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases. Circulation (2004) 0.85

Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans. Free Radic Biol Med (2012) 0.84

Transforming growth factor beta-1 and incidence of heart failure in older adults: the Cardiovascular Health Study. Cytokine (2012) 0.84

A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes. PLoS One (2011) 0.83

Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin. Expert Opin Drug Saf (2006) 0.82

PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J Clin Invest (2016) 0.81

Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes. Diabetes Care (2004) 0.81

More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes. Arterioscler Thromb Vasc Biol (2008) 0.80

SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. PLoS One (2013) 0.79

Implications of treatment that target protective mechanisms against diabetic nephropathy. Semin Nephrol (2012) 0.79

Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J (2006) 0.79

Summary statement IV: Obesity and diabetes: opportunities for translation of basic research. Vascul Pharmacol (2006) 0.79

A complex interplay of factors causes diabetic nephropathy. Metabolism (2010) 0.78

Endothelium-dependent delivery of insulin to muscle interstitium. Cell Metab (2011) 0.78

Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients? Diabetes Care (2005) 0.77

Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2007) 0.77

Sexual dysfunction as a marker of cardiovascular disease in males with 50 or more years of type 1 diabetes. Diabetes Care (2013) 0.77

Differential effects of bactericidal/permeability-increasing protein (BPI) analogues on retinal neovascularization and retinal pericyte growth. Invest Ophthalmol Vis Sci (2002) 0.76

Diabetes: Podocytes lose their footing. Nature (2010) 0.76

Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int (2008) 0.75

Characterization of factors affecting attainment of glycemic control in Asian Americans with diabetes in a culturally specific program. Diabetes Educ (2013) 0.75

Applications of inhibitors for protein kinase C and their isoforms. Methods Mol Biol (2003) 0.75

B-cell signaling: protein kinase Cdelta puts the brakes on. Curr Biol (2002) 0.75