Published in Cell on April 06, 2001
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science (2007) 6.70
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol (2004) 4.78
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev (2006) 4.18
A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome. Genome Res (2008) 4.06
BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer (2011) 3.85
BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol (2009) 3.79
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol (2008) 3.22
Mutations in BRIP1 confer high risk of ovarian cancer. Nat Genet (2011) 3.06
PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A (2009) 2.98
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev (2009) 2.49
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc Natl Acad Sci U S A (2004) 2.41
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev (2002) 2.26
RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev (2011) 2.00
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem (2008) 1.93
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A (2005) 1.91
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J (2007) 1.86
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J (2003) 1.82
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure (2004) 1.82
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat Res (2009) 1.80
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med (2011) 1.79
Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics (2004) 1.76
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol (2015) 1.73
Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase. Mol Cell Biol (2007) 1.72
Postreplicative mismatch repair. Cold Spring Harb Perspect Biol (2013) 1.67
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A (2001) 1.67
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell (2010) 1.65
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol (2013) 1.62
HapScope: a software system for automated and visual analysis of functionally annotated haplotypes. Nucleic Acids Res (2002) 1.60
G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci (2009) 1.54
DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair. Mol Cell Biol (2007) 1.53
Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks. DNA Repair (Amst) (2007) 1.52
Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer. Proc Natl Acad Sci U S A (2008) 1.50
PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem (2009) 1.50
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci (2009) 1.49
Functional impact of missense variants in BRCA1 predicted by supervised learning. PLoS Comput Biol (2006) 1.49
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints. Trends Cell Biol (2010) 1.44
Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence. Dev Cell (2011) 1.43
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem (2009) 1.43
Choreography of recombination proteins during the DNA damage response. DNA Repair (Amst) (2009) 1.40
Sequence conservation and differential expression of Marek's disease virus microRNAs. J Virol (2008) 1.34
Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase. Mol Cell (2009) 1.32
Mechanisms of BRCA1 tumor suppression. Cancer Discov (2012) 1.32
FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair. Cell Cycle (2011) 1.25
Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function. Oncogene (2009) 1.25
Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst) (2008) 1.23
Fanconi anemia and breast cancer susceptibility meet again. Nat Genet (2010) 1.22
The ubiquitin E3 ligase activity of BRCA1 and its biological functions. Cell Div (2008) 1.21
FANCJ couples replication past natural fork barriers with maintenance of chromatin structure. J Cell Biol (2013) 1.21
Telomeres: structures in need of unwinding. FEBS Lett (2010) 1.21
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Nucleic Acids Res (2012) 1.20
Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci. Mol Biol Cell (2004) 1.20
Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network. Chromosoma (2008) 1.18
Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Anal Biochem (2007) 1.18
Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals. Breast Cancer Res (2011) 1.17
Redox control of the DNA damage-inducible protein DinG helicase activity via its iron-sulfur cluster. J Biol Chem (2008) 1.16
A ChIP-chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response. Nucleic Acids Res (2009) 1.16
FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. J Biol Chem (2009) 1.15
Functional assays for BRCA1 and BRCA2. Int J Biochem Cell Biol (2006) 1.15
Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80. Mol Cell Biol (2008) 1.15
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand. Nucleic Acids Res (2006) 1.15
New players in the BRCA1-mediated DNA damage responsive pathway. Mol Cells (2008) 1.13
Transcription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells. BMC Genomics (2008) 1.12
BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. Mol Cell (2015) 1.12
Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1. Future Oncol (2011) 1.11
The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment. Oncogene (2012) 1.11
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass. Oncogene (2010) 1.10
The Fanconi anemia pathway and ubiquitin. BMC Biochem (2007) 1.10
Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer. BMC Cancer (2008) 1.09
TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage. Mol Cell Biol (2001) 1.09
Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer. PLoS One (2007) 1.08
Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions. Sci Transl Med (2012) 1.07
Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem (2010) 1.06
RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem (2012) 1.05
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem (2009) 1.04
Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer. Breast Cancer Res (2005) 1.03
BRCA1 tumor suppressor network: focusing on its tail. Cell Biosci (2012) 1.03
Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2 mutation status. Breast Cancer Res (2003) 1.03
BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability. J Mol Cell Biol (2011) 1.02
RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer. Carcinogenesis (2010) 1.02
Rescue of replication failure by Fanconi anaemia proteins. Chromosoma (2011) 1.02
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion. J Cell Biol (2005) 1.01
Structural characterization of BRCT-tetrapeptide binding interactions. Biochem Biophys Res Commun (2010) 1.01
BACH1 Ser919Pro variant and breast cancer risk. BMC Cancer (2006) 1.01
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Curr Mol Med (2009) 1.00
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction. Trends Genet (2011) 1.00
Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy. Curr Cancer Drug Targets (2009) 1.00
Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. Eur J Hum Genet (2008) 1.00
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA. Mutat Res (2009) 0.99
Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry (2008) 0.99
Long-range massively parallel mate pair sequencing detects distinct mutations and similar patterns of structural mutability in two breast cancer cell lines. Cancer Genet (2011) 0.98
Distinct functions of BRCA1 and BRCA2 in double-strand break repair. Breast Cancer Res (2001) 0.98
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell (1991) 15.76
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell (1997) 13.94
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell (1994) 13.76
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell (1988) 12.69
A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature (1994) 11.50
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell (2001) 8.99
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev (1994) 8.92
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74
SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev (1992) 8.60
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science (1995) 8.58
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell (1990) 8.30
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell (1998) 7.37
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell (1993) 7.19
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell (1998) 6.73
Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell (1991) 6.55
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell (1989) 6.43
Immunoaffinity chromatography of proteins. Methods Enzymol (1974) 6.40
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science (1999) 6.38
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58
E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer (1995) 5.24
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem (1996) 5.15
Binding and modulation of p53 by p300/CBP coactivators. Nature (1997) 5.12
A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol (2007) 5.12
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science (1999) 5.09
The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell (1992) 5.05
A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature (1994) 5.01
Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med (1993) 4.99
Identification of self peptides bound to purified HLA-B27. Nature (1991) 4.88
Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell (1999) 4.87
T antigen repression of SV40 early transcription from two promoters. Cell (1981) 4.83
Distinct functions of SR proteins in alternative pre-mRNA splicing. Science (1993) 4.79
The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. Nature (1999) 4.69
An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A (1996) 4.57
Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev (1992) 4.56
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature (1995) 4.40
In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature (2000) 4.38
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell (1991) 4.24
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev (2000) 4.23
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell (1994) 4.01
Universality and structure of the N-end rule. J Biol Chem (1989) 3.97
Spinocerebellar ataxia type 5 in a family descended from the grandparents of President Lincoln maps to chromosome 11. Nat Genet (1994) 3.89
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (1996) 3.88
SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell (1989) 3.88
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell (1998) 3.86
Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature (1992) 3.85
Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83
Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. Nature (1992) 3.82
Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med (2000) 3.72
Cloning of a human gene encoding the general transcription initiation factor IIB. Nature (1991) 3.67
Heterozygous ATM mutations do not contribute to early onset of breast cancer. Nat Genet (1997) 3.66
Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion. Cell (1980) 3.62
Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell (1992) 3.62
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell (1990) 3.61
Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Science (1995) 3.53
A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature (1996) 3.50
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature (2001) 3.50
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature (2000) 3.48
Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell (1991) 3.47
An RNA polymerase II elongation factor encoded by the human ELL gene. Science (1996) 3.46
Interaction of poliovirus polypeptide 3CDpro with the 5' and 3' termini of the poliovirus genome. Identification of viral and cellular cofactors needed for efficient binding. J Biol Chem (1994) 3.45
Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism. Genes Dev (1994) 3.45
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A (1996) 3.43
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing. Proc Natl Acad Sci U S A (1991) 3.43
Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell (2001) 3.43
Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39
Requirement of RSF and FACT for transcription of chromatin templates in vitro. Science (1998) 3.38
Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell (2001) 3.34
lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33
Infectious C-type virus isolated from a baboon placenta. Nature (1974) 3.32
Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells. Cell (1988) 3.29
p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell (1998) 3.27
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev (1996) 3.24
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science (1993) 3.24
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24
E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell (1994) 3.24
Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol (1972) 3.23
Role of IRS-2 in insulin and cytokine signalling. Nature (1995) 3.23
Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol (1996) 3.20
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell (1990) 3.19
Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Med (1996) 3.07
Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature (1995) 3.05
The p400 complex is an essential E1A transformation target. Cell (2001) 3.05
E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev (1994) 3.05
Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med (1996) 3.04