Published in J Biol Chem on July 10, 2007
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol (2010) 5.14
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum (2009) 3.61
Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta (2011) 1.73
Pharmacologic therapy for osteoarthritis--the era of disease modification. Nat Rev Rheumatol (2010) 1.34
The history of matrix metalloproteinases: milestones, myths, and misperceptions. Am J Physiol Heart Circ Physiol (2012) 1.22
Post-traumatic osteoarthritis: from mouse models to clinical trials. Nat Rev Rheumatol (2013) 1.15
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants. Inflamm Res (2009) 1.12
Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arterioscler Thromb Vasc Biol (2011) 1.05
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease. EXS (2012) 1.03
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate. Bioorg Med Chem (2008) 1.03
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates. J Biol Chem (2012) 1.02
MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer (2010) 1.01
Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis. Ann Rheum Dis (2009) 1.00
Inhibition of matrix metalloproteinase-2 by PARP inhibitors. Biochem Biophys Res Commun (2009) 0.95
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds. Bioorg Med Chem Lett (2011) 0.94
An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer. PLoS One (2012) 0.93
Kinetics and thermodynamics of irreversible inhibition of matrix metalloproteinase 2 by a Co(III) Schiff base complex. J Biol Inorg Chem (2012) 0.90
Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Curr Drug Targets (2013) 0.87
Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain. FASEB J (2013) 0.87
Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression. Arthritis Res Ther (2008) 0.84
Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates. J Biol Chem (2013) 0.84
Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. Curr Rheumatol Rep (2013) 0.84
Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation. J Biol Chem (2010) 0.83
Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro. J Med Chem (2014) 0.82
Strategic targeting of multiple water-mediated interactions: a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors. ChemMedChem (2013) 0.82
Molecular determinants of matrix metalloproteinase-12 covalent modification by a photoaffinity probe: insights into activity-based probe development and conformational variability of matrix metalloproteinases. J Biol Chem (2008) 0.81
Merging allosteric and active site binding motifs: de novo generation of target selectivity and potency via natural-product-derived fragments. ChemMedChem (2014) 0.80
Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem (2012) 0.79
RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis Cartilage (2016) 0.78
Cheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domain. PLoS One (2010) 0.78
New strategies for targeting matrix metalloproteinases. Matrix Biol (2015) 0.77
An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors. PLoS One (2012) 0.77
Molecular Recognition of the Catalytic Zinc(II) Ion in MMP-13: Structure-Based Evolution of an Allosteric Inhibitor to Dual Binding Mode Inhibitors with Improved Lipophilic Ligand Efficiencies. Int J Mol Sci (2016) 0.77
Key Pathways to Prevent Posttraumatic Arthritis for Future Molecule-Based Therapy. Cartilage (2013) 0.76
Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease. J Pharmacol Exp Ther (2015) 0.76
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor. ChemistryOpen (2017) 0.75
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. J Med Chem (2015) 0.75
Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease. Prog Mol Biol Transl Sci (2017) 0.75
Binary image representation of a ligand binding site: its application to efficient sampling of a conformational ensemble. BMC Bioinformatics (2010) 0.75
Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders. Prog Mol Biol Transl Sci (2017) 0.75
Matrix metalloproteinase collagenolysis in health and disease. Biochim Biophys Acta (2017) 0.75
Multiple-laboratory comparison of microarray platforms. Nat Methods (2005) 11.74
Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA (2009) 9.47
HMDB 3.0--The Human Metabolome Database in 2013. Nucleic Acids Res (2012) 9.21
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet (2002) 7.58
DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res (2013) 6.73
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol (2004) 4.40
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells. Nature (2012) 3.09
Assessment of the accuracy of portion size reports using computer-based food photographs aids in the development of an automated self-administered 24-hour recall. J Am Diet Assoc (2010) 2.95
Improvement of pathology in sub-Saharan Africa. Lancet Oncol (2013) 2.88
A novel aux/IAA28 signaling cascade activates GATA23-dependent specification of lateral root founder cell identity. Curr Biol (2010) 2.81
Robotic cloning and Protein Production Platform of the Northeast Structural Genomics Consortium. Methods Enzymol (2005) 2.54
Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer? J Trauma (2008) 2.52
Translational biomarker discovery in clinical metabolomics: an introductory tutorial. Metabolomics (2012) 2.18
A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proc Natl Acad Sci U S A (2006) 2.02
A single-center strategy to minimize blood transfusion in neonates and children undergoing cardiac surgery. Paediatr Anaesth (2015) 2.01
maxdLoad2 and maxdBrowse: standards-compliant tools for microarray experimental annotation, data management and dissemination. BMC Bioinformatics (2005) 1.94
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore. Proc Natl Acad Sci U S A (2009) 1.82
Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans. Annu Rev Microbiol (2003) 1.57
Prevalence of malnutrition and nutritional risk factors in patients undergoing alcohol and drug treatment. Nutrition (2012) 1.48
YMDB: the Yeast Metabolome Database. Nucleic Acids Res (2011) 1.48
Active screening in high-risk units is an effective and cost-avoidant method to reduce the rate of methicillin-resistant Staphylococcus aureus infection in the hospital. Infect Control Hosp Epidemiol (2006) 1.48
Can thallium-pertechnetate subtraction scanning play a role in the preoperative imaging for minimally invasive parathyroidectomy? Clin Nucl Med (2004) 1.47
Environmental factors associated with the distribution of Anopheles gambiae s.s in Ghana; an important vector of lymphatic filariasis and malaria. PLoS One (2010) 1.46
Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase. Protein Sci (2008) 1.45
Unraveling the evolution of auxin signaling. Plant Physiol (2010) 1.41
Epidemiology of hookworm infection in Kintampo North Municipality, Ghana: patterns of malaria coinfection, anemia, and albendazole treatment failure. Am J Trop Med Hyg (2011) 1.40
In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent. BMC Microbiol (2009) 1.40
4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution. J Med Chem (2006) 1.39
ECMDB: the E. coli Metabolome Database. Nucleic Acids Res (2012) 1.38
Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA. Microb Drug Resist (2009) 1.35
MedlineR: an open source library in R for Medline literature data mining. Bioinformatics (2004) 1.29
SMPDB 2.0: big improvements to the Small Molecule Pathway Database. Nucleic Acids Res (2013) 1.29
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem (2013) 1.26
Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats. Arthritis Rheum (2003) 1.26
Radioguided parathyroidectomy via VATS combined with intraoperative parathyroid hormone testing: the surgical approach of choice for patients with mediastinal parathyroid adenomas? J Bone Miner Res (2002) 1.22
Treatment of periodontal disease by photodisinfection compared to scaling and root planing. J Clin Dent (2007) 1.21
Statistical analyses of complex denaturing gradient gel electrophoresis profiles. J Clin Microbiol (2005) 1.18
Oral bacteria in multi-species biofilms can be killed by red light in the presence of toluidine blue. Lasers Surg Med (2002) 1.18
Development of a novel targeting system for lethal photosensitization of antibiotic-resistant strains of Staphylococcus aureus. Antimicrob Agents Chemother (2005) 1.14
Oral health in children with chronic renal failure. Pediatr Nephrol (2002) 1.14
Design and implementation of a controlled clinical trial to evaluate the effectiveness and efficiency of routine opt-out rapid human immunodeficiency virus screening in the emergency department. Acad Emerg Med (2009) 1.13
A small-molecule inhibitor of MDMX activates p53 and induces apoptosis. Mol Cancer Ther (2010) 1.13
Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6. J Biol Chem (2010) 1.12
Cultivable oral microbiota of domestic dogs. J Clin Microbiol (2005) 1.11
Characterization of Tn916S, a Tn916-like element containing the tetracycline resistance determinant tet(S). J Bacteriol (2004) 1.11
Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-beta1 expression. Toxicol Appl Pharmacol (2009) 1.09
Effect of betulinic acid on anticancer drug-resistant colon cancer cells. Basic Clin Pharmacol Toxicol (2007) 1.07
Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG-tin (IV) chlorin e6 conjugate. J Antimicrob Chemother (2002) 1.06
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors. Anal Biochem (2006) 1.04
Pregabalin is a potent and selective ligand for α(2)δ-1 and α(2)δ-2 calcium channel subunits. Eur J Pharmacol (2011) 1.04
Actinobacillus actinomycetemcomitans. J Med Microbiol (2002) 1.03
Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449). J Med Chem (2011) 1.03
Prevalence of periodontal pathogens in dental plaque of children. J Clin Microbiol (2004) 1.02
HLA-DRB1*04 allele is associated with severe malaria in northern Ghana. Am J Trop Med Hyg (2008) 1.02
PI3K signaling in neutrophils. Curr Top Microbiol Immunol (2010) 1.02
Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel. Lab Chip (2009) 1.01
Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J Med Chem (2006) 1.00
A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia (2011) 1.00
Determining the antibiotic resistance potential of the indigenous oral microbiota of humans using a metagenomic approach. FEMS Microbiol Lett (2006) 0.99
Performance evaluation of commercial miRNA expression array platforms. BMC Res Notes (2010) 0.98
The role of surfaces in catheter-associated infections. Chem Soc Rev (2009) 0.98
The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor. Mol Cell Biol (2012) 0.98
Prevalence and identification of tetracycline-resistant oral bacteria in children not receiving antibiotic therapy. FEMS Microbiol Lett (2003) 0.98
Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. Mol Pharmacol (2010) 0.98
MDM2 mediates ubiquitination and degradation of activating transcription factor 3. J Biol Chem (2010) 0.97
The maintenance in the oral cavity of children of tetracycline-resistant bacteria and the genes encoding such resistance. J Antimicrob Chemother (2005) 0.97
The genetic and molecular basis of bicuspid aortic valve associated thoracic aortopathy: a link to phenotype heterogeneity. Ann Cardiothorac Surg (2013) 0.97
Increasing accessibility for community participants at academic conferences. Prog Community Health Partnersh (2008) 0.96
Community-based research in AIDS-service organizations: what helps and what doesn't? AIDS Care (2009) 0.95
Antibody-directed photodynamic therapy of methicillin resistant Staphylococcus aureus. Microb Drug Resist (2004) 0.95
The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins. J Biol Chem (2014) 0.94
The promise and pitfalls of mass drug administration to control intestinal helminth infections. Curr Opin Infect Dis (2012) 0.94
Intestinal absorption characteristics of ketoprofen in rats. Biopharm Drug Dispos (2006) 0.94
Plant and fungal food components with potential activity on the development of microbial oral diseases. J Biomed Biotechnol (2011) 0.94
Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. J Med Chem (2008) 0.94
Evaluation of ATP bioluminescence assays for potential use in a hospital setting. Infect Control Hosp Epidemiol (2011) 0.93
Bis-spirolabdane-type diterpenoids from Leonurus sibiricus. J Nat Prod (2010) 0.93
Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis. Arthritis Res Ther (2010) 0.93
An integrated suite of modeling tools that empower scientists in structure- and property-based drug design. J Comput Aided Mol Des (2015) 0.93
Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog. Acta Crystallogr D Biol Crystallogr (2010) 0.93
Trends in multiplicity of Plasmodium falciparum infections among asymptomatic residents in the middle belt of Ghana. Malar J (2013) 0.92
Global phenotype screening and transcript analysis outlines the inhibitory mode(s) of action of two amphibian-derived, alpha-helical, cationic peptides on Saccharomyces cerevisiae. Antimicrob Agents Chemother (2007) 0.92
Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res (2002) 0.92
Comparison of the interproximal plaque removal efficacy of two powered toothbrushes using in vitro oral biofilms. Am J Dent (2002) 0.91
Molecular identification of Capnocytophaga spp. via 16S rRNA PCR-restriction fragment length polymorphism analysis. J Clin Microbiol (2005) 0.91
Randomized controlled trial of toothbrushing to reduce ventilator-associated pneumonia pathogens and dental plaque in a critical care unit. J Clin Periodontol (2011) 0.91
Inhibition of cell proliferation and AP-1 activity by acrolein in human A549 lung adenocarcinoma cells due to thiol imbalance and covalent modifications. Chem Res Toxicol (2002) 0.90
Biofilm-specific surface properties and protein expression in oral Streptococcus sanguis. Arch Oral Biol (2004) 0.90
Phenomic and transcriptomic analyses reveal that autophagy plays a major role in desiccation tolerance in Saccharomyces cerevisiae. Mol Biosyst (2010) 0.90
Effect of silver content on the structure and antibacterial activity of silver-doped phosphate-based glasses. Antimicrob Agents Chemother (2007) 0.90
The catalytic machinery of a key enzyme in amino Acid biosynthesis. J Amino Acids (2010) 0.90
Particulate Bioglass reduces the viability of bacterial biofilms formed on its surface in an in vitro model. Clin Oral Implants Res (2002) 0.89
Emergency department profits are likely to continue as the Affordable Care Act expands coverage. Health Aff (Millwood) (2014) 0.89