Published in Blood on June 27, 2007
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
Homologous recombination in DNA repair and DNA damage tolerance. Cell Res (2008) 3.86
PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A (2009) 2.98
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
DNA interstrand crosslink repair in mammalian cells: step by step. Crit Rev Biochem Mol Biol (2010) 1.82
Replication protein A: directing traffic at the intersection of replication and repair. Front Biosci (Landmark Ed) (2010) 1.77
G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci (2009) 1.54
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem (2009) 1.43
Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase. Mol Cell (2009) 1.32
Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst) (2008) 1.23
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Nucleic Acids Res (2012) 1.20
A ChIP-chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response. Nucleic Acids Res (2009) 1.16
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res (2014) 1.10
Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle (2008) 1.09
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem (2009) 1.04
Sequence-dependent base pair stepping dynamics in XPD helicase unwinding. Elife (2013) 1.02
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Curr Mol Med (2009) 1.00
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction. Trends Genet (2011) 1.00
Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy. Curr Cancer Drug Targets (2009) 1.00
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA. Mutat Res (2009) 0.99
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem (2013) 0.99
MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response. Haematologica (2011) 0.97
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome. Cell Mol Life Sci (2014) 0.95
FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses. Chromosoma (2010) 0.94
Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response. Mol Cell Biol (2013) 0.93
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity. EMBO J (2016) 0.92
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia. Front Genet (2014) 0.91
Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol Biol (2013) 0.91
Chl1 DNA helicase regulates Scc2 deposition specifically during DNA-replication in Saccharomyces cerevisiae. PLoS One (2013) 0.89
FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation. Oncotarget (2015) 0.87
Unwinding and rewinding: double faces of helicase? J Nucleic Acids (2012) 0.86
Mechanistic and biological aspects of helicase action on damaged DNA. Cell Cycle (2010) 0.86
Helicase-inactivating mutations as a basis for dominant negative phenotypes. Cell Cycle (2010) 0.86
Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner. J Biol Chem (2014) 0.85
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response. PLoS Genet (2012) 0.84
3-Methyladenine DNA glycosylase is important for cellular resistance to psoralen interstrand cross-links. DNA Repair (Amst) (2008) 0.84
The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization. J Biol Chem (2014) 0.82
Close encounters for the first time: Helicase interactions with DNA damage. DNA Repair (Amst) (2015) 0.80
A distinct triplex DNA unwinding activity of ChlR1 helicase. J Biol Chem (2015) 0.80
What is wrong with Fanconi anemia cells? Cell Cycle (2014) 0.79
Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutations. J Biol Chem (2014) 0.79
Solving the Telomere Replication Problem. Genes (Basel) (2017) 0.76
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids. Nucleic Acids Res (2017) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem (1997) 9.83
Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nat Genet (2006) 7.72
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev (2000) 7.29
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell (2001) 5.05
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. Nat Genet (2005) 4.92
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol (2004) 4.78
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A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res (2006) 4.49
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev (2006) 4.18
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Nat Genet (2005) 4.13
The Fanconi Anemia/BRCA pathway: new faces in the crowd. Genes Dev (2005) 3.90
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol Cell Biol (2003) 3.85
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell (2005) 3.44
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol (2004) 3.26
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. J Biol Chem (2000) 3.17
The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. Nat Genet (2005) 2.86
Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem (1999) 2.77
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier. Cancer Res (1998) 2.72
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains. Mol Cell (2006) 2.61
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc Natl Acad Sci U S A (2004) 2.41
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell (2004) 2.31
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure (2004) 1.82
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A. Nucleic Acids Res (1998) 1.80
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Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer. J Biol Chem (2005) 1.67
Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A. Nucleic Acids Res (2004) 1.60
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem (2005) 1.52
The Fanconi anemia pathway of genomic maintenance. Cell Oncol (2006) 1.52
Direct DNA binding activity of the Fanconi anemia D2 protein. J Biol Chem (2005) 1.33
BACH1 is a DNA repair protein supporting BRCA1 damage response. Oncogene (2006) 1.29
Dedicated to the core: understanding the Fanconi anemia complex. DNA Repair (Amst) (2006) 1.27
The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair. Exp Cell Res (2006) 1.24
Bipolar DNA translocation contributes to highly processive DNA unwinding by RecBCD enzyme. J Biol Chem (2005) 1.15
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand. Nucleic Acids Res (2006) 1.15
p53 modulates RPA-dependent and RPA-independent WRN helicase activity. Cancer Res (2005) 1.06
Assessing the link between BACH1 and BRCA1 in the FA pathway. Cell Cycle (2006) 1.02
DNA unwinding by Escherichia coli DNA helicase I (TraI) provides evidence for a processive monomeric molecular motor. J Biol Chem (2006) 1.02
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mech Ageing Dev (2003) 1.01
BRCA1 modulates ionizing radiation-induced nuclear focus formation by the replication protein A p34 subunit. J Cell Biochem (2002) 0.96
Hypersensitivity of Brca1-deficient MEF to the DNA interstrand crosslinking agent mitomycin C is associated with defect in homologous recombination repair and aberrant S-phase arrest. Oncogene (2005) 0.84
The 13th Fanconi anemia gene identified: FANCI--importance of the 'Fanconi anemia pathway' for cellular oncology. Cell Oncol (2007) 0.82
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev (2006) 4.18
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell (2005) 3.44
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev (2002) 2.26
Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem (2005) 2.11
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J (2007) 1.86
Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase. J Biol Chem (2002) 1.76
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer. J Biol Chem (2005) 1.67
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A. Nucleic Acids Res (2004) 1.60
G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem (2005) 1.52
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proc Natl Acad Sci U S A (2011) 1.45
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem (2009) 1.43
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS One (2007) 1.38
RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem (2005) 1.36
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. Hum Mol Genet (2004) 1.21
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Nucleic Acids Res (2012) 1.20
RECQ1 possesses DNA branch migration activity. J Biol Chem (2008) 1.19
Biochemical characterization of the WRN-FEN-1 functional interaction. Biochemistry (2002) 1.19
Biochemical characterization of Warsaw breakage syndrome helicase. J Biol Chem (2011) 1.19
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. Nucleic Acids Res (2002) 1.16
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand. Nucleic Acids Res (2006) 1.15
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein. J Biol Chem (2004) 1.14
A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster. Mol Cell Biol (2013) 1.10
The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. J Biol Chem (2003) 1.09
Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle (2008) 1.09
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Res (2005) 1.08
Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein. Nucleic Acids Res (2003) 1.07
p53 modulates RPA-dependent and RPA-independent WRN helicase activity. Cancer Res (2005) 1.06
Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene. Gene (2002) 1.06
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. J Biol Chem (2005) 1.05
Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst) (2010) 1.05
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem (2009) 1.04
Cockayne syndrome group B protein has novel strand annealing and exchange activities. Nucleic Acids Res (2006) 1.04
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Curr Mol Med (2009) 1.00
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction. Trends Genet (2011) 1.00
BRCA-FA pathway as a target for anti-tumor drugs. Anticancer Agents Med Chem (2008) 1.00
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product. Oncogene (2002) 1.00
DNA helicases as targets for anti-cancer drugs. Curr Med Chem Anticancer Agents (2005) 1.00
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem (2013) 0.99
Hitting the bull's eye: novel directed cancer therapy through helicase-targeted synthetic lethality. J Cell Biochem (2009) 0.97
Disease-causing missense mutations in human DNA helicase disorders. Mutat Res (2012) 0.95
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome. Cell Mol Life Sci (2014) 0.95
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med (2012) 0.95
Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol Cancer (2013) 0.94
Specific stimulation of human apurinic/apyrimidinic endonuclease by heat shock protein 70. DNA Repair (Amst) (2003) 0.93
Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response. Mol Cell Biol (2013) 0.93
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion. Cell Cycle (2014) 0.92
WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3. Aging (Albany NY) (2009) 0.92
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks. PLoS One (2013) 0.92
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures. Cell Cycle (2012) 0.91