Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
|
Science
|
2007
|
37.88
|
2
|
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
|
Nat Genet
|
2008
|
35.06
|
3
|
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
Science
|
2007
|
32.97
|
4
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
5
|
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
Nat Genet
|
2010
|
16.96
|
6
|
Genome-wide association analysis identifies 20 loci that influence adult height.
|
Nat Genet
|
2008
|
16.92
|
7
|
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
|
Nat Genet
|
2008
|
15.94
|
8
|
Metformin and reduced risk of cancer in diabetic patients.
|
BMJ
|
2005
|
13.04
|
9
|
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
|
Nat Genet
|
2007
|
12.65
|
10
|
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
Nat Genet
|
2012
|
11.09
|
11
|
Variants in MTNR1B influence fasting glucose levels.
|
Nat Genet
|
2008
|
10.85
|
12
|
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
Nat Genet
|
2012
|
7.59
|
13
|
A common variant of HMGA2 is associated with adult and childhood height in the general population.
|
Nat Genet
|
2007
|
6.87
|
14
|
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|
Nat Genet
|
2010
|
6.66
|
15
|
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes.
|
Diabetes Care
|
2009
|
6.17
|
16
|
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.
|
Nat Genet
|
2008
|
5.93
|
17
|
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
|
PLoS Genet
|
2009
|
5.81
|
18
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
19
|
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
|
Diabetes
|
2008
|
4.57
|
20
|
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
|
Nat Genet
|
2010
|
4.42
|
21
|
Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource use.
|
Diabetes Care
|
2003
|
4.23
|
22
|
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
Nat Genet
|
2014
|
4.13
|
23
|
Genome-wide association study identifies five loci associated with lung function.
|
Nat Genet
|
2009
|
4.10
|
24
|
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
|
N Engl J Med
|
2016
|
3.88
|
25
|
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
|
Diabetes
|
2008
|
3.76
|
26
|
Common variants in WFS1 confer risk of type 2 diabetes.
|
Nat Genet
|
2007
|
3.58
|
27
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
28
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
29
|
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
|
Nat Genet
|
2011
|
3.03
|
30
|
Common variants associated with plasma triglycerides and risk for coronary artery disease.
|
Nat Genet
|
2013
|
2.92
|
31
|
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
|
PLoS Genet
|
2012
|
2.34
|
32
|
Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability.
|
BMC Med Genet
|
2006
|
2.25
|
33
|
Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
|
Diabetes
|
2007
|
2.03
|
34
|
Screening for and treating left-ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deaths.
|
Lancet
|
2002
|
1.89
|
35
|
Comparison of cardiovascular risk between patients with type 2 diabetes and those who had had a myocardial infarction: cross sectional and cohort studies.
|
BMJ
|
2002
|
1.81
|
36
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
37
|
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.
|
PLoS Med
|
2013
|
1.70
|
38
|
Risk of cardiovascular disease and total mortality in adults with type 1 diabetes: Scottish registry linkage study.
|
PLoS Med
|
2012
|
1.69
|
39
|
Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness.
|
Int J Epidemiol
|
2012
|
1.67
|
40
|
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
|
Diabetes
|
2008
|
1.64
|
41
|
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.
|
Hum Mol Genet
|
2009
|
1.61
|
42
|
Underlying genetic models of inheritance in established type 2 diabetes associations.
|
Am J Epidemiol
|
2009
|
1.60
|
43
|
No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis.
|
Diabetes Obes Metab
|
2007
|
1.50
|
44
|
Effect of Metformin on mortality in patients with heart failure and type 2 diabetes mellitus.
|
Am J Cardiol
|
2010
|
1.50
|
45
|
Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy.
|
J Clin Endocrinol Metab
|
2009
|
1.36
|
46
|
Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
|
Diabetes
|
2009
|
1.34
|
47
|
Development and validation of a model for predicting emergency admissions over the next year (PEONY): a UK historical cohort study.
|
Arch Intern Med
|
2008
|
1.34
|
48
|
Locality deprivation and Type 2 diabetes incidence: a local test of relative inequalities.
|
Soc Sci Med
|
2007
|
1.30
|
49
|
Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.
|
Diabetes
|
2011
|
1.29
|
50
|
Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.
|
Arterioscler Thromb Vasc Biol
|
2004
|
1.26
|
51
|
Effect of socioeconomic status on mortality among people with type 2 diabetes: a study from the Scottish Diabetes Research Network Epidemiology Group.
|
Diabetes Care
|
2011
|
1.26
|
52
|
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
|
Diabetes
|
2013
|
1.25
|
53
|
Metformin in cancer treatment and prevention.
|
Annu Rev Med
|
2014
|
1.23
|
54
|
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe).
|
Invest Ophthalmol Vis Sci
|
2011
|
1.22
|
55
|
Interventions for impetigo.
|
Cochrane Database Syst Rev
|
2012
|
1.19
|
56
|
A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study.
|
Pharmacogenet Genomics
|
2008
|
1.19
|
57
|
Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study.
|
Pharmacogenet Genomics
|
2008
|
1.18
|
58
|
Reduced incidence of lower-extremity amputations in people with diabetes in Scotland: a nationwide study.
|
Diabetes Care
|
2012
|
1.14
|
59
|
Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study.
|
Circulation
|
2005
|
1.13
|
60
|
Mortality and hospitalization in patients after amputation: a comparison between patients with and without diabetes.
|
Diabetes Care
|
2006
|
1.09
|
61
|
The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study.
|
Circ Cardiovasc Genet
|
2009
|
1.07
|
62
|
Glycemic exposure and blood pressure influencing progression and remission of diabetic retinopathy: a longitudinal cohort study in GoDARTS.
|
Diabetes Care
|
2013
|
1.07
|
63
|
Derivation and validation of a prediction score for major coronary heart disease events in a U.K. type 2 diabetic population.
|
Diabetes Care
|
2006
|
1.07
|
64
|
Mortality in people diagnosed with type 2 diabetes at an older age: a systematic review.
|
Age Ageing
|
2006
|
1.04
|
65
|
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.
|
PLoS One
|
2012
|
1.02
|
66
|
Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
|
Diabetes
|
2012
|
1.00
|
67
|
Accidents in patients with insulin-treated diabetes: increased risk of low-impact falls but not motor vehicle crashes--a prospective register-based study.
|
J Trauma
|
2002
|
1.00
|
68
|
Diagnosis of type 2 diabetes at an older age: effect on mortality in men and women.
|
Diabetes Care
|
2004
|
0.98
|
69
|
Mortality from cerebrovascular disease in a cohort of 23 000 patients with insulin-treated diabetes.
|
Stroke
|
2003
|
0.98
|
70
|
Using continuous glucose monitoring to measure the frequency of low glucose values when using biphasic insulin aspart 30 compared with biphasic human insulin 30: a double-blind crossover study in individuals with type 2 diabetes.
|
Diabetes Care
|
2007
|
0.96
|
71
|
Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.
|
Diabetes
|
2009
|
0.95
|
72
|
Association of common variation in the PPARA gene with incident myocardial infarction in individuals with type 2 diabetes: a Go-DARTS study.
|
Nucl Recept
|
2005
|
0.95
|
73
|
The Walker Project: a longitudinal study of 48,000 children born 1952-1966 (aged 36-50 years in 2002) and their families.
|
Paediatr Perinat Epidemiol
|
2004
|
0.92
|
74
|
Relation of QT interval dispersion to the number of different cardiac abnormalities in diabetes mellitus.
|
Am J Cardiol
|
2002
|
0.91
|
75
|
Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study.
|
J Clin Endocrinol Metab
|
2010
|
0.90
|
76
|
Using web technology to support population-based diabetes care.
|
J Diabetes Sci Technol
|
2011
|
0.90
|
77
|
Impaired microvascular function in normal children: effects of adiposity and poor glucose handling.
|
J Physiol
|
2003
|
0.89
|
78
|
A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.
|
Biochem J
|
2005
|
0.86
|
79
|
Experimenting with clinical networks: the Australasian experience.
|
J Health Organ Manag
|
2012
|
0.84
|
80
|
A single nucleotide polymorphism on exon-4 of the gene encoding PPARdelta is associated with reduced height in adults and children.
|
J Clin Endocrinol Metab
|
2009
|
0.83
|
81
|
Commentary: a thesis that still warrants defence and promotion.
|
Int J Epidemiol
|
2012
|
0.83
|
82
|
Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.
|
Diabetes
|
2010
|
0.83
|
83
|
The epidemiology of liver disease in Tayside database: a population-based record-linkage study.
|
J Biomed Inform
|
2002
|
0.83
|
84
|
Evidence based medicine, guidelines and common sense.
|
Age Ageing
|
2004
|
0.83
|
85
|
Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study.
|
BMC Med Genet
|
2014
|
0.82
|
86
|
B-type natriuretic Peptide is associated with both augmentation index and left ventricular mass in diabetic patients without heart failure.
|
Am J Hypertens
|
2005
|
0.81
|
87
|
How much echo left ventricular hypertrophy would be missed in diabetics by applying the Losartan Intervention For Endpoint Reduction electrocardiogram criteria to select patients for angiotensin receptor blockade?
|
J Hypertens
|
2004
|
0.80
|
88
|
Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.
|
Pharmacogenet Genomics
|
2013
|
0.80
|
89
|
Genetic loci for retinal arteriolar microcirculation.
|
PLoS One
|
2013
|
0.80
|
90
|
B-type natriuretic peptide as an alternative way of assessing total cardiovascular risk in patients with diabetes mellitus.
|
Am J Cardiol
|
2005
|
0.79
|
91
|
Generation, validation and humanisation of a novel insulin resistant cell model.
|
Biochem Pharmacol
|
2010
|
0.79
|
92
|
The T allele of the C(677)T 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism may protect endothelial function in young, normal subjects.
|
Arterioscler Thromb Vasc Biol
|
2002
|
0.78
|
93
|
Screening using compressed digital retinal images successfully identifies retinopathy.
|
Diabetes Care
|
2003
|
0.78
|
94
|
Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis.
|
Cardiovasc Diabetol
|
2013
|
0.78
|
95
|
Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase.
|
PLoS One
|
2013
|
0.78
|
96
|
Birth weight does not predict blood pressure in a young working population: a sharp (Scottish Heart and Arterial Disease Risk Prevention) study.
|
Ann Epidemiol
|
2008
|
0.77
|
97
|
Copy number variation in the human Y chromosome in the UK population.
|
Hum Genet
|
2015
|
0.77
|
98
|
How could primary care meet the informatics needs of UK Biobank? A Scottish proposal.
|
Inform Prim Care
|
2003
|
0.77
|
99
|
Alzheimer's disease risk factor complement receptor 1 is associated with depression.
|
Neurosci Lett
|
2012
|
0.76
|
100
|
Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression.
|
Front Genet
|
2012
|
0.76
|
101
|
Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus.
|
BMC Genet
|
2003
|
0.75
|
102
|
Clues to duration of undiagnosed disease from retinopathy and maculopathy at diagnosis in type 2 diabetes: a cross-sectional study.
|
Br J Ophthalmol
|
2010
|
0.75
|
103
|
Herbal is not synonymous with safe.
|
Arch Dermatol
|
2002
|
0.75
|
104
|
Prediction of diabetic foot ulcer occurrence using commonly available clinical information: response to Boyko et al.
|
Diabetes Care
|
2006
|
0.75
|
105
|
Do general practice characteristics influence uptake of an information technology (IT) innovation in primary care?
|
Inform Prim Care
|
2008
|
0.75
|
106
|
A rare, rapidly growing purple tumor on the cheek. Chondroid syringoma.
|
Arch Dermatol
|
2004
|
0.75
|
107
|
Longer Patient Travel Times Associated with Decreased Follow-Up after Endovascular Aortic Aneurysm Repair (EVAR).
|
Am Surg
|
2017
|
0.75
|
108
|
Hepatic and splenic blush on computed tomography in children following blunt abdominal trauma: Is intervention necessary?
|
J Trauma Acute Care Surg
|
2016
|
0.75
|
109
|
Erratum to: Copy number variation in the human Y chromosome in the UK population.
|
Hum Genet
|
2015
|
0.75
|