Phosphoinositide regulation of TRP channels.

Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature (2015) 2.47

Transient receptor potential channels in the vasculature. Physiol Rev (2015) 1.14

Phosphoinositides regulate ion channels. Biochim Biophys Acta (2014) 1.09

Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel. J Gen Physiol (2015) 1.08

Regulation of the transient receptor potential channel TRPM3 by phosphoinositides. J Gen Physiol (2015) 1.06

Molecular and cellular mechanisms that initiate pain and itch. Cell Mol Life Sci (2015) 0.84

Phosphoinositide regulation of TRPV1 revisited. Pflugers Arch (2015) 0.84

Structure of the full-length TRPV2 channel by cryo-EM. Nat Commun (2016) 0.80

Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron (2017) 0.79

Dynamics of Phosphoinositide-Dependent Signaling in Sympathetic Neurons. J Neurosci (2016) 0.79

Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain. Biochemistry (2015) 0.77

Phosphoinositide signaling in somatosensory neurons. Adv Biol Regul (2015) 0.76

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels. Sci Rep (2016) 0.75

TRPM3 joins the ranks of PI(4,5)P2 sensitive ion channels. Channels (Austin) (2015) 0.75

Phospholipase C δ4 regulates cold sensitivity in mice. J Physiol (2016) 0.75

Photobiomodulation and the brain: a new paradigm. J Opt (2016) 0.75

Phosphoinositide kinases. Annu Rev Biochem (1998) 8.51

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature (1998) 6.32

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (2001) 6.26

The menthol receptor TRPM8 is the principal detector of environmental cold. Nature (2007) 6.16

TRPM8 is required for cold sensation in mice. Neuron (2007) 5.25

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science (2006) 5.10

Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron (2002) 4.58

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron (2003) 4.46

The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE (2001) 4.45

Regulation of cardiac Na+,Ca2+ exchange and KATP potassium channels by PIP2. Science (1996) 4.36

Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science (1998) 4.34

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci (2005) 4.00

PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89

PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science (1998) 3.88

The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol (2002) 3.63

Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells. J Cell Biol (2006) 3.56

A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science (2003) 3.51

The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron (2007) 3.48

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Neuron (2002) 3.37

A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron (2010) 3.31

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature (2011) 3.14

PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science (2012) 3.05

Anionic phospholipids activate ATP-sensitive potassium channels. J Biol Chem (1997) 2.99

Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci U S A (2003) 2.91

TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77

Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell (2011) 2.69

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66

Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet (2002) 2.63

Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate. J Neurosci (2005) 2.59

Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol (2006) 2.58

PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun (2010) 2.54

Dual regulation of TRPV1 by phosphoinositides. J Neurosci (2007) 2.48

Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates. Proc Natl Acad Sci U S A (1998) 2.48

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35

Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. Mol Cell (2007) 2.33

Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci (2005) 2.28

Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol (2007) 2.26

Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides. Physiol Rev (2010) 2.25

The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J (2006) 2.22

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest (2003) 2.09

Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proc Natl Acad Sci U S A (2003) 2.04

The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem (2008) 2.03

Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc Natl Acad Sci U S A (2007) 2.02

Activation of TRP channels by protons and phosphoinositide depletion in Drosophila photoreceptors. Curr Biol (2010) 2.02

Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. J Neurosci (2005) 1.97

Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. J Biol Chem (2005) 1.94

Membrane recognition and targeting by lipid-binding domains. Sci STKE (2003) 1.94

Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am J Hum Genet (2012) 1.91

TRP channels and lipids: from Drosophila to mammalian physiology. J Physiol (2006) 1.90

Transient receptor potential channels meet phosphoinositides. EMBO J (2008) 1.89

Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem (2005) 1.86

Stretch-activated ion channels: what are they? Physiology (Bethesda) (2010) 1.85

TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron (2013) 1.73

Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J Neurosci (2010) 1.66

Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates. J Neurosci (2007) 1.66

Inorganic polyphosphate modulates TRPM8 channels. PLoS One (2009) 1.64

PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol Cell Biol (2005) 1.64

The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63

Regulation of inositol lipid-specific phospholipase cdelta by changes in Ca2+ ion concentrations. Biochem J (1997) 1.60

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res (2007) 1.56

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol (2010) 1.56

Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell (2008) 1.52

Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47

Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proc Natl Acad Sci U S A (2004) 1.46

Voltage-sensing phosphatase: actions and potentials. J Physiol (2008) 1.45

Regulation of Drosophila transient receptor potential-like (TrpL) channels by phospholipase C-dependent mechanisms. J Physiol (2001) 1.45

Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron (2010) 1.44

Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44

Localization of the PIP2 sensor of TRPV1 ion channels. J Biol Chem (2011) 1.38

Regulation of TRP channels by PIP(2). Pflugers Arch (2006) 1.37

Determinants of molecular specificity in phosphoinositide regulation. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the endogenous lipid regulating TRPV1. J Biol Chem (2008) 1.37

Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation. J Physiol (2006) 1.35

PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+. J Gen Physiol (2005) 1.35

Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton. Pflugers Arch (1996) 1.33

The puzzle of TRPV4 channelopathies. EMBO Rep (2013) 1.33

Drosophila visual transduction. Trends Neurosci (2012) 1.32

Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation. J Neurosci (2005) 1.31

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31

Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29

The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A (2011) 1.29

Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms. Trends Biochem Sci (2012) 1.29

TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J Neurosci (2011) 1.28

Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels. Pflugers Arch (2008) 1.26

Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate. Cell Calcium (2007) 1.25

Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance. Prog Lipid Res (2010) 1.23

Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol (2009) 1.22

Regulation of voltage-gated potassium channels by PI(4,5)P2. J Gen Physiol (2012) 1.22

Molecular characteristics of phosphoinositide binding. Pflugers Arch (2007) 1.22

Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. J Biol Chem (2006) 1.21

Assaying phosphatidylinositol bisphosphate regulation of potassium channels. Methods Enzymol (2002) 1.21

Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate. J Neurosci (2010) 1.19

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity. Sci Rep (2011) 1.18

Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin. Proc Natl Acad Sci U S A (2001) 1.17

Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Arch (2007) 1.16

Phospholipids as modulators of K(ATP) channels: distinct mechanisms for control of sensitivity to sulphonylureas, K(+) channel openers, and ATP. Mol Pharmacol (2001) 1.16

Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J Physiol (2011) 1.16

Direct inhibition of the cold-activated TRPM8 ion channel by Gαq. Nat Cell Biol (2012) 1.15

ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes. Am J Physiol Cell Physiol (2006) 1.15

Dual-mode phospholipid regulation of human inward rectifying potassium channels. Biophys J (2011) 1.14