Published in Neuron on June 21, 2007
Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature (2013) 5.75
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Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet (2009) 2.32
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Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47
TRPV1 is activated by both acidic and basic pH. J Neurosci (2009) 1.37
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Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons. Proc Natl Acad Sci U S A (2015) 1.24
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Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate. J Neurosci (2010) 1.19
Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy. J Biol Chem (2011) 1.17
TRPV channels and vascular function. Acta Physiol (Oxf) (2010) 1.16
Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J Physiol (2011) 1.16
Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol (2008) 1.15
Molecular modeling of the full-length human TRPV1 channel in closed and desensitized states. J Membr Biol (2008) 1.11
A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1. Pain (2009) 1.08
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The endoplasmic reticulum of dorsal root ganglion neurons contains functional TRPV1 channels. J Biol Chem (2009) 1.04
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Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂. FASEB J (2011) 1.02
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Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One (2008) 1.01
Cryo-electron microscopy structure of the TRPV2 ion channel. Nat Struct Mol Biol (2016) 1.00
Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons. J Neurosci (2013) 0.99
Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res (2011) 0.99
Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4. PLoS One (2010) 0.98
Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel. J Gen Physiol (2012) 0.98
TRPV1: a stress response protein in the central nervous system. Am J Neurodegener Dis (2012) 0.98
Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry (2012) 0.97
Phosphoinositide regulation of TRP channels. Handb Exp Pharmacol (2014) 0.97
Regulation of TRPV1 ion channel by phosphoinositide (4,5)-bisphosphate: the role of membrane asymmetry. J Biol Chem (2014) 0.94
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Crystal structure of the epithelial calcium channel TRPV6. Nature (2016) 0.94
Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold. J Gen Physiol (2013) 0.93
Agonist- and Ca2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. J Biol Chem (2012) 0.93
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling. J Biol Chem (2010) 0.93
Identification of a tetrameric assembly domain in the C terminus of heat-activated TRPV1 channels. J Biol Chem (2011) 0.92
C-terminal dimerization activates the nociceptive transduction channel transient receptor potential vanilloid 1. J Biol Chem (2011) 0.92
Divide and conquer: high resolution structural information on TRP channel fragments. J Gen Physiol (2009) 0.91
Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics. Br J Pharmacol (2014) 0.91
TRPV1: A Potential Drug Target for Treating Various Diseases. Cells (2014) 0.91
The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1). J Physiol (2013) 0.90
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Regulation of transient receptor potential channels by the phospholipase C pathway. Adv Biol Regul (2013) 0.90
TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis. J Neurophysiol (2011) 0.89
Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport. Mol Pharmacol (2008) 0.88
Role of the transient receptor potential vanilloid 5 (TRPV5) protein N terminus in channel activity, tetramerization, and trafficking. J Biol Chem (2011) 0.88
Structural biology of TRP channels. Adv Exp Med Biol (2011) 0.87
Coarse architecture of the transient receptor potential vanilloid 1 (TRPV1) ion channel determined by fluorescence resonance energy transfer. J Biol Chem (2013) 0.87
Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization. J Biol Chem (2013) 0.87
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Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorg Med Chem (2008) 0.87
Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. J Neurosci (2009) 0.86
TRPV1 splice variants: structure and function. Front Biosci (Landmark Ed) (2010) 0.86
Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels. J Gen Physiol (2015) 0.86
Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel. J Biol Chem (2012) 0.86
PP2B/calcineurin-mediated desensitization of TRPV1 does not require AKAP150. Biochem J (2010) 0.85
β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem (2012) 0.85
Microtopographical features generated by photopolymerization recruit RhoA/ROCK through TRPV1 to direct cell and neurite growth. Biomaterials (2015) 0.85
Regulation of the putative TRPV1t salt taste receptor by phosphatidylinositol 4,5-bisphosphate. J Neurophysiol (2009) 0.85
AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin. Mol Pain (2011) 0.84
Phosphoinositide regulation of TRPV1 revisited. Pflugers Arch (2015) 0.84
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels. Mol Pain (2009) 0.84
The dynamic TRPA1 channel: a suitable pharmacological pain target? Curr Pharm Biotechnol (2011) 0.84
Trafficking of ThermoTRP Channels. Membranes (Basel) (2014) 0.83
Conservation of tubulin-binding sequences in TRPV1 throughout evolution. PLoS One (2012) 0.82
Role of the transient receptor potential vanilloid 1 in inflammation and sepsis. J Inflamm Res (2011) 0.82
TRP channel structural biology: new roles for an old fold. Neuron (2007) 0.82
TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision. Cells (2014) 0.82
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Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Sci Signal (2016) 0.81
Measuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRET. J Gen Physiol (2016) 0.81
Functional and structural studies of TRP channels heterologously expressed in budding yeast. Adv Exp Med Biol (2011) 0.81
How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy. Bioessays (2015) 0.80
Molecular bases of multimodal regulation of a fungal transient receptor potential (TRP) channel. J Biol Chem (2013) 0.80
A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activation. J Gen Physiol (2015) 0.79
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Origins of specificity in protein-DNA recognition. Annu Rev Biochem (2010) 4.43
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem (2004) 2.75
Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet (2009) 2.32
The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure (2011) 2.19
Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell (2007) 1.75
Splice form dependence of beta-neurexin/neuroligin binding interactions. Neuron (2010) 1.68
Two-step adhesive binding by classical cadherins. Nat Struct Mol Biol (2010) 1.67
Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter. Mol Cell (2006) 1.60
Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J Biol Chem (2006) 1.57
Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry (2008) 1.54
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Crystal structure of a potassium ion transporter, TrkH. Nature (2011) 1.25
Exome sequencing identifies a novel TRPV4 mutation in a CMT2C family. Neurology (2012) 1.14
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The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization. J Biol Chem (2007) 1.00
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Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel. J Gen Physiol (2012) 0.98
Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature (2013) 0.97
Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry (2012) 0.97
Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin) (2007) 0.95
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