Published in Aging (Albany NY) on February 05, 2009
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
Functional deficit associated with a missense Werner syndrome mutation. DNA Repair (Amst) (2013) 0.87
Mechanistic and biological aspects of helicase action on damaged DNA. Cell Cycle (2010) 0.86
Helicase-inactivating mutations as a basis for dominant negative phenotypes. Cell Cycle (2010) 0.86
The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress. PLoS One (2010) 0.85
Delineation of WRN helicase function with EXO1 in the replicational stress response. DNA Repair (Amst) (2010) 0.82
Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics. DNA Repair (Amst) (2012) 0.75
Genetic studies of human DNA repair proteins using yeast as a model system. J Vis Exp (2010) 0.75
Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure. Yeast (1995) 13.20
The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature (2003) 8.68
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol Cell Biol (1994) 7.31
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell (2003) 5.45
Mechanism of homologous recombination: mediators and helicases take on regulatory functions. Nat Rev Mol Cell Biol (2006) 4.79
Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci U S A (1989) 3.55
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Proc Natl Acad Sci U S A (1998) 3.14
The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease. Nat Genet (1998) 3.12
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Proc Natl Acad Sci U S A (2006) 3.00
Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem (1999) 2.77
A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. J Biol Chem (2006) 2.69
RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination. Mol Cell (1999) 2.64
Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol (2007) 2.56
Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae. Genetics (2000) 2.55
BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev (2008) 2.29
Homologous recombination resolution defect in werner syndrome. Mol Cell Biol (2002) 2.21
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. Cancer Res (2000) 2.13
Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol Cell Biol (2005) 2.06
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev (2008) 1.97
Mapping the DNA topoisomerase III binding domain of the Sgs1 DNA helicase. J Biol Chem (2000) 1.96
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
The HRDC domain of BLM is required for the dissolution of double Holliday junctions. EMBO J (2005) 1.84
Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae. Genetics (2002) 1.79
Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Nucleic Acids Res (2000) 1.63
Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem (2003) 1.62
Loss of Werner syndrome protein function promotes aberrant mitotic recombination. Genes Dev (2001) 1.61
Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex. J Biol Chem (2007) 1.59
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Differential regulation of human RecQ family helicases in cell transformation and cell cycle. Oncogene (2000) 1.46
Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast. Genes Cells (1999) 1.39
Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS One (2007) 1.38
WRN helicase expression in Werner syndrome cell lines. Nucleic Acids Res (2000) 1.32
Replication fork blockage by RTS1 at an ectopic site promotes recombination in fission yeast. EMBO J (2005) 1.32
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. Hum Mol Genet (2004) 1.21
RecQ helicase stimulates both DNA catenation and changes in DNA topology by topoisomerase III. J Biol Chem (2003) 1.20
Werner protein stimulates topoisomerase I DNA relaxation activity. Cancer Res (2003) 1.15
Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana. PLoS Genet (2008) 1.13
Functional analysis of human MutSalpha and MutSbeta complexes in yeast. Nucleic Acids Res (1999) 1.13
Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: studies of fusion proteins. Proc Natl Acad Sci U S A (2001) 1.11
Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle (2008) 1.09
The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C. J Biol Chem (2004) 1.08
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. J Biol Chem (2005) 1.05
A role for the fission yeast Rqh1 helicase in chromosome segregation. J Cell Sci (2005) 1.02
Understanding the roles of RecQ helicases in the maintenance of genome integrity and suppression of tumorigenesis. Biochem Soc Trans (2004) 0.95
The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1. DNA Repair (Amst) (2008) 0.91
Processing of DNA replication and repair intermediates by the concerted action of RecQ helicases and Rad2 structure-specific nucleases. Protein Pept Lett (2008) 0.82
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem (2005) 2.11
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J (2007) 1.86
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer. J Biol Chem (2005) 1.67
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A. Nucleic Acids Res (2004) 1.60
G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem (2005) 1.52
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proc Natl Acad Sci U S A (2011) 1.45
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem (2009) 1.43
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS One (2007) 1.38
RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem (2005) 1.36
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. Hum Mol Genet (2004) 1.21
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Nucleic Acids Res (2012) 1.20
RECQ1 possesses DNA branch migration activity. J Biol Chem (2008) 1.19
Biochemical characterization of Warsaw breakage syndrome helicase. J Biol Chem (2011) 1.19
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. Nucleic Acids Res (2002) 1.16
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand. Nucleic Acids Res (2006) 1.15
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein. J Biol Chem (2004) 1.14
The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. J Biol Chem (2003) 1.09
Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle (2008) 1.09
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Res (2005) 1.08
Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein. Nucleic Acids Res (2003) 1.07
p53 modulates RPA-dependent and RPA-independent WRN helicase activity. Cancer Res (2005) 1.06
Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene. Gene (2002) 1.06
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. J Biol Chem (2005) 1.05
Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst) (2010) 1.05
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem (2009) 1.04
Cockayne syndrome group B protein has novel strand annealing and exchange activities. Nucleic Acids Res (2006) 1.04
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Curr Mol Med (2009) 1.00
BRCA-FA pathway as a target for anti-tumor drugs. Anticancer Agents Med Chem (2008) 1.00
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction. Trends Genet (2011) 1.00
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product. Oncogene (2002) 1.00
DNA helicases as targets for anti-cancer drugs. Curr Med Chem Anticancer Agents (2005) 1.00
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem (2013) 0.99
Hitting the bull's eye: novel directed cancer therapy through helicase-targeted synthetic lethality. J Cell Biochem (2009) 0.97
Disease-causing missense mutations in human DNA helicase disorders. Mutat Res (2012) 0.95
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome. Cell Mol Life Sci (2014) 0.95
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med (2012) 0.95
Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response. Mol Cell Biol (2013) 0.93
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks. PLoS One (2013) 0.92
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures. Cell Cycle (2012) 0.91
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome. Hum Mutat (2012) 0.90
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
Human replication protein A melts a DNA triple helix structure in a potent and specific manner. Biochemistry (2008) 0.89
Helicases as prospective targets for anti-cancer therapy. Anticancer Agents Med Chem (2008) 0.88
Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle (2013) 0.87
DNA repair helicases as targets for anti-cancer therapy. Curr Med Chem (2007) 0.86
Helicase-inactivating mutations as a basis for dominant negative phenotypes. Cell Cycle (2010) 0.86
Mechanistic and biological aspects of helicase action on damaged DNA. Cell Cycle (2010) 0.86
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res (2013) 0.86
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function. J Biol Chem (2012) 0.86
Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A. J Biol Chem (2005) 0.85
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response. PLoS Genet (2012) 0.84
DNA helicases associated with genetic instability, cancer, and aging. Adv Exp Med Biol (2013) 0.83
Tetraplex binding molecules as anti-cancer agents. Recent Pat Anticancer Drug Discov (2006) 0.82
Processing of DNA replication and repair intermediates by the concerted action of RecQ helicases and Rad2 structure-specific nucleases. Protein Pept Lett (2008) 0.82
Delineation of WRN helicase function with EXO1 in the replicational stress response. DNA Repair (Amst) (2010) 0.82
Pathways defective in the human premature aging disease Werner syndrome. Biogerontology (2002) 0.81
Put on your thinking cap: G-quadruplexes, helicases, and telomeres. Aging (Albany NY) (2011) 0.80
Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent. J Biol Chem (2003) 0.79
DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion. J Biol Chem (2012) 0.79
What is wrong with Fanconi anemia cells? Cell Cycle (2014) 0.79
A new development in DNA repair modulation: discovery of a BLM helicase inhibitor. Cell Cycle (2013) 0.78
Molecular biology: The Bloom's complex mousetrap. Nature (2008) 0.78
DNA repair as a target for anti-cancer therapy. Anticancer Agents Med Chem (2008) 0.77
Molecular analyses of DNA helicases involved in the replicational stress response. Methods (2010) 0.77
Premature aging syndrome gene WRN genetically interacts with a topoisomerase. Cell Cycle (2009) 0.76
Genetic mutants illuminate the roles of RecQ helicases in recombinational repair or response to replicational stress. Cell Cycle (2010) 0.76
Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics. DNA Repair (Amst) (2012) 0.75
Genetic studies of human DNA repair proteins using yeast as a model system. J Vis Exp (2010) 0.75
Setting the stage for cohesion establishment by the replication fork. Cell Cycle (2012) 0.75
Finding a needle in the haystack: recognition of DNA damage by collaboration between DNA repair proteins able to perform DNA charge transport. Cell Cycle (2012) 0.75